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Energy & Environmental Materials 2024年第3期7卷 190-201页

作者： Sujeong Kim Boseok Seo Hyerim Park Younghwan Im Jeong Yeon Do Byung sub Kwak Namgyu Son Minkyu Kim Misook kang Department of Chemistry College of Natural SciencesYeungnam UniversityGyeongsan Gyeongbuk 38541Korea School of Chemical Engineering Yeungnam UniversityGyeongsan Gyeongbuk 38541Korea Department of Energy and Hydrocarbon Chemistry Graduate School of EngineeringKyoto UniversityKyoto 615-8510Japan Korea Evaluation Institute of Industrial Technology(Keit) Cheomdan-Ro 8-GilDong-GuDaegu 41069Korea Korea Electric Power Research Institute(KEPRI)105 Munji-ro Yooseong-guDaejeon 34056Korea

CuS is an encouraging photoelectrode candidate that meets the essential requirements for efficient solar-to-hydrogen production,but it has not been thoroughly studied.A CuS light absorber layer is grown by the self-assembly of copper and sulfur precursors on a carbon paper(CP)***,rGO is introduced as a buffer layer to control the optical and electrical properties of the *** well-ordered microstructural arrangement suppresses the recombination loss of electrons and holes owing to enhanced charge-carrier generation,separation,and *** potential reaching 10 mA cm^(-2)in 1.0 M KOH solution is significantly lowered to 0.87 V,and the photocurrent density at 1.23 V is 94.7 mA cm^(-2).The computational result reveals that the potential-determining step is sensitive to O^(*)stability;the lower stability of O^(*)in the thin layer of CuS/rGO decreases the free-energy gap between the initial and final states of the potential-determining step,resulting in a lowering of the onset *** faradaic efficiency for the photoelectrochemical oxygen evolution reaction in the optimized 2CuS/1rGO/CP photoanode is 98.60%,and the applied bias photon-to-current and the solar-to-hydrogen efficiencies are 11.2%and 15.7%,respectively,and its ultra-high performance is maintained for 250 *** record-breaking achievement indices may be a trigger for establishing a green hydrogen economy.

关键词： 15.7%-solar to hydrogen density functional theory lower photopotential p-CuS/rGO/CP photoanode photoelectrochemical oxygen evolution

Hepatoprotective effects of Nigella sativa seed extract against acetaminophen-induced oxidative stress

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 217-222页

作者： Gareeballa Osman Adam Md.Mahbubur Rahman Sei-Jin Lee Gi-Beum Kim hyung-sub kang Jin-Shang Kim Shang-Jin Kim Department of Veterinary Medicine and Surgery College of Veterinary Medicine.Sudan University of Science and Technology Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine.Chonbuk National University Korea Basic Science Institute Jeonju Center

Objective:To investigate the protective effects of Nigella sativa seed extract(NSSE) against acetaminophen(APAP)-induced hepaloloxicity in TIB-73 cells and ***:Toxicity in TIB-73 cells was induced with 10 μmol/L APAP and the protective effects of NSSE were evaluated at 25.50.75,100 μg/*** in rim examination,a total of 30 rals were equally divided into five experimental groups:normal control(vehicle),APAP(800 mg/kg body weight single IP injection) as a hepatotoxic control,and three APAP and NS pretreated(2 weeks) groups(APAP+NSSE 100 mg:APAP+NSSE 300 mg and APAP+NSSK 900 mg/kg).Results:TIB-73 cell viability was drastically decreased by(49.0±l.9)%after the 10 μmol/L APAP treatment,which also increased reactive oxygen species ***-treatment with NSSE at 25.50.75,and 100 μg/mL significantly improved cell viability and suppressed reactive oxygen species *** viro the APAP induced alterations in blood lactate levels,pH,anionic gap,and ion levels(HCO_3^-,Mg^(2+) and K^+),which tended to normalize with the NSSE *** NSSE also significantly decreased elevated serum levels of alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,and alkaline phosphatase induced by APAP,which correlated with decreased levels of hepatic lipid peroxidation(nialondialdehyde),increased superoxide dismutase levels,and reduced glutathione *** hepatic histology was also found in the treatment groups other than APAP ***:The in vitro and in vim findings of this study demonstrated that the NSSE has protective effects against APAP-induced hepalotoxicity and metabolic disturbances by improving antioxidant activities and suppressing both lipid peroxidation and ROS generation.

关键词： Nigella sativa Acetaminophen Antioxidants Oxidative stress TIB-73 cells Rat

Cellulose sub-nanometric ribbons:A new generation of nanocellulose and platform for biomaterials

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Journal of Bioresources and Bioproducts 2024年第1期9卷 1-2页

作者： Shaomin kang Yang Zhao Junlong Song Huining Xiao Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityNanjing 210037China Department of Chemical Engineering University of New BrunswickFredericton NB E3B 5A3Canada

With the tremendous progress of research in nanoscience,much attention has been paid to the bottom of the“nano world”:scales around one nanometer or even *** order to describe materials at this scale,a new concept c... 详细信息

关键词： biomaterials scales emerged

Extended wet sieving method for determination of complete particle size distribution of general soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 242-257页

作者： Shengnan Ma Yi Song Jiawei Liu Xingyu kang Zhongqi Quentin Yue Department of Civil Engineering The University of Hong KongHong KongChina

The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general *** paper extends the traditional method and presents an extended wet sieving *** extended method uses both the steel sieves and the nylon filter cloth *** apertures of the cloth sieves are smaller than 0.063 mm and equal 0.048 mm,0.038 mm,0.014 mm,0.012 mm,0.0063 mm,0.004 mm,0.003 mm,0.002 mm,and 0.001 mm,*** extended method uses five steps to separate the general soil into many material sub-groups of gravel,sand,silt and clay with known particle size *** complete PSD of the general soil is then calculated from the dry masses of the individual material *** extended method is demonstrated with a general soil of completely decomposed granite(CDG)in Hong Kong,*** silt and clay materials with different particle size ranges are further examined,checked and verified using stereomicroscopic observation,physical and chemical property *** results further confirm the correctness of the extended wet sieving method.

关键词： Particle size distribution(PSD) General soil Silt Clay Wet sieving Physical and chemical properties

Super-resolution imaging for in situ monitoring sub-cellular micro-dynamics of small molecule drug

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1864-1877页

作者： Huimin Chen Guiqian Fang Youxiao Ren Weiwei Zou kang Ying Zhiwei Yang Qixin Chen School of Pharmaceutical Sciences&Institute of Materia Medica Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi'an Jiaotong UniversityXi'an 710049China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Small molecule drugs play a pivotal role in the arsenal of anticancer pharmacological agents. Nonetheless, their small size poses a challenge when directly visualizing their localization, distribution, mechanism of action (MOA), and target engagement at the subcellular level in real time. We propose a strategy for developing triple-functioning drug beacons that seamlessly integrate therapeutically relevant bioactivity, precise subcellular localization, and direct visualization capabilities within a single molecular entity. As a proof of concept, we have meticulously designed and constructed a boronic acid fluorescence drug beacon using coumarin–hemicyanine (CHB). Our CHB design includes three pivotal features: a boronic acid moiety that binds both adenosine triphosphate (ATP) and adenosine diphosphate (ADP), thus depleting their levels and disrupting the energy supply within mitochondria;a positively charged component that targets the drug beacon to mitochondria;and a sizeable conjugated luminophore that emits fluorescence, facilitating the application of structured illumination microscopy (SIM). Our study indicates the exceptional responsiveness of our proof-of-concept drug beacon to ADP and ATP, its efficacy in inhibiting tumor growth, and its ability to facilitate the tracking of ADP and ATP distribution around the mitochondrial cristae. Furthermore, our investigation reveals that the micro-dynamics of CHB induce mitochondrial dysfunction by causing damage to the mitochondrial cristae and mitochondrial DNA. Altogether, our findings highlight the potential of SIM in conjunction with visual drug design as a potent tool for monitoring the in situ MOA of small molecule anticancer compounds. This approach represents a crucial advancement in addressing a current challenge within the field of small molecule drug discovery and validation.

关键词： Mitochondrial Drug beacon sub-cellular Small molecule Energy supply Anti-tumor

A Distributed Computing Algorithm for Electricity Carbon Emission Flow and Carbon Emission Intensity

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Protection and Control of Modern Power Systems 2024年第2期9卷 138-146页

作者： Xingping Wu Wei Yang Ning Zhang Chunlei Zhou Jinwei Song Chongqing kang Big Data Center of China Network Chinese Society of Electrical Engineering State Network Big Data Center Department of Electrical Engineering Tsinghua UniversityBeijingChina 不详 Big Data Center State Grid Corporation of ChinaBeijing 100052China Department of Electrical Engi-neering Tsinghua UniversityBeijingChina

The calculation of the indirect carbon emis-sion is essential for power system policy making,carbon market development,and power grid *** em-bedded carbon emissions of the electricity system are commonly calculated by carbon emission flow ***,the calculation procedure is time-consuming,especially for a country with 500-1000 thousand nodes,making it challenging to obtain nationwide carbon emis-sions intensity ***,the calculation procedure requires to gather all the grid data with high classified levels from different power grid companies,which can prevent data sharing and cooperation among different *** paper proposes a distributed computing algorithm for indirect carbon emission that can reduce the time consumption and provide privacy *** core idea is to utilize the sparsity of the nodes’flow matrix of the nationwide grid to partition the computing procedure into parallel sub-procedures exe-cuted in multiple *** flow and structure data of the regional grid are transformed irreversibly for pri-vacy protection,when transmitted between terminals.A 1-master-and-N-slave layout is adopted to verify the *** algorithm is suitable for large grid compa-nies with headquarter and branches in provinces,such as the State Grid Corporation of China.

关键词： Carbon emission flow cooperative computing carbon emission intensity matrix block par-tition power flow tracing parallel computing privacy protection

MoS_(x) nanowire networks derived from[Mo_(3)S_(13)]^(2−) clusters for efficient electrocatalytic hydrogen evolution

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Nano Research 2024年第8期17卷 6910-6915页

作者： Haoxuan Yu Junan Pan kang Chen Wang Chao Zechao Zhuang Sizhuo Feng Jianmei Chen Lingbin Xie Longlu Wang Qiang Zhao College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China Department of Chemical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology) Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China

Precise design and synthesis of sub-nano scale catalysts with controllable electronic and geometric structures are pivotal for enhancing the hydrogen evolution reaction(HER)performance of molybdenum sulfide(MoS_(2))and unraveling its structure−activity *** leveraging transition molybdenum polysulfide clusters as functional units for multi-level ordering,we successfully designed and synthesized MoS_(x)nanowire networks derived from[Mo_(3)S_(13)]^(2−) clusters via evaporationinduced self-assembly,which exhibit enhanced HER activity attributed to a high density of active sites and dynamic evolution behavior under cathodic ***_(x) nanowire networks electrode yields a current density of 100 mA·cm^(−2) at 142 mV in 0.5 M H_(2)SO_(4).This work provides an attractive prospect for optimizing catalysts at the sub-nano scale and offers insights into a strategy for designing catalysts in various gas evolution reactions.

关键词： MoS_(x) nanowire networks [Mo_(3)S_(13)]^(2−)clusters hydrogen evolution reaction(HER) sub-nano scale

The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses

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Virologica Sinica 2024年第4期39卷 609-618页

作者： Junsen Chen Junqing Sun Zepeng Xu Linjie Li Xinrui kang Chunliang Luo Qi Wang Xueyang Guo Yan Li Kefang Liu Ying Wu State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology Institute of Medical VirologyTaiKang Medical School(School of Basic Medical Sciences)Wuhan UniversityWuhan430071China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Beijing Life Science Academy Beijing102209China Faculty of Health Sciences University of MacaoMacaoSAR999078China

Foxes are susceptible to SARS-CoV-2 in laboratory settings,and there have also been reports of natural infections of both SARS-CoV and SARS-CoV-2 in *** this study,we assessed the binding capacities of fox ACE2 to important sarbecoviruses,including SARS-CoV,SARS-CoV-2,and animal-origin SARS-CoV-2 related *** findings demonstrated that fox ACE2 exhibits broad binding capabilities to receptor-binding domains(RBDs)of *** further determined the cryo-EM structures of fox ACE2 complexed with RBDs of SARS-CoV,SARS-CoV-2 prototype(PT),and Omicron *** structural analysis,we identified that the K417 mutation can weaken the ability of SARS-CoV-2 sub-variants to bind to fox ACE2,thereby reducing the susceptibility of foxes to SARS-CoV-2 *** addition,the Y498 residue in the SARS-CoV RBD plays a crucial role in forming a vital cation-πinteraction with K353 in the fox ACE2 *** interaction is the primary determinant for the higher affinity of the SARS-CoV RBD compared to that of the SARS-CoV-2 PT *** results indicate that foxes serve as potential hosts for numerous sarbecoviruses,highlighting the critical importance of surveillance efforts.

关键词： Sarbecoviruses SARS-CoV SARS-CoV-2 Fox ACE2 Omicron Cryo-EM structure

Superior mechanical properties and strengthening mechanisms of lightweight AlxCrNbVMo refractory high-entropy alloys(x=0,0.5,1.0)fabricated by the powder metallurgy process

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Journal of Materials Science & Technology 2021年第10期69卷 32-41页

作者： Byungchul kang Taeyeong Kong Ho Jin Ryu Soon hyung Hong Department of Material Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

Light and strong AlxCrNbVMo(x=0,0.5,and 1.0)refractory high-entropy alloys(RHEAs)were designed and fabricated via a the powder metallurgical *** microstructure of the AlxCrNbVMo alloys consisted of a single BCC crystalline structure with a sub-micron grain size of 2-3μm,and small amounts(<4 vol.%)of fine oxide *** homogeneous microstructure,without chemical segregation or micropores was achieved via high-energy ball milling and spark-plasma *** alloys exhibited superior mechanical properties at 25 and 1000℃compared to those of other ***,CrNbVMo alloy showed a yield strength of 2743 MPa at room ***,the yield strength of the CrNbVMo alloy at 1000℃was 1513 *** specific yield strength of the CrNbVMo alloy was increased by 27%and 87%at 25 and 1000℃,respectively,compared to the AlMo_(0.5) NbTa_(0.5)TiZr RHEA,which exhibited so far the highest specific yield strength among the cast *** addition of Al to CrNbVMo alloy was advantageous in reducing its reduce density to below 8.0 g/cm^(3),while the elastic modulus decreased due to the much lower elastic modulus of Al compared to that of the CrNbVMo *** analysis of the strengthening contributions,showed that the solid solution strengthening,arising from a large misfit effect due to the size and modulus,and the high shear modulus of matrix,was revealed to predominant strengthening mechanism,accounting for over 50%of the yield strength of the AlxCrNbVMo RHEAs.

关键词： High-entropy alloy Powder metallurgy Refractory Strengthening mechanisms Oxide dispersoids