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Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced β-cell damage by inhibiting NF-κB

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World Journal of Gastroenterology 2006年第27期12卷 4331-4337页

作者： Kang-Beom kwon Eun-Kyung Kim Eun-Sil Jeong Young-Hoon Lee Young-Rae Lee Jin-Woo Park Do-Gon Ryu Byung-hyun Park Department of Physiology School of Oriental MedicineWonkwang UniversityIksan 570-749South Korea Department of Oral Anatomy School of DentistryChonbuk National UniversityJeonju 561-756JeonbukSouth Korea Department of Biochemistry Medical SchoolInstitute for Healthcare Technology DevelopmentMedical Research CenterChonbuk National UniversityJeonju 561-756JeonbukSouth Korea

AIM： To clarify the mechanism underlying the antidiabetic activities of cortex cinnamomi extract （CCE）. METHODS： To induce in vivo diabetes, mice were injected with streptozotocin （STZ） via a tail vein （100 mg STZ/kg body weight）. To determine the effects of CCE, mice were administered CCE twice daily for 7 d by oral gavage starting 1 wk before the STZ injection. Blood glucose and plasma insulin concentration were measured as an index of diabetes. Also, to induce cytotoxicity of RINm5F cells, we treated with cytokines （IL-1β （2.0 ng/mL） and IFN-γ （100 U/mL））. Cell viability and nitric oxide production were measured colorimetrically. Inducible nitric oxide synthase （iNOS） mRNA and protein expression were determined by RT-PCR and Western blotting, respectively. The activation of NF-κβ was assayed by using gel mobility shift assays of nuclear extracts. RESULTS： Treatment of mice with STZ resulted in hyperglycemia and hypoinsulinemia, which was further evidenced by immunohistochemical staining of islets. However, the diabetogenic effects of STZ were completely prevented when mice were pretreated with CCE. The inhibitory effect of CCE on STZ-induced hyperglycemia was mediated through the suppression of iNOS expression. In rat insulinoma RINm5F cells,CCE completely protected against interleukin-1β and interferon-y-mediated cytotoxicity. Moreover, RINm5F cells incubated with CCE showed significant reductions in interleukin-1β and interferon-y-induced nitric oxide production and in iNOS mRNA and protein expression, and these findings correlated well with in vivo observations. CONCLUSION： The molecular mechanism by which CCE inhibits iNOS gene expression appears to involve the inhibition of NF-κβ activation, These results reveal the possible therapeutic value of CCE for the prevention of diabetes mellitus progression,

关键词： Cortex cinnamomi Diabetes Streptozotocin Cytokine NF-κβ

Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

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Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung Lee Jeong hyun Yoon Young-Woong Song Seok Daniel Namgung Taehoon Sung Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

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Pancreatic pseudocystocolonic fistula treated without surgical or endoscopic intervention

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World Journal of Gastroenterology 2014年第7期20卷 1882-1886页

作者： Jae Choon kwon Bo Yean Kim Ah Lim Kim Tae Hoon Kim Myung Il Park Ho Jin Jung Jang Hwan Lim Jae kwon Jung hyun Soo Kim Dong Wook Lee Division of Gastroenterology and Hepatology Department of Internal MedicineDaegu Fatima HospitalDong-gu Daegu701-600South Korea

We report here a case of pancreatic pseudocystocolic fistula that was treated without surgical or endoscopic intervention.A 76-year-old woman,presenting with a fever and epigastric pain,was referred to our *** months prior to this admission,the patient had been admitted to the hospital for acute *** computerized tomography(CT)revealed a 9 cm pseudocyst containing air,and a fistular opening was observed via *** colonoscopy,the abdominal pain was slightly improved,the fever subsided and laboratory results showed decreased C-reactive protein *** observed improvement was likely due to the cleansing of the bowel,which induced spontaneous drainage from the pseudocyst into the *** therapy was administered and daily bowel cleansing was performed using a polyethylene glycol *** three weeks,a follow-up CT revealed that the size of the pseudocyst had decreased significantly from 9 to 5.3 *** addition,laboratory tests were *** patient was able to resume a normal diet and was discharged in good overall health from the hospital,without aggravation of the symptoms.A colonoscopy performed 3 mo later and a follow-up CT performed 6 mo later confirmed that both the fistula and pseudocyst had completely disappeared.

关键词： Acute pancreatitis Pseudocyst Pseudocystocolic fistula

Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee Jeong hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis

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Bioactive Materials 2022年第1期7卷 14-25页

作者： Bo-Bae Seo Youngjoong kwon Jun Kim Ki hyun Hong Sung-Eun Kim Hae-Ryong Song Young-Min Kim Soo-Chang Song Center for Biomaterials Korea Institute of Science&TechnologySeoul02792South Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea Department of Orthopedic Surgery and Rare Diseases Institute Korea University Medical College Guro HospitalSeoul08308South Korea

Treatment of osteoarthritis(OA)by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory *** administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage degeneration,but they are usually insufficient to show local and long-term anti-inflammatory effects because of their fast clearance in the *** this study,we suggest an injectable anti-OA drug depot system for sustained drug release that provides long-term effective therapeutic *** poly(organophosphazene),which has temperature-dependent nanoparticle forming and sol-gel transition behaviors when dissolved in aqueous solution,was synthesized for triamcinolone acetonide(TCA)*** hydrophobic parts of the polymer can interact with hydrophobic parts of the TCA,the TCA was encapsulated into the self-assembled polymeric *** TCA-encapsulated polymeric nanoparticles(TePNs)were well dispersed in an aqueous solution below room temperature so that they can be easily injected as a sol state into an intra-articular ***,the TePNs solution transforms immediately to a viscose 3D hydrogel like a synovial fluid in the intra-articular region via the conducted body *** in vitro TCA release study showed sustained TCA release for six ***-time injection of the TePN hydrogel system in an early stage of OA-induced rat model showed a great inhibition effect against further OA *** OA-induced knees completely recovered as a healthy cartilage without any abnormal symptoms.

关键词： Thermosensitive hydrogel Triamcinolone acetonide Polymer nanoparticle Osteoarthritis Sustained release

Stimulation of melanogenesis by scoparone in B16 melanoma cells

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Acta Pharmacologica Sinica 2006年第11期27卷 1467-1473页

作者： Jeong-yeh YANG Jeung-hyunKOO Young-gilSONG Kang-beom kwon Ju-hyung LEE Hee-sook SOHN Byung-hyun PARK Eun-chung JHEE Jin-woo PARK Department of Biochemistry Dental SchoolChonbuk National UniversityJeonju 561-756Korea Department of Biochemistry Medical School Chonbuk National UniversityJeonju 561-756Korea Department of Physiology School of Oriental MedicineWon-Kwang UniversityIksan 570-749Korea Department of Preventive Medicine Medical School Department of Food Science and Human Nutrition College of Home EconomyChonbuk National UniversityJeonju 561-756Korea Department of Biochemistry Medical SchoolChonbuk National UniversityJeonju 561-756Korea Institute for Healthcare Technology DevelopmentChonbuk National UniversityJeonju 561-756Korea Department of Biochemistry Medical SchoolChonbuk National UniversityJeonju 561-756Korea Institute for Healthcare Technology Development Chonbuk National UniversityJeonju 561-756Korea

Aim:The effect of coumarin derivatives on melanogenesis was investigated inB16 murine melanoma ***:Melanin content and tyrosinase activitywere analyzed *** expression of tyrosinase,tyrosinase-related protein-1(TRP-1)and tyrosinase-related protein-2(TRP-2)were measuredeither by reverse transcription-polymerase chain reaction(RT-PCR)or ***:Among the coumarin derivatives studied,scoparone(6,7-dimethoxycoumarin)was the most potent;the 6-or 7-methoxy group was found tobe essential for the stimulation of *** melanin content was greatlyincreased by scoparone in a dose-dependent manner;there was no cytotoxicity atthe effective *** increased enzyme activity as well asprotein and mRNA expression of *** addition,mRNA of TRP-1 andTRP-2 were also increased after treatment with scoparone.H-89,an inhibitor ofprotein kinase A(PKA),completely inhibited the scoparone-induced increase ofmelanogenesis and the tyrosinase ***:These results suggestthat scoparone-induced stimulation of melanogenesis is likely to occur at thetranscriptional level of melanogenesis-related enzymes through PKA signaling.

关键词： melanogenesis scoparone (6,7-dimethoxy-coumarin) tyrosinase tyrosinase-related proteins protein kinase A

Nontarget screening using passive air and water sampling with a level Ⅱ fugacity model to identify unregulated environmental contaminants

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Journal of Environmental Sciences 2017年第12期29卷 84-91页

作者： In-Young Chung Yu-Mi Park hyun-Jeoung Lee Hyuk Kim Dong-Hoon Kim Il-Gyu Kim Sang-Min Kim Young-Sun Do Kwang-Seol Seok Jung-Hwan kwon Chemical Research Division Environmental Health Research Department National Institute of Environmental ResearchIncheon Division of Environmental Science and Ecological Engineering Korea University

It is thought that there are many unregulated anthropogenic chemicals in the *** risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry（GC × GC-TOFMS） was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane（PDMS） passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in2014（n = 149） were also screened for potential existence in the environment using a level Ⅱ fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.

关键词： Nontarget screening GC × GC-TOFMS Passive sampling Pollutant release and transfer register(PRTR) Fugacity model

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Korean single-center experience with femoral access closure using the ExoSeal device

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World Journal of Radiology 2018年第9期10卷 108-115页

作者： Yoonhee Han Jae hyun kwon Surin Park Department of Radiology Dongguk University Ilsan Hospital

AIM To report 17-mo experience of femoral artery puncture site closure during angiographic procedures using Exo Seal vascular closure devices(VCDs).METHODS Between November 2015 and April 2017, we performed 179 diagnostic and interventional angiographic procedures via a common femoral arterial *** Exo Seal VCD was used at the puncture site to achieve hemostasis in 125 *** evaluated the technical and procedural success rates, the complications, and the factors affecting the hemostasis time of the ExoSeal *** Technical and procedural successes were achieved in 176 cases(98.0%) and 128 cases(71.5%), *** failure occurred in 3(1.7%) *** 1 case(0.6%) a small hematoma developed, but there were no major *** the hemostasis-relevant variables, a history of drinking alcohol, low platelet(PLT) count, and high prothrombin time-international normalized ratio(commonly known as PT-INR) values were the statistically significant predictors of the need for longer manual compression(MC).There was no difference in the success rates between the repeat and single Exo Seal procedure groups, and repeated use of the ExoSeal did not affect hemostasis *** The ExoSeal VCD effectively achieves hemostasis, with few *** light MC may be needed with alcohol drinkers, low PLT count, and high PT-INR values.

关键词： Vascular closure device Femoral access Manual compression Angiography Hemostasis

Microscopic characteristics of the inferior tarsal muscle and its surroundings in Korean

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 126-130页

作者： Jung Min Park Mee Sook Roh Moo hyun Kim Woo Jin Jeung Won Yeol Ryu Yoon hyung kwon Hee Bae Ahn Department of Ophthalmology Maryknoll Hospital Department of Pathology College of Medicine Dong-A University Department of Cardiology College of Medicine Dong-A University Department of Ophthalmology College of Medicine Dong-A University

AIM: To investigate the detailed microscopic anatomic structures of the lower eyelid in Korean cadavers. METHODS: Eight lower eyelids of 4 formalin-fixed Asian cadavers (4 males; age range, 48-69 years; mean age, 60.2 years) were examined. Three perpendicular dissected sections with a 2mm thickness were obtained from each eyelid to investigate anatomic shapes, size and relationship with surrounding structures. One section was obtained from the midline and 2 the other sections were obtained from a 3mm apart from the lateral and medial tarsus margins. RESULTS: The inferior tarsal muscle fibers were not directly attached to the tarsus but were only linked to the tarsus with enclosed fibrous fascia. The inferior tarsal muscles connected loosely with the capsulopalpebral fascia anteriorly and the conjunctiva posteriorly. The inferior tarsal muscle runs horizontally to the tarsus according to the shape of muscle fibers. The capsulopalpebral fascia consisted of an anterior and posterior layer. The anterior layer reached the orbital septum and subcutaneous fat but the posterior layer forwarded into the tarsus. Lockwood’s ligament was separated from the inferior tarsal muscle and capsulopalpebral fascia or fused into the capsulopalpebral ***: This study suggests that the inferior tarsal muscle which runs horizontally and doesn’t insert directly into the tarsus, plays an important role in the movement and localization of the lower eyelid.

关键词： capsulopalpebral fascia inferior tarsal muscle lower eyelid