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Effect of lifestyle modification on hepatocellular carcinoma incidence and mortality among patients with chronic hepatitis B

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World Journal of Gastroenterology 2023年第24期29卷 3843-3854页

作者： Yewan Park Danbee Kang Dong hyun Sinn hyunsoo Kim yun Soo Hong Juhee Cho Geum-Youn Gwak Department of Internal Medicine Kyung Hee University HospitalSeoul 02447South Korea Department of Digital Health SAIHSTSungkyunkwan UniversitySeoul 06355South Korea Department of Clinical Research Design and Evaluation SAIHSTSungkyunkwan UniversitySeoul 06355South Korea Center for Clinical Epidemiology Samsung Medical CenterSungkyunkwan UniversitySeoul 06351South Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Departments of Epidemiology and Medicine and Welch Center for PreventionEpidemiology and Clinical ResearchJohns Hopkins Medical InstitutionsBaltimoreMD 21287United States

BACKGROUND Research exploring the influence of healthier lifestyle modification(LSM)on the risk of hepatocellular carcinoma(HCC)in patients with chronic hepatitis B(CHB)is *** To emulate a target trial to determine the effect of LSM on HCC incidence and mortality among patients with CHB by large-scale population-based observational *** Among the patients with CHB enrolled in the Korean National Health Insurance Service between January 1,2009,and December 31,2017,those aged≥20 years who drank alcohol,smoked cigarettes,and were sedentary were *** included at least one LSM,including alcohol abstinence,smoking cessation,and regular *** primary outcome was HCC development,and the secondary outcome was liver-related *** used 2:1 propensity score matching to account for *** With 48766 patients in the LSM group and 103560 in the control group,the adjusted hazard ratio(HR)for incident HCC and liver-related mortality was 0.92[95%confidence interval(CI):0.87-0.96]and 0.92(95%CI:0.86-0.99)in the LSM group,respectively,compared with the control *** the LSM group,the adjusted HR(95%CI)for incident HCC was 0.84(0.76-0.94),0.87(0.81-0.94),and 1.08(1.00-1.16)for alcohol abstinence,smoking cessation,and regular exercise,*** adjusted HR(95%CI)for liver-related mortality was 0.92(0.80-1.06),0.81(0.72-0.91),and 1.15(1.04-1.27)for alcohol abstinence,smoking cessation,and regular exercise,*** LSM lowered the risk of HCC and mortality in patients with ***,active LSM,particularly alcohol abstinence and smoking cessation,should be encouraged in patients with CHB.

关键词： Lifestyle modification Chronic hepatitis B Hepatocellular carcinoma Cancer Mortality

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Vertical graphene on flexible substrate,overcoming limits of crack-based resistive strain sensors

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npj Flexible Electronics 2022年第1期6卷 28-35页

作者： Hong Ryeol Na hyun Joo Lee Jae Ho Jeon Han-Jin Kim Sahng-Kyoon Jerng Sanjib Baran Roy Seung-hyun Chun Sunghun Lee Yong Ju yun Department of Physics and Astronomy Sejong UniversitySeoul 05006Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Korea Center for Energy Materials Research Korea Institute of Science and TechnologySeoul 02792Korea Graphene Research Institute Sejong UniversitySeoul 05006Korea

Resistive strain sensors(RSS)with ultrasensitivity have attracted much attention as multifunctional ***,since most ultrasensitive RSS are designed by cracked conductive metals,the sensing performance is severely degraded due to accumulated structural deformation with consecutive *** overcome such limitation,newly designed structures have been suggested,but the development of mechanosensors exhibiting superior stability and ultrasensitivity still remains a ***,we demonstrate that vertical graphene(VG)RSS with high sensitivity(gauge factor greater than 5000),remarkable durability(>10,000 cycles),and extraordinary resilience can serve multifunctional *** find that well-defined cracks on tufted network structure result in highly reversible resistance variation,especially revivable status even after broken current path,confirmed by microscopic in situ *** VG integrated with a wireless sensing system exhibits excellent timbre recognition *** findings provide inspirable insights for mechanosensing system,making VG a promising component for future practicable flexible sensor technologies.

关键词： strain durability Vertical

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Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

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Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park hyung-Gu Yu Eunbyul Kook Won-hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi yun hyun Huh Je-Hwang Ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

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Insulation Type Effect on the Direct Shear Behavior of Concrete Sandwich Panel(CSP)with Non-Shear Connectors

Insulation Type Effect on the Direct Shear Behavior of Concr...

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2012 International Conference of Health,Structure,Material and Environment(HSME 2012)

作者： Tae-Sik Oh seok-Joon Jang Kang-Min Lee hyun-Do yun Kyeryong Construction Company Dept.of Architectural Engineering Chungnam National University

Precast concrete sandwich panels(PCSP)are often used as exterior cladding of residential buildings due to thermal *** systems consist of two precast reinforced concrete walls separated by a layer of insulation and connected with connectors which penetrate the insulation layer and are anchored at two precast *** paper provides the pull-out test results of concrete sandwich panel(CSP)with non-shear *** variables in this study were the casting direction of reinforced concrete walls and types of *** results indicated that the types of insulations and casting direction have a significant effect on the bond strength between concrete wall and *** effect of insulation type is notable for CSP cast horizontally concrete walls.

关键词： Precast Concrete Sandwich Panel(PCSP) Shear Behavior Insulation

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Stable immobilization of lithium polysulfides using three-dimensional ordered mesoporous Mn_(2)O_(3) as the host material in lithium-sulfur batteries

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Carbon Energy 2024年第6期6卷 99-112页

作者： Sung Joon Park yun Jeong Choi hyun-seung Kim Min Joo Hong Hongjun Chang Janghyuk Moon Young-Jun Kim Junyoung Mun Ki Jae Kim Department of Energy Science Sungkyunkwan UniversitySuwonGyeonggi-doRepublic of Korea Department of Energy Engineering Konkuk UniversitySeoulRepublic of Korea Advanced Batteries Research Center Korea Electronic Technology InstituteSeongnamRepublic of Korea Department of Future Energy Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Department of Energy Systems Engineering Chung-Ang UniversitySeoulRepublic of Korea SKKU Advanced Institute of Nanotechnology Sungkyunkwan UniversitySuwonGyeonggi-doRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwonRepublic of Korea

Lithium-sulfur batteries(LSBs)have drawn significant attention owing to their high theoretical discharge capacity and energy ***,the dissolution of long-chain polysulfides into the electrolyte during the charge and discharge process(“shuttle effect”)results in fast capacity fading and inferior electrochemical *** this study,Mn_(2)O_(3)with an ordered mesoporous structure(OM-Mn_(2)O_(3))was designed as a cathode host for LSBs via KIT-6 hard templating,to effectively inhibit the polysulfide shuttle ***-Mn_(2)O_(3)offers numerous pores to confine sulfur and tightly anchor the dissolved polysulfides through the combined effects of strong polar-polar interactions,polysulfides,and sulfur chain *** OM-Mn_(2)O_(3)/S composite electrode delivered a discharge capacity of 561 mAh g^(-1) after 250 cycles at 0.5 C owing to the excellent performance of OM-Mn_(2)O_(3).Furthermore,it retained a discharge capacity of 628mA h g^(-1) even at a rate of 2 C,which was significantly higher than that of a pristine sulfur electrode(206mA h g^(-1)).These findings provide a prospective strategy for designing cathode materials for high-performance LSBs.

关键词： host material lithium-sulfur battery ordered mesoporous structure shuttle effect transition-metal oxides

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Hepatoprotective effect of manual acupuncture at acupoint GB34 against CCl_4-induced chronic liver damage in rats

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World Journal of Gastroenterology 2006年第14期12卷 2245-2249页

作者： yun-Kyoung Yim hyun Lee Kwon-Eui Hong Young-Il Kim Byung-Ryul Lee Tae-Han Kim Ji-Young Yi Department of Meridian & Acupoint College of Oriental Medicine Daejeon University12407 96-3Yongun-dongDong-guDaejeon 300-716South Korea Department of Acupuncture & Moxibustion Dunsan Oriental Hospital of Daejeon University 1136 Dunsan-dongSeo-guDaejeon 302-122South Korea

AIM： To investigate the hepatoprotective effect of manual acupuncture at Yanglingquan （GB34） on CCl4-induced chronic liver damage in rats. METHODS： Rats were injected intraperitoneally with CCh （1 mL/kg） and treated with manual acupuncture using reinforcing manipulation techniques at left GB34 （Yanglingquan） 3 times a week for 10 wk. A nonacupoint in left gluteal area was selected as a sham point. To estimate the hepatoprotective effect of manual acupuncture at GB34, measurement of liver index, biochemical assays including serum ALT, AST, ALP and total cholesterol, histological analysis and blood cell counts were conducted. RESULTS： Manual acupuncture at GB34 reduced the liver index, serum ALT, AST, ALP and total cholesterol levels as compared with the control group and the sham acupuncture group. It also increased and normalized the populations of WBC and lymphocytes. CONCLUSION： Manual acupuncture with reinforcing manipulation techniques at left GB34 reduces liver toxicity, protects liver function and liver tissue, and normalizes immune activity in CCh-intoxicated rats.

关键词： Manual acupuncture Yanglingquan (GB34) CCl4-induced liver damage Hepatoprotective effect

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Is a split-dose regimen of 2 L polyethylene glycol plus ascorbic acid tolerable for colonoscopy in an early morning visit to a comprehensive medical check-up?

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World Journal of Gastroenterology 2017年第6期23卷 1030-1037页

作者： Ji Yeon Seo Changhyun Lee Eun Hyo Jin Mi hyun yun Joo hyun Lim Hae Yeon Kang Jong In Yang Su Jin Chung Sun Young Yang Joo Sung Kim Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam CenterSeoul National University Hospital Department of Nursing Healthcare System Gangnam CenterSeoul National University Hospital

To evaluate the effectiveness and tolerability of a split-dose 2 L polyethylene glycol (PEG)/ascorbic acid (AA) regimen for healthy examinees who visited for comprehensive medical check-up in the early *** February 2015 to March 2015, examinees of average risk who were scheduled for a colonoscopy in the morning were retrospectively *** 189 examinees were divided into split-dose and non-split-dose groups. The adequacy of bowel preparation for the split-dose group vs the non-split-dose group was 96.8% vs 85.2%, respectively, P < 0.001, and the compliance of the last meal restriction was 74.6% vs 58.2%, respectively, P < 0.001. The sleep disturbance (P < 0.001) was more prevalent in the split-dose group, however the willingness to repeat the same preparation method (P = 0.243) was not different in both groups. The split-dose regimen was the most important factor influencing adequate bowel preparation in multivariate analysis (HR = 10.89, 95%CI: 6.53-18.17, P < 0.001).CONCLUSIONA split-dose regimen of 2 L PEG/AA for an early morning colonoscopy was more effective and showed better compliance for diet restriction without any difference in satisfaction and discomfort. Introducing a split-dose regimen of 2 L PEG/AA to morning colonoscopy examinees is effective and tolerable in a comprehensive medical check-up setting.

关键词： Compliance Early morning colonoscopy Effectiveness Split-dose regimen Tolerability

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Ethanol extract of Oenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus

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Neural Regeneration Research 2015年第2期10卷 271-276页

作者： Bai Hui Chen Joon Ha Park Jeong Hwi Cho In Hye Kim Bich Na Shin Ji Hyeon Ahn seok Joon Hwang Bing Chun Yan hyun Jin Tae Jae Chul Lee Eun Joo Bae yun Lyul Lee Jong Dai Kim Moo-Ho Won Il Jun Kang Department of Physiology College of Medicine and Institute of Neurodegeneration and Neuroregeneration Hallym University Department of Neurobiology School of Medicine Kangwon National University Department of Food Science and Biotechnology College of Agriculture and Life Sciences Kangwon National University Department of Integrative Traditional & Western Medicine Medical College Yangzhou University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Pediatrics Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Food Science and Nutrition Hallym University

Oenanthe javanica is an aquatic perennial herb that belongs to theOenanthe genus in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glu-tamate-induced neurotoxicity. However, few studies regarding effects ofOenanthe javanica on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract ofOenanthe javanica on cell proliferation and neu-roblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67 （an endogenous marker for cell proliferation） and doublecortin （a marker for neuroblast）. Our results showed thatOenanthe javanica extract signiifcantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was signiifcantly increased in the dentate gyrus of the Oenanthe javanica extract-treated group compared with the control group. However, we did not ifnd that vascular endothelial growth factor expression was increased in theOenanthe javanica extract-treated group compared with the control group. These results indicate thatOenanthe javanica extract improves cell proliferation and neuroblast differentiation by increasing brain-de-rived neurotrophic factor immunoreactivity in the rat dentate gyrus.

关键词： nerve regeneration Oenanthe javanica extract cell proliferation neuroblast differentiation brain-derived neurotrophic factor vascular endothelial growth factor rat neural regeneration

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LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 177-189页

作者： Oh Kwang Kwon In Hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae Na Yan Gao Sam seok Cho Sung Hwan Ki Youngshik Choe Jun Nyung Lee yun-Sok Ha Eun Ju Bae Tae Gyun Kwon Byung-hyun Park Sangkyu Lee BK21 Plus KNU Multi-Omics Based Creative Drug Research Team College of PharmacyResearch Institute of Pharmaceutical SciencesKyungpook National UniversityDaegu 41566Republic of Korea Department of Biochemistry and Molecular Biology Chonbuk National University Medical SchoolJeonjuJeonbuk 54896Republic of Korea College of Pharmacy Chosun UniversityGwangju 61452Republic of Korea Korea Brain Research Institute Daegu 41068Republic of Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Urology Kyungpook National University HospitalDaegu 41566Republic of Korea College of Pharmacy Chonbuk UniversityJeonjuJeonbuk 54896Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men *** 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival *** great efforts,the detailed mechanisms underlying castration-resistant PCa(CRPC)remain *** 5(SIRT5),an NAD+-dependent desuccinylase,is hypothesized to be a key regulator of various ***,compared to other SIRTs,the role of SIRT5 in cancer has not been extensively ***,we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa *** correlation between the decrease in the SIRT5 level and the patient’s reduced survival rate was also *** quantitative global succinylome analysis,we characterized a significant increase in the succinylation at lysine 118(K118su)of lactate dehydrogenase A(LDHA),which plays a role in increasing LDH *** a substrate of SIRT5,LDHA-K118su significantly increased the migration and invasion of PCa cells and LDH activity in PCa *** study reveals the reduction of SIRT5 protein expression and LDHA-K118su as a novel mechanism involved in PCa progression,which could serve as a new target to prevent CPRC progression for PCa treatment.

关键词： Sirtuin 5 Lactate dehydrogenase A Lysine succinylation PCa progression

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Effect of Cristobalite and Quartz on the Properties of Gypsum Bonded Investment

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Journal of Materials Science & Technology 2008年第1期24卷 143-144页

作者： yun-Jong Kim Sang-Bae Kim hyun-Hye Park Myeong-Deok Seo Byoung-Cheon Lee Man-So Han Taik-Nam Kim Sung-Baek Cho Korea Institute of Geoscience and Mineral Resources (KIGAM) Gajeong-dong 30 Yuseong-kuDaejeon 305-350Korea Department of Materials Engineering Graduate School Paichai UniversityDaejeon 302-735Korea Dept.of Dental Laboratory Technology Daejeon Health Science College Korea

Generally the gold investment material consists of cristobalite,quartz and *** physical property of gold investment materials depends on its thermal expansion coefficients,compressive strength,and particles size *** the thermal expansion coefficient of cristobalite and quartz are 2.6×10^-6/℃and 2.32×10^-6/℃respectively,the composition ratio of each components influence the thermal and physical properties of gold investment *** the clinical applications,it is necessary to improve the properties of gold investment materials such as homogeneous size distribution and thermal expansion *** the present study,effect of inorganic fillers such as cristobalite and quartz on gold alloy investment was investigated to improve the properties of *** compressive strength and thermal expansion coefficients of the specimens were *** results showed that cristobalite and quartz were homogeneously distributed by milling. The optimum compressive strength was obtained at the ratio of 42：22 cristobalite and quartz,respectively.

关键词： Investment Cristobalite Quartz Thermal expansion coefficient Compressivestrength

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