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Anti-cancer effect of ethylacetate fraction from Orostachys japonicus on HT-29 human colon cancer cells by induction of apoptosis through caspase-dependent signaling pathway

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Asian Pacific Journal of Tropical Medicine 2018年第5期11卷 330-335页

作者： Deok-Seon Ryu hyun-Ji lee Ji-Hye Kwon Dong-seok lee Department of Biomedical Laboratory Science Soonchunhyang University Department of Smart Foods and Drugs Graduate School of Inje University

Objective: To investigate the anti-colon cancer effects of ethylacetate fraction from Orostachys japonicus(0. japonicus) on HT-29 cancer cells. Methods: The viability of HT-29 cells was assayed by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 H-tetrazolium(MTS) method. Apoptosis induction and cell cycle inhibition were confirmed by fluorescein isothiocyanate and propidium iodide staining using flow *** changes in the nucleus were observed, using a fluorescence microscope with4',6-diamidino-2-phenylindole(DAPI) nuclear staining. The expression levels of the upstream and downstream proteins involved in the anti-cancer mechanism were confirmed by Western blotting. Results: After treating HT-29 cells with different concentrations of ethylacetate fraction from O. japonicus, the viability of cells decreased in a concentration-dependent manner,while apoptosis induction and apoptotic body formation increased. Cell cycle analysis showed that the arrest occurred at the sub-G_1 and S phase. Among the upstream and downstream proteins involved in anti-cancer activity, the level of B cell lymphoma-2 decreased, and the bcl-2-associated x protein increased. The level of pro-caspase-3, pro-caspase-8, and pro-caspase-9 decreased, while the level of cleaved-caspase-3, cleaved-caspase-8, and cleaved-caspase-9 increased. Moreover, the phosphorylation, that is, activation of extracellular signal regulated kinase 1/2, Jun-N-terminal kinase, and p38 increased. Conclusions: Combining the above results, it is thought that the survival of HT-29 cells is suppressed by ethylacetate fraction from0. japonicus through mitochondrial regulation-induced caspase cascade activation, induction of apoptosis and cell cycle arrest.

关键词： Orostachys japonicus HT-29 human colon cancer cells Anti-cancer activity Apoptosis Caspase cascade

Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

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Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung lee Jeong hyun Yoon Young-Woong Song seok Daniel Namgung Taehoon Sung Yoon-Sik lee Jong-seok lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song seok Daniel Namgung Hojung lee Jeong hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik lee Jong-seok lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

Usefulness of colonic tattooing using indocyanine green in patients with colorectal tumors

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World Journal of Clinical Cases 2018年第13期6卷 632-640页

作者： Jae Ho Park Hee seok Moon In Sun Kwon Gee Young Yun Seo Hee lee Dae Hwa Park Ju seok Kim Sun hyung Kang Eaum seok lee seok hyun Kim Jae Kyu Sung Byung seok lee hyun Yong Jeong Division of Gastroenterology Department of Internal Medicine Chungnam National University Hospital Chungnam National University college of Medicine Clinical Trials Center Chungnam National University Hospital

AIM To prove that tattooing using indocyanine green(ICG) is feasible in laparoscopic surgery for a colon *** From January 2012 to December 2016, all patients who underwent laparoscopic colonic surgery were retrospectively screened, and 1010 patients with colorectal neoplasms were included. Their lesions were tattooed with ICG the day before the operation. The tattooed group(TG) included 114 patients, and the non-tattooed group(NTG) was selected by propensity score matching of subjects based on age, sex, tumor staging, and operation method(n = 228). In total, 342 patients were enrolled. Between the groups, the changes in [Delta(Δ), preoperative-postoperative] the hemoglobin and albumin levels, operation time, hospital stay, oral ingestion period, transfusion, and perioperative complications were compared. RESULTS Preoperative TG had a shorter operation time(174.76 ± 51.6 min vs 192.63 ± 59.9 min, P < 0.01), hospital stay(9.55 ± 3.36 d vs 11.42 ± 8.23 d, P < 0.01), and postoperative oral ingestion period(1.58 ± 0.96 d vs 2.81 ± 1.90 d, P < 0.01). The Δ hemoglobin(0.78 ± 0.76 g/dL vs 2.2 ± 1.18 g/dL, P < 0.01) and Δ albumin(0.41 ± 0.44 g/dL vs 1.08 ± 0.39 g/dL, P < 0.01) levels were lower in the TG. On comparison of patients in the "N0" and "N1 or N2" groups, the N0 colon cancer group had a better operation time, length of hospital stay, oral ingestion period, Δ hemoglobin, and Δ albumin results than those of the N1 or N2 group. The operation methods affected the results, and laparoscopic anterior resection(LAR) showed similar results. However, for left and right hemicolectomy, both groups showed no difference in operation time or hospital *** Preoperative tattooing with ICG is useful for laparoscopic colectomy, especially in the N0 colon cancer group and LAR.

关键词： Colorectal neoplasm Laparoscopic surgery Endoscopic tattoo Indocyanine green Perioperative

Lubrication properties of silver-palladium alloy prepared by ion plating method for high temperature stud bolt

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 12-16页

作者： Jung-Dae KWON Sunghun lee Koo-hyun lee Jong-Joo RHA Kee-seok NAN Se-Hun KWON Materials Processing Division Korea Institute of Materials Science Changwon Gyeongnam 641-831 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

As a solid lubricant, silver-palladium (Ag-Pd) alloy coating was investigated for the application to high temperature stud bolt. A glue layer nickel (Ni) film was deposited on the surface of the hex bolt sample and then Ag-Pd alloy coating was performed on it using ion plating method. The friction coefficient of Ag-Pd alloy film coated bolt was lower than that of N-5000 oil coated bolt by the result of axial force measurement. The cyclic test of heat treatment was conducted to evaluate the durability of Ag-Pd alloy film coated bolt. In a cycle, sample was assembled into the block using torque wrench, followed by heating and disassembling. It was not successful to disassemble the N-5000 oil coated bolt from the block after only one cycle. However, the Ag-Pd alloy film coated bolt was able to be disassembled softly till 12 cycles.

关键词： solid lubricant silver-palladium alloy ion plating

Characteristic evaluation of Al_2O_3/CNTs hybrid materials for micro-electrical discharge machining

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 28-32页

作者： hyun-seok TAK Chang-Seung HA Ho-Jun lee hyung-Woo lee Young-Keun JEONG Myung-Chang KANG National Core Research Center for Hybrid Materials Solution Pusan National University Department of Electrical Engineering Pusan National University

The characteristic evaluation of aluminum oxide （A1203）/carbon nanotubes （CNTs） hybrid composites for micro-electrical discharge machining （EDM） was described. Alumina matrix composites reinforced with CNTs were fabricated by a catalytic chemical vapor deposition method. A1203 composites with different CNT concentrations were synthesized. The electrical characteristic of A1203/CNTs composites was examined. These composites were machined by the EDM process according to the various EDM parameters, and the characteristics of machining were analyzed using field emission scanning electron microscope （FESEM）. The electrical conductivity has a increasing tendency as the CNTs content is increased and has a critical point at 5% A1203 （volume fraction）. In the machining accuracy, many tangles of CNT in A1203/CNTs composites cause violent spark. Thus, it causes the poor dimensional accuracy and circularity. The results show that conductivity of the materials and homogeneous distribution of CNTs in the matrix are important factors for micro-EDM of A1203/CNTs hybrid composites.

关键词： A1203/CNTs hybrid materials micro-electrical discharge machining micro-hole electrical conductivity

Boosting overall water splitting by incorporating sulfur into NiFe(oxy)hydroxide

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Journal of Energy Chemistry 2022年第1期31卷 364-371,I0010页

作者： Chiho Kim Seong hyun Kim Seunghun lee Ilyeong Kwon Seong hyun Kim Shinho kim Changgyu seok Yoo Sei Park Yangdo Kim Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea BK21 Four Innovative Graduate Education Program for Global High-tech Materials&PartsPusan National UniversityBusan 46241Republic of Korea Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH).Pohang 37673Republic of Korea

Developing highly active and cost-effective electrocatalysts for enhancing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is a significant challenge for overall water ***-incorporated nickel iron(oxy)hydroxide(S-NiFeOOH)nanosheets were directly grown on commercial nickel foam using a galvanic corrosion method and a hydrothermal *** incorporation of sulfur into NiFeOOH enhanced the catalytic activity for the HER and OER in 1 M KOH *** enhanced catalytic activity is attributed to the change in the local structure and chemical states due to the incorporation of *** performance for overall water splitting was achieved with an alkaline water *** was realized by employing S-NiFeOOH as a bifunctional electrocatalyst,thereby outperforming a water electrolyzer that requires the usage of precious metal electrocatalysts(i.e.,Pt/C as the HER electrocatalyst and IrO_(2) as the OER electrocatalyst).Moreover,when driven by a commercial silicon solar cell,an alkaline water electrolyzer that uses S-NiFeOOH as a bifunctional electrocatalyst generated hydrogen under natural *** study shows that S-NiFeOOH is a promising candidate for a large-scale industrial implementation of hydrogen production for overall water splitting because of its low cost,high activity,and *** addition,the solar-driven water electrolyzer using S-NiFeOOH as a bifunctional electrocatalyst affords the opportunity for developing effective and feasible solar power systems in the future.

关键词： Overall water splitting Hydrogen production Sulfur incorporated NiFe(oxy)hydroxide Electrocatalysts Solar-driven water splitting

Electrochemical partial reduction of Ni(OH)_(2) to Ni(OH)_(2)/Ni via coupled oxidation of an interfacing NiAl intermetallic compound for robust hydrogen evolution

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Journal of Energy Chemistry 2023年第7期82卷 560-571,I0012页

作者： Young Hwa Yun Kwangsoo Kim Changsoo lee Byeong-Seon An Ji Hee Kwon Sechan lee MinJoong Kim Jongsu Seo Jong Hyeok Park Byung-hyun Kim hyun-seok Cho Hydrogen Research Department Korea Institute of Energy Research152 Gajeong-roYuseong-guDaejeon 34129Republic of Korea Computational Science&Engineering Laboratory Korea Institute of Energy Research152 Gajeong-roYuseong-guDaejeon 34129Republic of Korea Analysis Center for Energy Research Korea Institute of Energy Research152 Gajeong-roYuseong-guDaejeon 34129Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Ni-based porous electrocatalysts have been widely used in the hydrogen evolution reaction(HER)in alkaline water electrolysis,and the catalysts are produced by selective leaching of Al from Ni-Al *** is well known that chemical leaching of Ni-Al intermetallic compound(IMC)generates a high surface area in Ni(OH)_(2).However,the Ni(OH)_(2) produced by leaching the Ni-Al intermetallic compound retards the hydrogen evolution reaction,which is attributed to its weak hydrogen adsorption *** this study,we controlled the chemical state of Ni using plasma vapor deposition(PVD)followed by heat treatment,selective Al leaching,and electrochemical reduction.X-ray diffraction(XRD),scanning microscopy(SEM),transmission electron microscopy(TEM),and energy-dispersive X-ray spectroscopy(EDS)were used to confirm the phase evolution of the electrocatalysts during *** reveal that the heat-treated Ni-Al alloy with a thick Ni2Al3surface layer underwent selective Al leaching and produced biphasic interfaces comprising Ni(OH)_(2) and NiAl IMCs at the edges of the grains in the outermost surface *** oxidation of the interfacing NiAl IMCs facilitated the partial reduction of Ni(OH)_(2) to Ni(OH)_(2)/Ni in the grains during electrochemical reduction,as confirmed by X-ray photoelectron spectroscopy(XPS).An electrocatalyst containing partially reduced Ni(OH)_(2)/Ni exhibited an overpotential of 54 mV at 10 mA/cm^(2) in a half-cell measurement,and a cell voltage of 1.675 V at 0.4 A/cm2for single-cell operation.A combined experimental and theoretical study(density functional theory calculations)revealed that the superior HER activity was attributed to the presence of partially reduced metallic Ni with various defects and residual Al,which facilitated water adsorption,dissociation,and finally hydrogen evolution.

关键词： Raney nickel HERChemical leaching Intrinsic activity Partial reduction

Stevens-Johnson syndrome and concurrent hand foot syndrome during treatment with capecitabine:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4279-4284页

作者： Ha Rim Ahn Sang-Kyung lee hyun Jo Youn seok-Kweon Yun Il-Jae lee Division of Breast and Thyroid Surgery Department of SurgeryJeonbuk National UniversityJeonju 54907South Korea Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907South Korea Department of Dermatology Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Capecitabine is used in combination with lapatinib as palliative treatment for human epidermal growth factor receptor 2-positive metastatic breast *** most frequently reported adverse events attributed to capecitabine include diarrhea,hyperbilirubinemia,and hand-foot syndrome(HFS).A number of cutaneous adverse events have been attributed to capecitabine,including Stevens-Johnson syndrome(SJS)as a rare and potentially life-threatening mucocutaneous *** report the first case involving concurrent SJS and HFS after capecitabine and lapatinib *** SUMMARY A 70-year-old woman with a history of breast cancer treatment visited our hospital for evaluation of painful skin *** weeks earlier,she had been prescribed capecitabine plus lapatinib as treatment for metastatic breast *** subsequently developed worsening erythema and bullae on her palms and soles,as well as reddish macules on her back and chest *** evaluation of the chest wall lesions revealed extensive eosinophilic epidermal necrosis and separation of the epidermis from the *** capecitabine plus lapatinib treatment was discontinued immediately and treatment was started using systemic *** treatment resolved most lesions,although the lesions on her palms and soles required Vaseline gauze dressings,which resulted in ***,we determined that the patient had concurrent SJS and *** the dermatological problems resolved,the patient ultimately died because of multiple organ *** Oral capecitabine treatment carries a risk of both HFS and also life-threatening adverse cutaneous drug reactions,such as SJS.

关键词： Stevens-Johnson syndrome Hand-Foot syndrome Palliative treatment Capecitabine Breast neoplasms Case report