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World Journal of Gastroenterology 2014年第25期20卷 8221-8228页

作者： Jong Hwan choi Jae Hyuk choi Yoo Jin Lee hyung ki Lee Wang Yong choi Eun Soo kim Kyung Sik Park Kwang Bum Cho Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang Division of Gastroenterology and Hepatology Department of Internal Medicine Keimyung University School of MedicineDaegu 700-712South Korea

AIM: To compare outcomes using the novel portable endoscopy with that of nasogastric (NG) aspiration in patients with gastrointestinal bleeding.

关键词： Endoscopy Gastrointestinal bleeding Nasogastric aspiration

Marine ciliate community in relation to eutrophication of coastal waters in the Yellow Sea

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Chinese Journal of Oceanology and Limnology 2011年第1期29卷 118-127页

作者：徐奎栋 choi Joong ki 类彦立 YANG Eun Jin Institute of Oceanology Chinese Academy of Sciences Department of Oceanography Inha University Korea Polar Research Institute

We assessed the potential of marine ciliate community as an indicator to coastal water quality using water samples collected from four stations in thc Yellow Sea in the summer 2000. The four stations were characterized by different levels of pollution. The ciliate communities consisted primarily of tintinnids and aloricate ciliates that were 〈30 um. A total of 78 species were classified： 55 species at Station 2, 51 species each at Stations l and 4, and 47 species at Station 3. The mean number of species at each site was 29.2±2.0 （Station 1）, 28.5±2.9 （Station 2）, 27.8±1.7 （Station 3）, and 24.5±2.3 （Station 4）. The abundance was highly variable： 19 331±11 187 ind./L at Station 1, 7 960±5 639 ind./L at Station 2, 29 015±12 999 ind./L at Station 3, and 8 190±4 658 ind./L at Station 4. Our results suggest that neither the simple chemical analysis （e.g. chemical oxygen demand, dissolved inorganic nitrogen, and phosphate） nor the eutrophication/pollution index adequately described the water quality at the four stations. The same was true of the number of species and their abundance, both of which had no correlation with the chemical indices. In contrast, Margalef＇s diversity index values （3.12 at Station 2, 2.89 at Station 1, and 2.64 at Stations 3 and 4） generally discriminated the water quality status of the four stations. The difference in water quality among the stations was strongly supported by the pattern of species richness （i.e. the total number of species） of ciliates at each station. Our evaluation was consistent with the results of long-term water quality monitoring at the four stations. With increasing eutrophication, we observed also a compositional and functional shift in the ciliate assemblages from algivorous oligotrich/choreotrich to nonselective-omnivorous gymnostomatids to bacterivorous-detrivorous scuticociliatids. Thus, eiliates may be used to indicate the coastal water quality status of a given site.

关键词： biomonitoring chemical evaluation ciliates community structure eutrophication marine pollution

Cluster Analysis of Tropical Cyclones Making Landfall on the Korean Peninsula

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Advances in Atmospheric Sciences 2009年第2期26卷 202-210页

作者： ki-Seon choi Baek-Jo kiM Chee-Young choi Jae-Cheol NAM National Institute of Meteorological Research Seoul Republic of Korea Korea Meteorological Administration Seoul Republic of Korea

Cluster analysis has been performed on the tracks of 51 Tropical Cyclones （TCs） that made landfall on the Korean Peninsula （KP） for the period of 1951-2004. The classification technique of the landfalling tracks used in this study was the fuzzy clustering method （FCM） and the resultant silhouette coefficient suggested four clusters as an optimal cluster number. Most TCs of Cluster 2 and Cluster 3 （C-23） tended to pass through China's Mainland before landfall, but those of Cluster 1 and Cluster 4 （C-14） tended to mostly land after moving northward from the East China Sea （ECS） without passing over China's Mainland. The TC landfalling frequency of C-14 has begun to clearly increase since the late 1980s, particularly the maximum landfalling frequency in the early 2000s set a record for the 54-year analysis period. The ridge axis of the western North Pacific high （WNPH） of C-23 bends more equatorward than that of C-14, so that the monsoon trough of C-23 is located more equatorward than that of C-14. As a consequence, most TCs of C-23 tend to recurve inland of China, but over the ECS for C-14.

关键词： Korean Peninsula tropical cyclone landfall fuzzy cluster Arctic Oscillation Nino-3.4

阴茎假体植入术治疗勃起功能障碍548例分析

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中华泌尿外科杂志 2000年第12期21卷 755-757页

作者：辛钟成郭应禄 choi hyung ki 北京大学第一医院，100034 韩国Yonse大学

目的　了解阴茎假体植入术的手术合并症和机械信赖性 ,分析植入各种假体治疗阴茎勃起功能障碍患者的远期效果。　方法　利用随访调查表对 5 48例假体植入术后患者进行随访调查。　结果　 5 48例患者中 ,植入单件套可屈性假体 2 2 8例 (4... 详细信息

目的　了解阴茎假体植入术的手术合并症和机械信赖性 ,分析植入各种假体治疗阴茎勃起功能障碍患者的远期效果。　方法　利用随访调查表对 5 48例假体植入术后患者进行随访调查。　结果　 5 48例患者中 ,植入单件套可屈性假体 2 2 8例 (4 1.6 % ) ,单件套膨胀性假体 45例 (8.2 % ) ,三件套膨胀性假体 2 73例 (5 0 .2 % )。阴茎假体植入术后合并症发生率为 5 .1% (2 8/ 5 48) ,包括非机械性合并症 8例 (1.5 % ) ,机械性合并症 2 0例 (3 .6 % )。AMSMalleable 6 0 0可屈性假体和AMS70 0CXM三件套膨胀性假体的机械性合并症发生率分别为 1.3 % (3/ 2 2 8)和 5 .5 % (15 / 2 73) ,AMS70 0CXM三件套膨胀性假体的圆柱体泄漏 10例 ,占 3 .7% (10 / 2 73)。结论　AMS 70 0CXM三件套膨胀性假体的机械性能和隐蔽性有了显著提高。

关键词：阳萎勃起功能障碍阴茎假体植入术治疗

Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

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Bioactive Materials 2022年第8期7卷 182-205页

作者： Hwa Seung Han Song Yi Koo ki Young choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health ***,they are a significant resource for drug discovery in the development of modern *** many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to *** have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of *** review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and *** review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic ***,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound Nanoformulation Drug delivery Phototherapy

Development of genome engineering technologies in cattle: from random to specific

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Journal of Animal Science and Biotechnology 2018年第2期9卷 285-293页

作者： Soo-Young Yum ki-Young Youn Woo-Jae choi Goo Jang Department of Veterinary Clinical Science College of Veterinary Medicine and the Research Institute of Veterinary Science Seoul National University Farm Animal Clinical Training and Research Center Institute of Green Bio Science Technology Seoul National University Emergence Center for Food-Medicine Personalized Therapy System Advanced Institutes of Convergence Technology Seoul National University College of Veterinary Medicine Seoul National University

The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the ***, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle.

关键词： Cattle CRISPR-Cas9 Genome engineering technologies Transgenesis Transposon

Synergistic passivation of MAPbI_(3) perovskite solar cells by compositional engineering using acetamidinium bromide additives

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Journal of Energy Chemistry 2021年第8期30卷 755-762,I0016页

作者： Kyungeun Jung Weon-Sik Chae Jae Won choi ki Chul kim Man-Jong Lee Department of Chemistry Konkuk University143-701 SeoulSouth Korea Department of Advanced Technology Fusion Konkuk University143-701 SeoulSouth Korea Analysis Research Division Daegu CenterKorea Basic Science Institute702-701 DaeguSouth Korea Division of Chemical Engineering Konkuk University05029 SeoulSouth Korea

For the global commercialization of highly efficient and stable perovskite solar cells(PSCs),it is necessary to effectively suppress the formation of various defects acting as nonradiative recombination sources in perovskite light-harvesting *** defects between the charge-selective layer and the perovskite are easily formed in the solution process used to fabricate perovskite *** addition,owing to the difference in thermal expansion coefficients between the substrate and the perovskite film,internal residual tensile stress inevitably occurs,resulting in increased nonradiative ***,a simple compositional engineering scheme for realizing efficient and stable PSCs,which incorporates acetamidinium bromide(AABr)as an additive into the MAPbI_(3) lattice,is *** an additive,AABr has been found to provide synergistic multiple passivation for both internal and interfacial *** was found to effectively release the tensile strain of the MAPbI_(3) film by forming a structure stabilized by NH-I hydrogen bonds,as evidenced by calculations based on density functional theory(DFT).Furthermore,the incorporated AABr additives created a charge carrier recombination barrier to enhance charge collection capability by reducing interfacial ***,a power conversion efficiency(PCE)of 20.18%was achieved using a planar device employing AABr-incorporated MAPbI_(3).This was substantially higher than the 18.32% PCE of a pristine MAPbI_(3)-based ***,unencapsulated PSCs using AABr-incorporated MAPbI_(3) absorbers exhibited excellent long-term stability,maintaining>95% of initial PCE up to 1200 hours in ambient air.

关键词： Acetamidinium bromide Planar perovskite solar cell Tensile stress Interface passivation Recombination barrier

A Novel Technique of Measuring SOA Differential Carrier Lifetime and a -Factor Using SOA Optical Modulation Response

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光学学报 2003年第S1期23卷 503-504页

作者： ki-Hyuk Lee Woo-Young choi Department of Electrical and Electronic Engineering Yonsei University Seoul KoreaDepartment of Electrical and Electronic Engineering Yonsei University Seoul Korea

We demonstrate a new technique of measuring differential carrier lifetime and linewidth enhancement factor in a semiconductor optical amplifier. In our method, the optical responses and fiber transfer functions of a self-gain modulated SOA are measured and, from these, values of carrier lifetimes and linewidth enhancement factors are determined for various SOA input optical powers.

关键词： SOA in as A Novel Technique of Measuring SOA Differential Carrier Lifetime and a Factor Using SOA Optical Modulation Response of

Morbidity analysis of left hepatic trisectionectomy for hepatobiliary disease and live donor

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 362-369页

作者： Young-In Yoon Sung-Gyu Lee Deok-Bog Moon Shin Hwang ki-Hun kim Hui-Ju kim ki-Hoon choi Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine388-1 Poongnap-dongSongpa-guSeoul 138-736Korea Department of Surgery Gold Coast University HospitalSouthportQLD 4215Australia

Background:Despite remarkable advances in surgical techniques and perioperative management,left hepatic trisectionectomy(LHT)remains a challenging procedure with a somewhat high postoperative morbidity rate compared with less-extensive *** study aimed to analyze the short-and long-term outcomes of LHT and identify factors associated with the postoperative morbidity of this technically demanding surgical ***:The medical records of 53 patients who underwent LHT between June 2005 and October 2019 at a single institution were retrospectively *** independent prognostic factor of postoperative morbidity was analyzed using the logistic regression ***:Hepatocellular carcinoma was the most common indication for surgery(n=21),followed by hilar cholangiocarcinoma(n=14),intrahepatic cholangiocarcinoma(n=10),and other pathologies(including colorectal liver metastasis,hepatolithiasis,gallbladder cancer,living donor,hemangioma,and multilocular biliary cyst;n=8).The rates of postoperative morbidities of Clavien-Dindo grade 3 or higher and 90-day mortality were 39.6% and 1.9%,*** 1-,3-,and 5-year overall survival rates were 81.1%,61.4%,and 44.6%,*** analysis revealed that preoperative jaundice[hazard ratio(HR)=6.15,95%confidence interval(CI):1.57-24.17,P=0.009]and operative time>420 min(HR=4.66,95%CI:1.27–17.17,P=0.021)were independent predictors of postoperative ***:The in-hospital mortality of LHT surgery can be minimalized by a reliable preoperative evaluation of liver function and selection of the dominant anatomic features of right posterior sector,active and appropriate preoperative management for obstructive cholangitis and compensatory hypertrophy of the future remnant posterior sector,and the experience of the surgeon.

关键词： Left hepatic trisectionectomy Major hepatectomy Liver neoplasms Survival rate Morbidity

Installing a molecular truss beam stabilizes MOF structures

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npj Computational Materials 2022年第1期8卷 1110-1118页

作者： Hong ki kim Jong-Yeong Jung Gyumin Kang Mu-Hyun Baik Eun-Young choi Department of Chemistry Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Center for Catalytic Hydrocarbon Functionalizations Institute for Basic Science(IBS)Daejeon34141Republic of Korea Korea Science Academy of KAIST 105-47 Baegyanggwanmun-roBusanjin-guBusan47162Republic of Korea

Enhancing the stability and durability of metal-organic frameworks(MOFs)is vital for practical applications because many promising MOF materials suffer from phase transitions and/or structural decompositions with humidity being a particularly damaging *** mechanical engineering,the frame of buildings and furniture can be stabilized significantly by installing a truss *** the same principle,we functionalized the organic component of MOF-5 to contain a carbazole moiety that can act as a molecular truss beam by reaching across the corner and forming a stableπ–πinteraction with a phenyl group on the edge position of the *** structural support enhanced the stability of the MOF substantially,allowing the designed MOF to maintain compositional integrity under steam conditions at 90℃for~5 *** unmodified MOF-5 shows clear signs of structural collapse after~1 h.

关键词： beam moiety durability