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Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 935-940页

作者： Seong-Jae Kim Hwajin Kim Jeongsook Park Inyoung Chung hyug-moo kwon Wan-Sung Choi Ji-Myong Yoo Department of Ophthalmology School of MedicineGyeongsang National University Institute of Health Science Gyeongsang National University Department of Anatomy and Neurobiology BK21 Biomedical CenterSchool of MedicineGyeongsang National University School of Nano-Bioscience and Chemical Engineering Ulsan National Institute and Science and Technology

AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were ***: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with ***: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR.

关键词： aldose reductase diabetes tonicity response element binding protein retinopathy

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Ton EBP transcription factor promotes diabetic nephropathy via hyperglycemia-induced macrophage activation

Ton EBP transcription factor promotes diabetic nephropathy v...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Sun Woo Lim Soo Youn Choi Eun Jin Yoo Whaseon Lee-kwon Hwan Hee Lee Jun Ho Lee Satoru Sanada Afshin Parsa hyug moo kwon Transplantation Research Center Catholic University of Korea Department of Biological Sciences UNISTKorea Department of Medicine University of Maryland BaltimoreUSA

＜正＞Diabetic nephropathy（DN）is the leading cause of end-stage renal disease accounting for more than 50%of the *** is characterized by histological changes such as glomerular sclerosis and interstitial fibrosis,and functional changes such as proteinuria and renal *** develops slowly over＞10years in 30–40%of patients with *** therapy for DN as well as risk assessment of DN at early stages of diabetes is lacking.

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