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Clinical usefulness of ankle brachial index and brachial-ankle pulse wave velocity in patients with ischemic stroke

The Journal of Biomedical Research 2016年第4期30卷 285-291页

作者： hyung-suk lee Hye Lim lee Ho-seong Han Minju Yeo Ji Seon Kim Sung-Hyun lee Sang-Soo lee Dong-Ick Shin Department of Neurology Yuseong Sun General Hospital Daejeon 34084 Korea Department of Neurology Chungbuk National University College of Medicine Chungbuk National University Hospital Cheongju 28644 Korea

Ankle brachial index （ABI） and brachial-ankle pulse wave velocity （baPWV） are widely used noninvasive modalities to evaluate atherosclerosis. Recently, evidence has increased supporting the use of ABI and baPWV as markers of cerebrovascular disease. This study sought to examine the relationship between ABI and baPWV with ischemic stroke. This study also aimed to determine which pathogenic mechanism, large artery disease （LAD） or small vessel disease （SVD）, is related to ABI or baPWV. Retrospectively, 121 patients with ischemic stroke and 38 subjects with no obvious ischemic stroke history were recruited. First, ABI and baPWV were compared between the groups. Then, within the stroke group, the relevance of ABI and baPWV with regard to SVD and LAD, which were classified by brain magnetic resonance image （MRI） and magnetic resonance angiography （MRA） or computed tomography angiography （CTA） findings, was assessed. The baPWV was higher in the stroke group than non-stroke group （1,944.18±416.6 cm/s vs. 1,749.76±669.6 crn/s, P 〈 0.01）. Regarding LAD, we found that mean ABI value was lower in the group with extracranial large artery stenosis （P 〈 0.01）, and there was an inverse linear correlation between ABI and the grade of extracranial large artery stenosis （P〈 0.01）. For SVD, there was a significant correlation between SVD and baPWV （2,057.6±456.57 cm/s in the SVD （＋） group vs. 1,491±271.62 cm/s in the SVD （-） group; P 〈 0.01）. However, the grade of abnormalities detected in SVD did not correlate linearly with baPWV. These findings show that baPWV is a reliable surrogate marker ofischemic stroke. Furthermore, baPWVand ABI can be used to indicate the presence of small vessel disease and large arterial disease, respectively.

关键词： ABI baPWV small vessel disease intracranial artery stenosis extracranial artery stenosis

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee lee Kyoungho suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Fabrication and Characterization of Electrodeposited Ni-SiC-h/BN Composite Coatings

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Journal of Materials Science & Technology 2014年第8期30卷 796-802页

作者： Gobinda Gyawali hyung-suk Kim Khagendra Tripathi Tae-Ho Kim Soo Wohn lee Research Center for Eco-Multifunctional Nano Materials Sun Moon UniversityAsanRepublic of Korea Department of Environmental Engineering Sun Moon UniversityChungnam 336-708Republic of Korea

Ni—SiC—h/BN composite materials were prepared by electrodeposition technique with the dispersion of SiC（10 g/L） and h/BN nanosheets（10 g/L） in a nickel sulfamate electrolytic *** ratio of sodium dodecyl sulfate（SDS） and cetyltrymethyl ammonium bromide（CTAB） surfactants were used to evaluate the effect of surfactants on the properties of the electrodeposited composite *** coating samples were characterized by scanning electron microscopy,X-ray diffraction,Vickers microhardness test,scratch and tribology *** results revealed that the co-deposition of nanoparticles was significantly influenced by surfactants during electrodeposition *** or polyhedral nickel crystallites were observed at higher ratio of SDS/CTAB while smaller oval grains with refined surface morphologies were obtained at lower ratio of SDS/CTAB *** addition,wt%of particles co-deposition was increased,and Vickers microhardness,wear and coefficient of friction of the electrodeposited composite coatings were improved at increased CTAB and decreased SDS contents in the electrolyte during electrodeposition process.

关键词： Ni-SiC-h/BN Composite coating Surfactant Microstructure Scratch Wear

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Postoperative adjuvant chemoradiotherapy in D2-dissected gastric cancer: Is radiotherapy necessary after D2-dissection?

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World Journal of Gastroenterology 2014年第36期20卷 12900-12907页

作者： Jee suk Chang Woong Sub Koom Youngin lee Hong In Yoon hyung Sik lee Department of Radiation Oncology Yonsei University College of Medicine Seoul 120-752 South Korea Department of Radiation Oncology Dong-A University Hospital Busan 602-715 South Korea

Studies from the Far East have demonstrated that D2-dissection is superior to D0/1-dissection. The effect of postoperative chemoradiotherapy(CRT) after D2-dissection has not been accepted due to the lack of D2-dissection in Western countries, as well as the potential harmful effect of radiotherapy. In the current NCCN guideline, adjuvant chemotherapy alone is recommended in D2-dissected patients. However, three recent prospective randomized controlled trials in South Korea and China(ARTIST, NCC and Multicenter IMRT Trials) demonstrated that adjuvant CRT can be safely administered to D2-dissected patients with notable benefits. To identify the role of radiotherapy(RT) in the D2-dissected postoperative setting, clinical research attempts should include(1) identification of high-risk patients for loco-regional recurrence who might benefit from CRT;(2) modification of RT target volume based on the findings that failure patterns should be different after D1- and D2-dissection; and(3) integration of new RT techniques to decrease treatment-related toxicity. The present paper is a review of recent studies addressing these fields. Well-designed prospective randomized studies are needed to clearly define the role of adjuvant CRT in D2-dissected gastric cancer, however, future clinical studies should also focus on answering these questions.

关键词： Gastric cancer D2-dissection Recurrence Radiotherapy Chemotherapy

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SUBic:A Scalable Unsupervised Framework for Discovering High Quality Biclusters

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Journal of Computer Science & Technology 2013年第4期28卷 636-646页

作者： Jooil lee Yanhua Jin Won suk lee Department of Computer Science Yonsei University

A biclustering algorithm extends conventional clustering techniques to extract all of the meaningful subgroups of genes and conditions in the expression matrix of a microarray dataset. However, such algorithms are very sensitive to input parameters and show poor scalability. This paper proposes a scalable unsupervised biclustering framework, SUBic, to find high quality constant-row biclusters in an expression matrix effectively. A one-dimensional clustering algorithm is proposed to partition the attributes, that is, columns of an expression matrix into disjoint groups based on the similarity of expression values. These groups form a set of short transactions and are used to discover a set of frequent itemsets each of which corresponds to a bicluster. However, a bicluster may include any attribute whose expression value is not similar enough to others, so a bicluster refinement is used to enhance the quality of a bicluster by removing those attributes based on its distribution of expression values. The performance of the proposed method is comparatively analyzed through a series of experiments on synthetic and real datasets.

关键词： biclustering clustering expression matrix frequent itemset sub-matrix

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Study on wear behavior of plasma electrolytic oxidation coatings on aluminum alloy

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Rare Metals 2006年第z2期25卷 141-145页

作者： KANG suk-Bong lee Jung-Moo Department of Materials Engineering Korean Institute of Machinery & Materials Gyeongnam 641831 Korea

Thick and hard ceramic coatings were fabricated on A356 aluminum alloy by using plasma electrolytic oxidation(PEO) technique. The microstructure and phase composition of the PEO coatings were examined by using SEM and XRD method. It is found that the PEO coatings are mainly composed of crystalline α-Al2O3 and mullite. The dry sliding wear test of PEO coatings were carried out on a ring-on-ring wear machine. Results shows that there is hardly no wear loss of polished PEO coatings while the wear rate of uncoated aluminum alloy is 4.3×10-5 mm3·(N·m)-1 at a speed of 0.52 m·s-1 and a load of 40 N.

关键词： aluminum alloy plasma electrolytic oxidation ceramic coating wear

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Complete resection of large-cell neuroendocrine and hepatocellular carcinoma of the liver: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8277-8283页

作者： Byeong Gwan Noh hyung-Il Seo Young Mok Park suk Kim Seung Baek Hong So Jeong lee Division of HBP Surgery and Transplantation Department of SurgeryPusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Combined tumors comprising large-cell neuroendocrine carcinoma and hepatocellular carcinoma have been rarely reported in the *** SUMMARY We report a case of a 73-year-old woman with chronic hepatitis B suspected to have a malignant hepatic mass(segment 3;size,4.5 cm)and lymph node metastasis based on computed tomography and magnetic resonance *** being Child-Pugh class A,esophageal varices were *** underwent left lateral sectionectomy and lymph node *** examination revealed a collision tumor consisting of large-cell neuroendocrine(90%)and hepatocellular(10%)*** combined carcinoma had metastasized to one of the three lymph nodes *** patient recovered without any postoperative complications and was discharged in good condition on postoperative day *** chemotherapy was not *** recurrence occurred during a follow-up period of 24 *** To improve the therapeutic management of combined tumors in the liver,it is necessary to discuss each clinical experience and consider an appropriate method for the preoperative diagnosis and treatment.

关键词： Hepatocellular carcinoma Neuroendocrine carcinoma Chronic hepatitis B Case report

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Effect of Fe_2P in LiFePO_4/Fe_2P composite on electrochemical properties synthesized by MA and control of heat condition

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Rare Metals 2006年第z2期25卷 179-183页

作者： PARK Jong suk lee Kyung Tae lee Kyung Sub Department of Material Science and Engineering Hanyang University Seoul 133-731 Korea

In order to control the size and distribution of the high conductive Fe2P in LiFePO4/Fe2P composite, two different cooling rates (Fast: 15 ℃·min-1, Slow: 2 ℃·min-1) were employed after mechanical alloying. The discharge capacity of the fast cooled was 83 mAh·g-1 and the slow cooled 121 mAh·g-1. The particle size of the synthesized powder was examined by transmission electron microscopy and distribution of Fe2P was characterized using scanning electron microscopy (SEM). In addition, two-step heat treatment was carried out for better distribution of Fe2P. X-ray diffraction (XRD) and Rietveld refinement reveal that LiFePO4/Fe2P composite consists of 95.77% LiFePO4 and 4.33% of Fe2P.

关键词： LiFePO4/Fe2P composite mechanical alloying heat treatment discharge capacity

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Late Quaternary Paleoclimatic Change in the Ulleung Basin,East Sea,Korea

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Acta Geologica Sinica(English Edition) 2017年第1期91卷 263-269页

作者： Young-suk BAK Young-Up lee The Earth and Environmental System Research Center Chonbuk National University Jeonju 54896 South Korea

Paleoclimatic changes in the late Quaternary sediments deposited in the East Sea were analyzed by studying diatoms. A total of 95 species belonging to 47 genera were identified from the Core02GHP-02 of the Ulleung Basin in the East Sea, Korea. In the Core 02GHP-02, U-Oki（169–181 cm; 9.3 ka）, AT（464–465.5 cm; 22 ka） and U–Ym（556–559 cm; 33 ka） tephra layers were recognized. The chronological divisions of 02GHP-02 may be correlated with the climatic changes from the glacial interval（730–620 cm; MIS3）, to interstadial（620–500 cm; MIS3）, to the last glacial maximum（500–390 cm; MIS 2）, to the deglaciation（390–290 cm; MIS 2）, to the late glacial（290–190 cm; MIS 1）, and to the Holocene（190–10 cm; MIS 1）. It is speculated that diatoms were rarely found during the glacial interval when the 02GHP-02 core was deposited; during the interstadial（MIS 3） and deglaciation, a mixture of warm-water and cold-water species were found. In particular, Fragilariopsis doliolus seems to have appeared in the East Sea after 8 ka BP. In the lower layers of the Holocene deposits, cold-water species such as Neodenticula seminae were frequently found, while in the upper layers, warm-water species such as Hemidiscus cuneiformis were found in relatively large abundance. Therefore, the findings indicate that the climate became warmer during the transition from the lower layer to the upper layer of the Holocene deposits.

关键词： diatoms paleoclimatic change late Quaternary glacial interval MIS

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