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Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder

World Journal of Gastroenterology 2015年第1期21卷 269-275页

作者： Sung Pil Yun Nari Shin hyung il seo Department of Surgery Biomedical Research InstitutePusan National University HospitalBusan 602-739South Korea Department of Pathology Biomedical Research InstitutePusan National University HospitalBusan 602-739South Korea

AIM: To compare the demographics and survival rates between gallbladder adenocarcinoma(GB-adenocarcinoma) and small cell neuroendocrine carcinoma of the gallbladder(GB-NEC-SCC).METHODS: From March 2007 to September 2012,patients who underwent resection of tumor stage T2/T3 GB cancer were enrolled for this *** patients were included in this study,including 38 diagnosed with GB-adenocarcinoma and four diagnosed with *** the GB-adenocarcinoma group,a radical operation was performed in 28 patients,and ten patients underwent simple *** the GB-NEC-SCC group,a radical operation was performed in three patients,and one patient underwent simple *** analysis of the two groups was performed,including clinicopathologic features and survival ***: The median age of the patients was 68 y(range: 35-83 years) and females comprised 26/42 of the ***-adenocarcinoma patients were significantly older than GB-NEC-SCC patients(67.89 ± 11.15 vs 55.75 ± 10.31 years; P = 0.029).The median tumor size in GB-adenocarcinoma patients was 2.56 ± 1.75 cm and 3.98 ± 3.74 cm in GB-NEC-SCC patients; however,there was no significant difference between the two *** tumors > 2 cm,T stage(T2 vs T3),lymphovascular invasion,perineural invasion,lymph node metastasis and lymph node ratio showed no significant differences between the two *** overall survival rate of the 42 patients at five years was 77.0%.In the GB-adenocarcinoma group,the overall five-year survival rate was 74.8%,and survival in the GB-NEC-SCC group was 100%,which was not significantly different between the two ***: The strategy for treating patients with GB-NEC-SCC should be similar to that used for treating GB-adenocarcinoma,including radical cholecystectomy and liver resection.

关键词： Gallbladder adenocarcinoma Gallbladder cancer Radi

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Right trisegmentectomy with thoracoabdominal approach after transarterial embolization for giant hepatic hemangioma

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World Journal of Gastroenterology 2009年第27期15卷 3437-3439页

作者： hyung-il seo Hong Jae Jo Mun Sup Sim Suk Kim Department of Surgery Postgraduate School of Medicine and Medical Research Institute Pusan National UniversityBusan 602-739 South Korea Department of Radiology Postgraduate School of Medicine Pusan National UniversityBusan 602-739 South Korea

Hepatic hemangiomas need to be treated surgically in cases where they are accompanied with symptoms, have a risk of rupture, or are hardly distinguishable from malignancy. The present authors conducted embolization of the right hepatic artery one day before an operation for a huge hemangioma accompanied with symptoms and confirmed a decrease in its size. The authors performed a right trisegmentectomy through a J-shape incision, using a thoracoabdominal approach, and safely removed a giant hemangioma of 32.0 cm × 26.5 cm × 8.0 cm in size and 2300 g in weight. Even for inexperienced surgeons, a J-shape incision with a thoracoabdominal approach is considered a safe and useful method when right-side hepatectomy is required for a large mass in the right liver.

关键词： Hemangioma Transarterial embolization Thoracoabdominal approach

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Polysplenia syndrome with preduodenal portal vein detected in adults

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World Journal of Gastroenterology 2008年第41期14卷 6418-6420页

作者： hyung-il seo Tae Yong Jeon Mun Sup Sim Suk Kim Department of Surgery Postgraduate School of Medicine and Medical Research Institute Pusan National University Department of Radiology Postgraduate School of Medicine Pusan National University

Polysplenia syndrome, defined as the presence of multiple spleens of almost equal volume, is a rare condition involving congenital anomalies in multiple organ systems. We report this anomaly in a 41-year-old female who underwent a left lateral sectionectomy due to recurrent cholangitis and impacted left lateral duct stones. Polysplenia syndrome with preduodenal vein was diagnosed preoperatively by computed to-mography (CT) and surgery was done safely. Although the polysplenia syndrome with preduodenal portal vein (PDPV) in adult is rarely encountered, surgeons need to understand the course of the portal vein and exercise caution in approaching the biliary tract.

关键词： Polysplenia Polysplenia syndrome Preduodenal portal vein Intrahepatic duct stones Congenital anomaly

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Small-cell neuroendocrine carcinoma arising from an extra-hepatic bile duct:a case report

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Gastroenterology Report 2021年第4期9卷 380-382,I0003页

作者： Jae Ryong Shim Jae Ri Kim Youngmok Park hyung-il seo Division of HBP Surgery and Transplantation Pusan National University Yangsan HospitalYangsanKorea Department of Surgery Biomedical Research InstitutePusan National University HospitalGudeok-roSeoguBusanKorea

Introduction Neuroendocrine tumors(NETs)are neoplasms with variable malignant potential that may arise from neuroendocrine *** gastrointestinal tract is a common site for primary NETs and annually 1.3 for every 100,000 persons are newly detected[1,2].Although gastrointestinal NETs are common in the small bowel,appendix,rectum,and stomach,those that arise from the extra-hepatic bile duct are extremely rare(0.1%–0.4%)[3-5].

关键词：肝外胆管小细胞神经内分泌癌 neoplasms 病例报告

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Comparative analysis of radiofrequency ablation and resection for resectable colorectal liver metastases

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World Journal of Gastroenterology 2014年第2期20卷 525-531页

作者： Sanghwa Ko Hongjae Jo seongpil Yun Eunyoung Park Suk Kim hyung-il seo Department of Surgery Biomedical Research InstitutePusan National University HospitalBusan 602-739South Korea Department of Radiology Biomedical Research InstitutePusan National UniversityBusan 602-739South Korea

AIM:To evaluate the therapeutic efficacy of radiofrequency ablation(RFA)for resectable colorectal liver metastases(CRLM)compared with that of ***:Between June 2004 and June 2009,we retrospectively analyzed 29 patients with resectable CRLMs;17 patients underwent RFA,and 12 underwent hepatic *** of the patients were informed about the treatment modalities and were allowed to choose either of *** including an intraoperative approach was performed by a radiologist;otherwise,hepatic resection was performed by a *** analysis of the two groups was performed,including comparisons of gender,age,and clinical outcomes,such as primary tumor stage and survival ***:The mean tumor size was significantly larger in the resection group(3.59 cm vs 2.02 cm,P*** 5-year disease-free survival(DFS)rates were17.6%and 22.2%in the RFA and resection groups,respectively(P=0.119).Univariate analysis revealed that in cases of male gender,age>65 years,T stage3 cm,RFA resulted in significantly inferior 5-year DFS rates compared with surgical ***:Surgical resection revealed superior outcomes in the treatment of resectable CRLMs,particularly in cases with a hepatic tumor size>3 cm.

关键词： Colorectal neoplasm Metastasis Radiofrequency Hepatectomy Survival

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Multimodal treatments of right gastroepiploic arterial leiomyosarcoma with hepatic metastasis:A case report and review of the literature

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World Journal of Clinical Cases 2018年第8期6卷 219-223页

作者： hyung-il seo Dong-il Kim Youngsoo Chung Chang In Choi Minjoo Kim Sungpil Yun Suk Kim Do Youn Park Department of Surgery Biomedical Research InstitutePusan National University Hospital Department of Surgery Pusan National University Yangsan Hospital Department of Surgery On Hospital Department of Radiology Biomedical Research Institute Pusan National University Hospital Department of Pathology Biomedical Research Institute Pusan National University Hospital

Leiomyosarcoma of an artery is very rare, and cases with hepatic metastasis are even rarer. We describe a case of a 70-year-old man who after follow up due to rectal cancer, presented with an intra-abdominal hypervascular mass and a hepatic mass. After surgical resection, it was diagnosed as a leiomyosarcoma of the right gastroepiploic artery with hepatic metastasis. Multiple metastases had recurred at the liver. He has survived more than 53 mo through multimodal treatments(three surgical resections, radiofrequency ablation, transarterial chemoembolization, chemotherapies, and targeted therapy). Multimodal treatments, including active surgical resection, may behelpful in the treatment of aggressive diseases such as arterial leiomyosarcoma with metastasis.

关键词： Multimodal treatments Intra-abdominal arterial leiomyosarcoma Hepatic metastasis Arterial leiomyosarcoma Surgical resection

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Complete resection of large-cell neuroendocrine and hepatocellular carcinoma of the liver: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8277-8283页

作者： Byeong Gwan Noh hyung-il seo Young Mok Park Suk Kim Seung Baek Hong So Jeong Lee Division of HBP Surgery and Transplantation Department of SurgeryPusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Combined tumors comprising large-cell neuroendocrine carcinoma and hepatocellular carcinoma have been rarely reported in the *** SUMMARY We report a case of a 73-year-old woman with chronic hepatitis B suspected to have a malignant hepatic mass(segment 3;size,4.5 cm)and lymph node metastasis based on computed tomography and magnetic resonance *** being Child-Pugh class A,esophageal varices were *** underwent left lateral sectionectomy and lymph node *** examination revealed a collision tumor consisting of large-cell neuroendocrine(90%)and hepatocellular(10%)*** combined carcinoma had metastasized to one of the three lymph nodes *** patient recovered without any postoperative complications and was discharged in good condition on postoperative day *** chemotherapy was not *** recurrence occurred during a follow-up period of 24 *** To improve the therapeutic management of combined tumors in the liver,it is necessary to discuss each clinical experience and consider an appropriate method for the preoperative diagnosis and treatment.

关键词： Hepatocellular carcinoma Neuroendocrine carcinoma Chronic hepatitis B Case report

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Comparison of gemcitabine plus nab-paclitaxel and FOLFIRINOX in metastatic pancreatic cancer

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World Journal of Clinical Cases 2020年第17期8卷 3718-3729页

作者： Sung Yong Han Dong Uk Kim Young Mi seol Suk Kim Nam Kyung Lee Seung Baek Hong hyung-il seo Department of Internal Medicine and Biomedical Research Institute Division of GastroenterologyPusan National University HospitalBusan 49241South Korea Department of Hematology-Oncology Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Surgery Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Gemcitabine plus nab-paclitaxel(GA)and modified FOLFIRINOX(FFX)have been widely used as standard first-line treatment in pancreatic ***,it is unclear which regimen is more *** To evaluate a retrospective analysis comparing the efficacy and safety of FFX and GA as first-line chemotherapeutic regimens in patients with metastatic pancreatic *** We retrospectively analyzed and compared outcomes in 101 patients who presented with pancreatic cancer and were treated with either GA(n=54)or FFX(n=47).Moreover,we performed subgroup analysis based on the neutrophil/lymphocyte ratio(NLR)and Eastern Cooperative Oncology Group(ECOG)performance *** There were no significant differences between two groups in baseline characteristics,except for the ECOG performance *** median progression-free survival(PFS)(6.43 mo vs 4.90 mo,P=0.058)was comparable between two groups;however,median overall survival(OS)(10.17 mo vs 6.93 mo,P=0.008)was longer in patients who received GA *** patients with ECOG 0(PFS:8.93 mo vs 5.43 mo,P=0.002;OS:16.10 mo vs 6.97 mo,P=0.000)and those with NLR<3(PFS:8.10 mo vs 6.57 mo,P=0.008;OS:12.87 mo vs 9.93 mo,P=0.002),GA regimen showed higher *** GA regimen may be recommended to the patients with NLR<3 or ECOG 0 status although GA and FFX showed comparable efficacy outcomes in patients with metastatic pancreatic cancer.

关键词： Metastatic pancreatic carcinoma Chemotherapy FOLFIRINOX Nabpaclitaxel plus gemcitabine Predict marker Adverse event

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First-line chemotherapy in very elderly patients with metastatic pancreatic cancer:Gemcitabine monotherapy vs combination chemotherapy

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World Journal of Clinical Cases 2020年第18期8卷 4022-4033页

作者： Sung Yong Han Dong Uk Kim Young Mi seol Suk Kim Nam Kyung Lee Seung Baek Hong hyung-il seo Department of Internal Medicine and Biomedical Research Institute Division of GastroenterologyPusan National University HospitalBusan 49241South Korea Department of Internal Medicine and Biomedical Research Institute Division of Hematology-OncologyPusan National University HospitalBusan 49241South Korea Department of Radiology Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Surgery Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Combination chemotherapy(gemcitabine plus nab-paclitaxel and FOLFIRINOX)is widely used as the standard first-line treatment for pancreatic *** the severe toxicities of combination chemotherapy,gemcitabine monotherapy(G mono)could be used as a first-line treatment in very elderly patients or those with a low Eastern Cooperative Oncology Group ***,reports on the efficacy of G mono in patients older than 75 years are *** To evaluate the efficacy of G mono and combination chemotherapy by comparing their clinical outcomes in very elderly patients with pancreatic *** We retrospectively analyzed 104 older patients with pancreatic cancer who underwent chemotherapy with G mono(n=45)or combination therapy(n=59)as a first-line treatment between 2011 and *** patients were histologically diagnosed with ductal *** outcomes were progression-free survival and overall *** also analyzed subgroups according to age[65-74 years(elderly)and≥75 years(very elderly)].Propensity score matching was performed to compare the outcomes between the two chemotherapy *** The baseline characteristics were significantly different between the two chemotherapy groups,especially regarding age,ratio of multiple metastases,tumor burden,and Eastern Cooperative Oncology Group performance *** propensity score matching,the baseline characteristics were not significantly different between the chemotherapy groups in elderly and very elderly *** the elderly patients,the median progression-free survival(62 d vs 206 d,P=0.000)and overall survival(102 d vs 302 d,P=0.000)were longer in the combination chemotherapy ***,in the very elderly patients,the median progression-free survival(147 d and 174 d,respectively,P=0.796)and overall survival(227 d and 211 d,respectively,P=0.739)were comparable between the G mono and combination chemotherapy *** events occurred more frequently in the c

关键词： Combination chemotherapy Gemcitabine Pancreatic cancer Elderly Ductal carcinoma Adverse drug event

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Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging

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World Journal of Gastroenterology 2012年第31期18卷 4102-4117页

作者： Nam Kyung Lee Suk Kim Gwang Ha Kim Dong Uk Kim hyung il seo Tae Un Kim Dae Hwan Kang Ho Jin Jang Department of Radiology Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Internal Medicine Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Surgery Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 602-739South Korea Department of Radiology Yangsan Pusan National University HospitalSchool of MedicinePusan National UniversityYangsan 626-770South Korea Department of Internal Medicine Yangsan Pusan National University HospitalSchool of MedicinePusan National UniversityYangsan 626-770South Korea Department of Obstetrics and Gynecology Armed Forces Seoul HospitalSeoul 110-200South Korea

Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute *** for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the ***,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and *** previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic *** further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion *** detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance ***,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients.

关键词： Magnetic resonance imaging Diffusion-weighted imaging Biliary tract Gallbladder Pancreas

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