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Nano-Micro Letters 2024年第6期16卷 210-220页

作者： Hyeongtae Lim Hyeokjin kwon Hongki Kang Jae Eun Jang hyuk‑jun kwon Department of Electrical Engineering and Computer Science DGISTDaegu 42988South Korea Convergence Research Advanced Centre for Olfaction DGISTDaegu 42988South Korea

Advancements in sensor technology have significantly enhanced atmospheric ***,metal oxide and carbon(MO_(x)/C)hybrids have gained attention for their exceptional sensitivity and room-temperature sensing ***,previous methods of synthesizing MO_(x)/C composites suffer from problems,including inhomogeneity,aggregation,and challenges in ***,we introduce a refined method that employs a metal–organic framework(MOF)as a precursor combined with direct laser *** inherent structure of MOFs ensures a uniform distribution of metal ions and organic linkers,yielding homogeneous MO_(x)/C *** laser processing facilitates precise micropatterning(<2μm,comparable to typical photolithography)of the MO_(x)/C *** optimized MOF-derived MO_(x)/C sensor rapidly detected ethanol gas even at room temperature(105 and 18 s for response and recovery,respectively),with a broad range of sensing performance from 170 to 3,400 ppm and a high response value of up to 3,500%.Additionally,this sensor exhibited enhanced stability and thermal resilience compared to previous MOF-based *** research opens up promising avenues for practical applications in MOF-derived sensing devices.

关键词： Metal-organic frameworks Metal oxide Carbon composite Laser Gas sensor

Schottky barrier modulation of bottom contact SnO_(2) thin-film transistors via chloride-based combustion synthesis

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Journal of Materials Science & Technology 2023年第17期148卷 199-208页

作者： Bongho Jang junhee Lee Hongki Kang Jaewon Jang hyuk-jun kwon Department of Electrical Engineering and Computer Science DGISTDaegu 42988South Korea School of Electronic and Electrical Engineering Kyungpook National UniversityDaegu 41566South Korea School of Electronics Engineering Kyungpook National UniversityDaegu 41566South Korea Convergence Research Advanced Centre for Olfaction DGISTDaegu 42988South Korea

The enhanced carrier flow at the interface between Au and SnO_(2)semiconductors,which initially form Schottky contacts,is realized using chloride-based combustion ***-based combustion sys-tems can achieve chlorine(Cl)doping effects as well as conversion to crystalline SnO_(2)films at clearly lower temperatures(∼250℃)than conventional *** to the Cl doping effect,the high carrier concentration can induce thin potential barriers at the metal/semiconductor(MS)junctions,resulting in carrier injection by *** a result,compared to conventional SnO_(2)thin-film transistors,the de-vices fabricated by combustion synthesis exhibit significantly improved electrical performance with field-effect mobility of 6.52 cm 2/Vs(∼13 times),subthreshold swing of 0.74 V/dec,and on/offratio of∼10^(7)below 300℃.Furthermore,because of the enhanced tunneling carriers induced by the narrowed barrier width,the Schottky barriers are significantly reduced from 0.83 to 0.29 eV(65%decrease)at 250℃and from 0.42 to 0.17 eV(60%decrease)at 400℃.Therefore,chloride-based combustion synthesis can con-tribute to developing SnO_(2)-based electronics and flexible devices by achieving both high-quality oxide films and improved current flow at the MS interface with low-temperature annealing.

关键词： SnO_(2) Combustion Sol-gel Schottky contact Thin-film transistors

Key-Value Store Coupled with an Operating System for Storing Large-Scale Values

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Computers, Materials & Continua 2022年第11期73卷 3333-3350页

作者： Jeonghwan Im hyuk-Yoon kwon Graduate School of Data Science Seoul National University of Science and TechnologySeoulKorea Department of Industrial Engineering Graduate School of Data ScienceResearch Center for Electrical and Information ScienceSeoul National University of Science and TechnologySeoulKorea

The key-value store can provide flexibility of data types because it does not need to specify the data types to be stored in advance and can store any types of data as the value of the key-value *** types of studies have been conducted to improve the performance of the key-value store while maintaining its ***,the research efforts storing the large-scale values such as multimedia data files(e.g.,images or videos)in the key-value store were *** this study,we propose a new key-value store,WR-Store++aiming to store the large-scale values ***,it provides a new design of separating data and index by working with the built-in data structure of the Windows operating system and the file *** utilization of the built-in data structure of the Windows operating system achieves the efficiency of the key-value store and that of the file system extends the limited space of the storage *** also present chunk-based memory management and parallel processing of WR-Store++to further improve its performance in the GET *** the experiments,we show that WR-Store++can store at least 32.74 times larger datasets than the existing baseline key-value store,WR-Store,which has the limitation in storing large-scale data ***,in terms of processing efficiency,we show that WR-Store++outperforms not only WR-Store but also the other state-ofthe-art key-value stores,LevelDB,RocksDB,and BerkeleyDB,for individual key-value operations and mixed workloads.

关键词： Key-value stores large-scale values chunk-based memory management parallel processing

Sensitivity analysis of influencing parameters on slit-type barrier performance against debris flow using 3D-based numerical approach

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International Journal of Sediment Research 2021年第1期36卷 50-62页

作者： Minseop Kim Seungrae Lee Tae-hyuk kwon Shin-Kyu Choi jun-Seo Jeon Department of Civil and Environmental Engineering KAIST Building Safety Research Center & Seismic Safety Research Center KICT

Extreme rainfall-induced debris flow can be catastrophic to an urban area,and installation of slit-type barriers can prevent such damage while minimizing negative impact on ***,the performance of slit-type barriers against debris flows remains poorly identified partly due to the innate complexity in interactions between debris flow and solid *** paper investigated the flow behaviors of debris affected by slit-type barriers using the computational fluid dynamics(CFD) method,in which the numerical model based on the volume of fluid method was verified using the physical modeling *** sensitivity analysis was performed by building metamodels to determine the prima ry parameters influencing the barrier performance against debris flows among various variables,in which the effect of input properties and design parameters,particularly the soil concentration in fluidized debris,initial velocity and volume of debris,the barrier height,and the opening ratio,was evaluated from the perspectives of the flow energy reduction and debris *** initial velocity and volume of debris were found to play a significant role in determining the debris flow characteristics.A decrease in the opening ratio in the channel primarily facilitated the energy reduction and trapping due to the reduced opening ***,the barrier height exhibited a limited effect when the height was sufficiently high to block the debris flow *** addition,it was observed that the double barrier system effectively increased the energy reduction while keeping the benefit of open-type *** developed simulation method and obtained results provide an effective tool and an insight that can contribute to an optimum design of the debris-flow barrier.

关键词： Debris flow Slit-type barrier Numerical simulations Sensitivity analysis Mitigation effect

Neuroinflammation in neurodegenerative disorders:the roles of microglia and astrocytes

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Translational Neurodegeneration 2020年第4期9卷 535-546页

作者： hyuk Sung kwon Seong-Ho Koh Department of Neurology Hanyang University College of MedicineSeoulRepublic of Korea Department of Translational Medicine Hanyang University Graduate School of Biomedical Science&EngineeringSeoulRepublic of Korea

Neuroinflammation is associated with neurodegenerative diseases,such as Alzheimer's disease,Parkinson's disease,ancamyotrophic lateral *** and astrocytes are key regulators of inflammatory responses in the central nervous *** activation of microglia and astrocytes is heterogeneous and traditionally categorized as neurotoxi(M1-phenotype microglia and A1-phenotype astrocytes)or neuroprotective(M2-phenotype microglia and A2-phenotype astrocytes).However,this dichotomized classification may not reflect the various phenotypes of microgliaand *** relationship between these activated glial cells is also very complicated,and the phenotypic distribution can change,based on the progression of neurodegenerative diseases.A better understanding of the rolesof microglia and astrocytes in neurodegenerative diseases is essential for developing effective *** this review,we discuss the roles of inflammatory response in neurodegenerative diseases,focusing on the contributions of microglia and astrocytes and their *** addition,we discuss biomarkers to measure neuroinflammation andstudies on therapeutic drugs that can modulate neuroinflammation.

关键词： Neuroinflammation Neurodegenerative diseases Microglia Astrocytes

Question-Answering Pair Matching Based on Question Classification and Ensemble Sentence Embedding

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Computer Systems Science & Engineering 2023年第9期46卷 3471-3489页

作者： Jae-Seok Jang hyuk-Yoon kwon Department of Computer Science and Engineering Seoul National University of Science and TechnologySeoul01811Korea Department of Industrial Engineering/Graduate School of Data Science Seoul National University of Science and TechnologySeoul01811Korea

Question-answering(QA)models find answers to a given *** necessity of automatically finding answers is increasing because it is very important and challenging from the large-scale QA data *** this paper,we deal with the QA pair matching approach in QA models,which finds the most relevant question and its recommended answer for a given *** studies for the approach performed on the entire dataset or datasets within a category that the question writer manually *** contrast,we aim to automatically find the category to which the question belongs by employing the text classification model and to find the answer corresponding to the question within the *** to the text classification model,we can effectively reduce the search space for finding the answers to a given ***,the proposed model improves the accuracy of the QA matching model and significantly reduces the model inference ***,to improve the performance of finding similar sentences in each category,we present an ensemble embedding model for sentences,improving the performance compared to the individual embedding *** real-world QA data sets,we evaluate the performance of the proposed QA matching *** a result,the accuracy of our final ensemble embedding model based on the text classification model is 81.18%,which outperforms the existing models by 9.81%∼14.16%***,in terms of the model inference speed,our model is faster than the existing models by 2.61∼5.07 times due to the effective reduction of search spaces by the text classification model.

关键词： Question-answering text classification model data augmentation text embedding

Current status and challenges for cell-cultured milk technology: a systematic review

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1778-1792页

作者： hyuk Cheol kwon Hyun Su jung Vahinika Kothuri Sung Gu Han Department of Food Science and Biotechnology of Animal Resources Konkuk UniversitySeoulRepublic of Korea

Cellular agriculture is an innovative technology for manufacturing sustainable agricultural products as an alternative to traditional *** most cellular agriculture is predominantly centered on the production of cultured meat,there is a growing demand for an understanding of the production techniques involved in dairy products within cellular *** review focuses on the current status of cellular agriculture in the dairy sector and technical challenges for cell-cultured milk *** agriculture technology in the dairy sector has been classified into fermentation-based and animal cell culture-based cellular ***,various companies synthesize milk components through precision fermentation ***,several startup companies are pursuing animal cell-based technology,driven by public concerns regarding genetically modified organisms in precision fermentation ***,this review offers an up-to-date exploration of animal cell-based cellular agriculture to produce milk components,specifically emphasizing the structural,functional,and productive aspects of mammary epithelial cells,providing new information for industry and academia.

关键词： Cell culture system Cell-cultured milk Mammary epithelial cells Precision fermentation

Parasitic leiomyoma in the trocar site after laparoscopic myomectomy:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2895-2900页

作者： Chul Kyu Roh hyuk-Jae kwon Min jung jung Department of Surgery National Police HospitalSeoul 05715South Korea Department of Surgery Ajou University School of MedicineSuwon 16499South Korea Department of Pathology College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Laparoscopic myomectomy is increasingly used for resecting gynecological *** require morcellation for retrieval from the peritoneal ***,morcellated fragments may implant on the peritoneal cavity during *** fragments may receive a new blood supply from an adjacent structure and develop into parasitic *** leiomyomas can occur spontaneously or iatrogenically;however,trocar-site implantation is an iatrogenic complication of laparoscopic uterine *** describe a parasitic leiomyoma in the trocar-site after laparoscopic myomectomy with power *** SUMMARY A 50-year-old woman presented with a palpable abdominal mass without significant medical *** patient had no related symptoms,such as abdominal *** tomography findings revealed a well-defined contrast-enhancing mass measuring 2.2 cm,and located on the trocar site of the left abdominal *** had undergone laparoscopic removal of uterine fibroids with power morcellation six years *** differential diagnosis included endometriosis and neurogenic tumors,such as *** radiologic diagnosis was a desmoid tumor,and surgical excision of the mass on the abdominal wall was successfully *** patient recovered from the surgery without *** examination revealed that the specimen resected from the trocar site was a uterine *** Clinicians should consider the risks and benefits of laparoscopic vs laparotomic myomectomy for gynecological *** caution must be exercised for morcellation to avoid excessive tissue fragmentation.

关键词： Laparoscopic myomectomy Parasitic leiomyoma Trocar site Implantation Morcellation Case report

Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders:a systematic review and Meta-analysis of randomized clinical trials

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Chinese Journal of Natural Medicines 2021年第5期19卷 339-350页

作者： kwon hyuk-Ku Zhang Ting Wu Xuan Gao Qiu Jing Yi Park Sunmin Dept of Environm ental EngineeringHoseo UniversityAsanSouth Korea Dept of Food and NutritionObesity/Diabetes Research CenterHoseo UniversityAsanSouth Korea

The management of post-stroke complications plays an important role in the quality of ***-Tan Decoction(DTD;涤痰汤)is a widely used traditional Chinese *** study incorporated systematic review and meta-analysis to evaluate the efficacy of DTD in post-stroke neurological *** clinical trials(RCTs)were searched from English,Chinese and Korean electronic medical databases,by including the keywords"Di-Tan Tang","Di-Tan Decoction","Scour Phlegm Decoction","stroke",and"*** RCT included control(placebo,conventional therapy,or Western medicine)and experimental(DTD treatment)*** patients inflicted with stroke for 1-6 weeks,the outcomes of post-stroke neurological disorders were measured by scales for post-stroke symptoms and were classified as"completely healed","markedly effective","effective"and"ineffective".Totally,11 RCTs(n=490 controls and n=502 DTD subjects)were selected from 210 articles identified in the initial search.A metaanalysis of evaluation criteria in post-stroke symptoms revealed that the overall odds ratio(ORs)for alleviating post-stroke neurological disorders were 0.30-fold lower(95%CI=0.21-0.43)in the DTD group than the control(Western medicine)group(P<0.00001).Moreover,regardless of the type of stroke diagnostic scale applied(including NFA,HDS,and NIHSS),the overall post-stroke symptoms determined were less severe in the DTD group(n=219)than the control group(n=217).No adverse effects of DTD were observed in the 11 RCTs *** 11 studies used an appropriate method for randomization of subjects to evaluate the risk of bias(ROB),and 7 studies included allocation concealment as well as blinding of patients and ***-risk ROB was included in6 *** significant publication bias was derived from the funnel *** results indicate that the administration of DTD alone,and DTD in combination with Western medicine,exert greater efficacy for post-stroke complication therapy,than Western medicine administ

关键词： Di-Tan Decoction Post-stroke Adverse effects Randomized clinical trials Risk of bias

Regeneration-associated macrophages： a novel approach to boost intrinsic regenerative capacity for axon regeneration

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Neural Regeneration Research 2016年第9期11卷 1368-1371页

作者： Min jung kwon hyuk jun Yoon Byung Gon Kim Department of Brain Science Ajou University School of Medicine Suwon Republic of Korea Department of Neurology Ajou University School of Medicine Suwon Republic of Korea Neuroscience Graduate Program Department of Biomedical Sciences Ajou University Graduate School of Medicine Suwon Republic of Korea

Axons in central nervous system （CNS） do not regenerate spontaneously after injuries such as stroke and traumatic spinal cord iniury. Both intrinsic and extrinsic factors are responsible for the regeneration fail- ure, Although intensive research efforts have been invested on extrinsic regeneration inhibitors, the extent to which glial inhibitors contribute to the regeneration failure in viva still remains elusive. Recent exper- imental evidence has rekindled interests in intrinsic factors for the regulation of regeneration capacity in adult mammals. In this review, we propose that activating macrophages with pro-regenerative molecular signatures could be a novel approach for boosting intrinsic regenerative capacity of CNS neurons. Using a conditioning injury model in which regeneration of central branches of dorsal root ganglia sensory neu- rons is enhanced by a preceding injury to the peripheral branches, we have demonstrated that perineuronal macrophages surrounding dorsal root ganglia neurons are critically involved in the maintenance of en- hanced regeneration capacity. Neuron-derived chemokine （C-C motif） ligand 2 （CCL2） seems to mediate neuron-macrophage interactions conveying injury signals to perineuronal macrophages taking on a soley pro-regenerative phenotype, which we designate as regeneration-associated macrophages （RAMs）. Ma- nipulation of the CCL2 signaling could boost regeneration potential mimicking the conditioning injury, suggesting that the chemokine-mediated RAM activation could be utilized as a regenerative therapeutic strategy for CNS injuries.

关键词： axon regeneration conditioning injury neuron-macrophage interaction regeneration-associatedmacrophage cAMP CCL2 M2 polarization spinal cord injury