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Classifying extrahepatic bile duct metachronous carcinoma by de novo neoplasia site

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World Journal of Gastroenterology 2014年第11期20卷 3050-3055页

作者： hyung jun kwon Sang Geol Kim Jae Min Chun Yoon Jin Hwang Department of Surgery Kyungpook National University Medical CenterDaegu 702-210South Korea

Extrahepatic bile duct(EHBD)cancer may occur metachronously,and these cancers are resectable with a favorable *** aimed to identify the pattern of metachronous EHBD *** classified the cases of metachronous EHBD cancer reported in the literature thus far and investigated two new cases of metachronous EHBD cancer.A 70-year-old female underwent R0 bile duct resection for a type 1 Klatskin tumor(pT-1N0M0).A 70-year-old male patient underwent R0 bile duct resection for a middle bile duct cancer(pT2N1M0).Imaging studies of both patients taken at 14 and 24mo after first surgery respectively revealed a metachronous cholangiocarcinoma that required pancreaticoduodenectomy(PD).Histopathology of the both tumors after PD revealed cholangiocarcinoma invading the pancreas(pT3N0M0).Both patients have been free from recurrence for 6 years and 16 mo respectively after the second *** a review of the literature on these cases,we classified the pattern of metachronous EHBD cancer according to the site of de novo *** proximal remnant bile duct was most commonly *** EHBD cancer should be distinguished from an unresectable recurrent *** metachronous EHBD cancer may be helpful in identifying rare metachronous tumors.

关键词： Metachronous Extrahepatic bile duct Cancer Prognosis Recurrence

Prognostic factors in patients with middle and distal bile duct cancers

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World Journal of Gastroenterology 2014年第21期20卷 6658-6665页

作者： hyung jun kwon Sang Geol Kim Jae Min Chun Won Kee Lee Yoon Jin Hwang Department of Surgery Kyungpook National University Medical CenterDaegu 702-210South Korea Department of Surgery School of MedicineKyungpook National UniversityDaegu 700-422South Korea Department of Preventive Medicine School of Medicine Kyungpook National University Daegu 700-422South Korea

AIM: To identify the influence of the surgery type and prognostic factors in middle and distal bile duct cancers.

关键词： Distal extrahepatic bile duct cancer Lymphovascular invasion Tumor node metastasis Pancreaticoduodenectomy Bile duct resection Prognostic factor

Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.M.Liyanage Thilina U.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong hyung‑jun kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets Inhibitors

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4223-4234页

作者： Yeong-Bin Baek hyung-jun kwon Muhammad Sharif Jeongah Lim In-Chul Lee Young Bae Ryu Jae-In Lee Ji-Sun Kim Young-Seung Lee Dong-Hoon Kim Sang-Ik Park Don-Kyu Kim Jeong-Sun Kim Hyon EChoy Sunwoo Lee Hueng-Sik Choi Timothy FOsborne Tae-Il Jeon Kyoung-Oh Cho Laboratory of Veterinary Pathology College of Veterinary MedicineChonnam National UniversityGwangju61186Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Chemistry Chonnam National UniversityGwangju61186Republic of Korea Korean Collection for Type Cultures Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Animal Science Chonnam National UniversityGwangju61186Republic of Korea Department of Pharmacology Korea University College of MedicineSeoul02841Republic of Korea Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju61186Republic of Korea Department of Microbiology Chonnam National University Medical SchoolGwangju61486Republic of Korea School of Biological Sciences and Technology Chonnam National UniversityGwangju61186Republic of Korea Institute for Fundamental Biomedical Research Department of Medicine and Biological ChemistryJohns Hopkins University School of MedicineSt.PetersburgFL33701USA

The biosynthesis of host lipids and/or lipid droplets(LDs)has been studied extensively as a putative therapeutic target in diverse viral ***,directly targeting the LD lipolytic catabolism in virus-infected cells has not been widely ***,we show the linkage of the LD-associated lipase activation to the breakdown of LDs for the generation of free fatty acids(FFAs)at the late stage of diverse RNA viral infections,which represents a broad-spectrum antiviral *** of membrane transporter systems due to virus-induced cell injury results in intracellular malnutrition at the late stage of infection,thereby making the virus more dependent on the FFAs generated from LD storage for viral morphogenesis and as a source of *** replication of SARS-CoV-2 and influenza A virus(IAV),which is suppressed by the treatment with LD-associated lipases inhibitors,is rescued by supplementation with *** administration of lipase inhibitors,either individually or in a combination with virus-targeting drugs,protects mice from lethal IAV infection and mitigates severe lung lesions in SARS-CoV-2-infected ***,the lipase inhibitors significantly reduce proinflammatory cytokine levels in the lungs of SARS-CoV-2-and IAV-challenged animals,a cause of a cytokine storm important for the critical infection or mortality of COVID-19 and IAV *** conclusion,the results reveal that lipase-mediated intracellular LD lipolysis is commonly exploited to facilitate RNA virus replication and furthermore suggest that pharmacological inhibitors of LD-associated lipases could be used to curb current COVID-19-and future pandemic outbreaks of potentially troublesome RNA virus infection in humans.

关键词： linkage furthermore thereby

EXPERIMENTAL ESTIMATION OF A SCALING EXPONENT FOR TIP VORTEX CAVITATION VIA ITS INCEPTION TEST IN FULL-AND MODEL-SHIP

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Journal of Hydrodynamics 2012年第5期24卷 658-667页

作者： LEE Jeung-Hoon junG Jae-kwon LEE Kyung-jun HAN Jae-Moon PARK hyung-Gil SEO Jong-Soo Samsung Ship Model Basin(SSMB) Marine Research InstituteSamsung Heavy IndustriesScience TownDaejeon 305-380Korea

Tip vortex cavitation noise of marine propeller became primary concems to reduce hazardous environmental impacts from commercial ship or to keep the underwater surveillance of naval ships. The investigations of the tip vortex and its induced noise are normally conducted through the model test in a water cavitation tunnel. However the Reynolds number of model-test is much smaller than that of the full-scale, which subsequently results in the difference of tip vortex cavitation inception. Hence, the scaling law between model- and full-scales needs to be identified prior to the prediction and assessment of propeller noise in full scale. From previous researches, it is generally known that the incipient caivtation number of tip vortex can be represented as a power of the Reynolds number. However, the power exponent for scaling, which is the main focus of this research, has not been clearly studied yet. This paper deals with the estimation of scaling exponent based on tip vortex cavitation inception test in both full- and model-scale ships. Acoustical measurements as well as several kind of signal processing technique for an inception criterion suggest the scaling exponent as 0.30. The scaling value proposed in this study shows slight difference to the one of most recent research. Besides, extrapolation of model-ship noise measurement using the proposed one predicts the full-scale noise measurement with an acceptable discrepancy.

关键词： tip vortex cavitation underwater radiated noise scaling exponent

Enhanced electrical and optical properties of single- layered MoS2 by incorporation of aluminum

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Nano Research 2018年第2期11卷 731-740页

作者： hyung-jun Kim Suk Yang Hojoong Kim Jin Young Moon Kyung Park Yun-Jin Park Jang-Yeon kwon School of Integrated Technology Yonsei University Incheon Republic of Korea Yonsei Institute of Convergence Technology Incheon Republic of Korea

Electrical and optical enhancements of single-layer semiconducting materials such as transition metal dichalcogenides have recently been studied to achieve sensitive properties via external treatments, such as the formation of organic/ inorganic protecting layers on field-effect transistors （FETs）, thermal annealing, and nano-dot doping of sensors and detectors. Here, we propose a new analytical approach to electrical and optical enhancement through a passivation process using atomic layer deposition （ALD）, and demonstrate a synthesized MoS2 monolayer incorporated with A1 atoms in an A1203 passivation layer. The incorporated A1 atoms in the MoS2 monolayer are dearly observed by spherical aberration-corrected scanning transmission electron microscopy （Cs-STEM） and TEM-energy-dispersive X-ray spectroscopy results. We demonstrate that the chemically incorporated FETs exhibit highly enhanced mobilities of approximately 3.7 crn2-V-los-1, forty times greater than that of as-synthesized MoS2, with a three- fold improvement in the Dhotoluminescence properties.

关键词： MoS2 aluminum incorporation chemical vapor deposition atomic layer deposition

Adaptive Consistent Management to Prevent System Collapse on Shared Object Manipulation in Mixed Reality

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Computers, Materials & Continua 2023年第4期75卷 2025-2042页

作者： jun Lee Hyun kwon Department of Game Software Hoseo UniversityAsan-siKorea Department of Artificial Intelligence and Data Science Korea Military AcademySeoulKorea

A concurrency control mechanism for collaborative work is akey element in a mixed reality environment. However, conventional lockingmechanisms restrict potential tasks or the support of non-owners, thusincreasing the working time because of waiting to avoid conflicts. Herein, wepropose an adaptive concurrency control approach that can reduce conflictsand work time. We classify shared object manipulation in mixed reality intodetailed goals and tasks. Then, we model the relationships among goal,task, and ownership. As the collaborative work progresses, the proposedsystem adapts the different concurrency control mechanisms of shared objectmanipulation according to the modeling of goal–task–ownership. With theproposed concurrency control scheme, users can hold shared objects andmove and rotate together in a mixed reality environment similar to realindustrial sites. Additionally, this system provides MS Hololens and Myosensors to recognize inputs from a user and provides results in a mixed realityenvironment. The proposed method is applied to install an air conditioneras a case study. Experimental results and user studies show that, comparedwith the conventional approach, the proposed method reduced the number ofconflicts, waiting time, and total working time.

关键词： Mixed reality upper body motion recognition shared object manipulation adaptive task concurrency control

Laser‑Induced and MOF‑Derived Metal Oxide/Carbon Composite for Synergistically Improved Ethanol Sensing at Room temperature

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Nano-Micro Letters 2024年第6期16卷 210-220页

作者： Hyeongtae Lim Hyeokjin kwon Hongki Kang Jae Eun Jang Hyuk‑jun kwon Department of Electrical Engineering and Computer Science DGISTDaegu 42988South Korea Convergence Research Advanced Centre for Olfaction DGISTDaegu 42988South Korea

Advancements in sensor technology have significantly enhanced atmospheric ***,metal oxide and carbon(MO_(x)/C)hybrids have gained attention for their exceptional sensitivity and room-temperature sensing ***,previous methods of synthesizing MO_(x)/C composites suffer from problems,including inhomogeneity,aggregation,and challenges in ***,we introduce a refined method that employs a metal–organic framework(MOF)as a precursor combined with direct laser *** inherent structure of MOFs ensures a uniform distribution of metal ions and organic linkers,yielding homogeneous MO_(x)/C *** laser processing facilitates precise micropatterning(<2μm,comparable to typical photolithography)of the MO_(x)/C *** optimized MOF-derived MO_(x)/C sensor rapidly detected ethanol gas even at room temperature(105 and 18 s for response and recovery,respectively),with a broad range of sensing performance from 170 to 3,400 ppm and a high response value of up to 3,500%.Additionally,this sensor exhibited enhanced stability and thermal resilience compared to previous MOF-based *** research opens up promising avenues for practical applications in MOF-derived sensing devices.

关键词： Metal-organic frameworks Metal oxide Carbon composite Laser Gas sensor

Spatial Multi-Presence System to Increase Security Awareness for Remote Collaboration in an Extended Reality Environment

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Intelligent Automation & Soft Computing 2023年第7期37卷 369-384页

作者： jun Lee Hyun kwon Department of Game Software Hoseo UniversityAsan-siKorea Department of Artificial Intelligence and Data Science Korea Military AcademySeoulKorea

Enhancing the sense of presence of participants is an important issue in terms of security awareness for remote collaboration in extended ***,conventional methods are insufficient to be aware of remote situations and to search for and control remote *** study pro-poses a spatial multi-presence system that simultaneously provides multiple spaces while rapidly exploring these spaces as users perform collaborative work in an extended reality *** proposed system provides methods for arranging and manipulating remote and personal spaces by creating an annular screen that is invisible to the *** user can freely arrange remote participants and their workspaces on the annular *** users can simultaneously view various spaces arranged on the annular screen,they can perform collaborative work while simultaneously feeling the presence of multiple spaces and can be fully immersed in a specific *** addition,the personal spaces where users work can also be arranged through the annular *** to the results of the performance evaluations,users participating in remote collaborative works can visualize the spaces of multiple users simultaneously and feel their presence,thereby increasing their understanding of the ***,the proposed system reduces the time to perform tasks and gain awareness of the emergency in remote workspaces.

关键词： Extended reality spatial presence multi presence security awareness