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Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis

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World Journal of Gastroenterology 2022年第44期28卷 6294-6309页

作者： Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il Kim Sung Kook Kim Sang woo Lee Kyung Sik Park Kook Lae Lee Suck Chei Choi Jae-Young Jang Gwang Ha Kim In-kyung Sung Moo In Park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik Lee hyun Soo Kim Ki Bae Kim Yong Chan Lee Myung-Gyu Choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-hyun Kim hyunsoo Chung Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Korea University Anam HospitalSeoul 02841South Korea Department of Internal Medicine The Catholic University of KoreaYeouido ST.Mary’s HospitalSeoul 07260South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine Korea University Ansan HospitalAnsan-si 15355South Korea Department of Internal Medicine Keimyung University Dongsan HospitalDaegu 42601South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Internal Medicine Wonkwang University HospitalIksan 54538South Korea Department of Internal Medicine KyungHee University Medical CenterSeoul 02447South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 47241South Korea Department of Internal Medicine KKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Kosin University Gaspel HospitalBusan 49267South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu 42471South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-si 13620Gyeonggi-doSouth Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju-si 54907South Korea Department of Internal Medicine Chonnam National University HospitalGwangju 61469South Korea Department of Internal medicine Chungbuk National University School of MedicineCheong Ju 28644South Korea Department of Internal Medicine Severance HospitalSeoul 03722South Korea Department of Internal Medicine The Catholic University of KoreaSeoul ST.Mary’s HospitalSeoul 06591South Korea Digestive Disease Center Soon

BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal ***’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent *** To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight *** primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week *** secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life *** profiles and serum gastrin levels were compared between the *** Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life ***,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the *** Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week *** suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.

关键词： Gastroesophageal reflux Esophagitis Proton pump inhibitors Heartburn Quality of life

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The Effects of Adhesion Layer on Electrical Characteristics Performance in Bottomcontact Organic Thin Film Transistors

The Effects of Adhesion Layer on Electrical Characteristics ...

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2007亚洲显示国际会议

作者： Gun woo hyung Jun Ho Kim Seo Ji hyun Seo Ji Hoon Park II Houng Young Kwan Kim Department of Materials Science and Engineering Hongik University Seoul 121-791Korea Center for Organic Materials and Information DevicesHongik UniversitySeoul 121-791Korea Department of Electronic Engineering Hongik University Seoul 121-791Korea Center for Organic Materials and Information DevicesHongik UniversitySeoul 121 -791Korea Department of Information Display Hongik University Seoul 121-791Korea Center for Organic Materials and Information DevicesHongik UniversitySeoul 121-791Korea

We demonstrated that organic thin-film-transistors(OTFTs)can be fabricated by using organic gate insulators using a vapor deposition polymerization(VDP)*** basic material properties of organic thin-film fabricated by VDP method were investigated and organic thin film was adopted as adhesion layer to investigate electrical ***- film-transistors based on organic semiconductor(OTFTs)have received considerable attention because of their potential application in a variety of industries,since the performance of silicon TFTs can be replaced by *** the high-per- formance OTFTs,it is reported that the grown crystalline characteristics of pentacene are critically correlated with the sur- face energy for the *** this study,instead of polyimide which was well known gate insulators,6FDA-ODA was used as a polymeric adhesion layer deposited on inorganic gate insulator such as silicon nitride(SiN),which was formed by vapor deposition polymerization(VDP)instead of spin-coating *** have investigated the effect of the adhesion layer on the interfacial characteristics between Pentacene and *** hence,the The electrical characteristics of OTFTs using 6FDA-ODA as an adhesion layer could be compared and ***,bottom-contact structure adop- ting organic thin film fabricated by VDP method was investigated.

关键词： Organic Thin-film Transistor(OTFT) Vapor Deposition Polymerization(VDP) Adhesion Layer

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SiO2-Promoted Ni Bulk Catalyst for Single-Stage Water Gas Shift Reaction

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华东理工大学学报（自然科学版） 2010年第5期36卷 661-661页

作者： KIM Sung-Ho KIM Yun-tae UM Ji-hyun NAM Suk-woo LIM Tae-hoon LEE Ho-in School of Chemical and Biological Engineering and Research Center for Energy Conversion and Storage Seoul National University Seoul 151-744 Korea Center for Fuel Cell Research Korea Institute of Science and Technology Seoul 136-791 Korea

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Low-dose amitriptyline combined with proton pump inhibitor for functional chest pain

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World Journal of Gastroenterology 2013年第30期19卷 4958-4965页

作者： Se woo Park Hyuk Lee hyun Jik Lee Jun Chul Park Sung Kwan Shin Sang Kil Lee Yong Chan Lee Ji Eun Kim Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine Biostatistics Collaboration Unit Yonsei University College of Medicine

AIM:To investigate the efficacy of amitriptyline with proton pump inhibitor(PPI)for the treatment of functional chest pain(FCP).METHODS:This was a randomized,open-label trial investigating the addition of low dose amitriptyline(10 mg at bedtime)to a conventional dose of rabeprazole(20 mg/d)(group A,n = 20)vs a double-dose of rabeprazole(20 mg twice daily)(group B,n = 20)for patients with FCP whose symptoms were refractory to *** primary efficacy endpoints were assessed by global symptom score assessment and the total number of individuals with > 50% improvement in their symptom ***:The between-group difference in global symptom scores was statistically significant during the last week of treatment(overall mean difference;3.75 ± 0.31 vs 4.35 ± 0.29,the between-group difference;P 50%,whereas only 26.3% of patients in group B had a similar treatment response(70.6% vs 26.3%,P = 0.008).Specifically,patients in group A had a significantly greater improvement in the domains of body pain and general health perception than did patients in group B(52.37 ± 17.00 vs 41.32 ± 12.34,P = 0.031 and 47.95 ± 18.58 vs 31.84 ± 16.84,P = 0.01,respectively).CONCLUSION:Adding amitriptyline to a PPI was more effective than a double-dose of PPI in patients with FCP refractory to a conventional dose of PPI.

关键词： Functional chest pain Proton pump inhibitor Amitriptyline

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Development of controlled release bi-layered tablets containing oxycodone hydrochloride

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 178-178页

作者： Kyung Hun Kim Kyung Soo Lee Il woo Jung Jin Seob Oh Seo hyun Lim Sung Hoon Lee woo Heon Song Jun Sang Park GLPharmTech Corporation #714JungangInduspia V137Sagimakgol-roJungwon-guSeongnamGyeonggidoRepublic of Korea Department of Pharmaceutical Engineering Cheongju University298Daeseong-roCheongwon-guCheongjuChungcheongbuk-doRepublic of Korea

Oxycodone hydrochloride is a semi-synthetic opioid agonist that provides very effective relief for moderate to severe pain in cancer and post-operative patients. Controlled release oxycodone formulations have been studied to enhance the therapeutic effect by providing constant release over the whole dosing interval and improve patient’s convenience by reducing the frequency of administration as well.

关键词： Oxycodone Control release Bi-layered tablet IVIVC

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Improvement of Renewable Bioenergy Production in Microbial Fuel Cells with Saponin Supplementation

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Journal of Sustainable Bioenergy Systems 2021年第2期11卷 82-93页

作者： Skylar Choi Yongjin Park Immanuel H. Anaborne Jin Sik Song Ji woo Han So hyun Jeon Jaewoo Kim James Kim Jinkwon Lee Paul S. Chung Horace Greeley High School Chappaqua NY USA Deerfield Academy Deerfield MA USA Oakton High School Vienna VA USA School of Arts & Sciences University of Virginia Charlottesville VA USA School of Arts & Sciences Emory University Atlanta GA USA Bachelor of Science Villanova University Villanova PA USA College of Letters & Sciences University of California Los Angeles Los Angeles CA USA School of Arts & Sciences University of Michigan Ann Arbor MI USA Division of Biological Sciences Revelle College University of California San Diego CA USA Fuzbien Technology Institute Rockville MD USA

Microbial fuel cell (MFC) is one of renewable biofuel production technology that directly converts biomass to electricity. Cellulosic biomass is particularly attractive renewable resources for its low cost and abundance and neutral carbon balance. However, methanogenesis remains as a major factor limiting MFC performance. The current study reports that saponin addition at 0.05% w/v dose to anolyte in MFCs inhibited methanogenesis and improves power generation and cellulose fermentation. Mediator-less two chamber H-type MFCs were prepared using rumen fluid as anode inocula at 20% v/v of anolyte to convert finely ground pine tree (Avicel) at 2%, w/v to electricity. Saponin was added to the anode of MFC at 0.005% or 0.05% v/v dosage for treatment. MFC power and current across an external resistor were measured daily for 10d. On d10, collected gases from anode compartment were measured for total gas volume and analyzed for gas composition on gas chromatography. Supplementation of saponin to MFC at 0.005% did not have any effects on electricity generation or biogas production and composition. Saponin at 0.05% dose reduced 10% of methane prod

关键词： Microbial Fuel Cells Saponin Bioenergy

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Small cell carcinoma of the liver and biliary tract without jaundice

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World Journal of Gastroenterology 2013年第44期19卷 8146-8150页

作者： Jae-Min Jo Yoo-Kyung Cho Chang-Lim hyun Kyoung-Hee Han Ji-Young Rhee Jung-Mi Kwon woo-Kun Kim Sang-Hoon Han Department of Internal Medicine Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing Province South Korea Department of Pathology Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing ProvinceSouth Korea Jeju National University School of Medicine Jeju-si 890-716 Jeju Self-Governing Province South Korea

An 80-year-old woman presenting with chest pain was found to have a large,lobulated soft tissue mass in the liver and nearby tissues on abdominal computed tomography(CT).The tumor had invaded the common hepatic artery and main portal *** developed 4 wk later,at which point,a pancreas and biliary CT scan revealed a large mass in the right lobe of the liver and a hilar duct obstruction,which was found to be a small cell *** its rarity,liver and bile duct small cell carcinoma should be considered in the differential diagnosis of atypical chest pain without jaundice.

关键词： Extrapulmonary small cell carcinoma Jaundice Liver mass Bile duct mass Neuroendocrine tumor

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Retreatment with peginterferon and ribavirin in chronic hepatitis C

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World Journal of Gastroenterology 2015年第6期21卷 1994-1999页

作者： Yong Min Jo Sung wook Lee Sang Young Han Yang hyun Baek Soo Young Kim woo Jae Kim Ji Hye Ahn Ji Young Lee Department of Internal Medicine Dong-A University School of Medicine

The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis *** addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and ***,there are several challenges associated with the application of noveldrugs,such as new and more frequent adverse events,new drug interactions,and excessively high treatment *** additional concern is viral *** considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patients who are in need of *** retrospective study revealed that the sustained virologic response was not significantly reduced following peginterferon and ribavirin retreatment compared with the new *** suggest that patients who experience relapse shortly after completing treatment with peginterferon and ribavirin have a reasonable chance of achieving a sustained virologic response when retreated with these drugs alone.

关键词： Chronic hepatitis C Direct-acting antiviral agents

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Gastrointestinal stromal tumor solitary distant recurrence in the left brachialis muscle

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World Journal of Gastroenterology 2015年第20期21卷 6404-6408页

作者： Su-Sin Jin Hyeong-Seok Jeong hyun-Jin Noh woo-hyung Choi Seung-Hwa Choi Kang-Yeon Won Dong-Pil Kim Ji-Chan Park Mi-Kyong Joung Jeong-Goo Kim Hae-Joung Sul Seung-woo Lee Division of Gastroenterology Department of Internal MedicineDaejeon St.Mary’s HospitalThe Catholic University of Korea Department of Internal Medicine Anyang Sam Hospital Department of General Surgery Daejeon St.Mary’s HospitalThe Catholic University of Korea Department of Pathology Daejeon St.Mary’s HospitalThe Catholic University of Korea

Gastrointestinal stromal tumors(GISTs) are mesenchymal tumors of the gastrointestinal tract that are most commonly found in the stomach. Although GISTs can spread to the liver and peritoneum, metastasis to the skeletal muscle is very rare and only four cases have previously been reported. These cases involved concurrent skeletal metastases of primary GISTs or liver metastases. Here, we report the first case of a distant recurrence in the brachialis muscle after complete remission of an extra-luminal gastric GIST following a wedge resection of the stomach, omental excision, and adjuvant imatinib therapy for one year. Ten months after therapy completion, the patient presented with swelling and tenderness in the left arm. Magnetic resonance imaging revealed a large mass in the brachialis muscle, which showed positivity for c-kit and CD34 upon pathologic examination. This is the first reported case of a solitary distant recurrence of a GIST in the muscle after complete remission had been achieved.

关键词： Brachialis muscle Distant recurrence Gastrointestinal stromal tumor Skeletal metastasis Tyrosine kinase inhibitor

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Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes

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World Journal of Gastroenterology 2010年第26期16卷 3249-3257页

作者： Mi-Young Song Ui-Jin Bae Bong-Hee Lee Kang-Beom Kwon Eun-A Seo Sung-Joo Park Min-Sun Kim Ho-Joon Song Keun-Sang Kwon Jin-woo Park Do-Gon Ryu Byung-hyun Park Department of Biochemistry Medical School and Diabetes Research Center Chonbuk National University Jeonju Jeonbuk 561-756 South Korea Department of Physiology School of Oriental Medicine Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Food and Nutrition School of Human Environmental Science Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Herbology School of Oriental Medicine Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Preventive Medicine Medical School Chonbuk National University Jeonju Jeonbuk 561-756 South Korea

AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were completely abolished when mice were pretreated with NJE. Inhibition of streptozotocin-induced hyperglycemia by NJE was mediated by suppression of nuclear factor (NF)-κB activation. In addition, NJE protected against cytokine-mediated cytotoxicity. Incubation of RINm5F cells and islets with NJE resulted in a signif icant reduction in cytokine-induced NF-κB activation and downstream events, inducible nitric oxide synthase expression and nitric oxide production. The protective effect of NJE was further demonstrated by the normal insulin secretion of cytokine-treated islets in response to glucose. CONCLUSION: NJE provided resistance to pancreatic β-cell damage from cytokine or streptozotocin treatment. The β-cell protective effect of NJE is mediated by suppressing NF-κB activation.

关键词： Nardostachys jatamansi Cytokines Streptozotocin Pancreatic β cells Nuclear factor κB Nitric oxide Diabetes mellitus

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