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Simultaneous robot-assisted approach in a super-elderly patient with urothelial carcinoma and synchronous contralateral renal cell carcinoma:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7153-7162页

作者： Ji Kang yun Si hyun Kim Woong Bin Kim Hee Kyung Kim Sang Wook Lee Department of Urology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584South Korea Department of Urology Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151South Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584South Korea

BACKGROUND It is rare for urothelial and renal cell carcinomas to coexist in the same patient,and even rarer for them to be detected *** of this rarity,a standard treatment has not been established and studies about overall survival are ***,physicians must modify treatments according to the individual’s situation and the stage of each *** recent years,with advances in the instruments and techniques,minimal invasive robotic surgeries have become available for advanced-stage or high-risk *** SUMMARY An 85-year-old woman with a medical history of hypertension and hyperlipidemia visited our *** had visited her local hospital complaining of intermittent,painless,gross hematuria that had started 3 mo *** computed tomography,a right renal mass and left proximal ureteral mass with hydronephrosis were found *** decided to perform robot-assisted surgery on both sides during one *** renal function and kidney loading,right partial nephrectomy was performed first,followed by left nephroureterectomy with bladder cuff *** the 6-mo follow-up,no specific symptoms were reported and dialysis was not *** were no unusual findings in the imaging study,and regular follow-up and imaging studies are *** This case report assessed the feasibility of simultaneous minimal invasive robotic surgery as an alternative to conventional open or laparoscopic surgery.

关键词： Robot surgical procedure Renal cell carcinoma Transitional cell carcinoma Minimally invasive surgical procedures Case report

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Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers

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Food Science and Human Wellness 2024年第6期13卷 3311-3324页

作者： Hoon Kim Jongyeob Kim Byungdoo Hwang Sang Yong Park Ji-Yeon Shin Eun Byeol Go Jae Sil Kim Youngjin Roh Soon Chul Myung seok-Joong yun yung hyun Choi Wun-Jae Kim Sung-Kwon Moon Department of Food and Nutrition Chung-Ang UniversityAnseong 17546Republic of Korea SD Biotechnologies Seoul 07793Republic of Korea Department of Urology College of MedicineChung-Ang UniversitySeoul 06974Republic of Korea Department of Urology Chungbuk National UniversityChungbuk 361-763Republic of Korea Department of Biochemistry College of Oriental MedicineDongeui UniversityBusan 47340Republic of Korea Institute of Urotech CheongjuChungcheongbuk-do 361-763Republic of Korea

Krill oil(KO)exhibits various biological activities,such as anti-inflammatory and antitumor ***,the inhibitory effects of benign prostatic hyperplasia(BPH)in vitro and in vivo have not yet been *** study investigated the anti-BPH effects of KO extracted by an enzymatic hydrolysis *** treatment inhibited the proliferation of WMPY-1 and BPH-1 cells by induction of G0/G1 phase arrest through the modulation of positive and negative regulators in both prostate cell *** treatment stimulated phosphorylation of c-Jun N-terminal kinase(JNK)and p38 *** addition,KO changed the expression of BPH-related markers(5α-reductase,androgen receptor,FGF,Bcl-2,and Bax)and the activity of the proliferation-mediated NF-κB binding ***-induced levels of proliferation-mediated molecules of prostate cells were attenuated in the presence of siRNA-specific p-38(si-p38)and JNK(si-JNK).Furthermore,the administration of KO alleviated prostate size and weight and the cell layer thickness of prostate glands in a testosterone enanthate-induced BPH rat *** treatment altered the level of dihydrotestosterone in serum and the expression levels of BPH-related markers in prostate ***,KO-mediated inhibition of prostatic growth was validated by histological *** results suggest that KO has an inhibitory effect on BPH in prostate cells in vitro and in ***,KO might be a potential prophylactic or therapeutic agent for patients with BPH.

关键词： Proliferation G0/G1-phase cell cycle NF-κB Dihydrotestosterone

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Characteristics of nonvariceal upper gastrointestinal hemorrhage in patients with chronic kidney disease

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World Journal of Gastroenterology 2013年第43期19卷 7719-7725页

作者： Chang seok Bang Yong Seop Lee yun Hyeong Lee Hotaik Sung Hong Jun Park hyun Soo Kim Jin Bong Kim Gwang Ho Baik Yeon Soo Kim Jai Hoon Yoon Dong Joon Kim Ki Tae Suk Department of Internal Medicine Hallym University College of MedicineChuncheon 200-704South Korea Department of Biology Stanford UniversityStanfordCA 94305United States Department of Internal Medicine Yonsei University Wonju College of MedicineWonju 220-786South Korea

AIM:To evaluate the clinical characteristics of nonvariceal upper gastrointestinal hemorrhage(NGIH)in patients with chronic kidney disease(CKD).METHODS:From 2003 to 2010,a total of 72 CKD patients(male n=52,72.2%;female n=20,27.8%)who had undergone endoscopic treatments for NGIH were retrospectively *** findings,endoscopic features,prognosis,rebleeding risk factors,and mortality-related factors were *** characteristics of the patients and rebleeding-related data were recorded for the following variables:gender,age,alcohol use and smoking history,past hemorrhage history,endoscopic findings(the cause,location,and size of the hemorrhage and the hemorrhagic state),therapeutic options for endoscopy,endoscopist experience,clinical outcomes,and ***:The average size of the hemorrhagic site was 13.7±10.2 mm,and the most common hemorrhagic site in the stomach was the antrum(n=21,43.8%).The most frequent method of hemostasis was combination therapy(n=32,44.4%).The incidence of rebleeding was 37.5%(n=27),and 16.7%(n=12)of patients expired due to *** a multivariate analysis of the risk factors for rebleeding,alcoholism(OR=11.19,P=0.02),the experience of endoscopists(OR=0.56,P=0.03),and combination endoscopic therapy(OR=0.06,P=0.01)compared with monotherapy were significantly related to rebleeding after endoscopic *** a risk analysis of mortality after endoscopic therapy,only rebleeding was related to mortality(OR=7.1,P=0.02).CONCLUSION:Intensive combined endoscopic treatments by experienced endoscopists are necessary for the treatment of NGIH in patients with CKD,especially when a patient is an alcoholic.

关键词： Chronic kidney diseases Gastrointestinal hemorrhage Endoscopy Peptic ulcer Alcoholics

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Arabidopsis thaliana RECEPTOR DEAD KINASE1 Functions as a Positive Regulator in Plant Responses to ABA

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Molecular Plant 2017年第2期10卷 223-243页

作者： Dhinesh Kumar Ritesh Kumar Dongwon Baek Tae-Kyung hyun Woo Sik Chung Dae-Jin yun Jae-Yean Kim Division of Applied Life Sciences Plant Molecular Biology and Biotechnology Research Center Gyeongsang National University Jinju 660-701 Korea Department of Industrial Plant Science and Technology Conege of Agricultural Life and Environmental Sciences Chungbuk National University Cheongju 28644Korea These authors contributed equally to this article.

Abscisic acid （ABA） is a major phytohormone involved in important stress-related and developmental plant processes. Membrane-delimited ABA signal transduction plays an important role in early ABA signaling, but the molecular mechanisms connecting core signaling components to the plasma membrane remain un- clear. Plants have evolved a large number of receptor-like kinases （RLKs） to modulate diverse biological processes by perceiving extracellular stimuli and activating downstream signaling responses. In this study, a putative leucine-rich repeat-RLK gene named RECEPTOR DEAD KINASE1 （AtRDK1） was identified and characterized in Arabidopsis thaliana. RDK1 promoter-GUS analysis revealed that RDK1 is expressed ubiq- uitously in the various tissues in Arabidopsis, and its expression is mainly induced by ABA. In the presence of ABA, RDKl-deficient rdkl-1 and rdkl-2 lines showed significant resistance in cotyledon greening and root growth, whereas RDKl-overexpressing lines showed enhanced sensitivity. Consistently, the expres- sion of ABA-responsive genes was significantly downregulated in rdkl mutant seedlings, which were also hypersensitive to drought stress with increased water loss. Interestingly, RDK1 was found to be an atypical kinase localized to the plasma membrane and did not require its kinase activity during ABA-mediated inhi- bition of seedling development. Accordingly, RDK1 interacted in the plasma membrane with type 2C protein phosphatase ABSClSIC ACID INSENSITIVE1 （ABI1）; this interaction was further enhanced by exogenous application of ABA, suggesting that RDKl-mediated recruitment of ABI1 onto the plasma membrane is important for ABA signaling. Taken together, these results reveal an important role for RDK1 in plant responses to abiotic stress conditions in an ABA-dependent manner.

关键词： ABA abiotic stress Arabidopsis atypical kinases protein phosphatases receptor-like kinases

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Multiplexed DNA-functionalized graphene sensor with artificial intelligence-based discrimination performance for analyzing chemical vapor compositions

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Microsystems & Nanoengineering 2023年第2期9卷 113-125页

作者： yun Ji Hwang Heejin Yu Gilho Lee Iman Shackery Jin Seong Youngmo Jung Seung-hyun Sung Jongeun Choi Seong Chan Jun School of Mechanical Engineering Yonsei University500Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

This study presents a new technology that can detect and discriminate individual chemical vapors to determine the chemical vapor composition of mixed chemical composition in situ based on a multiplexed DNA-functionalized graphene(MDFG)nanoelectrode without the need to condense the original vapor or target *** the best of our knowledge,our artificial intelligence(Al)-operated arrayed electrodes were capable of identifying the compositions of mixed chemical gases with a mixed ratio in the early *** innovative technology comprised an optimized combination of nanodeposited arrayed electrodes and artificial intelligence techniques with advanced sensing capabilities that could operate within biological limits,resulting in the verification of mixed vapor chemical *** selective sensors that are tolerant to high humidity levels provide a target for"breath chemovapor fingerprinting"for the early diagnosis of *** feature selection analysis achieved recognition rates of 99%and above under low-humidity conditions and 98%and above under humid conditions for mixed chemical *** 1D convolutional neural network analysis performed better,discriminating the compositional state of chemical vapor under low-and high-humidity conditions almost *** study provides a basis for the use of a multiplexed DNA-functionalized graphene gas sensor array and artificial intelligence-based discrimination of chemical vapor compositions in breath analysis applications.

关键词： humidity functional intelligence

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Structural and Dielectric Properties of Dy-doped(Ba,Sr,Ca) TiO_3 Thick Films

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材料科学与工程学报 2007年第6期25卷 928-931页

作者： hyun-Ji Noh Sung-Gap Lee Sang-Man Park Sang-Eun yun Dept.of ceramic Engineering Eng.Res.Insti.Gyeongsang National University 900 GajwaJinju-siGyeongnam 660-701Korea

Preparation and electrocatalytic activities of Pt-TiO_2 nanotubes(Ba_ 0.57Sr_ 0.33Ca_ 0.10)TiO_3 powders,prepared by the sol-gel method,were doped MnCO_3 as acceptor and Dy_2O_3 as *** powder was mixed with an organic vehicle and BSCT thick films were fabricated by the screen-printing techniques on alumina *** structural and dielectric properties of BSCT thick films were investigated with variation of Dy_2O_3 *** a result of the differential thermal analysis(DTA),exothermic peak was observed at around 670℃ due to the formation of the polycrystalline perovskite *** the BSCT thick films showed the XRD patterns of a typical polycrystalline perovskite *** average grain size of BSCT thick films decreased with increasing amount of Dy_2O_*** relative dielectric constant and dielectric loss of the BSCT thick film doped Dy_2O_3 0.1mol% were 4637.4 and 1.6% at 1kHz,respectively.

关键词：介电性能结构性能镝厚膜丝网印刷术

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H_2S Sensing Characteristics of Thin Film SnO_2 Sensor with N_2 Treatment

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稀有金属材料与工程 2006年第A3期35卷 385-388页

作者： Jong-Won Kim Kwang-hyun yun Geon-Young Cha Gi-Hong Rue Duk-Dong Lee Jeung-Soo Huh Department of Nano-Science and Technology Sangyuk-Dong 1370Bukgu DaeguKorea Department of Materials Science and Metallurgy Sangyuk-Dong 1370Bukgu DaeguKorea School of Electronic Engineering Kyungpook National UniversitySangyuk-Dong 1370Bukgu DaeguKorea Department of Nano-Science and Technology Department of Materials Science and MetallurgySangyuk-Dong 1370Bukgu DaeguKorea

SnO_2 thin film sensors were fabricated by a thermal evaporation *** sensors were heated for thermal *** high porosity,SnO_2 thin film sensors were treated in a N_2 *** sensors that were treated with O_2 after being treated with N_2 showed 70 % sensitivity for 1×10~ -6) of H_2S,which is higher than the sensors that were only treated with O_*** Ni metal,as a catalyst,was evaporated on the thin film Sn on the Al_2O_3 *** sensor was heated to grow the Sn nanowire in a tube furnace with N_2 *** nanowire was heated for *** sensitivity of SnO_2 nanowire sensor was measured for 500×10~ -9) of H_*** selectivity of the SnO_2 nanowire sensor was compared with the thin film and the thick film SnO_*** sensor was measured for H_2S,CO,and NH_3 in this study.

关键词： SnO2 gas sensor N2 nanowire H2S

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Sorption enhanced catalytic CF4 hydrolysis with a three-stage catalyst-adsorbent reactor

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 537-544页

作者： Han, Jae-yun Kim, Chang-hyun Lee, Boreum Nam, Sung-Chan Jung, Ho-Young Lim, Hankwon Lee, Kwan-Young Ryi, Shin-Kun Advanced Materials and Devices Laboratory Korea Institute of Energy Research (KIER) Daejeon Korea Department of Chemical and Biological Engineering Korea University Seoul Korea Department of Advanced Materials and Chemical Engineering Catholic University of Daegu Gyeongbuk Korea Department of Environment and Energy Engineering Chonnam National University Gwangju Korea

In this study, we developed a three-stage catalyst-adsorbent reactor for the catalytic hydrolysis of CF4. Each stage is composed of a catalyst bed followed by an adsorbent bed using Ca（OH）2 to remove HF. The three stages are connected in series to enhance the hydrolysis of CF4 and eliminate a scrubber to dissolve HF in water at the same time. With a 10 wt-% Ce/AlaO3 catalyst prepared by the incipient wetness method using boehmite and a granular calcium hydroxide as an adsorbent, the CF4 conversion in our proposed reactor was 7%-23% higher than that in a conventional single-bed catalytic reactor in the temperature range of 923-1023 K. In addition, experimental and numerical simulation （Aspen HYSYS） results showed a reasonable trend of increased CF4 conversion with the adsorbent added and these results can be used as a useful design guideline for our newly proposed multistage reactor system.

关键词： PFCs catalytic hydrolysis calcium hydro-xide sorption enhanced process simulation

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A computational study of the chemokine receptor CXCR1 bound with interleukin-8

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Chinese Physics B 2018年第3期27卷 534-543页

作者： Yang Wang Cecylia Severin Lupala Ting Wang Xuanxuan Li Ji-Hye yun Jae-hyun Park Zeyu Jin Weontae Lee Leihan Tan Haiguang Liu Complex Systems Division Beijing Computational Science Research Center Beijing 100193 China Genome Center University of California Davis 451 East Health Science Drive Davis CA 95616 USA Department of Engineering physics Tsinghua University Beijing 100086 China Department of Biochemistry College of Life Science ＆ Biotechnology Yonsei University Seou103722 South Korea Department of Physics and Institute of Computational and Theoretical Studies Hong Kong Baptist University Hong Kong China

CXCR1 is a G-protein coupled receptor, transducing signals from chemokines, in particular the interleukin-8 （1L8） molecules. This study combines homology modeling and molecular dynamics simulation methods to study the structure of CXCRI-IL8 complex. By using CXCR4-vMIP-II crystallography structure as the homologous template, CXCRI-IL8 complex structure was constructed, and then refined using all-atom molecular dynamics simulations. Through extensive simulations, CXCRI-IL8 binding poses were investigated in detail. Furthermore, the role of the N-terminal of CXCR1 receptor was studied by comparing four complex models differing in the N-terminal sequences. The results indicate that the receptor N-terminal affects the binding of IL8 significantly. With a shorter N-terminal domain, the binding of IL8 to CXCR1 becomes unstable. The homology modeling and simulations also reveal the key receptor-ligand residues involved in the electrostatic interactions known to be vital for complex formation.

关键词： CXCRI-IL8 complex homology modeling ligand binding molecular dynamics

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Dopant-Tunable Ultrathin Transparent Conductive Oxides for Efficient Energy Conversion Devices

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Nano-Micro Letters 2021年第12期13卷 437-451页

作者： Dae yun Kang Bo-hyun Kim Tae Ho Lee Jae Won Shim Sungmin Kim Ha-Jun Sung Kee Joo Chang Tae Geun Kim School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Advanced Materials Engineering Kongju National UniversityCheonan 31080Republic of Korea Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

Ultrathin film-based transparent conductive oxides(TCOs)with a broad work function(WF)tunability are highly demanded for e cient energy conversion ***,reducing the film thickness below 50 nm is limited due to rapidly increasing resistance;furthermore,introducing dopants into TCOs such as indium tin oxide(ITO)to reduce the resistance decreases the transparency due to a trade-o between the two ***,we demonstrate dopant-tunable ultrathin(≤50 nm)TCOs fabricated via electric field-driven metal implantation(m-TCOs;m=Ni,Ag,and Cu)without com-promising their innate electrical and optical *** m-TCOs exhibit a broad WF variation(0.97 eV),high transmittance in the UV to visible range(89–93%at 365 nm),and low sheet resistance(30–60Ωcm-2).Experimental and theoretical analyses show that interstitial metal atoms mainly a ect the change in the WF without substantial losses in optical *** m-ITOs are employed as anode or cathode electrodes for organic light-emitting diodes(LEDs),inorganic UV LEDs,and organic photovoltaics for their universal use,leading to outstanding performances,even without hole injection layer for OLED through the WF-tailored *** results verify the proposed m-TCOs enable e ective carrier transport and light extraction beyond the limits of traditional TCOs.

关键词： Transparent conductive oxide Metal implantation High transparency Low sheet resistance Work function

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