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Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy

Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 51-59页

作者： seok-hyung kim Soomin Ahn Cheol-Keun Park Department of Pathology Samsung Medical CenterSungkyunkwan University School of Medicine

BACKGROUND:Progression of hepatocellular carcinoma (HCC) often leads to vascular invasion and intrahepatic metastasis,which correlate with recurrence after surgical treatment and poor *** may be an unusual cancer affected by continuous inflammation that can lead to consistent upregulation of transforming growth factor-β (TGF-β).Chronic inflammation shifts hepatocytic TGF-β signaling from the tumor-suppressive pSmad3C pathway to the oncogenic pSmad3L *** this study,we investigated the functional roles of Smad3 and its phosphoisoforms in the progression of ***:Tumor tissue microarrays of samples from 272 HCC patients who underwent curative surgical resection were used to detect the expression of Smad3,Smad4,pSmad3C (S423/425),pSmad3L (T179),pSmad3L (S204),and pSmad3L (S213).Disease-specific death was defined as 1) tumor occupying more than 80% of the liver,2) portal venous tumor thrombus (PVTT) proximal to the second bifurcation,3) obstructive jaundice due to tumor,4) distant metastases,or 5) variceal hemorrhage with PVTT proximal to the first *** the time of analysis,tumor recurrence was detected in 184 (67.6%) patients,and 96 (35.3%) had died of ***:Nuclear and cytoplasmic localization of Smad3,and nuclear localization of Smad4 were observed in 18.0%,9.9%,and 9.2% of HCCs,*** rates of Smad3 phosphoisoform-immunoreactive HCC varied according to the location of phosphorylation:pSmad3C (S423/425) 8.1%,pSmad3L (T179) 2.6%,pSmad3L (S204) 2.2%,and pSmad3L (S213) 10.3%.Multivariate analyses revealed that pSmad3C (S423/425) (P=0.022) was an independent predictor of longer recurrence-free ***3L (S213) (P=0.006),intrahepatic metastasis,multicentric occurrence,and liver cirrhosis were independent predictors of shorter recurrence- free *** Smad3 (P=0.006),larger tumor size,and intrahepatic metastasis were independent predictors of shorter disease-specific *** pSmad3L (S213) did not sh

关键词： Smad3 pSmad3C (S423/425) pSmad3L (S213) hepatocellular carcinoma hepatectomy survival

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Quintuple Band Antenna for Wireless Applications with Small Form Factor

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Computers, Materials & Continua 2021年第3期66卷 2241-2251页

作者： Amir Haider Tayyaba Khan MuhibUr Rahman Byung Moo Lee hyung seok kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Telecommunication Engineering University of Engineering and TechnologyTaxila47050Pakistan Department of Electrical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada

A coplanar waveguide-fed quintuple band antenna with a slotted circular-shaped radiator for wireless applications with a high isolation between adjacent bands is presented in this *** proposed antenna resonates at multiple frequencies with corresponding center frequencies of 2.35,4.92,5.75,6.52,and 8.46 *** intended functionality is achieved by introducing a circular disc radiator with five slots and a U-shaped slot in the *** proposed antenna exhibits coverage of the maximum set of wireless applications,such as satellite communication,worldwide interoperability for microwave access,wireless local area network(WLAN),long-distance radio telecommunications,and X-band/Satcom wireless *** simulation and measurement results of the proposed fabricated antenna demonstrate the high isolation between adjacent bands.A stable realized gain with an advantageous radiation pattern is achieved at the operating frequency *** proposed simple design,compact structure,and simple feeding technique make this antenna suitable for integration in several wireless communication applications,where the portability of devices is a significant *** proposed antenna is anticipated to be an appropriate candidate for WLAN,long-term evolution,and fifth-generation mobile communication because of its multi-operational bands and compact size for handheld devices.

关键词： Coplanar waveguide isolated adjacent bands satellite WiMAX WLAN 5G communication

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Multi-Gigabit CO-OFDM System over SMF and MMF Links for 5G URLLC Backhaul Network

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Computers, Materials & Continua 2021年第5期67卷 1747-1758页

作者： Amir Haider MuhibUr Rahman Tayyaba Khan Muhammad Tabish Niaz hyung seok kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Electrical Engineering Polytechnique MontrealMontrealCanada Department of Telecommunication Engineering University of Engineering and TechnologyTaxila47050Pakistan

The 5G cellular network aims at providing three major services:Massive machine-type communication(mMTC),ultra-reliable low-latency communications(URLLC),and enhanced-mobile-broadband(eMBB).Among these services,the URLLC and eMBB require strict end-to-end latency of 1 ms while maintaining 99.999%reliability,and availability of extremely high data rates for the users,*** of the critical challenges in meeting these requirements is to upgrade the existing optical fiber backhaul network interconnecting the base stations with a multigigabit capacity,low latency and very high reliability *** address this issue,we have numerically analyzed 100 Gbit/s coherent optical orthogonal frequency division multiplexing(CO-OFDM)transmission performance over 400 km single-mode fiber(SMF)and 100 km of multi-mode fiber(MMF)*** system is simulated over optically repeated and non-repeated SMF and MMF *** transmission is used,and the system is analyzed in a linear and non-linear *** system performance is quantified by bit error ratio(BER).Spectrally efficient and optimal transmission performance is achieved for 400 km SMF and 100 km MMF *** results designate thatMMF links can be employed beyond short reach applications by using them in the existing SMF infrastructure for long haul *** particular,the proposed CO-OFDM system can be efficiently employed in 5G backhaul *** multi-gigabit capacity and lower BER of the proposed system makes it a suitable candidate especially for the eMBB and URLLC requirements for 5G backhaul network.

关键词： CO-OFDM coherent transmission spectrally efficient optical communication optical networks dispersion eMBB URLLC 5G backhaul

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Relative-Position Estimation Based on Loosely Coupled UWB–IMU Fusion for Wearable IoT Devices

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计算机、材料和连续体（英文） 2023年第4期75卷 1941-1961页

作者： A.S.M.Sharifuzzaman Sagar Taein kim Soyoung Park Hee Seh Lee hyung seok kim Sejong University Seoul05006Korea Samsung Advanced Institute of Technology Suwon16678Korea

Relative positioning is one of the important techniques in collaborativerobotics, autonomous vehicles, and virtual/augmented reality (VR/AR)applications. Recently, ultra-wideband (UWB) has been utilized to calculaterelative position as it does not require a line of sight compared to a camerato calculate the range between two objects with centimeter-level ***, the single UWB range measurement cannot provide the relativeposition and attitude of any device in three dimensions (3D) because oflacking bearing information. In this paper, we have proposed a UWB-IMUfusion-based relative position system to provide accurate relative positionand attitude between wearable Internet of Things (IoT) devices in 3D. Weintroduce a distributed Euler angle antenna orientationwhich can be equippedwith the mobile structure to enable relative positioning. Moving average andmin-max removing preprocessing filters are introduced to reduce the standarddeviation. The standard multilateration method is modified to calculate therelative position between mobile structures. We combine UWB and IMUmeasurements in a probabilistic framework that enables users to calculatethe relative position between two nodes with less error. We have carried outdifferent experiments to illustrate the advantages of fusing IMU and UWBranges for relative positioning systems. We have achieved a mean accuracy of0.31m for 3D relative positioning in indoor line of sight conditions.

关键词： Relative position UWB IMU trilateration IoT bayesian filter

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A Real-Time Sequential Deep Extreme Learning Machine Cybersecurity Intrusion Detection System

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Computers, Materials & Continua 2021年第2期66卷 1785-1798页

作者： Amir Haider Muhammad Adnan Khan Abdur Rehman Muhib Ur Rahman hyung seok kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan School of Computer Science National College of Business Administration&EconomicsLahore54000Pakistan Department of Electrical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada

In recent years,cybersecurity has attracted significant interest due to the rapid growth of the Internet of Things(IoT)and the widespread development of computer infrastructure and *** is thus becoming particularly necessary to identify cyber-attacks or irregularities in the system and develop an efficient intrusion detection framework that is integral to *** have worked on developing intrusion detection models that depend on machine learning(ML)methods to address these security *** intelligent intrusion detection device powered by data can exploit artificial intelligence(AI),and especially ML,***,we propose in this article an intrusion detection model based on a Real-Time Sequential Deep Extreme Learning Machine Cybersecurity Intrusion Detection System(RTS-DELM-CSIDS)security *** proposed model initially determines the rating of security aspects contributing to their significance and then develops a comprehensive intrusion detection framework focused on the essential ***,we investigated the feasibility of our proposed RTS-DELM-CSIDS framework by performing dataset evaluations and calculating accuracy parameters to *** experimental findings demonstrate that the RTS-DELM-CSIDS framework outperforms conventional ***,the proposed approach has not only research significance but also practical significance.

关键词： Security DELM intrusion detection system machine learning

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Frequency-Agile WLAN Notch UWB Antenna for URLLC Applications

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Computers, Materials & Continua 2021年第5期67卷 2243-2254页

作者： Amir Haider MuhibUr Rahman Hamza Ahmad Mahdi NaghshvarianJahromi Muhammad Tabish Niaz hyung seok kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Electrical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of Electrical Engineering University of Engineering and TechnologyMardan23200Pakistan Department of Electrical and Computer Engineering McMaster UniversityHamilton ONL8S 4L8Canada

This paper introduces a compact dual notched UWB antenna with an independently controllable WLAN notched band integrated with fixed WiMAX *** proposed antenna utilizes a slot resonator placed in the main radiator of the antenna for fixed WiMAX band notch,while an inverted L-shaped resonator in the partial ground plane for achieving frequency agility within WLAN notched *** inverted L-shaped resonator is also loaded with fixed and variable capacitors to control and adjust the WLAN *** WLAN notched band can be controlled independently with a wide range of tunability without disturbing the WiMAX bandnotch *** by step design approach of the proposed antenna is discussed and the corresponding mathematical analysis of the proposed resonators are provided in both *** of the proposed antenna is performed utilizing commercially available 3D-EM simulator,Ansoft High Frequency Structure Simulator(HFSS).The proposed antenna has high selectivity with experimental validation in terms of reflection coefficient,radiation characteristics,antenna gain,and percentage radiation *** corresponding measured frequency response of the input port corresponds quite well with the calculations and simulations in both *** proposed antenna is advantageous and can adjust according to the device requirements and be one of the attractive candidates for overlay cognitive radio UWB applications and URLLC service in 5G tactile *** proposed multifunctional antenna can also be used for wireless vital signs monitoring,sensing applications,and microwave imaging techniques.

关键词： WiMAX UWB lower and upper WLAN single/dual notch behavior independent controlling notched behavior tunable band-notch behavior overlay cognitive radio applications frequency-agile WLAN notched antennas 5G URLLC tactile internet

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Effects of Cr doping on structural and electrochemical properties of Li_(4)Ti_(5)O_(12) nanostructure for sodium-ion battery anode

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Journal of Energy Chemistry 2021年第8期30卷 465-472,I0010页

作者： Sang Hyuk Gong Ji Hyeon Lee Dong Won Chun Jee-Hwan Bae Sung-Chul kim Seungho Yu Sahn Nahm hyung-seok kim Center for Energy Storage Research Korea Institute of Science and Technology5Hwarang-ro 14-gilSeongbuk-gu02792 SeoulRepublic of Korea Department of Materials Science and Engineering Korea University145Anam-roSeongbuk-gu02841 SeoulRepublic of Korea Department of Chemical and Biological Engineering Korea University145Anam-roSeongbuk-gu02841 SeoulRepublic of Korea Advanced Analysis Center Korea Institute of Science and Technology5Hwarang-ro 14-gilSeongbuk-gu02792 SeoulRepublic of Korea

Sodium-ion batteries are considered as promising alternatives to lithium-ion batteries,owing to their low cost and abundant raw *** the several candidate materials for the anode,spinel-type Li_(4)Ti_(5)O_(12)has potential owing to its superior safety originating from an appropriate operating voltage and the reversible Na^(+)intercalation ***,a low diffusion coefficient for Na^(+)and the insulating nature of LTO remains challenging for practical sodium-ion battery ***,we present a strategy for integrating physical and chemical approaches to achieve superior electrochemical properties in *** demonstrate that carefully controlling the amount of Cr doping is crucial to enhance the electrochemical properties of nanostructured *** Cr doped LTO shows a superior reversible capacity of 110 m Ah g^(-1) after 400 cycles at 1 C,with a three-fold higher capacity(75 m Ah g^(-1))at 10 C compared with undoped LTO *** suggests that appropriately Cr doped nanostructured LTO is a promising anode material for sodium-ion batteries.

关键词： Sodium-ion batteries Spinel type Li_(4)Ti_(5)O_(12) Anode materials Nanostructuring Cr-doping

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Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 657-660页

作者： Ho Hyun kim Jung Chul kim Eun Kyu Park Young Hoe Hur Yang seok Koh Chol Kyoon Cho hyung seok kim Hyun Jong kim Department of Surgery Chonnam National University Medical School GwangjuKorea Department of Pathology Chonnam National University Medical School GwangjuKorea

BACKGROUND:Undifferentiated embryonal sarcoma (UES) of the liver is a rare,highly malignant neoplasm with a poor prognosis occurring almost exclusively in late childhood (6-10 years of age).Only a few cases have been reported in adults accounting for less than 1% of all primary liver ***:A 47-year-old woman presented with a palpable mass in the left upper *** resonance imaging revealed a 12×10 cm cystic mass with hemorrhage in the left lateral segment of the *** initial impression was a hemorrhagic cystic tumor of the *** patient underwent a left lateral sectionectomy of the *** and immunohistochemistry helped make a diagnosis of ***:The patient recovered uneventfully and received systemic *** examination for follow-up revealed a metastatic lesion in the lumbar spine (L5).She was subjected to radiotherapy at the lumbar *** survived 48 ***:Although hepatic cyst as UES of the liver is difficult to diagnose because of its rarity in adults and lack of specific findings,it should be considered in a differential diagnosis.

关键词： embryonal sarcoma liver neoplasms cyst adult

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An image-based approach to the reconstruction of ancient architectures by extracting and arranging 3D spatial components

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Frontiers of Information Technology & Electronic Engineering 2015年第1期16卷 12-27页

作者： Divya Udayan J hyung seok kim Jee-In kim Internet and Multimedia Engineering Konkuk University Seoul 143- 701 Korea Department of Advanced Technology Fusion Konkuk University Seoul 143-701 Korea

The objective of this research is the rapid reconstruction of ancient buildings of historical importance using a single image. The key idea of our approach is to reduce the infinite solutions that might otherwise arise when recovering a 3D geometry from 2D photographs. The main outcome of our research shows that the proposed methodology can be used to reconstruct ancient monuments for use as proxies for digital effects in applications such as tourism, games, and entertainment, which do not require very accurate modeling. In this article, we consider the reconstruction of ancient Mughal architecture including the Taj Mahal. We propose a modeling pipeline that makes an easy reconstruction possible using a single photograph taken from a single view, without the need to create complex point clouds from multiple images or the use of laser scanners. First, an initial model is automatically reconstructed using locally fitted planar primitives along with their boundary polygons and the adjacency relation among parts of the polygons. This approach is faster and more accurate than creating a model from scratch because the initial reconstruction phase provides a set of structural information together with the adjacency relation, which makes it possible to estimate the approximate depth of the entire structural monument. Next, we use manual extrapolation and editing techniques with modeling software to assemble and adjust different 3D components of the model. Thus, this research opens up the opportunity for the present generation to experience remote sites of architectural and cultural importance through virtual worlds and real-time mobile applications. Variations of a recreated 3D monument to represent an amalgam of various cultures are targeted for future work.

关键词： Digital reconstruction 3D virtual world 3D spatial components Vision and scene understanding

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Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： hyung Wook Choi Hongdae Lee Jun Lu seok Bin Kwon Dong In Jeong Beum Jin Park Jiwon kim Bong Kyun Kang Gun Jang Dae Ho Yoon Ho seok Park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g^(-1) and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

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