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Oral cyclophosphamide-induced posterior reversible encephalopathy syndrome in a patient with ANCA-associated vasculitis:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6130-6137页

作者： Yire Kim Jihye Kwak Sehyun Jung Seunghye Lee Ha Nee jang hyun Seop Cho Se-Ho Chang hyun-Jung Kim Internal Medicine Gyeongsang National University HospitalJinju 52727South Korea Institute of Health Sciences Gyeongsang National UniversityJinju 52727South Korea Internal Medicine College of MedicineGyeongsang National UniversityJinju 52727South Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)manifests many neurological symptoms with typical features on neuroimaging studies and has various risk *** is one of the therapeutic agents for antineutrophil cytoplasmic antibody(ANCA)-associated *** as the sole cause of PRES has been reported in only a few ***,we report a unique case of early-onset oral cyclophosphamide-induced PRES in a patient with ANCA-associated *** SUMMARY A 73-year-old man was transferred to our hospital for sepsis due to acute *** had already received hemodialysis for two weeks due to septic acute kidney *** azotemia was not improved after sepsis resolved and perinuclear-ANCA was *** biopsy showed crescentic *** hemorrhage was observed on *** was initially treated with intravenous methylprednisolone and plasma exchange for one *** then,two days after adding oral cyclophosphamide,the patient developed generalized tonic-clonic *** diagnosed PRES by Brain magnetic resonance imaging(MRI)and *** were controlled with fosphenytoin 750 *** was suspected to be the cause of PRES and *** mentality was recovered after seven days and brain MRI showed normal state after two *** The present case shows the possibility of PRES induction due to short-term use of oral cyclophosphamide *** should carefully monitor neurologic symptoms after oral cyclophosphamide administration in elderly patients with underlying diseases like sepsis,renal failure and ANCA-associated vasculitis.

关键词： Cyclophosphamide Posterior reversible encephalopathy syndrome Antineutrophil cytoplasmic antibody-associated vasculitis Renal failure Case report

Development of Fok-I based nested polymerase chain reaction-restriction fragment length polymorphism analysis for detection of hepatitis B virus X region V5M mutation

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World Journal of Gastroenterology 2015年第47期21卷 13360-13367页

作者： Hong Kim seok-hyun Hong Seoung-Ae Lee Jeong-Ryeol Gong Bum-Joon Kim Department of Biomedical Sciences Microbiology and Immunology and Liver Research Institute Seoul National University College of Medicine

AIM: To develop a Fok-I nested polymerase chain reaction(PCR)-restriction fragment length polymorphism analysis(PRA) method for the detection of hepatitis B virus X region(HBx) V5 M ***: Nested PCR was applied into DNAs from 198 chronic patients at 2 different stages [121 patients with hepatocellular carcinoma(HCC) and 77 carrier patients]. To identify V5 M mutants, digestion of nested PCR amplicons by the restriction enzyme Fok-I(GGA TGN9↓) was done. For size comparison, the enzymetreated products were analyzed by electrophoresis on 2.5% agarose gels, stained with ethidium bromide, and visualized on a UV ***: The assay enabled the identification of 69 patients(sensitivity of 34.8%; 46 HCC patients and 23 carrier patients). Our data also showed that V5 M prevalence in HCC patients was significantly higher than in carrier patients(47.8%, 22/46 patients vs 0%, 0/23 patients, P < 0.001), suggesting that HBx Ag V5 M mutation may play a pivotal role in HCC generation in chronic patients with genotype C ***: The Fok-I nested PRA developed in this study is a reliable and cost-effective method to detect HBx Ag V5 M mutation in chronic patients with genotype C2 infection.

关键词： Hepatitis B virus X antigen Polymerasechain reaction-restriction fragment length polymorphismanalysis V5M mutation Hepatocellur carcinoma

Screw penetration of the iliopsoas muscle causing late-onset pain after total hip arthroplasty: A case report

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World Journal of Clinical Cases 2021年第32期9卷 10006-10012页

作者： hyung-seok Park Sang-Hong Lee Hong-Man Cho hyun-Bai Choi Suenghwan Jo Department of Orthopaedic Surgery Chosun University HospitalGwangju 61453South Korea Department of Orthopedics Gwangju Veterans HospitalGwangju 62284South Korea

BACKGROUND Postoperative pain following total hip arthroplasty(THA)may occur in a few patients but may pose a significant challenge to surgeons if the etiology is not ***,we report the case of a patient who developed late-onset pain following THA due to screw penetration of the iliopsoas *** SUMMARY We report the case of a 77-year-old man who developed inguinal pain 7 years after *** the symptoms resembled that of iliopsoas impingement by the acetabular cup,the pain resolved only when the supplementary acetabular screw protruding through the ilium was *** was performed using the pararectus *** patient was able to ambulate pain-free immediately after *** A protruded screw through the ilium may penetrate the iliopsoas muscle,causing pain following *** may resolve with the decompression of the protruded screw.

关键词： Acetabular cup Iliopsoas impingement Para-rectus approach Screw penetration Total hip arthroplasty Case report

Atypical progress of frozen shoulder after COVID-19 vaccination:A case report

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World Journal of Clinical Cases 2023年第15期11卷 3637-3642页

作者： hyun-seok Jo Hyeong-Min Kim Jae-Young Han Hyeng-Kyu Park Department of Physical and Rehabilitation Medicine Research Institute of Medical SciencesHeart Research CenterChonnam National UniversityChonnam National University Medical School&HospitalGwangju City 61469South Korea Department of Physical and Rehabilitation Medicine Regional Cardiocerebrovascular CenterCenter for Aging and GeriatricsResearch Institute of Medical SciencesHeart Research CenterChonnam National UniversityChonnam National University Medical School&HospitalGwangju City 61469South Korea

BACKGROUND After vaccination was mandated worldwide,various adverse effects associated with the coronavirus disease 2019(COVID-19)vaccination,including shoulder pain,have been ***,we report a case of new-onset shoulder pain after BNT162b2(Comirnaty,Pfizer-BioNTech)mRNA *** SUMMARY A 50-year-old man visited our rehabilitation center with left shoulder range of motion(ROM)limitation that had persisted for more than 5 *** history included no specific noteworthy events,except *** pain in the patient’s left deltoid muscle appeared 1 day after the second BNT162b2 vaccination and intensified to severe *** patient self-administered aspirin,with which the pain subsided immediately,whereas ROM limitation *** the first visit,the patient complained of dull pain and ROM restriction of the left shoulder(flexion 130°,abduction 110°,and external rotation 40°).Among the diagnostic studies conducted for the evaluation of the shoulder,magnetic resonance imaging showed a thickened coracohumeral *** conduction studies and needle electromyography showed no electrodiagnostic *** patient received comprehensive rehabilitation for 7 mo and had an overall improvement in pain and ROM of the left *** In this case of severe shoulder pain after COVID-19 vaccination that subsided immediately with aspirin treatment,the exact cause and mechanism of pain are ***,the clinical symptoms and diagnostic workups in our report suggest the possibility that the COVID-19 vaccination triggered an immunochemical response that resulted in shoulder pathology.

关键词： COVID-19 Vaccination Adhesive capsulitis Frozen shoulder Mechanism Case report

Sucrose induces flowering by degradation of the floral repressor Ghd7 via K48-linked polyubiquitination in rice

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Journal of Integrative Plant Biology 2024年第12期66卷 2683-2700页

作者： Lae-Hyeon Cho Jinmi Yoon Gibeom Baek Win Tun Hyeok Chan Kwon Dae-Woo Lee seok-hyun Choi Yang-seok Lee Jong-Seong Jeon Gynheung An Department of Plant Bioscience College of Natural Resources and Life SciencePusan National UniversityMiryang 50463Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang 50463Korea Department of Biological Sciences Inha UniversityIncheon 22212Korea Department of Biological Sciences and Bioengineering Inha University/Industry-Academia Interactive R&E Center for Bioprocess InnovationInha UniversityIncheon 22212Korea Crop Biotech Institute and Graduate School of Green-Bio Science Kyung Hee UniversityYongin 17104Korea

Sucrose functions as a signaling molecule in several metabolic pathways as well as in various developmental ***,the molecular mechanisms by which sucrose regulates these processes remain largely *** the present study,we demonstrate that sucrose promotes flowering by mediating the stability of a regulatory protein that represses flowering in *** application of sucrose promoted flowering by inducing florigen gene *** of sucrose levels in the phloem through genetic modifications,such as the overexpression of the vacuolar invertase OsVIN2 or the mutation of OsSUT2,a sucrose transporter,delayed *** of relative transcript levels of floral regulatory genes showed that sucrose activated Ehd1 upstream of the florigen,with no significant effect on the expression of other upstream *** of protein stability after sucrose treatment of major floral repressors revealed that the Ghd7 protein was specifically *** Ghd7 protein interacted with the E3 ligase IPA INTERACTING PROTEIN1(IPI1),and sucrose-induced K48-linked polyubiquitination of Ghd7 via IPI1,leading to protein *** defective in IPI1 delayed flowering,confirming its role in modulating proteins involved in *** conclude that sucrose acts as a signaling molecule to induce flowering by promoting Ghd7 degradation via IPI1.

关键词： flowering time Ghd7 IPI1 K48-linked poly-ubiquitination rice sucrose

Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

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Journal of Integrative Medicine 2024年第5期22卷 600-613页

作者： Mijung Yeom Sora Ahn Dae-hyun Hahm Sun-Young jang Se Hoon jang Su-Yang Park Jae-Hwan jang Jihan Park Ju-Young Oh In-Seon Lee Kyuseok Kim Soon-Kyeong Kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Department of Physiology School of MedicineKyung Hee UniversitySeoul 02447Republic of Korea BioNanocomposite Research Center Kyung Hee UniversitySeoul 02447Republic of Korea Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea College of Korean Medicine Kyung Hee UniversitySeoul 02447Republic of Korea Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju 52828Republic of Korea Department of Anatomy&Information Sciences College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea

Objective Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut *** has been proven to be effective in reducing AD symptoms without serious adverse events,but its underlying mechanism is not completely *** purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut *** AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11)***-like symptoms were assessed by lesion scores,scratching behavior,and histopathological changes;intestinal barrier function was measured by fecal output,serum lipopolysaccharide levels,histopathological changes,and mRNA expression of markers involved in intestinal permeability and *** microbiota was profiled using 16S rRNA gene sequencing from fecal *** Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening,and also significantly altered gut microbiota structure as revealed byβ-diversity indices and analysis of *** beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated ***,AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability,atrophy of the mucosal structure(reduced villus height and crypt depth),decreased expression of tight junctions and mucus synthesis genes,and increased expression of inflammatory mediators in the *** attenuated these abnormalities,which was gut *** Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier,providing new perspective for non-pharmacological strategies for

关键词： Atopic dermatitis Acupuncture Gut microbiota Intestinal barrier function

Endoscopic bilateral stent-in-stent placement for malignant hilar obstruction using a large cell type stent

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 633-639页

作者： Jin Myung Park Sang Hyub Lee Kwang hyun Chung Dong Kee jang Ji Kon Ryu Yong-Tae Kim Jae Min Lee Woo hyun Paik Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of Medicine Department of Internal Medicine Kangwon National University HospitalKangwon National University School of Medicine Department of Internal Medicine Gyeongsang National University HospitalGyeongsang National University College of Medicine Department of Internal Medicine Inje University Ilsan Paik Hospital

BACKGROUND： Bilateral stent-in-stent （SIS） self-expandable metal stent placement is technically chghallenging for palliation of unresectable malignant hilar obstruction. In the SIS technique, the uniform large cell type biliary stent facilitates contralateral stent deployment through the mesh of the first metallic stent. This study aimed to assess the technical success and clinical effectiveness of this technique with a uniform large cell type biliary stent. METHODS： Thirty-one patients who underwentlbilateral SIS placement using a large cell type stent were reviewed retrospectively. All patients showed malignant hilarl obstruction （Bismuth types Ⅱ, Ⅲ, Ⅳ） with different etiologies. RESULTS： Sixteen （51.6%） patients were male. The mean age of the patients was 67.0±14.0 years. Most patients were diagnosed as having hilar cholangiocarcinoma （58.1%） and gallbladder cancer （29.0%）. Technical success rate was 83.9%. Success was achieved more frequently in patients without masses obstructing the biliary confluence （MOC） than those with MOC （95.2% vs 60.0%, P=0.03）. Functional success rate was 77.4%. Complications occurred in 29.0% of the patients. These tended to occur more frequently in patients with MOC （50.0% vs 19.0%, P=0.11）. Median time to recurrent biliary obstruction was 188 days and median survival was 175 days. CONCLUSIONS： The large cell type stent can be used efficiently for bilateral SIS placement in malignant hilar obstruction. However, the risk of technical failure increases in patients with MOC, and caution is needed to prevent complications for these patients.

关键词： biliary tract disease cholangiocarcinoma endoscopic biliary drainage stent insertion

Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study

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Neural Regeneration Research 2013年第5期8卷 474-478页

作者： Ah Young Lee Sung Ho jang Sang seok Yeo Ensil Lee Yun Woo Cho Su Min Son Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Pediatrics College of Medicine Yeungnam University

We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients＇ functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg＇s balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected.

关键词： neural regeneration neuroimaging Dandy-Walker malformation cerebellar peduncle ataxia cerebral palsy functional ambulation category Berg's balance scale fractional anisotropy apparent diffusion coefficient diffusion tensor tractography diffusion tensor imaging grants-supported paper photographs-containing paper neuroregeneration

3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation

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Bioactive Materials 2024年第7期37卷 172-190页

作者： hyun Lee Dong-Sung Won Sinwoo Park Yubeen Park Ji Won Kim Ginam Han Yuhyun Na Min-Ho Kang seok Beom Kim Heemin Kang Jun-Kyu Park Tae-Sik jang Sang Jin Lee Su APark Sang Soo Lee Jung-Hoon Park hyun-Do Jung Department of Biomedical-Chemical Engineering The Catholic University of KoreaBucheon14662Gyeonggi-doRepublic of Korea Department of Biotechnology The Catholic University of KoreaBucheon14662Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88 Olympic-ro 43-gilSongpa-guSeoul05505Republic of Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul05505Republic of Korea Research Center Metamorp IncSeoul08584Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea IMT Inc Gwangju61086Republic of Korea School of Biomedical Convergence Engineering Pusan National UniversityYangsan50612Republic of Korea Biofunctional Materials Division of Applied Oral Sciences and Community Dental CareFaculty of DentistryThe University of Hong Kong34 Hospital RoadSai Ying PunHong Kong SARPR China Nano-Convergence Manufacturing Systems Research Division Korea Institute of Machinery and Materials(KIMM)Daejeon34103Republic of Korea Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of Medicine88Olympic-ro 43-GilSongpa-guSeoul05505Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Biliary strictures are characterized by the narrowing of the bile duct lumen,usually caused by surgical biliary injury,cancer,inflammation,and scarring from *** stent placement is a well-established method for the management of biliary ***,maintaining optimal mechanical properties of stents and designing surfaces that can prevent stent-induced tissue hyperplasia and biofilm formation are challenges in the fabrication of biodegradable biliary stents(BBSs)for customized *** study proposes a novel approach to fabricating functionalized polymer BBSs with nanoengineered surfaces using 3D *** 3D printed stents,fabricated from bioactive silica poly(ε-carprolactone)(PCL)via a sol-gel method,exhibited tunable mechanical properties suitable for supporting the bile duct while ensuring ***,a nanoengineered surface layer was successfully created on a sirolimus(SRL)-coated functionalized PCL(fPCL)stent using Zn ion sputtering-based plasma immersion ion implantation(S-PIII)treatment to enhance the performance of the *** nanoengineered surface of the SRL-coated fPCL stent effectively reduced bacterial responses and remarkably inhibited fibroblast proliferation and initial burst release of SRL in vitro *** physicochemical properties and biological behaviors,including in vitro biocompatibility and in vivo therapeutic efficacy in the rabbit bile duct,of the Zn-SRL@fPCL stent demonstrated its potential as a versatile platform for clinical applications in bile duct tissue engineering.

关键词： 3D printing Biodegradable biliary stent Functionalized polymer Zinc ion implantation Antibiofilm formation Anti-hyperplasia