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Comparison of the meibomian gland dysfunction in patients with chronic ocular graft-versus-host disease and Sjogren's syndrome

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 393-400页

作者： Won choi Jun Young Ha Ying Li Jung Han choi Yong Sok Ji Kyung chul Yoon Department of Ophthalmology and Research Institute of Medical Sciences Chonnam National University Medical School and Hospital

AIM: To investigate the abnormalities in the meibomian gland in patients with dry eye disease(DED) associated with chronic ocular graft-versus-host disease(coGVHD) in comparison with Sj?gren's syndrome(SS), a major form of aqueous deficient DED and meibomian gland dysfunction(MGD), a common cause of evaporative ***: A total 135 eyes of 135 subjects included in this study: patients with DED associated with coGVHD(n=30), patients with SS(n=35), patients with MGD(n=35), and normal controls(n=35). All participants completed the Ocular Surface Disease Index(OSDI) questionnaire, ocular surface examination [Schirmer test, tear film breakup time(TFBUT), and ocular surface staining], and meibomian gland assessment [meiboscore(gland dropout detected on meibography using infrared camera of the Keratograph 5 M), meibum expressibility score(MES), meibum quality score(MQS), lid margin abnormality]. In addition, correlations of meibomian gland characteristics with ocular surface parameters as well as disease severity score were investigated in coGVHD ***: The coGVHD group showed significantly higher meiboscore, MES, and MQS than the other 3 groups(all P<0.05). In the coGVHD group, parameters of meibomian gland showed a significant correlation each other and those of ocular surface. The correlation between meibomian gland parameters and severity score of co GVHD was also established(meiboscore, r=0.62; MES, r=0.47; MQS, r=0.47; lid margin abnormality score, r=0.55; all P<0.05).CONCLUSION: Patients with DED associated with co GVHD show poorer gland morphology and worse glandfunction than other types of DED. In addition, meibomian gland damage is not only associated with ocular surface damage but also disease severity of coGVHD.

关键词： chronic ocular graft-versus-host disease Sjogren's syndrome dry eye disease meibomian gland dysfunction meibography

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Gene expression profiling reveals sequential changes in gastric tubular adenoma and carcinoma in situ

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World Journal of Gastroenterology 2005年第13期11卷 1937-1945页

作者： Chang-Hee Lee Seung-hyun Bang Seung-Koo Lee Kyu-Young Song In-chul Lee Asan Institute for Life Sciences Department of Biochemistry Department of Pathology

AIM: To analyze the expression profiles of premalignant and/or preclinical lesions of gastric ***: We analyzed the expression profiles of normal gastric pit, tubular adenoma and carcinoma in situ using microdissected cells from routine gastric biopsies. For the DNA microarray analysis of formalin-fixed samples,we developed a simple and reproducible RNA extraction and linear amplification procedure applying two polymerasebinding sites. The amplification procedure took only 8 h and yielded comparable DNA microarray data between formalin-fixed tissues and unfixed ***: In comparison with normal pit, adenoma/carcinoma showed 504 up-regulated and 29 down-regulated genes at the expected false significance rate 0.15%. The differential expression between adenoma and carcinoma in situ was subtle: 50 and 22 genes were up-, and down-regulated in carcinomas at the expected false significance rate of 0.61%, respectively. Differentially expressed genes were grouped according to patterns of the sequential changes for the 'tendency analysis' in the gastric mucosaadenoma-carcinoma ***: Groups of genes are shown to reflect the sequential expression changes in the early carcinogenic steps of stomach cancer. It is suggested that molecular carcinogenic pathways could be analyzed using routinely processed biopsies.

关键词： Premalignant lesion Predinical lesion Gastric cancer

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Proximate and mineral components of Viscum album var. coloratum grown on eight different host tree species

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Journal of Forestry Research 2019年第4期30卷 1245-1253页

作者： chul-Woo Kim Chan-Hoon An hyun-Seok Lee Jae-Seon Yi Eun Ju Cheong Sang-hyun Lim Hee-Yeon Kim Forest Bioresources Department National Institute of Forest Science39 OnjeongroGwonseon-guSuwon 16631Republic of Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceSobaek-ro 2009PunggiYoungjuGyungsangbuk-do 36040Republic of Korea Program of Forest Resources Division of Forest ScienceCollege of Forest and Environmental SciencesKangwon National UniversityChuncheon 24341Republic of Korea Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment ServicesChuncheon 24203Republic of Korea

Mistletoes are parasite plants growing on various tree species,taking nutrients from the *** compounds of mistletoe were used in medicine and these mistletoes were commonly collected from oak species that were not well *** analyzed the nutritional value by measuring proximate and mineral components of Korean mistletoe(Viscum album ***)from various host *** was the most proximate component in both leaves and twigs followed crude protein,crude fiber,crude ash and crude *** the contents of the proximate components and minerals varied among hosts and between plant parts,leaves contained higher crude protein and ash,and more minerals except for magnesium than twigs,although no significant difference was found inmistletoe grown on Prunus *** were significant differences of proximate and mineral contents depending on the host *** grown on Chaenomeles sinensis contained higher levels of carbohydrates,crude fat,crude ash,magnesium,calcium,sodium,iron,and zinc than mistletoe grown on other *** grown on *** contained high mineral levels of potassium,copper and *** nutritional value of mistletoes were greatly influenced by the host species but among the hosts,specific nutrients accumulated in leaves more than in twigs,and vice *** on the analysis,Korean mistletoe contains relatively good quality of nutrients and has high potential for dietary supplements as well as for medicinal compounds.

关键词： Mistletoe Viscum album var coloratum Proximate compositions Mineral contents Nutritional value Host species

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Secondary craniofacial necrotizing fasciitis from a distant septic emboli: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11630-11637页

作者： Da-Woon Lee Si-hyun Kwak Hwan-Jun choi Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Institute of Tissue Regeneration College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea

BACKGROUND Craniofacial necrotizing fasciitis(CNF)is an uncommon but fatal infection that can spread rapidly through the subfascial planes in the head and neck *** usually progress rapidly,and early management is necessary to optimize *** SUMMARY A 43-year-old man visited our hospital with left hemifacial swelling involving the buccal and submandibular *** patient had fever for approximately 10 d before visiting the hospital,but did not report any other systemic *** tomography scan demonstrated an abscess with gas *** surgical drainage of the facial abscess,the patient’s systemic condition worsened and progressed to septic *** examination revealed pulmonary and renal *** percutaneous catheter drainage was performed at the renal abscess site,which caused improvement of *** patient showed no evidence of systemic complications during the 4-mo post-operative follow-up *** As the patient did not improve with conventional CNF treatment and symptoms only resolved after controlling the infection,the final diagnosis was secondary CNF with septic *** surgical decompression is important for CNF ***,if symptoms worsen despite early diagnosis and management,such as pus drainage and surgical intervention,clinicians should consider the possibility of a secondary abscess from internal organs.

关键词： Craniofacial necrotizing fasciitis Septic emboli Klebsiella pneumoniae Secondary Case report

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Fabrication of SiC_p/AA5083 composite via friction stir welding

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中国有色金属学会会刊：英文版 2012年第S3期22卷 634-638页

作者： Byung-Wook AHN Don-hyun choi Yong-Hwan KIM Seung-Boo JUNG School of Advanced Materials Science and Engineering Sungkyunkwan University

Microstructure and mechanical properties of SiCp /AA5083 composite fabricated by friction stir welding (FSW) were *** influence of the number of FSW passes on the distribution of SiC particles and mechanical properties in the joint was *** one pass,the SiC particles were entangled in the upper side of the stir zone (SZ).However,the particle distribution became more uniform after two passes due to the repeated stirring of the *** the SiC particles facilitate the grain refinement in the SZ by the pinning effect,the particle including region has much smaller grain size than the SZ without SiC *** SiCp /AA5083 composite region exhibits a Vickers hardness of HV90,which is much higher than the value of HV80 in the SZ produced by FSW without SiC particles.

关键词： metal matrix composite SiC particle friction stir welding mechanical property

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Formic acid as an alternative reducing agent for the catalytic nitrate reduction in aqueous media

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Journal of Environmental Sciences 2013年第8期25卷 1696-1702页

作者： Eun-kyoung choi Kuy-hyun Park Ho-bin Lee Misun Cho Samyoung Ahn Department of Environmental Education Sunchon National University

Formic acid was used for the nitrate reduction as a reductant in the presence of Pd：Cu/γ-alumina catalysts. The surface characteristics of the bimetallic catalyst synthesized by wet impregnation were investigated by SEM, TEM-EDS. The metals were not distributed homogeneously on the surface of catalyst, although the total contents of both metals in particles agreed well with the theoretical values. Formic acid decomposition on the catalyst surface, its influence on solution pH and nitrate removal efficacy was investigated. The best removal of nitrate （50 ppm） was obtained under the condition of 0.75 g/L catalyst with Pd：Cu ratio （4：1） and two fold excess of formic acid. Formic acid decay patterns resembled those of nitrate removal, showing a linear relationship between kf （formic acid decay） and k （nitrate removal）. Negligible amount of ammonia was detected, and no nitrite was detected, possibly due to buffering effect of bicarbonate that is in situ produced by the decomposition of formic acid, and due to the sustained release of H2 gas.

关键词： formic acid catalytic nitrate reduction Pd:Cu/γ-alumina catalyst H2 supply

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Effect of SiC particles on microstructure and mechanical property of friction stir processed AA6061-T4

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中国有色金属学会会刊：英文版 2012年第S3期22卷 614-618页

作者： Don-hyun choi Yong-Il KIM DAE-Up KIM Seung-Boo JUNG School of Advanced Materials Science and Engineering Sungkyunkwan University MEPL Sungkyunkwan University KITECH 838-11Palbok-dong 2-gaDeokjin-guJeonju-cityJeollabuk-do 561-844Korea

Friction stir processing of AA6061-T4 alloy with SiC particles was successfully carried *** particles were uniformly dispersed into an AA6061-T4 *** SiC particles promoted the grain refinement of the AA6061-T4 matrix by *** mean grain size of the stir zone (SZ) with the SiC particles was obviously smaller than that of the stir zone without the SiC *** microhardness of the SZ with the SiC particles reached about HV80 due to the grain refinement and the distribution of the SiC particles.

关键词： friction stir processing AA6061-T4 SiC particles pinning effect

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Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia

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Acta Pharmacologica Sinica 2007年第10期28卷 1645-1651页

作者： Jae-dong LEE Cheol PARK Yung hyun choi Gi-young KIM Department of Microbiology College of Natural Sciences Pusan National UniversityBusan 609-735 Department of Biochemistry Dongeui University College of Oriental MedicineBusan 614-054Korea Faculty of Applied Marine Science Cheju National UniversityJeju-siJeju Special Self-Governing Province 690-756Korea

Aim:Pro-inflammatory mediators,such as prostaglandin E2（PGE2） and nitric oxide（NO）,and pro-inflammatory cytokines such as interleukin （IL）-1β,IL-6,and TNF-α,play pivotal roles in brain *** anti-inflammatory properties are knownto be associated with significant reductions in pro-inflammatory mediators in *** the present study we investigate whether the effects of curcumin onthe production of pro-inflammatory mediators in lipopolysaccharide （LPS）-stimu-lated BV2 ***:Curcumin were administered and their effects onLPS-induced pro-inflammatory mediators were monitored by Western blottingand ***:Curcumin significantly inhibited the release of NO,PGE2,and pro-inflammatory cytokines in a dose-dependent *** alsoattenuated the expressions of inducible NO synthase and cyclooxygenase-2 mRNAand protein ***,curcumin suppressed NF-kB activation via thetranslocation of p65 into the *** data also indicate that curcumin exertsanti-inflammatory properties by suppressing the transcription of proinflammatorycytokine genes through the NF-kB signaling ***:Anti-inflam-matory properties of curcumin may be useful for treating the inflammatory anddeleterious effects of microglial activation in response to LPS stimulation.

关键词： curcumin inducible nitric oxide synthase cyclooxygenase-2 pro-inflammatory cytokines NF-kB

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Chromosomal assembly of the Antarctic toothfish(Dissostichus mawsoni)genome using third-generation DNA sequencing and Hi-C technology

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Zoological Research 2021年第1期42卷 124-129页

作者： Seung Jae Lee Jeong-Hoon Kim Euna Jo Eunkyung choi Jinmu Kim Seok-Gwan choi Sangdeok Chung hyun-Woo Kim hyun Park College of Life Sciences and Biotechnology Korea UniversitySeoul 02841Republic of Korea Division of Polar Life Science Korea Polar Research InstituteIncheon 21990Republic of Korea Unit of Research for Practical Application Korea Polar Research InstituteIncheon 21990Republic of Korea National Institute of Fisheries Science(NIFS) Busan 46083Republic of Korea Department of Marine Biology Pukyong National UniversityBusan 48513Republic of Korea

DEAR EDITOR,The Antarctic toothfish,Dissostichus mawsoni,belongs to the Nototheniidae family and is distributed in sub-zero temperatures below S60°latitude in the Southern ***,it is an attractive model species to study the stenothermal cold-adapted character *** this study,we successfully generated highly contiguous genome sequences of ***,which contained 1062 scaffolds with a N50 length of 36.98 Mb and longest scaffold length of 46.82 *** elements accounted for 40.87%of the *** also inferred 32914 protein-coding genes using in silico gene prediction and transcriptome sequencing and detected splicing variants using Isoform-Sequencing(Iso-Seq),which will be invaluable resource for further exploration of the adaptation mechanisms of Antarctic *** new high-quality reference genome of *** provides a fundamental resource for a deeper understanding of cold adaptation and conservation of species.

关键词： Antarctic latitude fish

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Antioxidant,lipid peroxidation inhibition and free radical scavenging efficacy of a diterpenoid compound sugiol isolated from Metasequoia glyptostroboides

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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 9-15页

作者： Vivek K.Bajpai Ajay Sharma Sun chul Kang Kwang-hyun Baek School of Biotechnology Yeungnam UniversityGyeongsanGyeongbook 712-749Republic of Korea

Objective:To investigate the antioxidant enicacy of a biologically active dilerpenoid compound sugiol isolated from Metasequoia glyptostroboides(***)in various antioxidant ***:An abietane type diterpenoid sugiol,isolated from ethyl acetate extract of *** cones,was analyzed for its antioxidant efficacy as reducing power ability and lipid peroxidation inhibition as well as its ability to scavenge free radicals such as 1,1-diphenyl-2-picryl hydrazyl,nitric oxide,superoxide and hydroxyl ***:The sugiol showed significant and concentration-dependent antioxidant and free radical scavenging ***,the sugiol exerted lipid peroxidation inhibitory effect by 76.3%as compared to a-tocopherol(80.13%)and butylaled hydroxyanisole(76.59%).In addition,the sugiol had significant scavenging activities of l,l-diphenyl-2-picryl hydrazyl,nitric oxide,superoxide and hydroxyl free radicals in a concentration-dependent manner by 78.83%,72.42%,72.99%and 85.04%,when compared to the standard compound ascorbic acid(81.69%,74.62%,73.00%and 73.79%)and a-tocopherol/butylated hydroxyanisole(84.09%,78.61%,74.45%and 70.02%),***:These findings justify the biological and traditional uses of *** or its secondary metabolites as confirmed by its promising antioxidant efficacy.

关键词： Sugiol Diterpenoid Antioxidant Free radicals Lipid peroxidation

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