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Chorioamnionitis caused by Serratia marcescens in a healthcare worker: A case report

World Journal of Clinical Cases 2021年第20期9卷 5689-5694页

作者： Sue Youn Park Min Ji kim Sanghee Park Nah Ihm kim hyung Hoon Oh Joungmin kim Department of Anesthesiology and Pain Medicine Chonnam National University Medical SchoolGwangju 61469South Korea Department of Pathology Chonnam National University Medical SchoolGwangju 61469South Korea Department of Internal Medicine Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Healthcare workers(HCWs)are at an increased risk for exposure to *** marcescens(***)is a gram-negative,opportunistic and nosocomial pathogen belonging to the Enterobacterieae family.A few case reports have been published of chorioamnionitis caused by *** *** changes during pregnancy can also affect the risk of ***,few studies have examined hospital-acquired bacterial infection in pregnant *** SUMMARY A 33-year-old woman,a resident in anesthesiology,was admitted at 14 wk gestation for fever with *** had no medical history other than contact dermatitis of both hands that started from the beginning of the *** was no obvious infection focus and no bacterial growth in blood *** was discharged after 1 wk of empirical antibiotic *** three weeks before the fever started,she had a blister on the site of contact dermatitis on both hands,she applied antibiotic ointment for three days and the blisters had *** 19 wk gestation,she had a high fever and was *** examination and image studies were nonspecific and the patient had no other *** grew in blood cultures at 19 wk *** with intravenous antibiotics was ***,she suffered a miscarriage at 224/7 wk ***,the amniotic membrane showed chorioamnionitis with a focal ***,a placenta tissue culture grew *** HCWs can be exposed to pathogens that can cause opportunistic infections such as *** affects the immune system,making it susceptible to opportunistic ***,pregnant HCWs may require more preventive measures,including hand hygiene and avoid risk factors(*** the skin).

关键词： Serratia marcescens Chorioamnionitis Healthcare workers Pregnancy Case report

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Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer

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Nano Research 2020年第6期13卷 1576-1585页

作者： Jee-Yeon Ryu You Jung Choi Eun-Jeong Won Emmanuel Hui Ho-shik kim Young-Seok Cho Tae-Jong Yoon Laboratory of Nanopharmacy College of PharmacyResearch Institute of Pharmaceutical Science and Technology(RIPST)Ajou UniversitySuwon16499Republic of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea Moogene Medi Co. Ltd.Seongnam13488Republic of Korea

The epidermal growth factor receptor(EGFR)pathway plays an important role in the progression of colorectal cancer(CRC).Anti-EGFR drugs based on antibodies have been widely used for treating CRC through inducing the cell death ***,the majority of CRC patients will inevitably develop drug-resistance during anti-EGFR drug treatment,which is mainly caused by a point mutation in the KRAS *** developed a nanoliposomal(NL)particle containing the Cas9 protein and a single-guide RNA(sgRNA)complex(Cas9-RNP),for genomic editing of the KRAS *** NL particle is composed of bio-compatible lipid compounds that can effectively encapsulate *** modifying the NL particle to include the appropriate antibody,it can specifically recognize EGFR expressing CRC and effectively deliver the gene-editing *** conditions of NL treatment were optimized using a KRAS mutated CRC in vivo mouse *** with KRAS-mutated CRC showed drug resistance against cetuximab,a therapeutic antibody *** treating the mice with the KRAS gene-editing NL particles,the implanted tumors showed a dramatic decrease in *** results demonstrated that this genomic editing complex has great potential as a therapeutic carrier system for the treatment of drug-resistant cancer caused by a point mutation.

关键词： nanoliposome clustered regularly interspaced short palindromic repeat and associated Cas9 nuclease(CRISPR/Cas9) KRAS mutation drug-resistance colorectal cancer

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Multi-Gigabit CO-OFDM System over SMF and MMF Links for 5G URLLC Backhaul Network

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Computers, Materials & Continua 2021年第5期67卷 1747-1758页

作者： Amir Haider MuhibUr Rahman Tayyaba Khan Muhammad Tabish Niaz hyung Seok kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Electrical Engineering Polytechnique MontrealMontrealCanada Department of Telecommunication Engineering University of Engineering and TechnologyTaxila47050Pakistan

The 5G cellular network aims at providing three major services:Massive machine-type communication(mMTC),ultra-reliable low-latency communications(URLLC),and enhanced-mobile-broadband(eMBB).Among these services,the URLLC and eMBB require strict end-to-end latency of 1 ms while maintaining 99.999%reliability,and availability of extremely high data rates for the users,*** of the critical challenges in meeting these requirements is to upgrade the existing optical fiber backhaul network interconnecting the base stations with a multigigabit capacity,low latency and very high reliability *** address this issue,we have numerically analyzed 100 Gbit/s coherent optical orthogonal frequency division multiplexing(CO-OFDM)transmission performance over 400 km single-mode fiber(SMF)and 100 km of multi-mode fiber(MMF)*** system is simulated over optically repeated and non-repeated SMF and MMF *** transmission is used,and the system is analyzed in a linear and non-linear *** system performance is quantified by bit error ratio(BER).Spectrally efficient and optimal transmission performance is achieved for 400 km SMF and 100 km MMF *** results designate thatMMF links can be employed beyond short reach applications by using them in the existing SMF infrastructure for long haul *** particular,the proposed CO-OFDM system can be efficiently employed in 5G backhaul *** multi-gigabit capacity and lower BER of the proposed system makes it a suitable candidate especially for the eMBB and URLLC requirements for 5G backhaul network.

关键词： CO-OFDM coherent transmission spectrally efficient optical communication optical networks dispersion eMBB URLLC 5G backhaul

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Polysplenia syndrome with preduodenal portal vein detected in adults

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World Journal of Gastroenterology 2008年第41期14卷 6418-6420页

作者： hyung-Il Seo Tae Yong Jeon Mun Sup Sim Suk kim Department of Surgery Postgraduate School of Medicine and Medical Research Institute Pusan National University Department of Radiology Postgraduate School of Medicine Pusan National University

Polysplenia syndrome, defined as the presence of multiple spleens of almost equal volume, is a rare condition involving congenital anomalies in multiple organ systems. We report this anomaly in a 41-year-old female who underwent a left lateral sectionectomy due to recurrent cholangitis and impacted left lateral duct stones. Polysplenia syndrome with preduodenal vein was diagnosed preoperatively by computed to-mography (CT) and surgery was done safely. Although the polysplenia syndrome with preduodenal portal vein (PDPV) in adult is rarely encountered, surgeons need to understand the course of the portal vein and exercise caution in approaching the biliary tract.

关键词： Polysplenia Polysplenia syndrome Preduodenal portal vein Intrahepatic duct stones Congenital anomaly

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Effects of warming,wetting and nitrogen addition on substrate-induced respiration and temperature sensitivity of heterotrophic respiration in a temperate forest soil

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Pedosphere 2021年第2期31卷 363-372页

作者： Mohammad MOONIS Jong-Kyu LEE Hyojin JIN Dong-Gill kim Ji-hyung PARK Department of Forest Environment Protection Kangwon National UniversityChuncheon 24341(Republic of Korea) Department of Environmental Science and Engineering Ewha Womans UniversitySeoul 03760(Republic of Korea) Wondo Genet College of Forestry and Natural Resources Hawassa UniversityP.O.Box 128Shashemene(Ethiopia)

Soil heterotrophic respiration and its temperature sensitivity are affected by various climatic and environmental ***,little is known about the combined effects of concurrent climatic and environmental changes,such as climatic warming,changing precipitation regimes,and increasing nitrogen(N)***,in this study,we investigated the individual and combined effects of warming,wetting,and N addition on soil heterotrophic respiration and temperature *** incubated soils collected from a temperate forest in South Korea for 60 d at two temperature levels(15 and 20℃,representing the annual mean temperature of the study site and 5℃warming,respectively),three moisture levels(10%,28%,and 50%water-filled pore space(WFPS),representing dry,moist,and wet conditions,respectively),and two N levels(without N and with N addition equivalent to 50 kg N ha^(-1)year^(-1)).On day 30,soils were distributed across five different temperatures(10,15,20,25,and 30℃)for 24 h to determine short-term changes in temperature sensitivity(Q_(10),change in respiration with 10℃increase in temperature)of soil heterotrophic *** completing the incubation on day 60,we measured substrate-induced respiration(SIR)by adding six labile substrates to the three types of *** treatment(increase from 28%to 50%WFPS)reduced SIR by 40.8%(3.77 to 2.23μg CO_(2)-C g^(-1)h^(-1)),but warming(increase from 15 to 20℃)and N addition increased SIR by 47.7%(3.77 to 5.57μg CO_(2)-C g^(-1)h^(-1))and 42.0%(3.77 to 5.35μg CO_(2)-C g^(-1)h^(-1)),respectively.A combination of any two treatments did not affect SIR,but the combination of three treatments reduced SIR by 42.4%(3.70 to 2.20μg CO_(2)-C g^(-1)h^(-1)).Wetting treatment increased Q_(10)by 25.0%(2.4 to 3.0).However,warming and N addition reduced Q_(10)by 37.5%(2.4 to 1.5)and 16.7%(2.4 to 2.0),*** coupled with wetting did not significantly change Q_(10),while warming coupled with N addition reduced Q

关键词： carbon dioxide decomposition global warming soil moisture soil organic carbon soil respiration Q_(10)

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Simple method of measuring ocular rotation in supine position during small incision lenticule extraction

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1331-1337页

作者： Jiho Song Hwanho Lee Moon Sun Jung Jae-hyung kim Seoul Daabom Eye Center CheongjuChungbuk 28396Republic of Korea Department of Ophthalmology Chungbuk National University HospitalCollege of MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea

AIM:To introduce a novel measurement method of static cyclotorsion in small incision lenticule extraction(SMILE)and to investigate the effect of preoperative parameters on cyclotorsion and the effect of cyclotorsion on postoperative ***:The medical records of 242 patients and 484 eyes who under went SMILE surger y were retrospectively *** intraocular pressure,refractive error,and corneal thickness were *** values and visual acuity were measured at 1d,1,3,and *** cyclotorsion in the supine position was measured by calculating the location and angle of the incision site of the cornea in the anterior slit photograph taken after ***:Of the total 484 eyes in 242 patients,preopera tive means phericale quivalent(SE)was-4.10±1.64 D,and the mean astigmatism was-0.82±0.74 *** distance visual acuity(UCVA)and SE improved significantly after the ***,219(45.2%)eyes had excyclotorsion,235(48.6%)eyes had incyclotorsion,and 30(6.2%)eyes had no *** right eyes tended to be excyclotorted,and the left eyes tended to be incyclotorted(P<0.01).The mean cyclotorsion was 1.18°±3.69°,and the mean absolute value of cyclotorsion was 3.14°±2.26°.The range of cyclotorsion was 0.5°–11.4°.It was found that the smaller the preoperative sphere,the higher the amount of cyclotorsion(r=0.11,P=0.016).There was no significant association between the amount of cyclotorsion and preoperative *** was no correlation between sex,preoperative corneal thickness,preoperative intraocular pressure,amount of cyclotorsion,and direction of *** ratio of right eye excyclotorsion and left eye incyclotorsion on 1d was higher than that at 1,3,and 6mo(all P<0.01).There was no difference between the 1,3,and 6mo results in the right and left eyes(P=0.15,P=0.16,respectively).CONCLUSION:The newly devised ocular cyclotorsion measurement method can be used to evaluate ocular cyclotorsion after ***

关键词： anterior slit photograph astigmatism cyclotorsion myopia small incision lenticule extraction

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Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins

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Journal of Pharmaceutical Analysis 2023年第3期13卷 305-314页

作者： Chi Soo Park Minju Kang Ahyeon kim Chulmin Moon Mirae kim Jieun kim Subin Yang Leeseul Jang Ji Yeon Jang Ha hyung kim Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974Republic of Korea

Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to ***-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte-associated antigen-4-immunoglobulin(CTLA4-Ig),were produced in Chinese hamster ovary cell lines;however,their linkage isomers have not been *** this study,N-glycans of CTLA4-Igs were released,labeled with procainamide,and analyzed by liquid chromatography-tandem mass spectrometry(MS/MS)to identify and quantify sialylated N-glycan linkage *** linkage isomers were distinguished by comparison of 1)intensity of the N-acetylglucosamine ion to the sialic acid ion(Ln/Nn)using different fragmentation stability in MS/MS spectra and 2)retention time-shift for a selective m/z value in the extracted ion *** isomer was distinctively identified,and each quantity(>0.1%)was obtained relative to the total N-glycans(100%)for all observed ionization *** sialylated N-glycan isomers with onlyα2-3 linkage(s)in WT were identified,and each isomer's sum of quantities was 50.4%.Furthermore,39 sialylated N-glycan isomers(58.8%)in mono-(3 N-glycans;0.9%),bi-(18;48.3%),tri-(14;8.9%),and tetra-(4;0.7%)antennary structures of mutant were obtained,which comprised mono-(15 N-glycans;25.4%),di-(15;28.4%),tri-(8;4.8%),and tetra-(1;0.2%)sialylation,respectively,with onlyα2-3(10 N-glycans;4.8%),bothα2-3 andα2-6(14;18.4%),and onlyα2-6(15;35.6%)linkage(s).These results are consistent with those forα2-3 neuraminidase-treated *** study generated a novel plot of Ln/Nn versus retention time to distinguish sialylated N-glycan linkage isomers in glycoprotein.

关键词： Therapeutic glycoprotein Sialylation Linkage isomer LC-MS/MS

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Coherent interface driven super-plastic elongation of brittle intermetallic nano-fibers at room temperature

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Journal of Materials Science & Technology 2022年第20期115卷 97-102页

作者： Eun-Ae Choi Seung Zeon Han hyung Giun kim Jee Hyuk Ahn Sung Hwan Lim Sangshik kim Nong-Moon Hwang Kwangho kim Jehyun Lee Department of Special Alloy Korea Institute of Materials ScienceChangwon 642-831Korea Gangwon Regional Division Korea Institute of Industrial TechnologyGangneung 210-340Korea Department of Advanced Materials Science&Engineering Kangwon National UniversityChuncheon 200-701Korea Department of Materials Science and Engineering ReCAPTGyeongsang National UniversityChinju 660-701Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 151-744Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Korea Department of Materials Science and Engineering Changwon National UniversityChangwon 641-773Korea

The intermetallic compound such as Ni_(2)Si has a brittle ***,monolithic intermetallic compounds have not yet been prepared by mechanical *** mechanical drawing of bulk CuNi_(2)Si alloy at room temperature,we observed more than 400%plastic elongation of hard and brittle Ni_(2)Si intermetallic *** calculation based on the density functional theory reveals that the fully coherent interface induces strain on the intermetallic compound surrounded by the matrix,and lowers the intrinsic stacking fault energy below the level required to break an interatomic *** new interface between the Ni_(2)Si intermetallic and Cu matrix formed by the plastic deformation is as stable as the original coherent interface formed by precipitation,and the activation energy of the newly formed interface to slip is similar to that of the Cu *** of these make plastic deformation of brittle Ni_(2)Si intermetallic possible by slip without failure.

关键词： Ni_(2)Si Intermetallic compound Plastic deformation Precipitation Brittle fiber Interface Density functional theory

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PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15

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Cellular & Molecular Immunology 2021年第2期18卷 385-397页

作者： Kyung Hwan kim Hong Kwan kim hyung-Don kim Chang Gon kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon hyunglae kim Jiae Koh Bo Mi Ku Su-hyung Park Myung-Ju Ahn Eui-Cheol Shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Thoracic and Cardiovascular Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Biomedical Science and Engineering Interdisciplinary Program Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Research Institute for Future Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoulRepublic of Korea Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer ***,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse ***,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer ***-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)***,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)*** and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 ***,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)*** together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies.

关键词： anti-PD-1 T cells TCF1 CD28 IL-15

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Nanostructured hafnium-doped strontium oxide film for homeotropic/homogeneous convertible liquid crystal alignment depending on the curing temperature

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International Journal of Smart and Nano Materials 2022年第4期13卷 597-611页

作者： Dong Hyun kim Dong Wook Lee Jin Young Oh Jonghoon Won Hae-Chang Jeong Dae-shik Seo IT Nano Electronic Device Laboratory Department of Electrical and Electronic EngineeringYonsei UniversitySeoulRepublic of Korea Department of Smart Manufacturing Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea Department of Electrical Electronic and Control Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea

A hafnium strontium oxide(HfSrO)liquid crystal(LC)alignment film was efficiently created through brush coating,and its ability to change the LC alignment direction was confirmed.A brush was applied to HfSrO sol coated on an indium-tin oxide substrate,after which the coating was solidified at var-ious curing *** was confirmed that a directional micro/nanostructure was formed above 280°C due to the shear stresses caused by the movement of the brush *** chemical changes were analyzed by using X-ray photoelectron spectroscopy and contact angle *** the curing temperature increased,the prevalence of oxygen bonds increased and the contact angle decreased,thereby increasing the surface *** anisotropic boundary of the micro-grooves and the van der Waals forces due to an increase in surface energy changed the alignment direction of LC mole-cules from vertical to horizontal,as verified through polarized optical microscopy and pretilt angle ***,the efficiency of the brush-coating method,which dramatically simplifies the LC alignment film process,was *** homeotropic/homogeneous LC alignment property of the HfSrO film produced through brush coating depending on the curing temperature provides an innovative approach for LC alignment.

关键词： Brush coating nanostructure solution process liquid crystal alignment

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