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Predictive factors for early distant metastasis after neoadjuvant chemoradiotherapy in locally advanced rectal cancer

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 252-264页

作者： hyojung park Departments of Radiation Oncology Dankook University HospitalDankook University College of MedicineCheonan 46115South Korea

BACKGROUND Distant relapse is the leading cause of cancer-related death in locally advanced rectal *** chemoradiation(NACRT)followed by surgery inevitably delays delivery of systemic *** patients show early distant metastasis before systemic *** To identify the most effective *** investigated prognostic factors for distant metastasis,especially early distant metastasis,using the standard treatment paradigm to identify the most effective treatments according to recurrence *** From January 2015 through December 2019,rectal cancer patients who underwent NACRT for having clinical T 3-4 or clinical N 1-2 disease according to the 8th American Joint Committee on Cancer staging system were *** was delivered to the whole pelvis with concomitant *** received surgery 6-8 wk after completion of *** chemotherapy was administered at the physician’s *** A total of 127 patients received ***-three patients(73.2%)underwent *** R0 resection rate was 89.2%in all *** tumor and node downstaging rates were 41.9%and 76.3%.Half the patients(n=69)received adjuvant chemotherapy after *** 3-year distant metastasis-free survival(DMFS)and overall survival(OS)rates were 81.7%and 83.5%.On univariate analyses,poorly differentiated tumors,>5 cm,involvement of mesorectal fascia(MRF),or presence of extramural involvement(EMVI)were associated with worse DMFS and *** patients showed distant metastasis at their first evaluation after *** with early distant metastasis were more likely to have poorly differentiated tumor(P=0.025),tumors with involved MRF(P=0.002),and EMVI(P=0.012)than those who did *** EMVI,the involvement of MRF,and poor histologic grade were associated with early distant *** order to control distant metastasis and improve treatment outcome,selective use of neoadjuvant treatment according to indivi

关键词： Rectal cancer Neoadjuvant chemoradiotherapy Distant metastasis Extramural venous invasion

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Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature

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World Journal of Clinical Cases 2018年第16期6卷 1189-1193页

作者： hyojung park Sang Gyu Choi Departments of Radiation Oncology Dankook University Hospital Dankook University College of Medicine

BACKGROUND Primary sebaceous carcinoma of lacrimal gland(SCLG) is extremely rare. Due to its clinical characteristics, it is often misdiagnosed. It is known to be aggressive so delay in diagnosis can increase the chance of local recurrence and metastasis. We report a case of primary *** SUMMARY A 75-year-old man was referred with a painful swelling in the right eyelid. Computed tomography scan demonstrates a 2.6 cm mass in upper outer quadrant of right orbit. After the incisional biopsy of the mass, he was diagnosed with squamous cell carcinoma of lacrimal gland. A right orbital exenteration, cervical lymph node dissection was performed. There was no involvement of the overlying periorbital skin, eyelid, or conjunctiva. Histological examination of the exenteration specimen showed tumor arising from the lacrimal gland, which had been entirely replaced by sebaceous carcinoma with sarcomatous and squamous differentiation. Neoplastic cells which were large and contained prominent nucleoli. Focal tumor remained in the posterior resection margin. Patient underwent adjuvant radiotherapy, total dose of 56 Gy with doseper-fraction 2 Gy to primary lesion. There has been no sign of recurrence until 2-years *** We report a rare case of sebaceous carcinoma arising from the lacrimal gland. Accurate diagnosis of SCLG is important for appropriate treatment and prognosis prediction.

关键词： Sebaceous carcinoma Lacrimal gland Case report Radiotherapy

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Enhancement of vertical phase separation in sequentially deposited organic photovoltaics through the independent processing of additives

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Journal of Energy Chemistry 2024年第7期94卷 768-777页

作者： Damin Lee Changwoo park Gayoung Ham Young Yong Kim Sung-Nam Kwon Junyeong Lee Sungjin Jo Seok-In Na hyojung Cha Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea Department of Energy Convergence and Climate Change Kyungpook National UniversityDaegu 41566Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)PohangGyeongbuk 37673Republic of Korea Department of Flexible and Printable Electronics Jeonbuk National UniversityJeonju-siJeollabuk-do 54896Republic of Korea School of Energy Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

Herein,the impact of the independent control of processing additives on vertical phase separation in sequentially deposited (SD) organic photovoltaics (OPVs) and its subsequent effects on charge carrier kinetics at the electron donor-acceptor interface are *** film morphology exhibits notable variations,significantly depending on the layer to which 1,8-diiodooctane (DIO) was *** incidence wide-angle X-ray scattering analysis reveals distinctly separated donor/acceptor phases and vertical crystallinity details in SD ***-of-flight secondary ion mass spectrometry analysis is employed to obtain component distributions in diverse vertical phase structures of SD films depending on additive *** addition,nanosecond transient absorption spectroscopy shows that DIO control significantly affects the dynamics of separated charges in SD *** SD OPVs,DIO appears to act through distinct mechanisms with minimal restriction,depending on the applied *** study emphasizes the significance of morphological optimization in improving device performance and underscores the importance of independent additive control in the advancement of OPV technology.

关键词： Sequential deposition Vertical phase separation Charge dynamics Organic photovoltaics Nonfullerene acceptors

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Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors——8 cases: A case report

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World Journal of Gastroenterology 2019年第16期25卷 2010-2018页

作者： Jwa Hoon Kim Min-Hee Ryu Young Soo park Hyun Jin Kim hyojung park Yoon-Koo Kang Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Pathology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

BACKGROUND Intra-abdominal desmoid tumors(DTs) can mimic recurrence or progression of gastrointestinal stromal tumors(GISTs). Differential diagnosis is important to avoid unnecessary or inappropriate *** SUMMARY All 8 patients experienced surgical resection of GIST, and median time to diagnosis of DT was 1.8 years after surgical resection. All sites of DT were in the peritoneum around the surgical sites of GIST. The following clinical suspicion coupled with radiological findings contributed to the suspicion of intraabdominal DTs:(1) Occurrence of a new single lesion in the peritoneum around the surgical sites of GIST;(2) uncontrolled lesion with imatinib while other lesions being controlled with imatinib;(3) well-defined ovoid shaped lesion with delayed or mild enhancement and absence of necrosis, hemorrhage, and cystic change on computed tomography; and(4) a lesion showing mild or no hypermetabolic activity on 18 fluorodeoxyglucose-positron emission tomography,contrary to initially hyperactive lesion of GIST. All DTs were surgically removed except for one unresectable DT and only one DT recurred at another site of peritoneum, which was also surgically *** Intra-abdominal DT should be a differential diagnosis for a new single lesion in patients with GIST.

关键词： Desmoid tumor Gastrointestinal stromal tumor Radiology Surgicalresection Imatinib mesylate Case report

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