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Defect Detection Model Using Time Series Data Augmentation and Transformation

Computers, Materials & Continua 2024年第2期78卷 1713-1730页

作者： Gyu-il Kim hyun Yoo Han-Jin Cho Kyungyong Chung Department of Computer Science Kyonggi UniversitySuwon-si16227Korea Contents Convergence Software Research Institue Kyonggi UniversitySuwon-si16227Korea Department of Energy IT Engineering Far East UniversityEumsung-gun27601Korea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon-si16227Korea

Time-series data provide important information in many fields,and their processing and analysis have been the focus of much ***,detecting anomalies is very difficult due to data imbalance,temporal dependence,and ***,methodologies for data augmentation and conversion of time series data into images for analysis have been *** paper proposes a fault detection model that uses time series data augmentation and transformation to address the problems of data imbalance,temporal dependence,and robustness to *** method of data augmentation is set as the addition of *** involves adding Gaussian noise,with the noise level set to 0.002,to maximize the generalization performance of the *** addition,we use the Markov Transition Field(MTF)method to effectively visualize the dynamic transitions of the data while converting the time series data into *** enables the identification of patterns in time series data and assists in capturing the sequential dependencies of the *** anomaly detection,the PatchCore model is applied to show excellent performance,and the detected anomaly areas are represented as heat *** allows for the detection of anomalies,and by applying an anomaly map to the original image,it is possible to capture the areas where anomalies *** performance evaluation shows that both F1-score and Accuracy are high when time series data is converted to ***,when processed as images rather than as time series data,there was a significant reduction in both the size of the data and the training *** proposed method can provide an important springboard for research in the field of anomaly detection using time series ***,it helps solve problems such as analyzing complex patterns in data lightweight.

关键词： Defect detection time series deep learning data augmentation data transformation

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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung hyun Kim Jae-il Park Deug-chan Lee Kyung-Min Choi wonWoo Lee Ji-won Park Bohyun Yun Su-Hyeon Cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

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Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

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Cellular & Molecular Immunology 2024年第4期21卷 393-408页

作者： Sujin Lee Yeunjung Ko hyun Woo Lee won Joon Oh Hun Gi Hong Dinuka Ariyaratne Se Jin Im Tae Jin Kim Department of Immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of Immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:Immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and il-10-secreting capacities than did CD80^(low)MZ B ***,CD80^(high)MZ B cells survived 2-Gy whole-body irradiation,whereas CD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of CD80^(low)MZ B cells led to accelerated development of type II collagen(CII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BCRs)that recognized double-stranded DNA or CII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BCR sequences than CD80^(low)MZ B *** transfer experiments showed that CD21^(+)CD23^(+)transitional 2 MZ precursors preferentially generated CD80^(low)MZ B cells and that a proportion of CD80^(low)MZ B cells were converted into CD80^(high)MZ B cells;in contrast,CD80^(high)MZ B cells stably remained CD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their CD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BCR specificity.

关键词： Marginal Zone B Cell CD80 Autoreactivity Radioresistance

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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon hyung il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung Lee Seung Baek Hong Ji hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

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14-Day Repeated Dose Toxicity and Genotoxicity Studies of Cimicifuga heracleifolia Komarov Water Extract

14-Day Repeated Dose Toxicity and Genotoxicity Studies of Ci...

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亚洲实验动物学会联合会（AFLAS）第三次会议暨中国实...

作者： Jong-Rhan Kim Ji-Ran You Seung-hyun Kim Euna Kwon Yun-Soon Kim Eun-Young Cho Jung-Hee Yoon Soon-Duk Lee Yoon-Mi Hwang Hye-Jung Jeong Dae-Young Seok Jung-Gi Kim hyun-il won Ja-June Jang Doo-hyun Jeong Hee-Chan Kim Byeong-Cheol Kang Kook-hyun Lee Jeong-Hwan Che Clinical Research Institute Seoul National University Hospital Seoul National University College of Medicine Seoul 110-744KOREA

＜正＞Cimicifuga heracleifolia Komarov（CH） is used traditionally as a herbal remedy for many ***,published literature suggests that large doses of cimicifuga racemosa might be associated with ***,its long-term toxicity was not evaluated *** study was performed to evaluate 14-day repeated dose toxicity（RDT） and genotoxicity of CH extract according to the USNTP protocol and GLP guideline. To determine the appropriate dosage of CH extract administration,14-days RDT study were performed.14-days repeated dose study was performed to dosage levels of 0.125,0.25,0.5,1 and 2g/kg/day in F344/N *** test substance-related effect were observed in some criteria included mortality;clinical signs;body weight changes;urinalysis,organ weight,gross findings and histopathological findings. In reverse mutation assay of CH extract using Salmonella typhimurium TA98,TA100,TA102,TA1535 and TA1537,test substance was diluted to 5 dosage levels of 312.5,625,1,250,2,500 and 5,000μg/plate with D.D.W..Each tester strain was exposed to the test item with and without metabolic activation *** extract might not have reverse mutagenicity under the condition of this study. Chromosome aberration test of CH extract was performed to evaluate its clastogenic potential in Chinese Hamster Lung fibroblast（CHL） cell *** test substance was diluted to 3 dosage levels of 2,500,1,250,625fig/*** were exposed to test items for 6 or 24 hours in the absence of metabolic activation system,or for 6 hours in the presence of metabolic activation *** was no statistically significant increase in the number of structural or numeric aberrant metaphases at any dose both in the presence and absence of metabolic activation. A micronucleus test o{ CH extract was performed using ICR *** test substance was orally administered to 3 groups of 8-week old male ICR mice at dosage levels of 2,1,and 0.5g/kg *** 3 *** male mice were used in each test *** a

关键词： Good Laboratory Practice(GLP) Cimicifuga heracleifolia water extract Korea National Toxicology Program

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Optimal concentration of mesenchymal stem cells for fracture healing in a rat model with long bone fracture

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World Journal of Stem Cells 2022年第12期14卷 839-850页

作者： Myung-Seo Kim hyun-Ju Chung Kang-il Kim Department of Orthopaedic Surgery School of MedicineKyung Hee University and Kyung Hee University Hospital at GangdongSeoul 05278South Korea Department of Core Research Laboratory Clinical Research InstituteKyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND There is still no consensus on which concentration of mesenchymal stem cells(MSCs)to use for promoting fracture healing in a rat model of long bone *** To assess the optimal concentration of MSCs for promoting fracture healing in a rat *** Wistar rats were divided into four groups according to MSC concentrations:Normal saline(C),2.5×10^(6)(L),5.0×10^(6)(M),and 10.0×10^(6)(H)*** MSCs were injected directly into the fracture *** rats were sacrificed at 2 and 6 wk *** bone formation[bone volume(BV)and percentage BV(PBV)]was evaluated using micro-computed tomography(CT).Histological analysis was performed to evaluate fracture healing *** protein expression of factors related to MSC migration[stromal cell-derived factor 1(SDF-1),transforming growth factor-beta 1(TGF-β1)]and angiogenesis[vascular endothelial growth factor(VEGF)]was evaluated using western blot *** expression of cytokines associated with osteogenesis[bone morphogenetic protein-2(BMP-2),TGF-β1 and VEGF]was evaluated using real-time polymerase chain *** Micro-CT showed that BV and PBV was significantly increased in groups M and H compared to that in group C at 6 wk post-fracture(P=0.040,P=0.009;P=0.004,P=0.001,respectively).Significantly more cartilaginous tissue and immature bone were formed in groups M and H than in group C at 2 and 6 wk post-fracture(P=0.018,P=0.010;P=0.032,P=0.050,respectively).At 2 wk post fracture,SDF-1,TGF-β1 and VEGF expression were significantly higher in groups M and H than in group L(P=0.031,P=0.014;P<0.001,P<0.001;P=0.025,P<0.001,respectively).BMP-2 and VEGF expression were significantly higher in groups M and H than in group C at 6 wk postfracture(P=0.037,P=0.038;P=0.021,P=0.010).Compared to group L,TGF-β1 expression was significantly higher in groups H(P=0.016).There were no significant differences in expression levels of chemokines related to MSC migration,angiogenesis and cytokines associated

关键词： Rat model Femoral shaft fracture Mesenchymal stem cells Direct injection Optimal concentration Fracture healing

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T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine:A case report

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世界临床病例杂志 2023年第26期11卷 6200-6205页

作者： Sungwoo Park Eun Jeong Jeong Jung Hun Kang Gyeong-won Lee Se-il Go Dong-hyun Lee Eun-Ha Koh Division of Hematology and Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52727South Korea Department of Internal Medicine Institute of Health SciencesGyeongsang National University Changwon HospitalGyeongsang National University School of MedicineChangwon 52828South Korea Department of Laboratory Medicine Gyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52828South Korea

BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid ***,consensus regarding the ideal management strategy for MPAL is yet to be established,owing to its *** SUMMARY A 55-year-old male was diagnosed with T/myeloid ***,prednisolone,daunorubicin,and L-asparaginase were administered as induction *** shock occurred 10 days after induction,and bone marrow examination following recovery from sepsis revealed refractory *** and decitabine were administered as chemotherapy-free induction therapy to reduce the infection *** were no serious infections,including febrile neutropenia,at the end of the *** receiving two additional cycles of venetoclax/decitabine,the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response(CR)to *** CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.

关键词： Mixed-phenotype acute leukemia Venetoclax Decitabine Case report

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SlowFast Based Real-Time Human Motion Recognition with Action Localization

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Computer Systems Science & Engineering 2023年第11期47卷 2135-2152页

作者： Gyu-il Kim hyun Yoo Kyungyong Chung Department of Computer Science Kyonggi UniversitySuwon16227Korea Contents Convergence Software Research Institute Kyonggi UniversitySuwon16227Korea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon16227Korea

Artificial intelligence is increasingly being applied in the field of video analysis,particularly in the area of public safety where video surveillance equipment such as closed-circuit television(CCTV)is used and automated analysis of video information is ***,various issues such as data size limitations and low processing speeds make real-time extraction of video data *** analysis technology applies object classification,detection,and relationship analysis to continuous 2D frame data,and the various meanings within the video are thus analyzed based on the extracted basic *** recognition is key in this *** recognition is a challenging field that analyzes human body movements,requiring the interpretation of complex movements of human joints and the relationships between various *** deep learning-based human skeleton detection algorithm is a representative motion recognition ***,motion analysis models such as the SlowFast network algorithm,have also been developed with excellent ***,these models do not operate properly in most wide-angle video environments outdoors,displaying low response speed,as expected from motion classification extraction in environments associated with high-resolution *** proposed method achieves high level of extraction and accuracy by improving SlowFast’s input data preprocessing and data structure *** input data are preprocessed through object tracking and background removal using YOLO and DeepSORT.A higher performance than that of a single model is achieved by improving the existing SlowFast’s data structure into a frame unit *** on the confusion matrix,accuracies of 70.16%and 70.74%were obtained for the existing SlowFast and proposed model,respectively,indicating a 0.58%increase in *** detection,based on behavioral classification,the existing SlowFast detected 2,341,164 cases,whereas the proposed model detected 3,11

关键词： Artificial intelligence convolutional neural network video analysis human action recognition skeleton extraction

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Fibrillary gelation and dedoping of PEDOT:PSS fibers for interdigitated organic electrochemical transistors and circuits

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npj Flexible Electronics 2022年第1期6卷 330-340页

作者： Young Jin Jo Soo Young Kim Jeong Hun hyun Byeonghak Park Seunghwan Choy Gyan Raj Koirala Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Korea

As one of conducting polymers,PEDOT:PSS,is commonly used in organic electronics,especially for bioelectronics due to its advantages such as high electrical and ionic conductivity,solution-processability and *** bioelectronics with the PEDOT:PSS requires advanced techniques to obtain physical/chemical modification of the PEDOT:PSS for improved performance and various *** satisfy these demands,fibrillary gelation of PEDOT:PSS by injection to choline acetate,an ionic liquid,with a constant flow rate was used in this study to make a conductive fiber and improve characteristics of PEDOT:*** fibers by fibrillary gelation showed enhanced electrical conductivity of about 400 S cm^(-1) and volumetric capacitance of about 154 F cm^(−3) which would be strongly beneficial to be utilized for organic electrochemical transistors(OECTs),resulting in a high transconductance of 19 mS in a ***,dedoping of the conductive fibers by PEI(polyethyleneimine)enabled the creation of enhancement-mode *** inverters were then fabricated by connecting depletion and enhancement-mode *** results demonstrate that these conductive fibers and electronic-textiles are suitable candidates for applications in bio-integrated electronics.

关键词： fibers doping digit

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Adaptive Electrospinning System Based on Reinforcement Learning for Uniform‑Thickness Nanofiber Air Filters

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Advanced Fiber Materials 2023年第2期5卷 617-631页

作者： Seok Hyeon Hwang Jin Yeong Song hyun il Ryu Jae Hee Oh Seungwook Lee Donggeun Lee Dong Yong Park Sang Min Park School of Mechanical Engineering Pusan National University63‑2 Busan University‑roGeumjeong‑guBusan 46241South Korea Smart Manufacturing Technology R&D Group Korea Institute of Industrial Technology320 Techno Sunhwan‑roYuga‑eupDalseong‑gunDaegu 42994Republic of Korea

Electrospinning is a simple and versatile method to produce nanofiber ***,owing to bending instability that occurs during the electrospinning process,electrospinning has frequently produced a non-uniform-thickness nanofiber filter,which deteriorates its air ***,an adaptive electrospinning system based on reinforcement learning(E-RL)was developed to produce uniform-thickness nanofiber *** E-RL accomplished a real-time thickness measurement of an electrospun nanofiber filter by measuring the transmitted light through the nanofiber filter using a camera placed at the bottom of the collector and converting it into thickness using the Beer–Lambert *** on the measured thickness,the E-RL detected the non-uniformity of the nanofiber filter thickness and manipulated the movable collector to alleviate the non-uniformity of the thickness by a pre-trained reinforcement learning(RL)*** the training of the RL algo-rithm,the nanofiber production simulation software based on the empirical model of the deposition of the nanofiber filter was developed,and the training process of the RL algorithm was repeated until the optimal policy was *** the training process with the simulation software,the trained model was transferred to the adaptive electrospinning *** the movement of the collector under the optimal strategy of RL algorithm,the non-uniformity of such nanofiber filters was significantly reduced by approximately five times in standard deviation and error for both simulation and *** finding has great potential in improving the reliability of electrospinning process and nanofiber filters used in research and industrial fields such as environment,energy,and biomedicine.

关键词： Electrospinning Nanofiber filter Uniform thickness Reinforcement learning Deep Q-network

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