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Comparison of Perinatal Outcomes in Late Preterm Spontaneous and Indicated Preterm Birth Neonates

Open Journal of Obstetrics and Gynecology 2016年第12期6卷 661-668页

作者： Dasom Chun Eun Hye Yoo Ji Young Lee hyun Mi Kim Mi Ju Kim Won Joon Seong hyun-hwa cha Department of Obstetrics and Gynecology Kyungpook National University Hospital Kyungpook National University School of Medicine Daegu Korea

Objective: We aimed to compare the perinatal outcomes in late preterm spontaneous and indicated birth neonates. Methods: We studied 289 late preterm births, classified as either aspontaneous late preterm birth (sLPTB) group (preterm labor with intact membranes and preterm premature rupture of membranes) or an indicated late preterm birth (iLPTB) group (hypertensive disorder in pregnancy, placental causes, and maternal diseases), according to the delivery indication. We then compared the maternal and neonatal characteristics and perinatal outcomes, including the Apgar score, admission to the neonatal intensive care unit (NICU) or special care nursery (SCN), duration of NICU stay, and the rate of composite morbidity (antibiotic use, hypoglycemia, hypocalcemia, hyperbilirubinemia requiring phototherapy, respiratory support, and respiratory distress syndrome). Results: A total of 198 neonates were in the sLPTB group and 91 were in the iLPTB group. In spite of greater gestational age at the time of delivery in the iLPTB group, the mean birth weight was lower than that in the sLPTB group. Additionally, the iLPTB group showed lower Apgar scores, and higher rates of NICU or SCN admission, respiratory support, and hypoglycemia, but there was no difference in the rate of composite morbidity between the two groups. Conclusion: iLPTB neonates had lower birth weights despite greater gestational age than those in the sLPTB group, but there was no difference in the rate of composite morbidity between the two groups.

关键词： Composite Morbidity Indicated Preterm Birth Late Preterm Birth Perinatal Outcomes Spontaneous Preterm Birth

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Suppression of pheromone biosynthesis and mating behavior by RNA interference of pheromone gland-specific fatty acyl reductase in Maruca vitrata

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Insect Science 2022年第4期29卷 1135-1144页

作者： Wook hyun cha Dae-Weon Lee Department of Biosafety Kyungsung UniversityBusanRepublic of Korea Metabolomics Research Center for Functional Materials Kyungsung UniversityBusanRepublic of Korea

In moths,various enzymes,such as fatty acid synthases,fatty acyl desaturases,and fatty acyl reductases(FARs),are involved in pheromone *** particular,pheromone gland-specific FAR(pgFAR)plays an important role in converting the functional group from carboxylic to alcohol during pheromone biosynthesis.A novel pgFAR of Maruca vitrata,Mvi-pgFAR,was identified through transcriptome sequencing of its pheromone *** investigate the involvement of Mvi-pgFAR in pheromone biosynthesis,Mvi-pgFAR was cloned from the pheromone gland and suppressed by RNA interference(RNAi).Mvi-pgFAR harbored several conserved motifs related to NAD(P)H-binding,N-glycosylation,and adenosine/guanosine triphosphate *** analysis revealed that Mvi-pgFAR with other lepidopteran pgFARs formed an independent ***-pgFAR was specifically expressed only in the pheromone *** real-time polymerase chain reaction showed that the diurnal expression levels of Mvi-pgFAR in the pheromone gland were the highest at 2 h before the *** primarily confirming Mvi-pgFAR suppression by RNAi,(E,E)-10,12-hexadecadienal(E10E12-16:Ald),a major sex pheromone component,was quantified by gas *** Mvi-pgFAR was successfully suppressed,E10E12-16:Ald production was reduced by up to half of that of the control,and the mating rate was subsequently *** results demonstrate that Mvi-pgFAR downregulation can suppress mating behavior by changing the relative sex pheromone component ratio,suggesting that Mvi-pgFAR can be used as a novel control target.

关键词： (EE)-10,12-hexadecadienal gas chromatography Maruca viruta pgFAR RNAi sex pheromone

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Improvement of light uniformity by lighting arrangement for standardized crop production

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Journal of Central South University 2014年第11期21卷 4311-4319页

作者： Lee hwa-Soo Kwon Sook-Youn Lim Jae-hyun Department of Computer Science and Engineering Kongju National UniversityCheonan 331-717 Korea

In a commercialized, fully artificial plant factory, artificial luminaire is arranged in a unified way using a general illumination theory, an actual measurement, or an empirical methodology. However, with these methods, lightings are implemented without considering specific optical characteristics of lighting or material characteristics of each component that constructs a cultivation system, resulting in an amount of light that becomes irregular. The amount of lighting is closely related with the growth and quality of crops, and the deviation between points where cultivated crops are located causes quality difference in the produced crops, thus impairing the economic feasibility of a plant factory. In this regard, a simulation to figure out an optimum lighting layout was performed. Arrangements based on the spectrum distribution of light source and reflector materials were implemented to ascertain the distance between lighting and height of lighting and gather information in the pre-treatment process to improve the uniformity of light in the plant cultivation system. Improvement of around 15% in light uniformity is achieved compared with the existing system after the simulation is carried out. This result would reduce the deviation in crop growth to make uniform quality crop production possible.

关键词： high-quality crop light uniformity improvement optimal lighting layout fully artificial plant factory Relux simulation

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Intraoperative neurophysiological monitoring in spinal surgery

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World Journal of Clinical Cases 2015年第9期3卷 765-773页

作者： Jong-hwa Park Seung-Jae hyun Department of Neurosurgery Spine CenterSeoul National University Bundang Hospital Seoul National University College of Medicine

Recently, many surgeons have been using intraoperative neurophysiological monitoring(IOM) in spinal surgery to reduce the incidence of postoperative neurological complications, including level of the spinal cord, cauda equina and nerve root. Several established technologies are available and combined motor and somatosensory evoked potentials are considered mandatory for practical and successful IOM. Spinal cord evoked potentials are elicited compound potentials recorded over the spinal cord. Electrical stimulation is provoked on the dorsal spinal cord from an epidural electrode. Somatosensory evoked potentials assess the functional integrity of sensory pathways from the peripheral nerve through the dorsal column and to the sensory cortex. For identification of the physiological midline, the dorsal column mapping technique can be used. It is helpful for reducing the postoperative morbidity associated with dorsal column dysfunction when distortion of the normal spinal cord anatomy caused by an intramedullary cord lesion results in confusion in localizing the midline for the myelotomy. Motor evoked potentials(MEPs) consist of spinal, neurogenic and muscle MEPs. MEPs allow selective and specific assessment of the functional integrity of descending motor pathways, from the motor cortex to peripheral muscles. Spinal surgeons should understand the concept of the monitoring techniques and interpret monitoring records adequately to use IOM for the decision making during the surgery for safe surgery and a favorable surgical outcome.

关键词： Motor-evoked potentials Somatosensoryevoked potentials Intraoperative neurophysiological monitoring Direct wave Spinal surgery

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Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression

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World Journal of Gastroenterology 2014年第11期20卷 3011-3017页

作者： Sang hwa Lee Sung-Im Do hyun-Soo Kim Department of Pathology Aerospace Medicine Research CenterAerospace Medical CenterRepublic of Korea Air ForceChungcheongbuk-do 363-849South Korea Department of Pathology Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea

AIM: To investigate the effect of hypoxia or hyperoxia on the progression of hepatic fibrosis and to examine the role of transforming growth factor-β (TGF-β) in the livers of rats exposed to hypoxic or hyperoxic con... 详细信息

关键词： Hepatic fibrosis, Cirrhosis, Hypoxia, Hyperoxia, Transforming growth factor-β

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Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction

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Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon hyun Park Sung Woo Park Bong Yun cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae hwa Kim Jae Min Lee Kang Seo Park Department of Internal Medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and Metabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and Metabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal Medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal Medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal Medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil

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Effects of Initial and Boundary Conditions on Heavy Rainfall Simulation over the Yellow Sea and the Korean Peninsula:Comparison of ECMWF and NCEP Analysis Data Effects and Verification with Dropsonde Observation

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Advances in Atmospheric Sciences 2024年第9期41卷 1787-1803页

作者： Jiwon hwaNG Dong-hyun cha Donghyuck YOON Tae-Young GOO Sueng-Pil JUNG Department of Civil Urban Earth and Environmental Engineering Ulsan National Institute of Science and TechnologyUlsan 44919South Korea Program in Atmospheric and Oceanic Sciences Princeton UniversityPrincetonNew Jersey 08544USA National Institute of Meteorological Sciences NIMSJeju 63568South Korea

This study evaluated the simulation performance of mesoscale convective system(MCS)-induced precipitation,focusing on three selected cases that originated from the Yellow Sea and propagated toward the Korean *** evaluation was conducted for the European Centre for Medium-Range Weather Forecasts(ECMWF)and National Centers for Environmental Prediction(NCEP)analysis data,as well as the simulation result using them as initial and lateral boundary conditions for the Weather Research and Forecasting ***,temperature and humidity profiles from 3D dropsonde observations from the National Center for Meteorological Science of the Korea Meteorological Administration served as validation *** showed that the ECMWF analysis consistently had smaller errors compared to the NCEP analysis,which exhibited a cold and dry bias in the lower levels below 850 *** model,in terms of the precipitation simulations,particularly for high-intensity precipitation over the Yellow Sea,demonstrated higher accuracy when applying ECMWF analysis data as the initial *** advantage also positively influenced the simulation of rainfall events on the Korean Peninsula by reasonably inducing convective-favorable thermodynamic features(i.e.,warm and humid lower-level atmosphere)over the Yellow *** conclusion,this study provides specific information about two global analysis datasets and their impacts on MCS-induced heavy rainfall simulation by employing dropsonde observation ***,it suggests the need to enhance the initial field for MCS-induced heavy rainfall simulation and the applicability of assimilating dropsonde data for this purpose in the future.

关键词： initial conditions dropsonde heavy rainfall forecast global model analysis evaluation

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Dual cycloid gear mechanism for automobile safety pretensioners

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Journal of Central South University 2012年第2期19卷 365-373页

作者： SHIN Joong-ho KIM chang-hyun YUN Pyeong-hwa KWON Soon-man Department of Mechanical Design and Manufacturing Changwon National University

The most conventional vehicle pretensioner system consists of an internal gear pair with involute teeth. However, it has been well known that the corresponding gear pairs are relatively weak under the situation of impact loadings. To improve this phenomenon, a new pretensioning gear system with cycloid teeth rather than the involute ones was proposed, and dual cycloidal gear mechanisms were designed for satisfying geometric constraints and dynamic loading conditions. The simulations of the prototypes were conducted by LS-DYNA program and the experiments for a prototype were performed for a dynamic model with impact loading devices. The results show that the better operation and the smoother motion are confirmed in the proposed cycloidal gear system rather than the conventional one without interferences between gear teeth under the impact of a crash.

关键词： seat belt pretensioner internal gear pairs involute gear dual cycloid gear

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Gastrosplenic fistula occurring in lymphoma patients: Systematic review with a new case of extranodal NK/T-cell lymphoma

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World Journal of Gastroenterology 2017年第35期23卷 6491-6499页

作者： Dong Hyeok Kang Jimi Huh Jong hwa Lee Yoong Ki Jeong Hee Jeong cha Department of Radiology Ulsan University HospitalUniversity of Ulsan College of Medicine Department of Pathology Ulsan University HospitalUniversity of Ulsan College of Medicine

AIM To provide the overall spectrum of gastrosplenic fistula(GSF) occurring in lymphomas through a systematic review including a patient at our *** A comprehensive literature search was performed in the MEDLINE database to identify studies of GSF occurring in lymphomas. A computerized search of our institutional database was also performed. In all cases, we analyzed the clinicopathologic/radiologic features, treatment and outcome of GSF occurring in lymphomas. RESULTS A literature search identified 25 relevant studies with 26 patients. Our institutional data search added 1 patient. Systematic review of the total 27 cases revealed that GSF occurred mainly in diffuse, large B-cell lymphoma(n = 23), but also in diffuse, histiocytic lymphoma(n = 1), Hodgkin's lymphoma(n = 2), and NK/T-cell lymphoma(n = 1, our patient). The common clinical presentations are constitutional symptoms(n = 20) and abdominal pain(n = 17), although acute gastrointestinal bleeding(n = 6) and infection symptoms due to splenic abscess(n = 3) are also noted. In all patients, computed tomography scanning was very helpful for diagnosing GSF and for evaluating the lymphoma extent. GSF could occur either post-chemotherapy(n = 10) or spontaneously(n = 17). Surgical resection has been the most common treatment. Once patients have recovered from the acute illness status after undergoing surgery, their long-term outcome has been favorable. CONCLUSION This systematic review provides an overview of GSF occurring in lymphomas, and will be helpful in making physicians aware of this rare disease entity.

关键词： Gastrosplenic fistula Lymphoma NK/T-cell lymphoma Systematic review

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Diagnostic value of maximal-outer-diameter and maximal-mural-thickness in use of ultrasound for acute appendicitis in children

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World Journal of Gastroenterology 2009年第23期15卷 2900-2903页

作者： Bo-Kyung Je Sung-Bum Kim Seung hwa Lee Ki Yeol Lee Sang Hoon cha Department of Radiology College of Medicine Korea University #516 Gojan1-Dong Danwon-Gu Ansan-City Gyeonggi-Do 425-707 South Korea Department of Internal Medicine Dongshin Hospital #430 Hongeundong Seodaemungu Seoul 120-100 South Korea

MM： To evaluate the maximal-outer-diameter （MOD） and the maximal-mural-thickness （MMT） of the appendix in children with acute appendicitis and to determine their optimal cut-off values to diagnose acute appendicitis.METHODS： In total, 164 appendixes from 160 children between 1 and 17 years old （84 males, 76 females; mean age, 7.38 years） were examined by high-resolution abdominal ultrasound for acute abdominal pain and the suspicion of acute appendicitis. We measured the MOD and the MMT at the thickest point of the appendix. Patients were categorized into two groups according to their medical records： patients who had surgery （surgical appendix group） and patients who did not have surgery （non-surgical appendix group）. Data were analyzed by MedCalc v.9.3. The rank sum test （Mann-Whitney test） was used to evaluate the difference in the MOD and the MMT between the two groups. ROC curve analysis was used to determine the optimal cut-off value of the MOD and the MMT on diagnosis of acute appendicitis.RESULTS： There were 121 appendixes （73.8%） in the non-surgical appendix group and 43 appendixes （26.2%） in the surgical appendix group. The median MOD differed significantly between the two groups （0.37 cm vs 0.76 cm, P〈 0.0001）, and the median MMT also differed （0.15 cm vs 0.33 cm, P 〈 0.0001）. The optimal cut-off value of the MOD and the MMT for diagnosis of acute appendicitis in children was 〉 0.57 cm （sensitivity 95.4%, specificity 93.4%） and 〉 0.22 cm （sensitivity 90.7%, specificity 79.3%）, respectively.CONCLUSION： The MOD and the MMT are reliable criteria to diagnose acute appendicitis in children. An MOD 〉 0.57 cm and an MMT 〉 0.22 cm are the optimal criteria.

关键词： Appendicitis Ultrasonography Pediatrics Diagnosis ROC curve

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