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Proximate and mineral components of Viscum album var. coloratum grown on eight different host tree species

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Journal of Forestry Research 2019年第4期30卷 1245-1253页

作者： Chul-Woo Kim Chan-Hoon An hyun-seok lee Jae-Seon Yi Eun Ju Cheong Sang-hyun Lim Hee-Yeon Kim Forest Bioresources Department National Institute of Forest Science39 OnjeongroGwonseon-guSuwon 16631Republic of Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceSobaek-ro 2009PunggiYoungjuGyungsangbuk-do 36040Republic of Korea Program of Forest Resources Division of Forest ScienceCollege of Forest and Environmental SciencesKangwon National UniversityChuncheon 24341Republic of Korea Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment ServicesChuncheon 24203Republic of Korea

Mistletoes are parasite plants growing on various tree species,taking nutrients from the *** compounds of mistletoe were used in medicine and these mistletoes were commonly collected from oak species that were not well *** analyzed the nutritional value by measuring proximate and mineral components of Korean mistletoe(Viscum album ***)from various host *** was the most proximate component in both leaves and twigs followed crude protein,crude fiber,crude ash and crude *** the contents of the proximate components and minerals varied among hosts and between plant parts,leaves contained higher crude protein and ash,and more minerals except for magnesium than twigs,although no significant difference was found inmistletoe grown on Prunus *** were significant differences of proximate and mineral contents depending on the host *** grown on Chaenomeles sinensis contained higher levels of carbohydrates,crude fat,crude ash,magnesium,calcium,sodium,iron,and zinc than mistletoe grown on other *** grown on *** contained high mineral levels of potassium,copper and *** nutritional value of mistletoes were greatly influenced by the host species but among the hosts,specific nutrients accumulated in leaves more than in twigs,and vice *** on the analysis,Korean mistletoe contains relatively good quality of nutrients and has high potential for dietary supplements as well as for medicinal compounds.

关键词： Mistletoe Viscum album var coloratum Proximate compositions Mineral contents Nutritional value Host species

Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss

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Nano-Micro Letters 2024年第4期16卷 269-292页

作者： Moon Sung Kang Yeuni Yu Rowoon Park Hye Jin Heo seok hyun lee Suck Won Hong Yun Hak Kim Dong‑Wook Han Department of Cogno‑Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Republic of Korea Medical Research Institute School of MedicinePusan National UniversityYangsan 50612Republic of Korea Department of Anatomy School of MedicinePusan National UniversityYangsan 50612Republic of Korea Engineering Research Center for Color‑Modulated Extra‑Sensory Perception Technology Pusan National UniversityBusan 46241Republic of Korea Department of Biomedical Informatics School of MedicinePusan National UniversityYangsan 50612Republic of Korea Periodontal Disease Signaling Network Research Center and Dental and Life Science Institute School of DentistryPusan National UniversityYangsan 50612Republic of Korea BIO‑IT Fusion Technology Research Institute Pusan National UniversityBusan 46241Republic of Korea Present Address:Osstem Implant Inc. Seoul 07789Republic of Korea

Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient *** overcome these limitations,tissue-engineered scaffolds have emerged as a promising *** this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue *** PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and *** vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 ***,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML *** insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT ***,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast *** findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery.

关键词： Ti_(3)C_(2)T_(x)MXene nanoparticle Ternary nanofibrous matrices Myogenesis Regeneration of volumetric muscle loss Next generation sequencing

Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents

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World Journal of Gastroenterology 2015年第11期21卷 3308-3316页

作者： Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon hyun seok lee Chang Heon Yang Yong Kook lee Dong Wook lee Sung Kook Kim Tae Oh Kim Jonghun lee hyung Wook Kim Sam Ryong Jee Seun Ja Park hyun Jin Kim Division of Gastroenterology Department of Internal MedicineKeimyung University School of Medicine Division of Gastroenterology Department of Internal MedicinePusan National University School of Medicine Division of Gastroenterology Department of Internal MedicineYeungnam University College of Medicine Division of Gastroenterology Department of Internal MedicineCatholic University of Daegu School of Medicine Division of Gastroenterology Department of Internal MedicineKyungpook National University School of Medicine Division of Gastroenterology Department of Internal MedicineDongguk University School of Medicine Division of Gastroenterology Department of Internal MedicineInje University College of Medicine Division of Gastroenterology Department of Internal MedicineDong-A University Medical Center Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine Division of Gastroenterology Department of Internal MedicineGyeongsang National University School of Medicine

AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF ***:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected *** failed to show response or were intolerant to conventional treatments,including steroids or *** measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were ***:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used *** anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of *** patients(8%)had *** cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF ***(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk ***:Anti-TNFs significantly increase the risk of TB infection in Korean patients with *** considerable burden of TB and marked immunosuppression might be attributed to this risk.

关键词： Tuberculosis Anti-TNF Korea Inflammatory bowel dis

Helicobacter pylori in middle ear of children with

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Chinese Medical Journal 2011年第24期124卷 4275-4278页

作者： PARK Chul-won CHUNG Jae-ho MIN hyun-jung KIM Kyung-rae TAE Kyung CHO seok-hyun lee Seung-hwan Department of Otolaryngology-Head and Neck Surgery School ofMedicine Hanyang University Seoul Korea

Background Otitis media with effusion （OME） is a common pediatric disease, but its pathogenesis remains uncertain. The relationship between OME and Helicobacter pylori （HP） is currently being studied, and a relationship has not yet been confirmed. The purpose of this study was to show that a relationship does exist between HP and OME. Methods The study consisted of 60 patients who were diagnosed with OME and had ventilation tube insertions with or without an adenoidectomy. This study included an additional 30 patients who had only received an adenoidectomy without being diagnosed with OME. The effusion samples were analyzed with polymerase chain reaction （PCR） and the campylobacter-like organism （CLO） test. The adenoid tissue samples were analyzed with the CLO test. Results Eighteen patients among the 60 patients （30%） tested positive for HP. In the cases with adenoids, 15.6% of the OME patients and 13.3% of the adenoidectomy only patients were positive for HP. There were no differences between the prevalence of HP in the adenoids of OME patients and the patients without OME. Conclusion HP can be considered one of the causes of OME.

关键词： Helicobacter pylori otitis media effusion

Risk factors and therapeutic results of early local recurrence after transcatheter arterial chemoembolization

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World Journal of Gastroenterology 2014年第22期20卷 6995-7004页

作者： Woo Sun Rou Byung seok lee Hee seok Moon Eaum seok lee seok hyun Kim Heon Young lee Division of Gastroenterology Department of Internal MedicineChungnam National University College of MedicineDaejeon 301-721South Korea Division of Gastroenterology Department of Internal MedicineChungnam National University College of MedicineDaejeon 301-721South Kore

AIM: To identify factors affecting early local recurrence after transcatheter arterial chemoembolization (TACE) and investigate treatments and outcomes for local recurrence.

关键词： Chemoembolization Hepatocellular carcinoma Recurrence Survival Lipiodol

Cortical activation pattern during shoulder simple versus vibration exercises： a functional near infrared spectroscopy study

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Neural Regeneration Research 2017年第8期12卷 1294-1298页

作者： Sung Ho Jang Sang seok Yeo Seung hyun lee Sang hyun Jin Mi Young lee Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu Republic of Korea Department of Physical Therapy College of Health Science Dankook University Cheonan-si Republic of Korea Robot System Research Division Daegu Gyeongbuk Institute of Science & Technology Daegu Republic of Korea Department of Physical Therapy College of Health and Therapy Daegu Haany University Gyeongsan-si Republic of Korea

To date, the cortical effect of exercise has not been fully elucidated. Using the functional near infrared spectroscopy, we attempted to compare the cortical effect between shoulder vibration exercise and shoulder simple exercise. Eight healthy subjects were recruited for this study. Two different exercise tasks（shoulder vibration exercise using the flexible pole and shoulder simple exercise） were performed using a block paradigm. We measured the values of oxygenated hemoglobin in the four regions of interest： the primary sensory-motor cortex（SM1 total, arm somatotopy, and leg and trunk somatotopy）, the premotor cortex, the supplementary motor area, and the prefrontal cortex. During shoulder vibration exercise and shoulder simple exercise, cortical activation was observed in SM1（total, arm somatotopy, and leg and trunk somatotopy）, premotor cortex, supplementary motor area, and prefrontal cortex. Higher oxygenated hemoglobin values were also observed in the areas of arm somatotopy of SM1 compared with those of other regions of interest. However, no significant difference in the arm somatotopy of SM1 was observed between the two exercises. By contrast, in the leg and trunk somatotopy of SM1, shoulder vibration exercise led to a significantly higher oxy-hemoglobin value than shoulder simple exercise. These two exercises may result in cortical activation effects for the motor areas relevant to the shoulder exercise, especially in the arm somatotopy of SM1. However, shoulder vibration exercise has an additional cortical activation effect for the leg and trunk somatotopy of SM1.

关键词： nerve regeneration functional near infrared spectroscopy cortical activation shoulder vibrationexercise flexible pole neural regeneration

Comparative study on discharge conditions in micro-hole electrical discharge machining of tungsten carbide (WC-Co) material

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中国有色金属学会会刊：英文版 2009年第B09期19卷 114-118页

作者： hyun-seok TAK Chang-Seung HA Dong-hyun KIM Ho-Jun lee Hae-June lee Myung-Chang KANG National Core Research Center for Hybrid Materials Solution Pusan National University Department of Electrical Engineering Pusan National University

WC-Co is used widely in die and mold industries due to its unique combination of hardness, strength and wear-resistance. For machining difficult-to-cut materials, such as tungsten carbide, micro-electrical discharge machining(EDM) is one of the most effective methods for making holes because the hardness is not a dominant parameter in EDM. This paper describes the characteristics of the discharge conditions for micro-hole EDM of tungsten carbide with a WC grain size of 0.5 μm and Co content of 12%. The EDM process was conducted by varying the condenser and resistance values. A R-C discharge EDM device using arc erosion for micro-hole machining was suggested. Furthermore, the characteristics of the developed micro-EDM were analyzed in terms of the electro-optical observation using an oscilloscope and field emission scanning electron microscope.

关键词：电火花加工碳化钨钴难切削材料硬质合金放电扫描电子显微镜微孔模具行业

Prognostics and health management of alkaline water electrolyzer: Techno-economic analysis considering replacement moment

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Energy and AI 2023年第3期13卷 160-168页

作者： hyunjun lee Jiwon Gu Boreum lee hyun-seok Cho Hankwon Lim School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea Hydrogen Research Department Future Energy Research DivisionKorea Institute of Energy Research152 Gajeong-roYuseongDaejeonRepublic of Korea Graduate School of Carbon Neutrality Ulsan National Institute of Science and Technology50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea Carbon Neutrality Demonstration and Research Center Ulsan National Institute of Science and Technology50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea

Recently,considerable attention has been paid to the installation of renewable energy capacity to mitigate global CO_(2) emissions.H_(2) produced using water electrolysis and renewable energy is regarded as a clean energy carrier,generating electricity without CO_(2) emissions,called‘Green H 2’.In this paper,a prognostics and health man-agement model for an alkaline water electrolyzer was proposed to predict the load voltage on the electrolyzer to obtain the state of health *** prognostics and health management model was developed by training historical operating data via machine learning models,support vector machine and gaussian process regression,showing the root mean square error of 1.28×10^(−3) and 8.03×10^(−6).In addition,a techno-economic analysis was performed for a green H_(2) production system,composed of 1 MW of photovoltaic plant and 1 MW of alkaline water electrolyzer,to provide economic insights and feasibility of the system.A levelized cost of H_(2) of$6.89 kgH_(2)−1 was calculated and the potential to reach the levelized cost of H_(2) from steam methane reforming with carbon capture and storage was shown by considering the learning rate of the photovoltaic module and ***,the replacement of the alkaline water electrolyzer at around 10 years was preferred to increase the net present value from the green H_(2) production system when capital expenditure and replacement cost are low enough.

关键词： Green H_(2) Alkaline water electrolysis Prognostics and health management Voltage degradation Techno-economic analysis Replacement

Inhibitory effects of rapamycin on the different stages of hepatic fibrosis

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World Journal of Gastroenterology 2014年第23期20卷 7452-7460页

作者： Yun Jeung Kim Eaum seok lee seok hyun Kim Heon Young lee Seung Moo Noh Dae Young Kang Byung seok lee Department of Internal Medicine Chungnam National University School of MedicineDaejeon 301-721South Korea Department of Surgery Chungnam National University School of MedicineDaejeon 301-721South Korea Department of Pathology Chungnam National University School of MedicineDaejeon 301-721South Korea

AIM: To investigate and compare the inhibitory effects of rapamycin in the different stages of liver fibrosis.

关键词： Liver cirrhosis Sirolimus Transforming growth factor beta Platelet-derived growth factor Ribosomal protein S6 kinases