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Propagating acoustic waves on a culture substrate regulate the directional collective cell migration

Microsystems & Nanoengineering 2021年第6期7卷 87-96页

作者： Chikahiro Imashiro Byungjun Kang Yunam lee Youn-Hoo Hwang Seonghun Im Dae-Eun Kim Kenjiro Takemura hyungsuk lee Institute of Advanced Biomedical Engineering and Science Tokyo Women’s Medical UniversityShinjukuJapan Department of Mechanical Engineering Keio UniversityYokohamaJapan School of Mechanical Engineering Yonsei UniversitySeoulKorea

Collective cell migration plays a critical role in physiological and pathological processes such as development,wound healing,and *** studies have demonstrated how various types of chemical,mechanical,and electrical cues dictate the collective migratory behaviors of *** an acoustic cue can be advantageous because of its noninvasiveness and biocompatibility,cell migration in response to acoustic stimulation remains poorly *** this study,we developed a device that is able to apply surface acoustic waves to a cell culture substrate and investigated the effect of propagating acoustic waves on collective cell *** migration distance estimated at various wave intensities revealed that unidirectional cell migration was enhanced at a critical wave intensity and that it was suppressed as the intensity was further *** increased migration might be attributable to cell orientation alignment along the direction of the propagating wave,as characterized by nucleus *** actin bundles indicative of a high traction force were observed in cells subjected to propagating acoustic waves at the critical *** device and technique can be useful for regulating cellular functions associated with cell migration.

关键词： healing collective stimulation

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Circulating immune cell landscape in patients who had mild ischaemic stroke

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Stroke & Vascular Neurology 2022年第4期7卷 319-327,I0020-I0022页

作者： Young-Eun Cho Hyangkyu lee Heekyong R.Bae hyungsuk Kim Sijung Yun Rany Vorn Ann Cashion Mary Jo Rucker Mariam Afzal Lawrence Latour Jessica Gill College of Nursing The University of IowaIowa CityIowaUSA National Institute of Nursing Research National Institutes of HealthBethesdaMarylandUSA Mo-Im Kim Nursing Research Institute College of NursingYonsei UniversitySeoulSouth Korea National Eye Institute National Institutes of HealthBethesdaMarylandUSA Predictiv Care IncSunnyvaleCaliforniaUSA School of Nursing Johns Hopkins UniversityBaltimoreMarylandUSA College of Nursing University of Tennessee Health Science CenterMemphisTennesseeUSA Suburban Hospital BethesdaMarylandUSA National Institute of Neurological Disorders and Stroke National Institutes of HealthBethesdaMarylandUSA

Introduction Patients who had a mild ischaemic stroke who present with subtle or resolving symptoms sometimes go undiagnosed,are excluded from treatment and in some cases clinically *** immune cells are potential biomarkers that can assist with diagnosis in ischaemic *** the transcriptomic changes of each cell population caused by ischaemic stroke is critical because they work closely in a complicated *** this study,we investigated peripheral blood mononuclear cells(PBMCs)transcriptomics of patients who had a stroke using a single-cell RNA sequencing to understand peripheral immune response after mild stroke based on the gene expression in an unbiased *** Transcriptomes of PBMCsfrom 10 patients who had an acute ischaemic stroke within 24 hours after stroke onset were compared with 9 race-matched/age-matched/gender-matched *** PBMCs were prepared with ddSeqTM(Illumina-BioRad)and sequenced on the Illumina NovaSeq 6000 *** Notable population changes were observed in patients who had a stroke,especially in NK cells and CD14+*** number of NK cells was increased,which was further confirmed by flow *** analysis implied that the activity of NK cells also is enhanced in patients who had a ***14+monocytes were clustered into two groups;dendritic cell-related CD14+monocytes and NK cell-related CD14+*** found CD14+monocyte subclusters were dramatically reduced in patients who had a *** This is the first study demonstrating the increased number of NK cells and new monocyte subclusters of mild ischaemic stroke based on the transcriptomic *** findings provide the dynamics of circulating immune response that could assist diagnosis and potential therapeutic development of mild ischaemic stroke.

关键词： patients diagnosis Circulating

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