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Paradoxical carbon dioxide embolism during laparoscopic hepatectomy without intracardiac shunt:A case report

World Journal of Clinical Cases 2022年第9期10卷 2908-2915页

作者： Soeun Jeon Jeong-Min Hong Hyeon Jeong lee Yesul Kim Hyunjong Kang Boo-young Hwang Dowon lee young-hoon Jung Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Laparoscopic hepatectomy has recently become popular because it results in less bleeding than open ***,CO_(2)embolism occurs more *** CO_(2)embolisms during laparoscopic surgery are self-resolving and non-symptomatic;however,severe CO_(2)embolism may cause hypotension,cyanosis,arrhythmia,and cardiovascular *** particular,paradoxical CO_(2)embolisms are highly likely to cause neurological *** report a case of paradoxical CO_(2)embolism found on transesophageal echocardiography(TEE)during laparoscopic hepatectomy,although the patient had no intracardiac *** SUMMARY A 71-year-old man was admitted for laparoscopic left *** left hepatic vein ligation,the inferior vena cava was accidentally *** observed a sudden drop in oxygen saturation to 85%,decrease in systolic blood pressure(SBP)below 90 mm Hg,and reduction in end-tidal CO_(2)to 24 mm Hg.A“mill-wheel”murmur was auscultated over the *** fraction of inspired oxygen was increased to 100%with 5 cm H2O of positive end-expiratory pressure(PEEP)and hyperventilation was *** infusion was increased to maintain SBP above 90 mm Hg.A TEE probe was inserted,revealing gas bubbles in the right side of the heart,left atrium,left ventricle,and ascending *** surgeon reduced the pneumoperitoneum pressure from 17 to 14 mm Hg and repaired the damaged vessel ***,the patient’s hemodynamic status *** patient was transferred to the intensive care unit,recovering well without *** TEE monitoring is important to quickly determine the presence and extent of embolism in patients undergoing laparoscopic hepatectomy.

关键词： Carbon dioxide Embolism Laparoscopy Pneumoperitoneum Transesophageal echocardiography Case report

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Acupuncture for Bell's Palsy:A Systematic Review and Meta-analysis

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Chinese Journal of Integrative Medicine 2012年第1期18卷 48-55页

作者： Jong-In Kim Myeong Soo lee Tae-young Choi Hyangsook lee hyo-Jung Kwon Department of Acupuncture and Moxibustion College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea Brain Disease Research Center Korea Institute of Oriental Medicine DaejeonRepublic of Korea Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea

Objective： To assess the clinical evidence for and against acupuncture as a treatment for Bell＇s palsy. Methods： We conducted a literature search of 15 databases from their inception to December 2010 without language restrictions. We included all randomized clinical trials （RCTs） regardless of their controls. Methodological quality was evaluated using the Cochrane risk of bias assessment tool. Results： Of the 3 474 articles, only eight RCTs met our inclusion criteria. Four RCTs tested the effects of acupuncture against drug therapy on disease response rate. The meta-analysis of these data showed significant improvements in the acupuncture group [n=463, risk ratio （RR）=1.07, 95% CI： 1.02 to 1.13; P=0.006, I^2=0%]. Six RCTs tested the effects of acupuncture plus drug therapy versus drug therapy alone. The meta-analysis of this set of RCTs also showed the favorable effects of acupuncture on disease response rate （n=512, RR=1.11, 95% CI： 1.05 to 1.17; P=0.001, I^2=13%）. Conclusions： The evidence supporting the effectiveness of acupuncture for treating Bell＇s palsy is limited. The number and quality of trials are too low to form firm conclusions. Further rigorous RCTs are warranted but need to overcome the many limitations of the current evidence.

关键词： acupuncture Bell's palsy systematic review

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Epidural blood patch for spontaneous intracranial hypotension with subdural hematoma: A case report and review of literature

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World Journal of Clinical Cases 2022年第1期10卷 388-396页

作者： Se Hee Choi Youn young lee Won-Joong Kim Anesthesiology and Pain Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea Anesthesiology and Pain Medicine School of MedicineEwha Womans UniversitySeoul 07985South Korea

BACKGROUND Cerebrospinal fluid(CSF)leakage at C1/2 in spontaneous intracranial hypotension(SIH)is *** hematoma(SDH),a serious complication of SIH,may lead to neurological *** report presents a case of SDH after spontaneous C1/2 CSF leakage,which was treated with a targeted epidural blood patch(EBP).CASE SUMMARY A 60-year-old man with no history of trauma was admitted to our hospital with orthostatic headache,nausea,and *** computed tomography imaging revealed bilateral,subacute to chronic *** magnetic resonance imaging(MRI)findings were SDH with dural enhancement in the bilateral cerebral convexity and posterior fossa and mild sagging,suggesting *** the patient underwent burr hole trephination,the patient’s orthostatic headache was *** myelography led to a suspicion of CSF leakage at C1/***,we performed a targeted cervical EBP using an epidural catheter under fluoroscopic *** 5 d after EBP,a follow-up MR myelography revealed a decrease in the interval size of the CSF *** his symptoms improved,the patient still complained of headaches;therefore,we repeated the targeted cervical EBP 6 d after the initial ***,his headache had almost disappeared on the 8th day after the repeated *** Targeted EBP is an effective treatment for SDH in patients with SIH due to CSF leakage at C1/2.

关键词： Cerebrospinal fluid Chronic subdural hematoma Epidural blood patch Myelography Spontaneous intracranial hypotension Case report

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Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration

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Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： Se-Hwan lee Kang-Gon lee Jaeyeon lee Yong Sang Cho Min-Soo Ghim Soojin Kim Su-Jin Heo Yongdoo Park young-Sam Cho Bu-Kyu lee McKay Orthopaedic Research Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mechanical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mechanical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MECHABIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site,or if the bone tissue is in poor ***,an effective bone graft in terms of both osteoconductivity and osteoinductivity is required for clinical ***,the three-dimensional(3D)kagome structure has been shown to be advantageous for bone tissue regeneration due to its mechanical *** this study,a polycaprolactone(PCL)kagome-structure scaffold containing a hyaluronic acid(HA)-based hydrogel was fabricated using a 3D printing *** retention capacity of the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks,and the results were compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing HA-based hydrogel and bulk-type HA-based *** retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo imaging system *** further reinforce the osteoinductivity of the kagome-structure scaffold,a PCL kagome-structure scaffold with bone morphogenetic protein-2(BMP-2)containing HA hydrogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration characteristics were evaluated with hematoxylin and eosin(H&E),Masson’s trichrome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic hydrogel Bone morphogenetic protein-2(BMP-2)

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Hopping-Aware Cluster Header Capability for Sensor Relocation in Mobile IoT Networks

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Intelligent Automation & Soft Computing 2023年第5期36卷 1613-1625页

作者： Moonseong Kim Jaeyoung Park young-Joon Kim Woochan lee Department of IT Convergence Software Seoul Theological UniversityBucheon14754Korea Department of Computer Engineering Hongik UniversitySeoul04066Korea Department of Electronic Engineering Gachon UniversitySeongnam13120Korea Department of Electrical Engineering Incheon National UniversityIncheon22012Korea

Mobile sensor nodes such as hopping sensors are of critical importance in data ***,the occurrence of sensing holes is unavoidable due to the energy limitation of the ***,it is evident that the relocation of mobile sensors is the most desirable method to recover the sensing *** previous research conducted by the authors so far demonstrated the most realistic hopping sensor relocation scheme,which is suitable for the distributed *** previous studies,the cluster header plays an essential role in detecting the sensing hole and requesting the neighboring cluster to recover the sensing hole that occurred in the sensor ***,the limitations of the cluster header in the previously proposed relocation protocol are not fully *** the cluster header jumps more frequently than non-header nodes,its energy con-sumption is relatively high compared to other ***,it is most likely to lead to header node failure and can lead to data loss on the *** this paper,the jumping ability and energy consumption of the cluster header are seriously *** ability to replace cluster headers in case of failure is also *** results show that the data collection time can be further increased,which demonstrates the validity of the proposed algorithms.

关键词： Hopping sensor mobileinternetofthings relocationprotocol header node numericalsimulation

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Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles

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Bioactive Materials 2022年第2期7卷 20-34页

作者： Donghyun lee Soonmin Kwon Seok-young Jang Eunyoung Park Yeeun lee Heebeom Koo Department of Medical Life Sciences Department of Biomedicine&Health Sciencesand Catholic Photomedicine Research InstituteCollege of MedicineThe Catholic University of Korea222 Banpo-daeroSeocho-guSeoul06591Republic of Korea

Photodynamic therapy(PDT)has been applied in clinical treatment of tumors for a long ***,insufficient supply of pivotal factors including photosensitizer(PS),light,and oxygen in tumor tissue dramatically reduces the therapeutic efficacy of *** have received an influx of attention as drug carriers,and recent studies have demonstrated their promising potential to overcome the obstacles of PDT in tumor *** optimization for passive targeting,ligand modification for active targeting,and stimuli-responsive release achieved efficient delivery of PS to tumor *** trials using upconversion NPs,two-photon lasers,X-rays,and bioluminescence have provided clues for efficient methods of light delivery to deep *** have been made to overcome unfavorable tumor microenvironments via artificial oxygen generation,Fenton reaction,and combination with other chemical *** this review,we introduce these creative approaches to addressing the hurdles facing PDT in *** particular,the studies that have been validated in animal experiments are preferred in this review over proof-of-concept studies that were only performed in cells.

关键词： Photodynamic therapy Nanoparticle Tumor-targeting Drug delivery Tissue penetration

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Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

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Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji lee Sieun lee Sung Yong Ahn young‐Ho Ahn Jihee lee Kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

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Quantum-dot and organic hybrid light-emitting diodes employing a blue common layer for simple fabrication of full-color displays

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Nano Research 2022年第7期15卷 6477-6482页

作者： Suhyeon lee Donghyo Hahm Suk-young Yoon Heesun Yang Wan Ki Bae Jeonghun Kwak Department of Electrical and Computer Engineering Seoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center(ISRC) Seoul National UniversitySeoul 08826Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) School of Nano Science&TechnologySungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Materials Science and Engineering Hongik UniversitySeoul 04066Republic of Korea

Colloidal quantum-dot(QD)light-emitting diodes(QLEDs)have been in the forefront of future display devices due to their outstanding optoelectronic ***,a complicated solution-process for patterning the red,green,and blue QDs deteriorates the QLED performance and limits the resolution of full-color ***,we report a novel concept of QD–organic hybrid light-emitting diodes by introducing an organic blue common layer(BCL)which is deposited through a common mask over the entire *** from the optimized device structure,red and green QLEDs retained their color coordinates despite the presence of the ***,adopting the BCL improved the external quantum efficiency of green and red QLEDs by 38.4%and 11.7%,respectively,due to the Förster resonance energy transfer from the BCL to the adjacent QD *** the BCL structure,we could simply demonstrate a full-color QD-organic hybrid device in a single *** believe that this device architecture is practically applicable for easier fabrication of solution-processed,highresolution,and full-color displays with reduced process steps.

关键词： quantum-dot light-emitting diode(QLEDs) organic light-emitting diode blue common layer full-color display reduced process step

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Parameterization of below-cloud scavenging for polydisperse fine mode aerosols as a function of rain intensity

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Journal of Environmental Sciences 2023年第10期132卷 43-55页

作者： Chang Hoon Jung Hyung-Min lee Dasom Park young Jun Yoon Yongjoo Choi Junshik Um Seoung Soo lee Ji Yi lee Yong Pyo Kim Department of Health Management Kyungin Women’s UniversityIncheon 21041Korea Department of Environmental Science and Engineering Ewha Woman’s UniversitySeoulKorea Department of Environmental Engineering Konkuk UniversitySeoulKorea Korea Polar Research Institute IncheonKorea Department of Environment Hankuk University of Foreign StudiesYonginKorea Department of Atmospheric Sciences Pusan National UniversityBusanKorea Earth System Science Interdisciplinary Center University of MarylandCollege ParkMDUSA Research Center for Climate Sciences Pusan National UniversityBusanKorea Department of Chemical Engineering and Materials Science Ewha Womans UniversitySeoulKorea

The below-cloud aerosol scavenging process by precipitation is one of the most important mechanisms to remove aerosols from the *** to its complexity and dependence on both aerosol and raindrop sizes,wet scavenging process has been poorly treated,especially during the removal of fine *** makes the numerical simulation of below-cloud scavenging in large-scale aerosolmodels *** consider the slip effects of submicron particles,a simplified expression for the diffusion scavenging was developed by approximating the Cunningham slip correction *** derived analytic solution was parameterized as a simple power function of rain intensity under the assumption of the lognormal size distribution of *** resultant approximated expression was compared to the observed data and the results of previous studies including a 3D atmospheric chemical transport model *** with the default GEOS-Chem coefficient of 0.00106R0.61 and the observation-based coefficient of 0.0144R0.9268,the coefficient of a and b in∧m=aRb spread in the range of 0.0002-0.1959 for a and 0.3261-0.525 for b over a size distribution of GSD of 1.3–2.5 and a geometric mean diameter of 0.01-2.5μ***,this study showed that the scavenging coefficient varies widely by orders of magnitude according to the size distribution of particles and rain *** study also demonstrated that the obtained simplified expression could consider the theoretical approach of aerosol *** proposed analytic approach showed that results can be effectively applied for reduced computational burden in atmospheric modeling.

关键词： Below-cloud scavenging Polydisperse aerosol Parameterization Cunningham correction factor Scavenging coefficient

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Weight loss maintenance after bariatric surgery

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World Journal of Clinical Cases 2023年第18期11卷 4241-4250页

作者： young-Hye Cho youngin lee Jung In Choi Sae Rom lee Sang Yeoup lee Department of Family Medicine Pusan National University School of MedicineYangsan 50612South Korea Department of Family Medicine Pusan National University Yangsan HospitalYangsan 50612South Korea Family Medicine and Biomedical Research Institute Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Medical Education Pusan National University School of MedicineYangsan 50612South Korea

Metabolic and bariatric surgery(MBS)is an effective treatment for patients with morbid obesity and its ***,many patients experience weight regain(WR)after achieving their nadir *** the definition of WR is challenging as postoperative WR has various *** factors for WR after MBS include anatomical,racial,hormonal,metabolic,behavioral,and psychological factors,and evaluating such factors preoperatively is ***-term regular follow-up and timely treatment by a multidisciplinary team are important because WR after surgery is *** lifestyle interventions that focus on appropriate dietary education,physical activity education or interventions,and behavioral psychological interventions are suggested,more well-designed studies are needed because studies evaluating intervention methods and the effectiveness of WR prevention are *** drugs can be used to prevent and manage patients with WR after MBS;however,more research is needed to determine the timing,duration,and type of anti-obesity drugs used to prevent WR.

关键词： Metabolic and bariatric surgery Weight regain Obesity Roux-en-Y gastric bypass Laparoscopic sleeve gastrectomy

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