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Inhibitory Mechanisms of Water Extract of Oplopanax elatus on Lipopolysaccharide-lnduced Inflammatory Responses in RAW 264.7 Murine Macrophage Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 670-676页

作者： Ki Sun Kwon hyun Lim Yong Soo Kwon Myong Jo Kim Ji Hye yoo Nam Ho yoo hyun Pyo Kim College of Pharmacy Kangwon National UniversityChuncheon(24341)Republic of Korea Department of Bio-Resource Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Bioherb Research Institute Kangwon National UniversityChuncheon(24341)Republic of Korea

Objective:To study the anti-inflammatory action and cellular mechanism of Oplopanax ***:A hot water extract of OE(WOE)was prepared and a major constituent,syringin,was successfully *** content in WOE was found to be 214.0 p.g/g dried plant(w/w).Their anti-inflammatory activities were examined using RAW 264.7 macrophages and a mouse model of croton oil-induced ear ***:In lipopolysaccharide(LPS)-treated RAW 264.7 cells,a mouse macrophage cell line,WOE was found to significantly and strongly inhibit cyclooxygenase-2(COX-2)-induced prostaglandin E2(PGE2)production[half maximal inhibitory concentration(IC50)=135.2μg/mL]and inducible nitric oxide synthase(iNOS)-induced NO production(IC50=242.9μg/mL).In the same condition,WOE was revealed to inhibit NO production by downregulating iNOS expression,mainly by interrupting mitogen activated protein kinases(MAPKs)/activator protein-1(AP-1)*** activation of all three major MAPKs,p38 MAPK,extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase,was inhibited by WOE(50-300μg/mL).On the other hand,WOE reduced PGE2 production by inhibiting COX-2 enzyme activity,but did not affect COX-2 expression *** addition,WOE inhibited the production of proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-α.In croton oil-induced ear edema in mice,oral administration of WOE(50-300 mg/kg)dose-dependently inhibited edematic ***:Water extract of OE exhibited multiple anti-inflammatory action mechanisms and may have potential for treating inflammatory disorders.

关键词： Oplopanax elatus Chinese medicine stem syringin anti-inflammation RAW 264.7

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Multiple-Object Tracking Using Histogram Stamp Extraction in CCTV Environments

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Computers, Materials & Continua 2023年第12期77卷 3619-3635页

作者： Ye-Yeon Kang Geon Park hyun yoo Kyungyong Chung Division of AI Computer Science and Engineering Kyonggi UniversitySuwon16227Korea Contents Convergence Software Research Institute Kyonggi UniversitySuwon16227Korea

Object tracking,an important technology in the field of image processing and computer vision,is used to continuously track a specific object or person in an *** technology may be effective in identifying the same person within one image,but it has limitations in handling multiple images owing to the difficulty in identifying whether the object appearing in other images is the *** tracking the same object using two or more images,there must be a way to determine that objects existing in different images are the same ***,this paper attempts to determine the same object present in different images using color information among the unique information of the ***,this study proposes a multiple-object-tracking method using histogram stamp extraction in closed-circuit television *** proposed method determines the presence or absence of a target object in an image by comparing the similarity between the image containing the target object and other *** this end,a unique color value of the target object is extracted based on its color distribution in the image using three methods:mean,mode,and interquartile *** Top-N accuracy method is used to analyze the accuracy of each method,and the results show that the mean method had an accuracy of 93.5%(Top-2).Furthermore,the positive prediction value experimental results show that the accuracy of the mean method was 65.7%.As a result of the analysis,it is possible to detect and track the same object present in different images using the unique color of the *** the results,it is possible to track the same object that can minimize manpower without using personal information when detecting objects in different *** the last response speed experiment,it was shown that when the mean was used,the color extraction of the object was possible in real time with 0.016954 *** this,it is possible to detect and track the same object in real time when using the proposed

关键词： Data mining deep learning object detection object tracking real-time object detection multiple object image processing

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Theoretical study of particle and energy balance equations in locally bounded plasmas

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Plasma Science and Technology 2024年第12期26卷 89-98页

作者： hyun-Su JUN Yat Fung TSANG Jae Ok yoo Navab SINGH Institute of Microelectronics(IME) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Republic of Singapore

In this study,new particle and energy balance equations have been developed to predict the electron temperature and density in locally bounded *** particle and energy balance equations assume that all plasma within a reactor is completely confined only by the reactor ***,in industrial plasma reactors for semiconductor manufacturing,the plasma is partially confined by internal reactor *** predict the effect of the open boundary area(A′_(L,eff))and ion escape velocity(u_(i))on electron temperature and density by developing new particle and energy balance ***,we found a low ion escape velocity(u_(i)/u_(B)≈0.2)and high open boundary area(A′_(L,eff)/A_(T,eff)≈0.6)to result in an approximately 38%increase in electron density and an 8%decrease in electron temperature compared to values in a fully bounded ***,we suggest that the velocity of ions passing through the open boundary should exceedω_(pi)λ_(De)under the condition E^(2)_(0)?(Φ/λ_(De))^(2).

关键词： particle balance equation energy balance equation low temperature plasmas

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The interplay between direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C

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Hepatoma Research 2020年第3期6卷 15-23页

作者： Sun Hong yoo Jung hyun Kwon Department of Internal Medicine Catholic University Liver Research CenterThe Catholic University of KoreaSeoul 06591Korea

Direct-acting antivirals(DAAs)have been introduced for the treatment of hepatitis C virus,and the sustained virological response rate after DAAs was reported to be over 95%.Because of the high sustained virological response rate,the risk of hepatocellular carcinoma(HCC)was expected to be ***,an unexpected high risk of HCC recurrence after DAA treatment was reported,and thus the dispute about the association of DAA and HCC *** present article reviews the interplay between DAAs and HCC.

关键词： Chronic hepatitis C hepatocellular carcinoma direct-acting antivirals

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Obesity and novel management of inflammatory bowel disease

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World Journal of Gastroenterology 2023年第12期29卷 1779-1794页

作者： Jee hyun Kim Chang-Myung Oh Jun Hwan yoo Department of Gastroenterology CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13496South Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and TechnologyGwangju 62465South Korea Institute of Basic Medical Sciences CHA University School of MedicineSeongnam 13496South Korea

Obesity is prevalent within the inflammatory bowel disease(IBD)population,particularly in newly developed *** epidemiological studies have suggested that 15%-40%of IBD patients are obese,and there is a potential role of obesity in the pathogenesis of *** dysfunction of mesenteric fat worsens the inflammatory course of Crohn’s disease and may induce formation of strictures or ***,obesity may affect the disease course or treatment response of *** the increasing data supporting the pathophysiologic and epidemiologic relationship between obesity and IBD,obesity control is being suggested as a novel management for ***,this review aimed to describe the influence of obesity on the outcomes of IBD treatment and to present the current status of pharmacologic or surgical anti-obesity treatments in IBD patients.

关键词： Obesity Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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Time-Frequency Characteristics of the Relationships Between Tropical Indo-Pacific SSTs

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Advances in Atmospheric Sciences 2007年第3期24卷 343-359页

作者： Song YANG 丁晓利郑大伟 Soo-hyun yoo NOAA ＇s Climate Prediction Center 5200 Auth Road Camp Springs MD 20746 USA Department of Land Surveying and Geo-Informatics Hong Kong Polytechnic University Center for Astrogeodynamics Research Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 RSIS/Climate Prediction Center 5200 Auth Road Camp Springs MD 20746 USA

In this study, several advanced analysis methods are applied to understand the relationships between the Nino-3.4 sea surface temperatures （SST） and the SSTs related to the tropical Indian Ocean Dipole （IOD）. By analyzing a long data record, the authors focus on the time-frequency characteristics of these relationships, and of the structure of IOD. They also focus on the seasonal dependence of those characteristics in both time and frequency domains. Among the Nino-3.4 SST, IOD, and SSTs over the tropical western Indian Ocean （WIO） and eastern Indian Ocean （EIO）, the WIO SST has the strongest annual and semiannual oscillations. While the Nino-3.4 SST has large inter-annual variability that is only second to its annual variability, the IOD is characterized by the largest semiannual oscillation, which is even stronger than its annual oscillation. The IOD is strongly and stably related to the EIO SST in a wide range of frequency bands and in all seasons. However, it is less significantly related to the WIO SST in the boreal winter and spring. There exists a generally weak and unstable relationship between the WIO and EIO SSTs, especially in the biennial and higher frequency bands. The relationship is especially weak in summer and fall, when IOD is apparent, but appears highly positive in winter and spring, when the IOD is unimportantly weak and even disappears. This feature reflects a caution in the definition and application of IOD. The Nino-3.4 SST has a strong positive relationship with the WIO SST in all seasons, mainly in the biennial and longer frequency bands. However, it shows no significant relationship with the EIO SST in summer and fall, and with IOD in winter and spring.

关键词： Indian Ocean dipole ENSO time-frequency relationship coherence analysis

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Abnormal Behavior Detection Using Deep-Learning-Based Video Data Structuring

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Intelligent Automation & Soft Computing 2023年第8期37卷 2371-2386页

作者： Min-Jeong Kim Byeong-Uk Jeon hyun yoo Kyungyong Chung Department of Computer Science Kyonggi UniversitySuwon-si16227Gyeonggi-doKorea Contents Convergence Software Research Institute Kyonggi UniversitySuwon-si16227Gyeonggi-doKorea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon-si16227Gyeonggi-doKorea

With the increasing number of digital devices generating a vast amount of video data,the recognition of abnormal image patterns has become more ***,it is necessary to develop a method that achieves this task using object and behavior information within video *** methods for detecting abnormal behaviors only focus on simple motions,therefore they cannot determine the overall behavior occurring throughout a *** this study,an abnormal behavior detection method that uses deep learning(DL)-based video-data structuring is *** and motions are first extracted from continuous images by combining existing DL-based image analysis *** weight of the continuous data pattern is then analyzed through data structuring to classify the overall *** performance of the proposed method was evaluated using varying parameter settings,such as the size of the action clip and interval between action *** model achieved an accuracy of 0.9817,indicating excellent ***,we conclude that the proposed data structuring method is useful in detecting and classifying abnormal behaviors.

关键词： Deep learning object detection abnormal behavior recognition classification data structuring

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Enhanced third-harmonic generation by manipulating the twist angle of bilayer graphene

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Light(Science & Applications) 2021年第2期10卷 176-185页

作者： Seongju Ha Nam Hun Park Hyeonkyeong Kim Jiseon Shin Jungseok Choi Sungmin Park Ji-Yun Moon Kwanbyung Chae Jeil Jung Jae-hyun Lee Youngdong yoo Ji-Yong Park Kwang Jun Ahn Dong-il Yeom Department of Energy Systems Research Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Korea Research Institute of Standards and Science Daejeon 34113Republic of Korea Department of Physics University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Smart Cities University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Materials Science and Engineering Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Chemistry Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Physics Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea

Twisted bilayer graphene(tBLG)has received substantial attention in various research fields due to its unconventional physical properties originating from Moire *** electronic band structure in tBLG modified by interlayer interactions enables the emergence of low-energy van Hove singularities in the density of states,allowing the observation of intriguing features such as increased optical conductivity and photocurrent at visible or near-infrared ***,we show that the third-order optical nonlinearity can be considerably modified depending on the stacking angle in *** third-harmonic generation(THG)efficiency is found to significantly increase when the energy gap at the van Hove singularity matches the three-photon resonance of incident *** study on electrically tuneable optical nonlinearity reveals that the gate-controlled THG enhancement varies with the twist angle in tBLG,resulting in a THG enhanced up to 60 times compared to neutral monolayer *** results prove that the twist angle opens up a new way to control and increase the optical *** tBLG,,suggesting rotation-induced tuneable nonlinear optics in stacked two-dimensional material systems.

关键词： twist angle harmonic

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Boosting overall water splitting by incorporating sulfur into NiFe(oxy)hydroxide

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Journal of Energy Chemistry 2022年第1期31卷 364-371,I0010页

作者： Chiho Kim Seong hyun Kim Seunghun Lee ilyeong Kwon Seong hyun Kim Shinho kim Changgyu Seok yoo Sei Park Yangdo Kim Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea BK21 Four Innovative Graduate Education Program for Global High-tech Materials&PartsPusan National UniversityBusan 46241Republic of Korea Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH).Pohang 37673Republic of Korea

Developing highly active and cost-effective electrocatalysts for enhancing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is a significant challenge for overall water ***-incorporated nickel iron(oxy)hydroxide(S-NiFeOOH)nanosheets were directly grown on commercial nickel foam using a galvanic corrosion method and a hydrothermal *** incorporation of sulfur into NiFeOOH enhanced the catalytic activity for the HER and OER in 1 M KOH *** enhanced catalytic activity is attributed to the change in the local structure and chemical states due to the incorporation of *** performance for overall water splitting was achieved with an alkaline water *** was realized by employing S-NiFeOOH as a bifunctional electrocatalyst,thereby outperforming a water electrolyzer that requires the usage of precious metal electrocatalysts(i.e.,Pt/C as the HER electrocatalyst and IrO_(2) as the OER electrocatalyst).Moreover,when driven by a commercial silicon solar cell,an alkaline water electrolyzer that uses S-NiFeOOH as a bifunctional electrocatalyst generated hydrogen under natural *** study shows that S-NiFeOOH is a promising candidate for a large-scale industrial implementation of hydrogen production for overall water splitting because of its low cost,high activity,and *** addition,the solar-driven water electrolyzer using S-NiFeOOH as a bifunctional electrocatalyst affords the opportunity for developing effective and feasible solar power systems in the future.

关键词： Overall water splitting Hydrogen production Sulfur incorporated NiFe(oxy)hydroxide Electrocatalysts Solar-driven water splitting

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Electrical characteristics and detailed interfacial structures of Ag/Ni metallization on polycrystalline thermoelectric SnSe

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Journal of Materials Science & Technology 2019年第5期35卷 711-718页

作者： Yeongseon Kim Younghwan Jin Giwan yoon In Chung Hana yoon Chung-Yul yoo Sang hyun Park Separation and Conversion Materials Laboratory Korea Institute of Energy Research 152 Gajeong-ro Yuseong-gu Daejeon 34129 Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology 291 Daehak-ro Yuseong-gu Daejeon 34142 Republic of Korea Department of Physics Chungnam National University 99 Daehak-ro Yuseong-gu Daejeon 34134 Republic of Korea School of Chemical and Biological Engineering Seoul National University 1 Gwanak-ro Gwanak-gu Seoul 08826 Republic of Korea

SnSe is a promising thermoelectric material with a high figure of merit in single crystal form, which has stimulated continuous research on polycrystalline SnSe. In this study, we investigated a metallization techniques for polycrystalline SnSe to achieve highly efficient and practical SnSe thermoelectric modules. The Ag/Ni metallization layers were formed on pristine polycrystalline SnSe using various deposition technique: sputter coating Ni, powder Niand foil Ni by spark plasma sintering. Structural analysis demonstrated that the microstructure and con tact resistance could be different according to the metallization process, despite using the same metals. The Ag/Ni metallization layer using foil Ni acted as an effective diffusion barrier and minimized electrical contact resistance (2.3×10^-4Ωcm^2). A power loss in the thermoelectric module of only 5% was demonstrated using finite element simulation.

关键词： Thermoelectric Metallization Electric contact material Interface microstructure SnSe

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