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Optimal concentration of mesenchymal stem cells for fracture healing in a rat model with long bone fracture

World Journal of Stem Cells 2022年第12期14卷 839-850页

作者： Myung-Seo Kim hyun-ju chung Kang-Il Kim Department of Orthopaedic Surgery School of MedicineKyung Hee University and Kyung Hee University Hospital at GangdongSeoul 05278South Korea Department of Core Research Laboratory Clinical Research InstituteKyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND There is still no consensus on which concentration of mesenchymal stem cells(MSCs)to use for promoting fracture healing in a rat model of long bone *** To assess the optimal concentration of MSCs for promoting fracture healing in a rat *** Wistar rats were divided into four groups according to MSC concentrations:Normal saline(C),2.5×10^(6)(L),5.0×10^(6)(M),and 10.0×10^(6)(H)*** MSCs were injected directly into the fracture *** rats were sacrificed at 2 and 6 wk *** bone formation[bone volume(BV)and percentage BV(PBV)]was evaluated using micro-computed tomography(CT).Histological analysis was performed to evaluate fracture healing *** protein expression of factors related to MSC migration[stromal cell-derived factor 1(SDF-1),transforming growth factor-beta 1(TGF-β1)]and angiogenesis[vascular endothelial growth factor(VEGF)]was evaluated using western blot *** expression of cytokines associated with osteogenesis[bone morphogenetic protein-2(BMP-2),TGF-β1 and VEGF]was evaluated using real-time polymerase chain *** Micro-CT showed that BV and PBV was significantly increased in groups M and H compared to that in group C at 6 wk post-fracture(P=0.040,P=0.009;P=0.004,P=0.001,respectively).Significantly more cartilaginous tissue and immature bone were formed in groups M and H than in group C at 2 and 6 wk post-fracture(P=0.018,P=0.010;P=0.032,P=0.050,respectively).At 2 wk post fracture,SDF-1,TGF-β1 and VEGF expression were significantly higher in groups M and H than in group L(P=0.031,P=0.014;P<0.001,P<0.001;P=0.025,P<0.001,respectively).BMP-2 and VEGF expression were significantly higher in groups M and H than in group C at 6 wk postfracture(P=0.037,P=0.038;P=0.021,P=0.010).Compared to group L,TGF-β1 expression was significantly higher in groups H(P=0.016).There were no significant differences in expression levels of chemokines related to MSC migration,angiogenesis and cytokines associated

关键词： Rat model Femoral shaft fracture Mesenchymal stem cells Direct injection Optimal concentration Fracture healing

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Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo HA Hyo-Young JEONG ju Hun LEE hyun-jung chung Division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary Arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leachate multi-scale structure eating quality processing technology

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Comparison Study and Forensic Analysis between Experiment and Coupled Dynamics Simulation for Submerged Floating Tunnel Segment with Free Ends under Wave Excitations

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 155-174页

作者： Woo Chul chung chungkuk Jin Moo hyun Kim ju-young Hwang Division of Mechanical Engineering Korea Maritime&Ocean UniversityBusanSouth Korea Department of Ocean Engineering and Marine Sciences Florida Institute of TechnologyMelbourneFLUSA Department of Ocean Engineering Texas A&M UniversityCollege StationTXUSA Department of Civil Engineering Dong-Eui UniversityBusanSouth Korea

This paper presents dynamic-behavior comparisons and related forensic analyses of a submerged floating tunnel(SFT)between numerical simulation and physical experiment under regular and irregular *** experiments are conducted in the 3Dwave tank with 1:33.3 scale,and the corresponding coupled time-domain simulation tool is devised for *** entire SFT systemconsists of a long concrete tunnel and 12 tubular aluminummooring *** numerical simulation models,the Cummins equation with 3D potential theory including second-order wave-body interaction effects and the much simpler Morison-equation-based formula with the lumped-massbased line model,are designed and *** analyses for mooring-line adjustments in the simulation are carried out in view of the best representation of the physical *** that,the measured pre-tension distribution and systemstiffness of twelvemooring lines arewell reproduced in the ***,the dynamic responses and mooring tensions of the SFT are compared under regular and irregular *** measured and simulated results coincide reasonably well for both regular-and irregular-wave conditions.

关键词： Submerged floating tunnel comparative study forensic analysis mooring-line modeling dynamic response mooring tension

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Copper telluride with manipulated carrier concentrations for high-performance solid-state thermoelectrics

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Journal of Materials Science & Technology 2022年第34期129卷 190-195页

作者： hyun ju Dabin Park Minsu Kim Jooheon Kim G.W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Chemical Engineering&Materials Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Intelligent Energy and Industry Graduate SchoolChung-Ang UniversitySeoul 06974Republic of Korea Department of Advance Materials Engineering Chung-Ang UniversityAnseong 17546Republic of Korea

This study proposed a strategy for effectively diminishing the carrier concentration in Cu_(2)Te by introducing graphene sheets,Based on thermoelectric property measurements and single parabolic band modeling,the incorporated graphene effectively reduced the carrier concentration,not only enhancing the thermoelectric performance of the Cu_(2)Te/graphene composite but also substantially improving its figure of merit up to ~1.47 at 1000 K,which is 268% higher than that of pristine Cu_(2)Te,This study gives an insight into the control of carrier concentration and thermoelectric properties in Cu_(2)Te,and it could be extended to other copper chalcogenides for excellent thermoelectrics.

关键词： Thermoelectric Copper telluride Graphene Carrier concentration Single parabolic band model

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Identical-video retrieval using the low-peak feature of a video's audio information

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第3期11卷 151-159页

作者： Myoung-beom chung Il-ju KO Department of Media Soongsil University

The recognition and retrieval of identical videos by combing through entire video files requires a great deal of time and memory space. Therefore, most current video-matching methods analyze only a part of each video's image frame information. All these methods, however, share the critical problem of erroneously categorizing identical videos as different if they have merely been altered in resolution or converted with a different codec. This paper deals instead with an identical-video-retrieval method using the low-peak feature of audio data. The low-peak feature remains relatively stable even with changes in bit-rate or codec. The proposed method showed a search success rate of 93.7% in a video matching experiment. This approach could provide a technique for recognizing identical content on video file share sites.

关键词： Video retrieval Video DNA Audio signal processing Audio feature extraction

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Effects of compressive stress on the nonlinear electromechanical behavior of ferroelectric ceramics

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Science China(Technological Sciences) 2006年第1期49卷 29-37页

作者： LEE jung-ju KIM hyun Cheol Department of Mechanical Engineering KAIST Taejon 305-701 Korea

The effects of compressive stress parallel and perpendicular to the polar axis of PZT ceramics on the nonlinear electromechanical behavior of the materials has been experimentally studied. A domain-switching model that divides each 180° switching to two successive 90° switching is proposed to explain these effects. In the case of stress parallel to the polar axis, domain switching in the ceramics is approximately axisymmetric and can be simulated by an analytical model. While in the case of stress perpendicular to the polar axis, domain switching is three-dimensional and cannot be simplified. The simulated re-sults that match the experiments well show the validity of the proposed domain-switching model.

关键词： ferroelectric ceramics, domain switching, electromechanical, PZT.

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Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第27期22卷 6127-6134页

作者： Kwang Il Kim Hye Kyung chung ju Hui Park Yong Jin Lee Joo hyun Kang Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences Korea Drug Development Platform using Radio-Isotope Korea Institute of Radiological and Medical Sciences

Hepatocellular carcinoma (HCC) is one of the most common cancers in Eastern Asia, and its incidence is increasing globally. Numerous experimental models have been developed to better our understanding of the pathogenic mechanism of HCC and to evaluate novel therapeutic approaches. Molecular imaging is a convenient and up-to-date biomedical tool that enables the visualization, characterization and quantification of biologic processes in a living subject. Molecular imaging based on reporter gene expression, in particular, can elucidate tumor-specific events or processes by acquiring images of a reporter gene’s expression driven by tumor-specific enhancers/promoters. In this review, we discuss the advantages and disadvantages of various experimental HCC mouse models and we present in vivo images of tumor-specific reporter gene expression driven by an alpha-fetoprotein (AFP) enhancer/promoter system in a mouse model of HCC. The current mouse models of HCC development are established by xenograft, carcinogen induction and genetic engineering, representing the spectrum of tumor-inducing factors and tumor locations. The imaging analysis approach of reporter genes driven by AFP enhancer/promoter is presented for these different HCC mouse models. Such molecular imaging can provide longitudinal information about carcinogenesis and tumor progression. We expect that clinical application of AFP-targeted reporter gene expression imaging systems will be useful for the detection of AFP-expressing HCC tumors and screening of increased/decreased AFP levels due to disease or drug treatment.

关键词： Alpha-fetoprotein Hepatocellular carcinoma Molecular imaging Reporter gene Tumor-specific enhancer/promoter

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Effect of Radiant Spectral Characteristics on Performance of a Near-Infra-Red Heating Module

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Journal of Thermal Science 2011年第6期20卷 510-515页

作者： ju-hyun Kim Won-Taek Choi Minsub Han School of Mechanical System Engineering University of Incheon Araytech IncheonKorea

We simulated the heat transfer phenomena of the heating module that is primarily based on the radiant energy in the near-infra-red(NIR) *** the module,the power emitted by the lamp filament is distributed to the lamp glass,reflector,and the target medium,which are cooled by an air *** radiant heat transfer is simulated by using the ray-tracing scheme,in which the spectral characteristics of the emission and the materials are *** heat transport from the lamp glass to the cooling air is analyzed by using the finite volume *** the lamp-filament temperature rises in the range of 3000-3400K,the NIR radiant power on the target medium ***,the lamp-glass temperature also rises,and the proportion of the NIR power to the entire radiation has a peak in the temperature *** spectral distributions of the absorbed energies in all the components in the module are highly non-uniform,and a monochromatic model of the radiant heat transfer may result in a significant discrepancy.

关键词： Computational Fluid Dynamics(CFD) Curing Drying Coating process

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Deep Learning-Based Action Classification Using One-Shot Object Detection

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Computers, Materials & Continua 2023年第8期76卷 1343-1359页

作者： hyun Yoo Seo-El Lee Kyungyong chung Contents Convergence Software Research Institute Kyonggi UniversitySuwon-si16227Korea Department of Public Safety Bigdata Kyonggi UniversitySuwon-si16227Korea Division of Computer Science and Engineering Kyonggi UniversitySuwon-si16227Korea

Deep learning-based action classification technology has been applied to various fields,such as social safety,medical services,and *** an action on a practical level requires tracking multiple human bodies in an image in real-time and simultaneously classifying their *** are various related studies on the real-time classification of actions in an ***,existing deep learning-based action classification models have prolonged response speeds,so there is a limit to real-time *** addition,it has low accuracy of action of each object ifmultiple objects appear in the ***,it needs to be improved since it has a memory overhead in processing image *** learning-based action classification using one-shot object detection is proposed to overcome the limitations of multiframe-based analysis *** proposed method uses a one-shot object detection model and a multi-object tracking algorithm to detect and track multiple objects in the ***,a deep learning-based pattern classification model is used to classify the body action of the object in the image by reducing the data for each object to an action *** to the existing studies,the constructed model shows higher accuracy of 74.95%,and in terms of speed,it offered better performance than the current studies at 0.234 s per *** proposed model makes it possible to classify some actions only through action vector learning without additional image learning because of the vector learning feature of the posterior neural ***,it is expected to contribute significantly to commercializing realistic streaming data analysis technologies,such as CCTV.

关键词： Human action classification artificial intelligence deep neural network pattern analysis video analysis

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Bilateral cerebral infarction in diabetic ketoacidosis and bilateral internal carotid artery occlusion:A case report and review of literature

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World Journal of Clinical Cases 2021年第15期9卷 3787-3795页

作者： Yi-chung Chen Su-ju Tsai Department of Physical Medicine and Rehabilitation Chung Shan Medical University HospitalTaichung 40201Taiwan

BACKGROUND Diabetic ketoacidosis(DKA)is a serious complication of type 1 diabetes mellitus(T1DM).Very rarely does DKA lead to cerebral edema,and it is even rarer for it to result in cerebral *** internal carotid artery occlusion(BICAO)is also rare and can cause fatal ***,case reports about acute cerebral infarction throughout both internal carotid arteries with simultaneous BICAO are very *** this study,we present a patient with BICAO,T1DM,hypertension,and hyperlipidemia,who had a catastrophic bilateral cerebral infarction after a DKA *** briefly introduce BICAO and the mechanisms by which DKA results in cerebral *** SUMMARY A 41-year-old woman presented with ischemic stroke that took place 3 mo prior over the left corona radiata,bilateral frontal lobe,and parietal lobe with right hemiplegia and Broca’s *** had a history of hypertension for 5 years,hyperlipidemia for 4 years,hyperthyroidism for 3 years,and T1DM for 31 *** first brain magnetic resonance imaging not only revealed the aforementioned ischemic lesions but also bilateral internal carotid artery *** was admitted to our ward for rehabilitation due to prior stroke *** took place on hospital day *** hospital day 6,she had a new massive infarction over the bilateral anterior cerebral artery and middle cerebral artery *** weeks of aggressive treatment,she remained in a coma and on mechanical ventilation due to respiratory *** discussion with her family,compassionate extubation was performed on hospital day 29 and she *** DKA can lead to cerebral infarction due to several *** people with existing BICAO and several stroke risk factors such as hypertension, T1DM,hyperlipidemia, DKA has the potential to cause more serious ischemic strokes.

关键词： Type 1 diabetes mellitus Diabetic ketoacidosis Bilateral internal carotid artery occlusion Cerebral infarction Case report

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