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Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B

World Journal of Gastroenterology 2012年第47期18卷 6987-6995页

作者： Tae Jung yun Jin Yong Jung chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim hyung joon Yim bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun chang Duck Kim Ho Sang Ryu Department of Internal Medicine Korea University College of MedicineSeoul 136-705South Korea Department of Biostatistics Korea University College of MedicineSeoul 136-705South Korea

AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis ***:We included 154 consecutive patients in two treatment groups:the "add-on" group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the "switch/combination" group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as *** "switch/combination" group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the "add-on" group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the "add-on" group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the "add-on" group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment.

关键词： Chronic hepatitis B Lamivudine-resistant Adefovir Combination therapy Roadmap concept

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Truncated Ice Nucleation Protein-Based Cell-surface Display of Green Fluorescent Protein in Escherichia coli

Truncated Ice Nucleation Protein-Based Cell-surface Display ...

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首届中国青年学者微生物遗传学学术研讨会

作者： Li Lin cha hyung-joon Gang Dong-gyun yu Ziniu Laboratory of Agricultural Microbiology, School of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China Department of Chemical Engineering & Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790-784, Korea

The truncated ice nucleation protein InaK from Pseudomonas syringae KCTC1832 strain with only N-terminal domain (InaK-N), was newly achived as an anchoring motif to display the noninvasive reporter, green fluorescence... 详细信息

关键词： Ice-nucleating protein cell-surface display anchoring motif green fluorescent protein

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Damage Detection of Composite Plates Using Finite Element Analysis Based on Structural Health Monitoring

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材料科学与工程（中英文B版） 2011年第1期1卷 14-21页

作者： Kyoung-Tak Kang Heoung-Jae Chun Jin Ah Lee joon-hyung Byun Moon-Kwang Um Sang-Kwan Lee Byung-SunKim School of Mechanical Engineering Yonsei University 262 Seongsanno Seodaemun-Gu Seoul 120-749 Korea Korea Institute of Materials Science 66 Sangnam-Dong Changwon Kyungnam 641-010 Korea

Delamination in composite structures plays a major role in lowering structural strength and stiffness, consequently downgrading system integrity and reliability. The aim of this paper is to show that Lamb waves may be effectively generated using piezoelectric transducers embedded inside a composite plate for health monitoring application. A Lamb wave-based quantitative identification technique for delamination in VARTM composite structures was established. Propagation of Lamb waves in composite plates was evaluated using dynamic FEM analysis. Then, an experiment is carried out to verify the validity of the analytical study based on finite element models. The study was carried out to assess damages in composite plate by fusing information from multiple sensing paths of the embedded network. It was based on the Hilbert transform, signal correlation and probabilistic searching. The obtained results show that satisfactory detection of defects could be achieved by proposed method

关键词：动态有限元分析结构健康监测复合板损伤检测基础 Hilbert变换压电传感器 Lamb波

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The Study on Sulfur and Nickel Distribution Behavior of Nickel between Fe-Ni alloy and MgO-FeO-SiO2 Slag System

The Study on Sulfur and Nickel Distribution Behavior of Nick...

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Ninth International Conference on Molten Slags,Fluxes and Salts(MOLTEN12)

作者： Ki Deok Kim hyung Sub Eom Eun Jin Jung Wan Wook Huh Dong joon Min Department of Materials Science and Engineering Yonsei UniversitySeoul 120-749Korea RIST(Research Institute of Industrial Science & Technology) Gangwon Province210-340Korea

The dissolution behavior of nickel in the MgO-SiO 2-FeO slag system was investigated by using the thermodynamic equilibrium *** distribution ratio between molten MgO-SiO 2-FeO slag and molten Fe-Ni alloy at 1773 K and 1873 K was measured to understand the dissolution mechanism of nickel into the *** dependence of oxygen partial pressure and basicity on the distribution of nickel was *** distribution behavior between slag and Fe-Ni alloy increased with higher oxygen partial pressure showing a dependence of 1/*** basic slag systems near the olivine saturated composition,the nickel distribution ratio increased with higher basicity showing a slope of 1 and for acidic slag systems near the cristobalite saturated composition,the nickel distribution ratio decreased with higher basicity showing a slope *** dissolution behavior of nickel in the MgO-SiO 2-FeO slag system showed two independent mechanisms similar to that found in the CaO-SiO 2-CaF 2 *** distribution ratio of sulfur between the（CaO）-MgO-FeO-SiO 2 slag and Fe-Ni alloy at high temperature was also investigated to understand the refining ability of Ferronickel smelting slag by chemical equilibrating *** experimental results indicated that sulfide capacity in terms of the slag composition of MgO-FeO-SiO 2 slag and temperature was increased with increasing FeO and CaO contents as well as *** FeO is considered to work as relatively basic component in this slag system that has low *** the effect of components of slag on sulfide capacity,CaO and FeO is considered to be more effective basic oxide than MgO in MgO-FeO-SiO 2 slag system while the effect of FeO on sulfide capacity was gradually retarded with increasing *** effect of CaO on MgO solubility of slag and the relationship between sulfide and Ni oxide capacities was also discussed.

关键词： nickel distribution ratio basicity amphoteric behavior sulfide capacity

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Performance Analysis of an Adaptive Hybrid Search Code Acquisition Technique in the Case of Multiple Pilot Signals

Performance Analysis of an Adaptive Hybrid Search Code Acqui...

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IEEE第14届国际个人无线移动通信大会

作者： hyung-Rae Park Yeon-Sil Yang Sang-Sik Yoon Sang-Ho Lee Sung-joon Cho School of Electronics Telecommunications and Computer Engineering Hankuk Aviation University Republic of Korea School of Electronics Telecommunications and Computer Engineering Hankuk Aviation University Republic of Korea School of Electronics Telecommunications and Computer Engineering Hankuk Aviation University Republic of Korea School of Electronics Telecommunications and Computer Engineering Hankuk Aviation University Republic of Korea School of Electronics Telecommunications and Computer Engineering Hankuk Aviation University Republic of Korea

The performance of an adaptive hybrid search code acquisition technique is analyzed for CDMA cellular networks in the case of multiple pilot signals. An analytical expression for the mean acquisiti

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Is endoscopic submucosal dissection safe for papillary adenocarcinoma of the stomach?

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World Journal of Gastroenterology 2015年第13期21卷 3944-3952页

作者： Hyun Jeong Lee Gwang Ha Kim Do Youn Park bong Eun Lee Hye Kyung Jeon joon hyung Jhi Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research Institute Pusan National University Hospital Busan 602-739South Korea Department of Pathology Pusan National University School of MedicineBusan 602-739South Korea

AIM: To identify the clinicopathological predictors of lymph node(LN) metastasis and evaluate the outcomes of endoscopic submucosal dissection(ESD) in papillary adenocarcinoma-type early gastric cancers(EGCs).METHODS: From January 2005 to May 2013, 49 patients who underwent surgical operation and 24 patients who underwent ESD for papillary adenocarcinomatype EGC were enrolled to identify clinicopathological characteristics and predictive factors of LN metastasis and to evaluate the outcomes of ESD for papillary adenocarcinoma-type ***: Most papillary adenocarcinoma-type EGCs were located in the lower third of the stomach and had an elevated macroscopic shape. The overall prevalence of LN metastasis was 18.3%(9/49). The presence of lymphovascular invasion was found to be a predictor of LN metastasis(P = 0.016). According to current indication criteria of ESD, 6 and 11 of the 49 patients had absolute and expanded indications for ESD, respectively. Two patients(11.8%) with expanded indication for ESD had LN metastasis. Of the 24 patients who underwent ESD, 13(54%) achieved out-of-ESD indication, with 9 of those 13 patients undergoing surgical operation due to non-curative resection. CONCLUSION: The use of ESD should be carefully considered for papillary adenocarcinoma-type EGC with suspected ESD indication after pre-treatment work-up because of the higher frequency of LN metastasis and additional surgeries.

关键词： Gastric cancer Papillary adenocarcinoma Endoscopic

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Neoadjuvant chemoradiotherapy followed by D2 gastrectomy in locally advanced gastric cancer

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World Journal of Gastroenterology 2015年第9期21卷 2711-2718页

作者： Mi Sun Kim joon Seok Lim Woo Jin hyung Yong chan Lee Sun Young Rha Ki chang Keum Woong Sub Koom Department of Radiation Oncology Yonsei University College of MedicineSeoul 120-752South Korea Department of Radiology Yonsei University College of MedicineSeoul 120-752South Korea Department of Surgery Yonsei University College of MedicineSeoul 120-752South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Department of Medical Oncology Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy(NACRT) for resectability of locally advanced gastric cancer(LAGC).METHODS:Between November 2007 and January 2014,29 patients with LAGC(clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT followed by D2 gastrectomy were included in this *** was evaluated with radiologic and endoscopic exams before and after *** threedimensional conformal radiotherapy,patients received 45 Gy,with a daily dose of 1.8 *** entire tumor extent and the regional metastatic lymph nodes were included in the gross tumor *** presenting with a resectable tumor after NACRT received a total or subtotal gastrectomy with D2 *** pathologic tumor response was evaluated using Japanese Gastric Cancer Association histologic evaluation *** morbidity was evaluated using the National Cancer Institute-Common Terminology Criteria for Adverse Events version *** survival(OS) and progression-free survival(PFS) rates were estimated using a Kaplan-Meier analysis and compared using the log-rank ***:All patients were assessed as unresectable ***-four patients(24/29; 82.8%) showed LAGC on positron emission tomography-computed tomography(CT) and contrast-enhanced CT,whereas four patients(4/29; 13.8%) with vague invasion orabutment to an adjacent organ underwent diagnostic *** patient(1/29; 3.4%),initially assessed as a resectable case,underwent an "open and closure" after the tumor was found to be *** to an adjacent organ(34.5%) was the most common reason for *** clinical response rate one month after NACRT was 44.8%.After NACRT,69%(20/29) of patients had a resectable *** the 20 patients with a resectable tumor,18 patients(62.1%) underwent a D2 *** R0 resection rate was 94.4% and two patients(2/18; 11.1%) showed a complete *** median follow-

关键词： Advanced gastric cancer D2 gastrectomy Neoadjuvant

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Prediction of the indication criteria for endoscopic resection of early gastric cancer

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World Journal of Gastroenterology 2015年第39期21卷 11160-11167页

作者： Jae Hyun Park Si hyung Lee joon Mo Park chan Seo Park Kyung Sik Park Eun Soo Kim Kwang Bum Cho Department of Internal Medicine Yeungnam University College of Medicine Department of Internal Medicine Keimyung University College of Medicine

AIM: To find risk factors of lymph node metastasis(LNM) in early gastric cancer(EGC) and to find proper endoscopic therapy indication in ***: We retrospectively reviewed the 2270 patients who underwent curative operation for EGC from January 2001 to December 2008. EGC was defined as malignant lesions that do not invade beyond the submucosal layer of the stomach wall irrespective of presence of lymph node ***: Among 2270 enrolled patients, LNM was observed in 217(9%) patients. LNM in intramucosal(M) cancer and submucosal(SM) cancer was detectedin 3 8( 2. 8 %, 3 8 / 1 3 4 0) patients and 1 7 9(19%, 179/930) patients, respectively. In univariate analysis, the risk factors for LNM in EGC were size of tumor, Lauren classification, ulcer, lymphatic invasion, vascular invasion, and depth of invasion. However, in multivariate analysis, size of tumor, lymphatic invasion, vascular invasion, and depth of invasion were risk factors for LNM in EGC. Size of tumor, lymphatic invasion, vascular invasion, and depth of invasion were risk factors for LNM in cases of intramucosal cancer and submucosal cancer. In particular, there was no lymph node metastasis in cases of well differentiated early gastric cancer below 1 cm in size without ulcer regardless of lymphovascular ***: Tumor size, perilymphatic-vascular invasion, and depth of invasion were risk factors for LNM in EGC. There was no LNM in EGC below 1 cmregardless risk factors.

关键词： Early gastric cancer Lymph node metastasis Endosco

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化石燃料+太阳能=未来发电

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上海电力 2009年第6期22卷 516-521页

作者： Dave UgoLini Justin Zachary hyung joon Park 徐慧超上海外国语大学

太阳能热发电对人类环境的改善及电力行业的可持续发展,具有重要的战略意义,也是21世纪的一种重要能源产业。文章介绍可再生能源发展与应用的推广瓶颈,重点分析了3种聚焦型太阳热能(CSP)的集热技术及应用情况,提出了将可再生能源技术与... 详细信息

太阳能热发电对人类环境的改善及电力行业的可持续发展,具有重要的战略意义,也是21世纪的一种重要能源产业。文章介绍可再生能源发展与应用的推广瓶颈,重点分析了3种聚焦型太阳热能(CSP)的集热技术及应用情况,提出了将可再生能源技术与传统发电技术相结合,取长补短,是一种切实可行的解决办法。可以预见,未来发电的趋势是将传统的火力发电技术与太阳能热发电技术相结合。

关键词：混合循环电厂集热器聚焦型太阳热能太阳能热发电

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Investigation on Infectious Agents of Aborted Pig Fetuses and Its Correlation with PRRSV MLV Vaccine

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Journal of Agricultural Science and Technology(A) 2017年第4期7卷 282-287页

作者： Woo-Taek Oh Van-Giap Nguyen hyung-joon Moon Jee-Hoon Lee Hye-Kwon Kim Seong-Jun Park Hee-Chun Chung bong-Kyun Park Department of Veterinary Medicine Virology Lab College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University Daehak-ro 1 Gwanak-gu Seou108826 Korea Department of Veterinary Microbiology and Infectious Diseases Faculty of Veterinary Medicine Vietnam National University ofAgriculture Hanoi 50877 Vietnam Viral Infectious Disease Research Unit Green Cross Veterinary Products Yongin 17066 Republic of Korea Viral Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Korea Forensic Medicine Division Daegu Institute National Forensic Service Chilgok 34054 Korea

Infectious agents causing aborted fetus problems in domestic pigs were investigated in this study. More than 10 different infectious agents were known to cause abortion in swine and the major eight viruses among them were inspected. One hundred twelve samples of aborted fetuses from nine provinces in South Korea were collected during April to November, 2013 in this study for the diagnosis of infectious agents causing abortions in pigs. Eight major infection viruses were examined in this study mainly using various diagnostic kits and reverse transcriptase polymerase chain reaction （RT-PCR）. Positive rate of the detection differed from each viruses. In this study, the main focus was the porcine reproductive and respiratory syndrome virus （PRRSV）, which took the second large portion in the positive rate of detection, and then its ORF5 gene was compared with modified live virus （MLV） vaccine strain to figure out the influence of vaccine on disease. Between four positive samples＇ sequence, two of them were 99.9%-100% similar to MLV vaccine strain and two other samples were 88.6%-92.7% similar. Similarity rate of the sequences between the vaccine and virus from aborted fetuses are very crucial, because it implies that abortion in swine can be made due to the usage of vaccine not only by the infection of field virus, and if MLV vaccine actually do have an impact on the infection, usage of the vaccine should be reconsidered.

关键词： Abortion infectious agents domestic pig PRRSV MLV vaccine.

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