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Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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中医杂志:英文版 2023年第4期43卷 686-694页

作者： Dong-Wook kang Jae-Gyun Choi Hee Ju Song Jaehyuk Kim Miae Lee Taehee Kim suk-Yun kang Yeonhee Ryu Hwa Seung Yoo Jin Sun Lee Jin Bong Park Sang Do Lee hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

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Intraoperative photodynamic therapy for tracheal mass in non-small cell lung cancer:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3915-3920页

作者： Hee suk Jung hyun Jung Kim Kwan Wook Kim Department of Thoracic and Cardiovascular Surgery CHA Bundang Medical CenterSeongnam-si 13496South Korea

BACKGROUND Tracheal neoplasms represent less than 0.1%of all malignancies and have no established treatment *** resection with reconstruction is the primary *** study demonstrates successful treatment of concurrent lung and tracheal tumors using surgical excision and intraoperative photodynamic therapy(PDT),highlighting the effectiveness and safety of this *** SUMMARY A 74-year-old male with a history of smoking and chronic obstructive pulmonary disease was diagnosed with tracheal squamous cell carcinoma and right lower lobe adenocarcinoma.A multidisciplinary team created a treatment plan involving tumor resection and *** tracheal tumor was removed through a tracheal incision and this was followed by intraluminal *** trachea was repaired and a right lower lobectomy was *** patient received a second PDT treatment postoperatively and was discharged 10 d after the tracheal surgery,without *** then underwent platinum-based chemotherapy for lymphovascular invasion of lung ***-month postoperative bronchoscopy revealed normal tracheal mucosa with a scar at the resection site and no evidence of tumor recurrence in the trachea or *** Our case of concurrent tracheal and lung cancers was successfully treated with surgical excision and intraoperative PDT which proved safe and effective in this patient.

关键词： Tracheal neoplasm Non-small cell lung carcinoma Pulmonary surgical procedure Photochemotherapy Prognosis Case report

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Hepatocellular carcinoma presenting as organized liver abscess:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8078-8083页

作者： Sung Hyeok Ryou hyun Deok Shin suk Bae Kim Department of Internal Medicine Dankook University College of MedicineCheonan 31116ChungnamSouth Korea

BACKGROUND Hepatocellular carcinoma(HCC)is difficult to treat and has a high mortality rate,emphasizing the importance of early diagnosis and *** characteristic radiologic findings and underlying liver disease are present,a diagnosis can be made without a ***,when HCC is accompanied by a liver abscess,diagnosis might be delayed by atypical radiologic *** case report aims to assist in the diagnosis of HCC,which can manifest in various *** SUMMARY A 75-year-old male presented to the Emergency Department with worsening fever and mental *** was diagnosed with liver cirrhosis six months *** computed tomography(CT)raised our suspicion of an organized liver abscess.A follow-up CT scan after four weeks of antibiotic treatment showed a decrease in the liver lesion ***,high fever recurred,and C-reactive protein increased to 14 mg/*** of the liver lesion was performed,but no bacteria were *** culture revealed the presence of *** patient received an additional four weeks of antibiotics and antifungal agents before being *** 10 mo later,a CT scan showed an increase in the lesion size,and biopsy was *** biopsy revealed an organized abscess with focal carcinomatous changes,for which surgery was *** histopathological examination revealed HCC,clear-cell *** nontumor liver tissue showed cirrhosis and an organized *** Even if a liver abscess is suspected in a patient with cirrhosis,the possibility of HCC should be considered.

关键词： Liver abscess Hepatocellular carcinoma Infection Diagnosis Case report

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Gradient Si-and Ti-doped Fe_(2)O_(3) hierarchical homojunction photoanode for efficient solar water splitting:Effect of facile microwave-assisted growth of Si-FeOOH on Ti-FeOOH nanocorals

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Journal of Energy Chemistry 2023年第2期77卷 27-37,I0002页

作者： Tae Sik Koh Periyasamy Anushkkaran Weon-Sik Chae hyun Hwi Lee Sun Hee Choi Jum suk Jang Division of Biotechnology College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

The construction of a homojunction is an effective approach for addressing issues such as slow charge separation and charge-transfer kinetics in *** the present work,we designed a gradient Si-and Ti-doped Fe_(2)O_(3) homojunction photoanode to improve the photoelectrochemical(PEC)performance of a Ti-doped Fe_(2)O_(3) ***-FeOOH nanocorals were synthesized using a hydrothermal process,and Si-FeOOH was grown on Ti-FeOOH nanocorals using a rapid and facile microwaveassisted(MW)*** varying the MW irradiation time,the thickness of the Si/Ti:Fe_(2)O_(3) photoanode was adjusted and an optimized 3-Si/Ti:Fe_(2)O_(3) photoelectrode was achieved with a significantly enhanced photocurrent density(1.37 mA cm^(-2) at 1.23 V ***)and a cathodic shift of the onset potential(150 mV)compared with that of bare Ti-Fe_(2)O_(3).This enhanced PEC performance can be ascribed to homojunction formation and Si gradient *** Si dopant increased the donor concentration and the formation of a homojunction improved the intrinsic built-in electric field,thereby promoting charge separation and charge ***,the as-formed homojunction passivated the surfacetrapping states,consequently improving the charge transfer efficiency(60%at 1.23 VRHE)at the photoanode/electrolyte *** findings could pave the way for the microwave-assisted fabrication of diverse efficient homojunction photoanodes for PEC water splitting applications.

关键词： Homojunction Microwave-assisted Hematite Gradient doping PEC water splitting

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Priapism secondary to penile metastasis of rectal cancer

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World Journal of Gastroenterology 2009年第33期15卷 4209-4211页

作者： Ji Chan Park Wook hyun Lee Min Kyu kang suk Young Park Division of Oncology Department of Internal MedicineThe Catholic University of KoreaDaejeon St. Mary's Hospital

Metastatic penile carcinoma is rare and usually originates from genitourinary tumors. The presenting symptoms or signs have been described as nonspecific except for priapism. Rectal adenocarcinoma is a very unusual source of metastatic penile carcinoma. We report a case of metastatic penile carcinoma that originated from the rectum. Symptomatic improvement occurred with palliative radiotherapy.

关键词：直肠癌阴茎异常发生症状非特异性转移性起源

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Transverse myelitis caused by herpes zoster following COVID-19 vaccination:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1419-1425页

作者： Su-Yeon Cho Bo-hyun Jang Jun-Won Seo suk-Whee Kim Kyung-Joon Lim hyun-Young Lee Dong-Joon Kim Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Internal Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea

BACKGROUND Transverse myelitis(TM)is characterized by sudden lower extremity progressive weakness and sensory impairment,and most patients have a history of advanced viral infection symptoms.A variety of disorders can cause TM in association with viral or nonviral infection,vascular,neoplasia,collagen vascular,and iatrogenic,such as *** has become common through the global implementation against coronavirus disease 2019(COVID-19)and reported complications like herpes zoster(HZ)activation has *** SUMMARY This is a 68-year-old woman who developed multiple pustules and scabs at the T6-T9 dermatome site 1 wk after vaccination with the COVID-19 vaccine(Oxford/AstraZeneca([ChAdOx1S{recombinant}]).The patient had a paraplegia aggravation 3 wk after HZ symptoms *** magnetic resonance imaging(MRI)showed transverse myelitis at the T6–T9 *** was acyclovir with steroids combined with physical *** neurological function was slowly restored by Day *** HZ developed after COVID-19 vaccination,which may lead to more severe ***,HZ treatment itself should not be *** neurological complications worsen after appropriate management,an immediate diagnostic procedure,such as magnetic resonance imaging and laboratory tests,will start and should treat the neurological complications.

关键词： Herpes zoster Transverse myelitis Paraplegia COVID-19 Vaccination Case report

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Does the discrepancy in histologic differentiation between a forceps biopsy and an endoscopic specimen necessitate additional surgery in early gastric cancer?

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World Journal of Gastrointestinal Oncology 2017年第8期9卷 319-326页

作者： Jae Seung Soh hyun Lim Ho suk kang Jong Hyeok Kim Kab Choong Kim Department of Internal Medicine University of Hallym College of Medicine Hallym University Sacred Heart Hospital Department of Surgery University of Hallym College of Medicine Hallym University Sacred Heart Hospital

AIM To investigate the clinicopathological variables in early gastric cancer(EGC) patients in relation to differentiation *** The data of 265 specimens from 240 patients with EGC, who had undergone radical operation at Hallym University Sacred Heart Hospital from 2010 to 2015, were retrospectively analyzed. We evaluated clinical, endoscopic, and histopathological data according to histological *** Clinically significant discrepancy rate showed the difference in differentiated type(well and moderately differentiated) and undifferentiated type(poorly differentiated and signet ring cell) between endoscopic biopsies and postoperative specimens was 9.4%(25/265). There were no differences in tumor location, size, gross pattern, and number of biopsies. Specimens having histological discrepancy showed more submucosal invasion(72.0% vs 49.6%, P = 0.033) and lymph node involvement(24.0% vs 7.9%, P = 0.009) than specimens having non-discrepancy. The rate of a positive epidermal growth factor receptor status was higher in specimens having discrepancy than in specimens having non-discrepancy(81.0% vs 55.4%, P = 0.035).CONCLUSION The discordance of histologic differentiation is associated with higher submucosal invasion and lymph node metastases in EGC. Patients have histological discrepancy may require additional surgical treatments.

关键词：早胃的癌症组织学的差异区别 Clinicopathological 因素内视镜的治疗外科的治疗

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Detection of Apple Marssonina Blotch with PLSR, PCA, and LDA Using Outdoor Hyperspectral Imaging

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光谱学与光谱分析 2020年第4期40卷 1309-1314页

作者： Soo hyun Park Youngki Hong Mubarakat Shuaibu Sangcheol Kim Won suk Lee Department of Agricultural and Biological Engineering University of FloridaGainesvilleFL 32611United States Department of Agricultural Engineering National Academy of Agricultural ScienceRDAJeonju 55365South Korea Smart Farm Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-do 25451South Korea

In this study, hyperspectral images were used to detect a fungal disease in apple leaves called Marssonina blotch(AMB). Estimation models were built to classify healthy, asymptomatic and symptomatic classes using partial least squares regression(PLSR), principal component analysis(PCA), and linear discriminant analysis(LDA) multivariate methods. In general, the LDA estimation model performed the best among the three models in detecting AMB asymptomatic pixels, while all the models were able to detect the symptomatic class. LDA correctly classified asymptomatic pixels and LDA model predicted them with an accuracy of 88.0%. An accuracy of 91.4% was achieved as the total classification accuracy. The results from this work indicate the potential of using the LDA estimation model to identify asymptomatic pixels on leaves infected by AMB.

关键词： Apple Marssonina blotch Hyperspectral imaging PLSR PCA LDA

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Severe mediastinitis and pericarditis after endobronchial ultrasoundguided transbronchial needle aspiration:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10723-10727页

作者： Jeong suk Koh Yoon Joo Kim Da hyun kang Jeong Eun Lee Song-I Lee Department of Pulmonary and Critical Care Medicine Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)is a safe and minimally invasive diagnostic tool for mediastinal and hilum ***,infectious complications may occur after *** these,mediastinitis and pericarditis are *** SUMMARY A 67-year-old woman was referred to our hospital due to paratracheal lymph node enlargement on chest computed tomography(CT).EBUS-TBNA was performed on the lymph node lesions,and prophylactic oral antibiotics were *** days after EBUS-TBNA,the patient visited the emergency room with a high fever and chest *** test results revealed leukocytosis with a left shift and elevated C-reactive protein level(25.7 mg/dL).Chest CT revealed the formation of a mediastinal abscess in the right paratracheal lymph node and pericardial and bilateral pleural *** patient received intravenous antibiotic treatment,cardiac drainage through pericardiocentesis,and surgical *** patient recovered favorably and was discharged 31 d after the *** Mediastinitis and pericarditis after EBUS-TBNA are rare but should be considered even after the use of prophylactic antibiotics.

关键词： Endoscopic ultrasound-guided fine needle aspiration Complication Mediastinitis Pericarditis Antibiotics Case report

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Lithofacies modeling by multipoint statistics and economic evaluation by NPV volume for the early Cretaceous Wabiskaw Member in Athabasca oilsands area, Canada

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Geoscience Frontiers 2018年第2期9卷 441-451页

作者： Kwang hyun Kim Kyungbook Lee hyun suk Lee Chul Woo Rhee hyun Don Shin Petroleum and Marine Research Division Korea Institute of Geoscience and Mineral Resources Department of Earth and Environmental Sciences Chungbuk National University Department of Energy Resources Engineering Inha University

The static modeling and dynamic simulation are essential and critical processes in petroleum exploration and development. In this study, lithofacies models for Wabiskaw Member in Athabasca, Canada are generated by multipoint statistics(MPS) and then compared with the models built by sequential indicator simulation(SIS). Three training images(Tls) are selected from modern depositional environments;the Orinoco River Delta estuary, Cobequid bay-Salmon River estuary, and Danube River delta environment. In order to validate lithofacies models, average and variance of similarity in lithofacies are calculated through random and zonal blind-well *** random six-blind-well test, similarity average of MPS models is higher than that of SIS model. The Salmon MPS model closely resembles facies pattern of Wabiskaw Member in subsurface. Zonal blind-well tests show that successful lithofacies modeling for transitional depositional setting requires additional or proper zonation information on horizontal variation, vertical proportion, and secondary *** Wabiskaw Member is frontier oilsands lease, it is impossible to evaluate the economics from production data or dynamic simulation. In this study, a dynamic steam assisted gravity drainage(SAGD)performance indicator(SPIDER) on the basis of reservoir characteristics is calculated to build 3 D reservoir model for the evaluation of the SAGD feasibility in Wabiskaw Member. SPIDER depends on reservoir properties, economic limit of steam-oil ratio, and bitumen price. Reservoir properties like porosity,permeability, and water saturation are measured from 13 cores and calculated from 201 well-logs. Three dimensional volumes of reservoir properties are constructed mostly based on relationships among properties. Finally, net present value(NPV) volume can be built by equation relating NPV and SPIDER. The economic area exceeding criterion of US$ 10,000 is identified, and the ranges of reservoir properties are estimated. NPV-volume-generati

关键词： Oilsands Multipoint statistics (MPS) Reservoir static modeling Economic evaluation Net present value (NPV) SAGD, and SPIDER

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