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Role of adjuvant chemotherapy on recurrence and survival in patients with resected ampulla of Vater carcinoma

World Journal of Gastrointestinal Oncology 2023年第4期15卷 677-688页

作者： Se Jun Park Kabsoo Shin In-Ho kim Tae Ho Hong Younghoon kim myung-ah Lee Division of Medical Oncology Department of Internal MedicineThe Catholic University of KoreaSeoul St.Mary’s HospitalSeoul 06591South Korea Department of General Surgery The Catholic University of KoreaSeoul St.Mary’s HospitalSeoul 06591South Korea Department of Pathology The Catholic University of KoreaSeoul St.Mary’s HospitalSeoul 06591South Korea

BACKGROUND Owing to rarity of disease and lack of prospective studies, data supporting the role of adjuvant chemotherapy in ampulla of Vater(AoV) carcinoma is *** To evaluate whether adjuvant chemotherapy cases for AoV carcinoma had better disease-free survival(DFS) rates than cases of observation following curative *** We retrospectively analyzed the association between adjuvant chemotherapy and DFS and overall survival(OS) in patients with stage IB-Ⅲ AoV carcinoma who underwent curative surgical resection. Fluorouracil-based adjuvant chemotherapy was administered after surgery at the discretion of the physician. Adjusted multivariate regression models were used to evaluate the association between adjuvant chemotherapy and survival *** Of the total 104 patients who underwent curative surgery, 52 received adjuvant chemotherapy. Multivariate analysis revealed that higher histologic grade [hazard ratio(HR) = 2.24, P = 0.046], advanced tumor stage(HR = 1.85, P = 0.030), and vascular invasion(HR = 2.14, P = 0.010) were associated with shorter DFS. Adjuvant chemotherapy improved DFS compared to the observation group(HR =0.50, P = 0.015) and tended to be associated with a longer OS, although the difference was not statistically significant(HR = 0.58, P = 0.098).CONCLUSION Among patients with resected AoV carcinoma, the adjuvant chemotherapy group was not associated with a significant survival benefit compared to the observation group. However, on multivariate analysis adjusting for prognostic factors, adjuvant chemotherapy following surgery was an independent prognostic factor for DFS in patients with resected AoV carcinoma. Further studies are needed to investigate the effectiveness of adjuvant chemotherapy according to histologic phenotype.

关键词： Ampulla of Vater carcinoma Adjuvant chemotherapy Prognosis Recurrence

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Internal modification in transparent hybrid germanium-silica plates using plasma formation induced by a femtosecond laser

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中国有色金属学会会刊：英文版 2012年第S3期22卷 808-812页

作者： Ji-Wook YOON Jung-Kyu PARK Kwang-Ho kim myung-Chang KANG Sung-Hak CHO Nano Machining Laboratory Korea Institute of Machinery and Materials Department of Nano-Mechatronics University of Science and Technology National Core Research Center for Hybrid Materials Solution Pusan National University

The fabrication of an internal diffraction grating with photoinduced refractive index modification in planar hybrid germanium-silica plates was demonstrated using low-density plasma formation excited by a high-intensity femtosecond (150 fs) Ti:sapphire laser (λp=790 nm).The refractive index modifications with diameters ranging from 400 nm to 3 μm were photoinduced after plasma formation occurred upon irradiation with peak intensities of more than 2×1013 W/*** graded refractive index profile was fabricated to be a symmetric around from the center of the point at which low-density plasma occurred.

关键词： diffraction grating refractive index modification plasma formation hybrid germanium-silica plate femtosecond laser

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Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era （from KAMIR-NIH registry）

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Journal of Geriatric Cardiology 2018年第9期15卷 574-584页

作者： Dae-Won kim Sung-Ho Her Ha Wook Park Kiyuk Chang Wook Sung Chung Ki Bae Seung myung Ho Jeong hyo-Soo kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae kim Young Jo kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung Division of Cardiology Daejeon St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Division of Cardiology Seoul St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Chonnam National University Hospital Gwangju South Korea Seoul National University Hospital Seoul South Korea Sungkyunkwan Universtiy Samsung Medical Center Seoul South Korea Chungnam National University Hospital Daejeon South Korea Chungbuk National University Hospital Cheongju South Korea Kyungpook National University Hospital Daegu South Korea Keimyung University Dongsan Medical Center Daegu South Korea Yeungnam University Hospital Daegu South Korea Pusan National University Hospital Busan South Korea Wonkwang University Hospital Iksan South Korea Chonbuk National University Hospital Jeonju South Korea Statistical Manager Institute of Toxicology Daejeon South Korea

Objectives To evaluate the age-related one-year major adverse cardiocerebrovascular events （MACCE） after percutaneous coronary intervention （PCI） in acute myocardial infarction （AMI）. We analyzed the association between age and one-year MACCE after AMI. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institue of Health （KAMIR-NIH） between November 2011 and December 2015 were classified into four groups according to age （Group I, 〈 60 years, n = 4199; Group II, 60-70 years, n = 2577; Group III; 70-80 years, n = 2774; Group IV, ≥ 80 years, n = 1018）. Patients were analyzed for one-year composite of MACCE （cardiac death, myocardial infarction, target vessel revascularization, cerebrovascular events） after AMI. Results The one-year MACCE in AMI were 3.5% （Group I）, 6.3% （Group II）, 9.6% （Group III） and 17.6% （Group IV）. After adjustment for confounding para- meters, the analysis results showed that patients with AMI had incremental risk of one-year MACCE [Group II, adjusted hazard ratios （aHR） = 1.224, 95% CI： 0.965-1.525, P = 0.096; Group III, aHR = 1.316, 95% CI： 1.037-1.671, P= 0.024; Group IV, aHR = 1.975, 95% CI： 1.500-62.601, P〈 0.001） compared to Group I. Especially, cardiac death in the composite of primary end point played a major role in this effect （Group II, aHR = 1.335, 95% CI： 0.941-1.895, P= 0.106; Group III, aHR = 1.575, 95% CI： 1.122-2.210, P= 0.009; Group IV, aHR = 2.803, 95% CI： 1.937-4.054, P 〈 0.001）. Conclusions Despite advanced techniques and medications for PCI in AMI, age still exerts a powerful influence in clinical outcomes. Careful approaches, even in the modem era of developed cardiology are needed for aged-population in AMI intervention.

关键词： Acute myocardial infarction Aged-population Major adverse cardiocerebrovascular events

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The contribution of gender and age on early and late mortality following ST-segment elevation myocardial infarction： results from the Korean Acute Myocardial Infarction National Registry with Registries

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Journal of Geriatric Cardiology 2018年第3期15卷 205-214页

作者： Ae-Young Her Etm-Seok Shin Yong Hoon kim Scot Garg myung Ho Jeong Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea Department of Cardiology Ulsan University Hospital University of Ulsan College of Medicine Ulsan Republic of Korea East Lancashire Hospitals NHS Trust Blackburn Lancashire UK The Heart Center of Chonnam National University Hospital Gwangju Republic of Korea

Background Although previous studies using Korean data have already reported higher rates of mortality in women, it is less clear whether these gender differences in prognosis post ST-segment elevation myocardial infarction （STEMI）, are age dependent. The aim of this study is to examine the gender-age interaction with early and late mortality in patients with STEMI enrolled in the Korean nationwide regis-try. Methods This prospective study stratified outcomes according to gender and age from 17,021 STEMI patients. We compared in-hospital, early （30 days） and late （12 months） mortality between gender to examine the gender-age interaction in multivariable models. Results In younger women （〈 60 years）, in-hospital [5.8% vs. 2.5%, P 〈 0.001; unadjusted odds ratios （OR）： 2.41, 95% confidence inter-vals （CI）： 1.59-3.66], early （6.2% vs. 2.6%, P 〈 0.001; unadjusted OR： 2.4, 95% CI： 2.12-2.72） and late mortality （7.0% vs. 3.1%, P 〉 0.001; unadjusted OR： 2.33, 95% CI： 2.08-2.61） were significantly higher compared with men. However, after adjustment for patient characteristics, Killip class ≥ 3, symptom to balloon time and major bleeding, and in-hospital bleeding, overall early and late mortality were no longer re-lated to gender in any age groups. Conclusions Among a Korean population with STEMI, higher early and late mortality in younger women may be explained by poor patient characteristics, higher Killip class ≥3, longer symptom to balloon time and more frequent major bleeding. Therefore, based on gender-age differences, more precise and aggressive preventive strategies focused on risk factor reduction, education and more intensive management for yotmger women should be performed.

关键词： Age Gender Mortality ST-segment elevation myocardial infarction

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Greenhouse gas emission reduction in public buildings according to greenhouse gas reduction policies in Daegu

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Journal of Chongqing University 2012年第1期11卷 36-43页

作者： kim hyo-kyung YEO myung-kil JEON Gyu-yeob HONG Won-hwa kim Kwang-woo School of Architecture and Civil Engineering Kyungpook National UniversityDaegu 702-701Republic of Korea Jeju National University Jeju 690-756Republic of Korea Seoul National University Seoul 158-867Republic of Korea

The issues related to climate change such as depletion of energy resources and continuous high oil prices,global warming,and development of clean energy are adopted and discussed as a national agenda *** cope with these domestic and foreign energy and environmental problems actively,government must prepare prudently in methodology of greenhouse gas ***,as energy consumption of buildings accounts for 26 of national consumption,plans to reduce energy consumption of buildings are *** region has a unique nature of energy consumption or consumption patterns,thus an appropriate policy or goal to reduce greenhouse gas (GHG) should be *** this,effects on the current policies for GHG as well as nature of energy consumption of buildings should be *** analyzed quantitatively the effectiveness of policies to reduce GHG emission in public buildings.

关键词： Daegu public buildings Rreenhouse gas emission reduction oolicies

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Incidental frontoparietal parasagittal meningioma in a patient with acute bilateral optic neuritis

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 1064-1066页

作者： Su-Ho Lim Sung-Hyuk Moon myung-Mi kim Department of Ophthalmology Daegu Veterans Health Service Medical Center Department of Ophthalmology Yeungnam University College of Medicine Department of Ophthalmology Inje University Busan Paik Hospital

Dear Sir,Bilateral optic neuritis is not a rare condition in children following a viral syndrome[1].In contrast,simultaneous bilateral optic neuritis without known systemic disease has been considered a rare condition in adults[2].In addition,incidental extra-axial meningioma in a patient with bilateral optic neuritis has not been *** authors present a first case report on incidental parasagittal meningioma with bilateral optic neuritis.

关键词： Figure NMO

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Prevalence and prognosis of acute pancreatitis in critically ill patients with COVID-19

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 399-402页

作者： Dongju Kang SuHo Park Changkyo Oh YuJin kim JinBae kim SangHoon Park myung Seok Lee JaeKeun Park Department of Internal Medicine Kangnam Sacred Heart HospitalHallym University College of MedicineSeoul 07441Korea

Background:Coronavirus disease 2019(COVID-19)is a global pandemic *** addition to the well-known respiratory and fever symptoms,gastrointestinal symptoms have also been *** study aimed to evaluate the prevalence and prognosis of patients with COVID-19 infection complicated with acute pancreatitis in intensive care unit(ICU).Methods:This was a retrospective observational cohort study,and patients aged 18 years or older,ad-mitted into the ICU in a single tertiary center from January 1,2020,to April 30,2022 were *** were identified by electronic medical records and reviewed *** primary outcome was the prevalence of acute pancreatitis among ICU patients with *** secondary outcomes were the length of hospital stay,need for mechanical ventilation(MV),need for continuous renal replacement therapy(CRRT),and in-hospital ***:A total of 4133 patients,admitted into the ICU,were *** these patients,389 were infected by COVID-19,and 86 were diagnosed with acute ***-19 positive patients were more likely to present with acute pancreatitis than COVID-19 negative patients(odds ratio=5.42,95%confidence interval:2.35-6.58,P<0.01).However,the length of hospital stay,need for MV,need for CRRT,and in-hospital mortality were not significantly different between acute pancreatitis patients with and without COVID-19 ***:Severe COVID-19 infections may cause acute pancreas damage in critically ill ***-ever,the prognosis may not differ between acute pancreatitis patients with and without COVID-19 infec-tion.

关键词： Acute pancreatitis COVID-19 Coronavirus infections Intensive care unit

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Development of a Concentration Measurement Technique for Steady State Solid-liquid Mixing using a Neural Network

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Journal of Thermal Science 2013年第5期22卷 478-483页

作者： Deog Hee Doh Joo Ho Yum Gyeong Rae Cho myung Ho kim Gyong Won Ryu Masahiro Takei Division of Mechanical and Energy Systems Engineering Korea Maritime UniversityYeongdo-gu Busan Korea Graduate School Korea Maritime UniversityYeongdo-gu Busan Korea R&D Institute-5 Agency for Defense DevelopmentJochiwongil 462Yuseong Daejeon 305-152 Korea Graduate School of Mechanical Engineering Artificial Science Division Chiba UniversityJapan

A measurement technique that can measure the concentration of the solid particles in liquid flow was *** measurement system consists of a color camera and three LCD *** solid particles were put at the bottom of a cylindrical mixing tank in which JetA1 oil was *** mixing of the solid particles was performed by rotating a propeller type agitator with three different rotation speed(500,600,700 r/min).Mixing state was visualized by the LCD displays and a color *** color intensity of the glass particles changes with their *** color information was decoded into three principle colors R,G,and B so that,the calibration curve of color-to-concentration was performed using these information.A neural network was used for this *** transient concentration field of the solid particles was quantitatively visualized.

关键词： Solid particles JetA1 oil Transient mixing Neural Network Concentration

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Functions of hepatic non-parenchymal cells in alcoholic liver disease

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Liver Research 2019年第2期3卷 80-87页

作者： Won-Mook Choi myung-Ho kim Won-Il Jeong Laboratory of Liver Research Graduate School of Medical Science and EngineeringKorea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Gastroenterology Liver CenterAsan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

Alcoholic liver disease(ALD)represents a wide spectrum of disease from simple steatosis to *** there have been multiple attempts to treat ALD,its treatment is still based on abstinence from alcohol and using corticosteroids in specified ***,nearly 40%of patients with ALD who are in need of treatment are unresponsive to the current treatments,which implies a new paradigm shift for the treatment of ***,earlier studies have focused on the abnormal metabolism occurring in the hepatocytes as a protagonist in the pathogenesis of ***,increasing evidence suggests that non-parenchymal cells,such as hepatic stellate cells(HSCs),Kupffer cells,liver sinusoidal endothelial cells,and immune cells around the hepatocytes have critical roles in multiple stages of ALD either by direct or indirect cell-to-cell *** instance,in the early stage of ALD,Kupffer cells and HSCs located closely to hepatocytes contribute to the development of alcoholic steatosis and inflammation through the secretion of various inflammatory cytokines(immunologic pathways)and the activation of the endocannabinoid system(metabolic pathways).While the stage of ALD progresses to alcoholic hepatitis and fibrosis,various cell-to-cell interactions with infiltrating immune cells become highly significant at the multicellular *** review explains the diverse roles of non-parenchymal cells in the progression of ALD,as well as potential therapeutic strategies to treat ALD.

关键词： Alcoholic liver disease(ALD) Hepatic stellate cell(HSC) Immune cell Kupffer cell Natural killer(NK)cell Steatosis Steatohepatitis Fibrosis

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Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates

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World Journal of Gastroenterology 2014年第4期20卷 1061-1066页

作者： Seung Bae Yoon Jae myung Park Jong-Yul Lee Myong Ki Baeg Chul-Hyun Lim Jin Soo kim Yu Kyung Cho In Seok Lee Sang Woo kim myung-Gyu Choi Division of Gastroenterology Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To investigate whether proton pump inhibitor (PPI) pretreatment influences Helicobacter pylori eradication rate.

关键词： Proton pump inhibitor Helicobacter pylori Urea breath test Antibiotics Drug resistance

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