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Fabrication of two-layer flexible copper clad laminate by electroless-Cu plating on surface modified polyimide

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中国有色金属学会会刊：英文版 2009年第4期19卷 970-974页

作者： Soo-Min HWANG Jun-hyung LIM Chang-Min LEE Eui-Cheol PARK Jun-Hyuk choi Jinho JOO Hoo-Jeong LEE Seung-Boo JUNG School of Advanced Materials Science and Engineering Sungkyunkwan University

A flexible copper clad laminate(FCCL) was fabricated using electroless-and electro-Cu plating processes and the effects of pre-treatment time on the adhesion strength of the FCCL were evaluated based on interfacial *** neutralization and catalyst time were varied in the range of 0-20 min and 0.1-10 min,respectively,and the interfacial condition of the FCCL was characterized by atomic force microscopy(AFM) and X-ray photoelectron spectroscopy(XPS).It is observed that the peel strength increases significantly as the neutralization and catalyst time *** strength as high as 7.2-7.3 N/cm is obtained as the neutralization and catalyst time increase up to 20 min and 10 min,respectively,which is comparable to the strength achieved by the conventional laminating and sputtering *** improvements are probably due to an increase in the surface roughness of polyimide(PI),the activated surface condition,and the adsorption of palladium ions/atoms(Pd) on the PI surface which act as nucleation sites for Cu.

关键词：聚酰亚胺表面改性化学制备层压板铜电镀铜箔软性 X射线光电子能谱

Synergistic stimulation of surface topography and biphasic electric current promotes muscle regeneration

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Bioactive Materials 2022年第5期7卷 118-129页

作者： Indong Jun Na Li Jaehee Shin Jaeho Park Young Jun kim Hojeong Jeon Hyuk choi Jae-Gu Cho Byoung Chan choi hyung-Seop Han Jae-Jun Song Environmental Safety Group Korea Institute of Science&Technology Europe(KIST-EUROPE)Saarbrücken66123Germany Department of Otorhinolaryngology-Head and Neck Surgery Korea University College of MedicineSeoul02841Republic of Korea Department of Medical Sciences Graduate School of MedicineKorea UniversitySeoul02841Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science&Technology(KIST)Seoul02792Republic of Korea Laser Surface Texturing Group AYECLUSGyeonggi-do14255Republic of Korea

Developing a universal culture platform that manipulates cell fate is one of the most important tasks in the investigation of the role of the cellular *** study focuses on the application of topographical and electrical field stimuli to human myogenic precursor cell(hMPC)cultures to assess the influences of the adherent direction,proliferation,and differentiation,and induce preconditioning-induced therapeutic ***,a topographical surface of commercially available culture dishes was achieved by femtosecond laser *** detachable biphasic electrical current system was then applied to the hMPCs cultured on laser-textured culture ***-textured topographies were remarkably effective in inducing the assembly of hMPC myotubes by enhancing the orientation of adherent hMPCs compared with flat ***,electrical field stimulation through laser-textured topographies was found to promote the expression of myogenic regulatory factors compared with nonstimulated *** such,we successfully demonstrated that the combined stimulation of topographical and electrical cues could effectively enhance the myogenic maturation of hMPCs in a surface spatial and electrical field-dependent manner,thus providing the basis for therapeutic strategies.

关键词： Topography Electrical field stimulation Femtosecond laser Human myogenic precursor cell Cell therapy

Nutritional risk index as a predictor of postoperative wound complications after gastrectomy

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World Journal of Gastroenterology 2012年第7期18卷 673-678页

作者： Cheong Ah Oh Dae Hoon kim Seung Jong Oh Min Gew choi Jae hyung Noh Tae Sung Sohn Jae Moon Bae Sung kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine50 Irwon-dongGangnamguSeoul 135-710South Korea

AIM： To investigate the correlation between the nutri- tional risk index （NRI） and postoperative wound com- plications.

关键词： Nutritional risk index Wound complication Gastric cancer

Somatostatin adjunctive therapy for non-variceal upper gastrointestinal rebleeding after endoscopic therapy

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World Journal of Gastroenterology 2011年第29期17卷 3441-3447页

作者： Cheol Woong choi Dae Hwan Kang hyung Wook kim Su Bum Park Kee Tae Park Gwang Ha kim Geun Am Song Mong Cho Department of Internal Medicine Pusan National University School of Medicine and Medical Research InstituteYangsan-siGyeongsangnam-do 626-770South Korea

AIM:To evaluate the effect of pantoprazole with a somatostatin adjunct in patients with acute non-variceal upper gastrointestinal bleeding(NVUGIB).METHODS:We performed a retrospective analysis of a prospective database in a tertiary care university *** October 2006 to October 2008,we enrolled 101 patients with NVUGIB that had a high-risk stigma on *** 24 h of hospital admission,all patients underwent endoscopic *** successful endoscopic hemostasis,all patients received an 80-mg bolus of pantoprazole followed by continuous intravenous infusion(8 mg/h for 72 h).The somatostatin adjunct group(n=49)also received a 250-μg bolus of somatostatin,followed by continuous infusion (250μg/h for 72 h).Early rebleeding rates,disappearance of endoscopic stigma and risk factors associated with early rebleeding were ***:Early rebleeding rates were not significantly different between treatment groups(12.2%vs 14.3%,P=0.766).Disappearance of endoscopic stigma on the second endoscopy was not significantly different between treatment groups(94.2%vs 95.9%,P=0.696).Multivariate analysis showed that the complete Rockall score was a significant risk factor for early rebleeding(P =0.044,OR:9.080,95%CI:1.062-77.595).CONCLUSION:The adjunctive use of somatostatin was not superior to pantoprazole monotherapy after successful endoscopic hemostasis in patients with NVUGIB.

关键词： Somatostatin Pantoprazole Gastrointestinal bleeding Rebleeding

Multimodal treatments of right gastroepiploic arterial leiomyosarcoma with hepatic metastasis:A case report and review of the literature

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World Journal of Clinical Cases 2018年第8期6卷 219-223页

作者： hyung-Il Seo Dong-Il kim Youngsoo Chung Chang In choi Minjoo kim Sungpil Yun Suk kim Do Youn Park Department of Surgery Biomedical Research InstitutePusan National University Hospital Department of Surgery Pusan National University Yangsan Hospital Department of Surgery On Hospital Department of Radiology Biomedical Research Institute Pusan National University Hospital Department of Pathology Biomedical Research Institute Pusan National University Hospital

Leiomyosarcoma of an artery is very rare, and cases with hepatic metastasis are even rarer. We describe a case of a 70-year-old man who after follow up due to rectal cancer, presented with an intra-abdominal hypervascular mass and a hepatic mass. After surgical resection, it was diagnosed as a leiomyosarcoma of the right gastroepiploic artery with hepatic metastasis. Multiple metastases had recurred at the liver. He has survived more than 53 mo through multimodal treatments(three surgical resections, radiofrequency ablation, transarterial chemoembolization, chemotherapies, and targeted therapy). Multimodal treatments, including active surgical resection, may behelpful in the treatment of aggressive diseases such as arterial leiomyosarcoma with metastasis.

关键词： Multimodal treatments Intra-abdominal arterial leiomyosarcoma Hepatic metastasis Arterial leiomyosarcoma Surgical resection

Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

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World Journal of Gastroenterology 2017年第9期23卷 1627-1636页

作者： Hyeong Seok Nam Dae Hwan Kang hyung Wook kim Cheol Woong choi Su Bum Park Su Jin kim Dae Gon Ryu Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan-siGyeongsangnam-do 50612South Korea

To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of self-expandable metal stent (SEMS).METHODSThis was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography (ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis (PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were *** the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients, pancreatic cancer in 79, and non-pancreatic or non-biliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients (3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy (cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP *** ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.

关键词： Endoscopic sphincterotomy Endoscopic retrograde cholangio pancreatography Complications Pancreatitis Bleeding Cholestasis Self-expandable metal stent

Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors?

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World Journal of Gastroenterology 2017年第11期23卷 2037-2043页

作者： Su Bum Park Dong Jun kim hyung Wook kim Cheol Woong choi Dae Hwan Kang Su Jin kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanGyeongsangnam-do 626-770South Korea

AIM To evaluate the importance of endoscopic ultrasonography(EUS) for small(≤ 10 mm) rectal neuroendocrine tumor(NET) *** Patients in whom rectal NETs were diagnosed by endoscopic resection(ER) at the Pusan National University Yangsan Hospital between 2008 and 2014 were included in this study. A total of 120 small rectal NETs in 118 patients were included in this study. Histologic features and clinical outcomes were analyzed, and the findings of endoscopy, EUS and histology were compared. RESULTS The size measured by endoscopy was not significantly different from that measured by EUS and histology(r = 0.914 and r = 0.727 respectively). Accuracy for the depth of invasion was 92.5% with EUS. No patients showed invasion of the muscularis propria or metastasis to the regional lymph nodes. All rectal NETswere classified as grade 1 and demonstrated an L-cell phenotype. Mean follow-up duration was 407.54 ± 374.16 d. No patients had local or distant metastasis during the follow-up periods. CONCLUSION EUS is not essential for ER in the patient with small rectal NETs because of the prominent morphology and benign behavior.

关键词： Neuroendocrine tumor Small Rectal Endoscopic ultrasonography Histology Endoscopy

Assessment of disease activity by fecal immunochemical test in ulcerative colitis

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World Journal of Gastroenterology 2016年第48期22卷 10617-10624页

作者： Dae Gon Ryu hyung Wook kim Su Bum Park Dae Hwan Kang Cheol Woong choi Su Jin kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or *** All of 21 patients with MES 0 had negative FIT( 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not

关键词： Ulcerative colitis Fecal immunochemical test Mayo endoscopic subscore Biomarker Disease activity

Development of RP-HPLC method for simultaneous determination of docetaxel and curcumin in rat plasma: Validation and stability

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 105-113页

作者： Dong Wuk kim Abid Mehmood Yousaf Dong Xun Li Jong Oh kim Chul Soon Yong Kwan hyung Cho Han-Gon choi College of Pharmacy&Institute of Pharmaceutical Science and Technology Hanyang University55 Hanyangdaehak-roSangnok-guAnsan 426-791South Korea Faculty of Pharmacy University of Central Punjab1-Khayaban-e-JinnahJoharLahore54000Pakistan National Pharmaceutical Engineering Centre for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Traditional Chinese Medicine56 Yangming RoadNanchangJiangxi330006China College of Pharmacy Yeungnam University214-1Dae-DongGyongsan 712-749South Korea College of Pharmacy Inje University197Inje-roGimhae621-749South Korea

The purpose of the present research was to develop a suitable, simple, precise, accurate,robust, and reproducible RP-HPLC method for a reliable simultaneous quantification of docetaxel(DTX) and curcumin(CCM) in rat plasma samples using paclitaxel(PTX) as an internal standard. The samples were assayed by the Agilent 1260 Infinity HPLC instrument using a Capcell Pak C8 column(4.6 mm × 150 mm, 5 μm) under isocratic conditions. The mobile phase consisted of acetonitrile and triple distilled water(40/60, v/v) with a flow rate of 1.0 ml/min. The eluent was monitored at 230 nm for simultaneous measurement of curcumin and docetaxel. The method was validated by determining system suitability, selectivity, sensitivity, linearity, inter-day and intra-day precision, accuracy, robustness, and stability in accordance with the guidelines of the United States Food and Drug Administration(FDA).The developed chromatographic method proved to be simple, precise, accurate, robust and reproducible. Moreover, the samples showed stability at room temperature over a period of 48 h. Thus, this method would be employed for routine simultaneous quantification of docetaxel and curcumin in rat plasma samples.

关键词： Curcumin Docetaxel HPLC Plasma-extraction Simultaneous determination Validation