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A herbal pair of Scutellaria barbata D. Don and Scleromitrion diffusum(Willd.) R.J. Wang induced ferroptosis in ovarian cancer A2780 cells via inducing heme catabolism and ferritinophagy

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Journal of Integrative Medicine 2024年第6期22卷 665-682页

作者： Zhen Wang Min Liu Guang-xing Li Liu Zhang Kai-yue Ding Si-qi Li Bing-qing Gao Peng Chen hyok-chol choe Lun-yue Xia Yu-tong Yang Yi Liu Xue Sui Jun-nan Ma Lin Zhang Institute (College) of Integrative Medicine Dalian Medical University Department of General Surgery the First Affiliated Hospital of Dalian Medical University Advanced Institute of Medical Sciences Dalian Medical University Department of Clinical Medicine Sinuiju Medical University

Objective: Despite the combination of Scutellaria barbata D. Don and Scleromitrion diffusum(Willd.) ***(SB-SD) being a recognized Chinese medicinal herbal pair that is commonly used in the treatment of ovarian cancer, there is a poor understanding of their pharmacological mechanisms. This study examines the antitumor properties and potential mechanisms of SB-SD on human ovarian cancer A2780 cells through a multi-omics approach, establishing a pharmacological basis for clinical ***: A range of mass ratios and reagents were used in the hot reflux extraction of SB-SD. The inhibitory effect of the SB-SD extracts on A2780 cell proliferation was assessed using the cell-counting kit 8assay. A zebrafish tumor implantation model was used to evaluate the effects of SB-SD extracts on tumor growth and metastasis in vivo. Transcriptomics and proteomics were used to investigate alterations in biological pathways in A2780 cells after treatment with different concentrations of SB-SD extract. Cell cycle,cell apoptosis, intracellular free iron concentration, intracellular reactive oxygen species(ROS) concentration, malondialdehyde(MDA), and mitochondrial membrane potential were measured. Real-time quantitative reverse transcription polymerase chain reaction and Western blotting were utilized to investigate the effects of heme catabolism and ferritinophagy on ferroptosis induced by SB-SD extract in A2780 ***: The 70% ethanol extract of SB-SD(a mass ratio of 4:1) inhibited A2780 cell proliferation significantly with a half maximal inhibitory concentration of 660 μg/m L in a concentration-and timedependent manner. Moreover, it effectively suppressed tumor growth and metastasis in a zebrafish tumor implantation model. SB-SD extract induced the accumulation of free iron, ROS, MDA, and mitochondrial damage in A2780 cells. The mechanisms might involve the upregulated expression of ferritinophagyrelated genes microtubule-associated protein 1 light chain 3, auto

关键词： Ferritinophagy Ferroptosis Heme catabolism Ovarian cancer Proteomic Scleromitrion diffusum (Willd.) R.J. Wang Scutellaria barbata D. Don Transcriptomic

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Experimental study on the characteristics of DBD plasma coal liquefaction by using coal nanopowder

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Plasma Science and Technology 2019年第11期21卷 86-92页

作者： Song chol PAK Kuk Song HAN Yong Jun KIM Hak chol choe Faculty of Physical Science Kimchaek University of Technology

A new method for liquefying coal using dielectric barrier discharge plasma has been *** utilizing waste oil as the solvent and processing coal nano powder in the plasma for 10 min,we have attained a liquid yield of more than 80%.The experiment shows that not only the coal nanopowder promoted the liquefaction process,but hydrogen radicals improved the liquid yield *** the plasma processing,the phenomenon of the changing color of the nanopowder solution and not producing a solid residue has been obviously *** rational parameters that affected the liquefaction of coal nanopowder have been achieved through the experiment,and the liquefied products have been analyzed.

关键词： liquefaction DBD plasma coal nanopowder

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An advanced integrated framework for moving object tracking

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 861-877页

作者： Gwang-Min choe Tian-jiang WANG Fang LIU Chun-Hwa choe Hyo-Son SO chol-Ung PAK School of Computer Science and Technology Huazhong University of Science and Technology School of Computer Science and Technology Kim Il Sung University School of Wireless Engineering Huichon Institute of Technology

This paper first introduces the concept of a geogram that captures richer features to represent the objects. The spatiogram contains some moments upon the coordinates of the pixels corresponding to each bin, while the geogram contains information about the perimeter of grouped regions in addition to features in the *** we consider that a convergence process of mean shift is divided into obvious dynamic and steady states,and introduce a hybrid technique of feature description, to control the convergence process. Also, we propose a spline resampling to control the balance between computational cost and accuracy of particle filtering. Finally, we propose a boosting-refining approach, which is boosting the particles positioned in the ill-posed condition instead of eliminating the ill-posed particles, to refine the particles. It enables the estimation of the object state to obtain high accuracy. Experimental results show that our approach has promising discriminative capability in comparison with the state-of-the-art approaches.

关键词： Geogram Mean shift Hybrid gradient descent algorithm Particle filter Spline resampling Matrix condition number

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Influence of Vanadium Content on Hot Deformation Behavior of Low-Carbon Boron Microalloyed Steel

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Acta Metallurgica Sinica(English Letters) 2020年第5期33卷 705-715页

作者： Kwang-Su Kim Lin-Xiu Du Hyo-sung choe Tae-Hyong Lee Gyong-chol Lee Department of Materials Science and Engineering Kim Chaek University of TechnologyPyongyang 999093Democratic People’s Republic of Korea State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

Single-pass compression tests were performed to investigate the hot deformation behavior of low-carbon boron microalloyed steel containing three various vanadium contents at 900-1100℃and strain rate of 0.01-10 s-1 using the MMS-300 thermal mechanical *** flow stress curves of investigated steels were obtained under the different deformation conditions,and the effects of the deformation temperature and strain rate on the flow stress were *** characteristic points of flow stress were obtained from the stress dependence of strain hardening rate;the activation energy of investigated steels was determined by the regression analysis;the flow stress constitutive equations were developed;the effect of vanadium content on the flow stress and dynamic recrystallization(DRX)was *** result showed that the flow stress and activation energy(3-6.5 kJ mol-1)of the steel containing 0.18 wt%V were significantly higher than those of the steels with0.042 wt%and 0.086 wt%V,which was related to the increase in solute drag and precipitation effects for higher vanadium *** analysis showed that the addition of vanadium can delay the initiation and the rate of DRX.

关键词： Boron microalloyed steel Vanadium Flow stress Hot deformation Dynamic recrystallization

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Late Pleistocene spore-pollen record and climatic change at the Chongphadae Cave Site,Democratic People's Republic of Korea

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Journal of Palaeogeography 2023年第4期12卷 624-636页

作者： Se Chan Kim Rye Sun choe Il Nam Kim chol U Ryong Il Kang Institute of Human Evolution and Development History Faculty of HistoryKim Il Sung UniversityTaesong DistrictPyongyangDemocratic People's Republic of Korea

We present a detailed pollen record and interpretations of late Pleistocene climatic change at the Chongphadae Cave Site, Democratic People's Republic of Korea. The mean annual paleotemperature and mean annual paleoprecipitation of the site were calculated using the temperature index and precipitation index based on ecological features and geographical distribution of each taxon. Temperature index and precipitation index range from 8.8℃ to 10.4℃ and from 805.0 mm to 963.1 mm, respectively. Four dates(radiocarbon, uranium series, fission track, and paleomagnetic excursion dating) of the deposit profile investigated yield a range of ~21.3 ka BP to ~117 ka BP, geochronologically corresponding to the late Pleistocene, and extend from the last interglacial highstand through the Last Glacial Maximum. Our results are thus consistent with the climatic shift from interglacial to glacial conditions, provide evidence that the environments of the region, which was reconstructed from the paleoclimatic index, changed from a mild and humid to a cool and dry climate during the late Pleistocene, and suggest trends similar to those of several parts of the Northern Hemisphere which lie in the same latitudinal zone as our study area.

关键词： Chongphadae cave Pollen Climatic change Late Pleistocene Mean annual temperature Mean annual precipitation

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Intelligent back analysis of geotechnical parameters for time-dependent rock mass surrounding mine openings using grey Verhulst model

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Journal of Central South University 2021年第10期28卷 3099-3116页

作者： Un chol HAN Chung Song choe Kun Ui HONG Hyon Il HAN School of Science and Engineering Kim Chaek University of TechnologyPyongyang 999093Democratic People's Republic of Korea Faculty of Mining Engineering Kim Chaek University of TechnologyPyongyang 999093Democratic People's Republic of Korea

In this paper,we present a new method of intelligent back analysis(IBA)using grey Verhulst model(GVM)to identify geotechnical parameters of rock mass surrounding tunnel,and validate it via a test for a main openings of−600 m level in Coal Mine“6.13”,Democratic People's Republic of *** displacement components used for back analysis are the crown settlement and sidewalls convergence monitored at the end of the openings excavation,and the final closures predicted by *** non-linear relation between displacements and back analysis parameters was obtained by artificial neural network(ANN)and Burger-creep viscoplastic(CVISC)model of ***,the optimal parameters were determined for rock mass surrounding tunnel by genetic algorithm(GA)with both groups of measured displacements at the end of the final excavation and closures predicted by *** maximum absolute error(MAE)and standard deviation(Std)between calculated displacements by numerical simulation with back analysis parameters and in situ ones were less than 6 and 2 mm,***,it was found that the proposed method could be successfully applied to determining design parameters and stability for tunnels and underground cavities,as well as mine openings and stopes.

关键词： intelligent back analysis(IBA) grey Verhulst model(GVM) closure prediction mine openings burgercreep viscoplastic(CVISC)model

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低碳氮比废水处理微氧升流式膜生物反应器SNAD工艺启动运行与微生物菌群研究

低碳氮比废水处理微氧升流式膜生物反应器SNAD工艺启动运行与微生...

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作者： choe JIN hyok 北京化工大学

学位级别：硕士

城市生活污水呈现出低碳氮比的趋势,因此大大降低了传统生化法脱氮除碳效率,若使废水能够达标排放通常需要投入大量的资源和较高的成本。SNAD工艺是在微氧条件下,短程硝化、厌氧氨氧化和短程反硝化同时进行的新型生物脱氮技术,是一种经... 详细信息

城市生活污水呈现出低碳氮比的趋势,因此大大降低了传统生化法脱氮除碳效率,若使废水能够达标排放通常需要投入大量的资源和较高的成本。SNAD工艺是在微氧条件下,短程硝化、厌氧氨氧化和短程反硝化同时进行的新型生物脱氮技术,是一种经济环保的脱氮除碳工艺。膜生物反应器(MBR)实现了水力停留时间和污泥龄的彻底分离,进而保持高浓度的微生物量,因此有利于实现生长速率较慢的厌氧氨氧化细菌(AnAOB)和亚硝化细菌(AOB)等自养菌的培养和富集。本实验主要以C/N=0.5,总氮容积负荷(NLR)=0.9Kg-N/(m3·d)的模拟废水作为研究对象,研究分析在微氧升流式膜生物反应器中SNAD启动与其长期运行过程中的脱氮除碳效果,以及微生物菌群结构的变化。(1)在180天的启动运行期间,平均氨氮转换率达86.5%,平均出水NO2--N浓度为7.1 mg/L,平均出水NO3--N浓度为13.2 mg/L,平均TN去除率为75.2%,总氮去除负荷(NRR)为0.7 Kg-N/(m3·d),而COD去除率达到77%。(2)脱氮除碳路径计算表明,当假设亚硝酸盐氧化菌(NOB)作用可以忽略时,反硝化对总氮去除的贡献率为29.1%,厌氧氨氧化(Anammox)过程对总氮去除的贡献率达70.9%,其在总氮去除过程中占较大优势。(3)在反硝化阶段,NO2--N消耗的COD占总去除量的97%,而NO3--N消耗的COD只占总去除量的3%。考虑到NOB的作用,本实验采用([NH4+-N]inf-[NH4+-N]eff-[NO2-N]eff)/[NO3-N]eff比率,评估SNAD系统中AOB、AnAOB和NOB的作用,AOB和AnAOB的活性越高,比率越大。(4)366天的长期运行中,在稳定期氨氮去除率为68.5%,平均总氮去除率57.5%,平均COD去除率为75%。(5)在长期运行过程中,随着运行时间的增加,反应器中AnAOB菌群的含量逐渐增高和活性逐渐提升,反应器中污泥的平均粒径逐渐增长,污泥粒径 d(0.5)从 121.489μm 增加到 160.039μm,而 MLVSS/MLSS比值从0.65降到0.53。(6)通过高通量测序分析发现,在属水平上出现的厌氧氨氧化菌为Candidatus Jettenia,短程亚硝化菌为 Nitrosomonas 和 Phaeodactylibacter,反硝化菌为 Denitratisoma、noranknaerolineaceae、norank__rdenticatenia 和 Citrobacter 等。在 SNAD 系统中将混合液分为颗粒污泥与絮体污泥,其中AnAOB菌种分别占44.17%、0.79%,AOB菌种分别占0.16%、3.05%,反硝化菌的菌种分别占25.93%、18.57%。絮体污泥中的好氧菌优先消耗反应器内部的溶解氧,进而为颗粒污泥中的厌氧菌和兼性厌氧菌营造缺氧环境,实现SNAD工艺中厌氧菌,兼性厌氧菌和好氧菌共同存在。

关键词：低C/N MBR-SNAD 脱氮除碳途径微生物菌群

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What physicians should know about the management of chronic hepatitis B in children: East side story

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World Journal of Gastroenterology 2014年第13期20卷 3582-3589页

作者： Hun-Jee choe Byung-Ho choe Seoul National University College of Medicine Seoul 110-799South Korea Department of Pediatrics Kyungpook National University School of MedicineDaegu 700-721South Korea

Understanding the natural course of chronic hepatitis B virus(HBV)infection is very important for the management and treatment of chronic hepatitis B in *** on treatment guidelines,the management of HBV carriers and treatment of active hepatitis have been advancing and resulted in increased survival,as well as decreased risks of complications such as liver cirrhosis and hepatocellular *** of a continuing medical education(CME)program for primary physicians becomes an important responsibility of pediatric *** could prevent misdiagnosis and unnecessary treatment that could lead to liver complications or antiviral *** addition,education of patients and their parents is necessary to achieve better therapeutic outcomes.

关键词： Hepatitis B virus Natural course Diagnosis Treatment Lamivudine Resistance

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Fouling evaluation on membrane distillation used for reducing solvent in polyphenol rich propolis extract

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Chinese Journal of Chemical Engineering 2018年第3期26卷 477-483页

作者： Norhaziyana Hamzah choe Peng Leo School of Chemical Engineering Engineering Campus Universiti Sains Malaysia

Membrane distillation(MD) has not been widely studied in the concentrate of phenolic rich solution in comparison to osmotic distillation. In this work, the potential of MD to reduce solvent in the polyphenol rich propolis extract was further investigated. Polyvinylidene fluoride(PVDF) membranes were engineered with the smaller pore size for the less hydrophobic surface in order to avoid wetting, allowing only the solvent vapor to be transferred from the warm feed into the cold permeate. All the membranes exhibited more than 95% rejection of phenolic and flavonoid compounds. Although the hydrophilic membranes exhibited less fouling, they displayed a lower flux than the hydrophobic membrane due to the hindrance in the wetted pores. The hydrophobic membrane was seriously fouled by the phenolic acid as shown in the Fourier transform infrared spectroscopy spectrum. Pore plugging occurred on these hydrophobic membranes as confirmed in the scanning electron microscope images.

关键词： Membrane distillation Propolis Fouling

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Spontaneous high-frequency action potential

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Science China(Life Sciences) 2011年第4期54卷 311-335页

作者： Wonchae choe Department of Biochemistry and Molecular Biology Medical Research Center and Biomedical Science InstituteSchool of MedicineKyung Hee University

Action potential,which is the foundation of physiology and electrophysiology,is most vital in physiological *** work starts by detecting cardiac electrophysiology(tachyarrhythmias),combined with all spontaneous discharge phenomena in vivo such as wound currents and spontaneous neuropathic pain,elaborates from generation,induction,initiation,to all of the features of spontaneous high-frequency action potential--SSL action potential mechanism,i.e.,connecting-end hyperpolarization initiates spontaneous depolarization and action potential in somatic *** work resolves the conundrums of in vivo spontaneous discharge in tachyarrhythmias,wounds,denervation supersensitivity,neurogenic pain(hyperalgesia and allodynia),epileptic discharge and diabetic pain in pathophysiological and clinical researches that have puzzled people for a hundred years.

关键词： action potential spontaneous high-frequency action potential tachyarrhythmias atrial fibrillation wound denervation supersensitivity neurogenic pain hyperalgesia and allodynia epileptic discharge diabetic pain regeneration and development

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