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Clinical effectiveness of diquafosol ophthalmic solution 3%in Korean patients with dry eye disease:a multicenter prospective observational study

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1518-1526页

作者： Youngsub Eom hyo myung kim Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea Department of Ophthalmology Korea University Ansan HospitalGyeonggi-do 15355Republic of Korea Department of Ophthalmology Korea University Anam HospitalSeoul 02841Republic of Korea

AIM:To investigate the effectiveness of diquafosol ophthalmic solution 3%administered in Korean patients with dry eye disease in real-world clinical ***:Diquafosol was administered for 8 wk to 3 patient groups who received diquafosol as add-on therapy to existing medication(Add group,n=150);received diquafosol only(Monotherapy group,n=196);or discontinued part of their existing medication in favor of diquafosol(Switch group,n=11).Tear break-up time(TBUT),cornea and conjunctival staining based on National Eye Institute/Industry scoring scheme,subjective symptoms using the Ocular Surface Disease Index(OSDI)questionnaire,and meibum quality and expressibility were evaluated at baseline,week 4,and week ***:The mean TBUT increased(from 3.46,3.92,and 5.84 s,respectively,to 5.15,5.53,and 8.59 s,respectively)and corneal staining score decreased(from 2.23,2.24,and 3.09,respectively,to 0.85,0.97,and 1.64,respectively)in a time-dependent manner from baseline to week 8 in all three *** staining score,OSDI questionnaire,and meibum quality and expressibility improved over time from baseline to week 8 in the Add and Monotherapy groups,but differences were not statistically significant in the Switch ***:Diquafosol improves subjective symptoms and objective signs in patients treated with existing medicines combined with diquafosol and treated solely with *** can be used as an effective therapeutic agent for dry eye disease or additionally applied in patients who have insufficient response to existing medicines.

关键词： dry eye disease diquafosol ophthalmic solution routine clinical practice

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Effect of natural extract eye drops in dry eye disease rats

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1023-1030页

作者： Soo Youn Choi Youngsub Eom Jee Yong kim Dong Hoon Jang Jong Suk Song hyo myung kim Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea BGN World Tower Eye Clinic Seoul 05551Republic of Korea Department of Ophthalmology Korea University Ansan HospitalKorea University College of MedicineGyeonggi-do 15355Republic of Korea Medical O Co. Ltd.Seoul 06025Republic of Korea

AIM:To investigate the therapeutic effect of natural extract eye drops containing bee venom,musk,and deer antlers in dry eye disease(DED)animal ***:Scopolamine-injected DED rats and lacrimal gland-excised rats were allocated into control,saline,and natural extract groups respectively and a normal group(lacrimal gland excision was not performed)in lacrimal gland-excised *** eye drop instillation 4 times a day for 5 d,corneal fluorescein staining(CFS)scores,tear MUC5AC levels,and tear lactic dehydrogenase(LDH)levels were ***:In scopolamine-injected rats,the natural extract-treated group had significantly lower CFS scores(1.7±0.5,4.7±1.4,3.8±1.9,P=0.006)and tear LDH levels(0.10±0.01,0.19±0.01,0.16±0.08 OD,P=0.014)but higher tear MUC5AC levels(12.9±3.7,7.9±2.0,9.7±3.6 ng/m L,P=0.041)compared with the control and saline-treated *** were no significant differences between the control and saline-treated *** lacrimal gland-excised rats,the natural extract-treated group also had lower CFS scores(4.3±1.2,11.5±2.3,9.0±1.9,P<0.001,P=0.001)and tear LDH levels(0.30±0.08,0.48±0.12,0.39±0.05 OD,P<0.05)but higher tear volume(4.3±0.9,1.9±0.7,2.8±1.1 mm,P=0.005,P=0.124)and tear MUC5 AC levels(8.2±2.0,2.9±1.2,5.4±2.2 ng/m L,P<0.001,P=0.047)compared with the control and saline-treated *** were no significant differences in the CFS scores,tear MUC5AC level,and tear LDH level between the normal and natural extracttreated ***:The natural extract consisting of bee venom,musk,and deer antlers may have effectiveness in DED treatment by restoring the damaged ocular surface,increasing tear volume,and recovering the tear mucin layer in DED rats.

关键词： bee venom musk deer antler natural extract dry eye disease rat

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Rainbow halos occur less following implantation of extended range of vision one-piece intraocular lenses vs diffractive bifocal intraocular lenses

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 913-919页

作者： Jae-hyung kim Youngsub Eom Seo Yeon Park Soo Youn Choi Ho Sik Hwang Jun-Heon kim Jong Suk Song hyo myung kim Seoul Daabom Eye Center Cheongju 28568Republic of Korea Department of Ophthalmology Ansan HospitalKorea University College of Medicine.Seoul 15355Republic of Korea BGN World Tower Eye Clinic Seoul 05551Republic of Korea Department of Ophthalmology Yeouido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 07345Republic of Korea Joeunnun Vision Clinic Seoul 06134Republic of Korea

AIM:To evaluate clinical outcomes following implantation of an extended range of vision intraocular lens(IOL),the ZXR00,and a diffractive multifocal IOL with+2.75 diopters(D)add power,the ***:Totally 30 patients who underwent either bilateral implantation of the ZXR00 IOL with intended emmetropia(ZXR00 emmetropia group:20 eyes)and intended micromonovision(ZXR00 monovision group:20 eyes),or bilateral implantation of the ZKB00 IOL with intended emmetropia(ZKB00 group:20 eyes)were included in this *** acuity at 4 m,80,and 40 cm;and the types of halos(misty,fine,and rainbow)were analyzed at one and three months after ***:There were no significant differences in distance visual acuity among the three *** mean uncorrected intermediate visual acuity was better in the ZXR00 emmetropia and monovision groups(0.02 logMAR and 0.02 logMAR,respectively)than in the ZKB00 group(0.14 logMAR).The mean uncorrected near visual acuity was worse in the ZXR00 emmetropia group(0.26 logMAR)than in the ZXR00 monovision and ZKB00 groups(0.12 logMAR and 0.10 logMAR,respectively).There was an increased incidence of rainbow halos in the ZKB00 group vs in either ZXR00 group(P=0.033).CONCLUSION:Implantation of the ZXR00 IOL with intended micromonovision provide superior visual acuity than implantation of the ZXR00 IOL with intended *** ZXR00 IOLs tend to show a lower incidence of rainbow halos than did the ZKB00 IOL.

关键词： halos intraocular lens diffractive bifocal multifocal rainbow halos

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Pseudomembranous conjunctivitis in a patient with DRESS syndrome

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 309-311页

作者： Young Joo Lee Youngsub Eom Seo Yeon Park Jung Jin Shin Young Choi Jong Suk Song hyo myung kim Department of Ophthalmology Korea University Ansan HospitalGyeonggi-do 15535Republic of Korea Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea Department of Ophthalmology Emory University School of MedicineAtlantaGA 30322USA BGN Jamsil Lotte Tower Eye Clinic Seoul 05551Republic of Korea Department of Dermatology Korea University Ansan HospitalGyeonggi-do 15355Republic of Korea Shin’s Eye Clinic Chungcheongnam-do 31513Republic of Korea

Dear Editor,Drug rash with eosinophilia and systemic symptoms(DRESS)syndrome is a drug reaction featuring high fever,eosinophilia,skin rashes,and multi-organ involvement that may be *** manifestations,including cicatrizing conjunctivitis,corneal infiltration,and anterior uveitis,are rarely reported[1-6]but may cause serious complications if ***,it is important to diagnose DRESS syndrome in patients with ocular features promptly with appropriate *** article reports a case diagnosed with DRESS syndrome associated with pseudomembranous conjunctivitis secondary to carfilzomib.

关键词： membranous conjunctivitis involvement

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A new dimmer for alternating-current directly driven light-emitting-diode lamp

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Journal of Central South University 2012年第2期19卷 374-379页

作者： kim Jong-hyun RYU myung-hyo YOON hyok-min SONG Eui-ho School of Mechatronics Changwon National University

A new dimmer using a mental-oxide-semiconductor field-effect transistor (MOSFET) for alternating-current (AC) directly driven light-emitting-diode (LED) lamp was presented. The control method of proposed dimmer is pulse width control (PWM) method. Compared with the conventional phase-controlled dimmer, the proposed PWM dimmer can produce sine wave and did not cause harmonics problem. Furthermore, the proposed control method did not amplify the light flicker due to the independence of input voltage. Therefore, the PWM dimmer can be used as the dimmer of the AC LED lamp instead of the conventional phase-controlled dimmer. The experimental result shows that the proposed PWM dimmer has good performances.

关键词： alternating-current directly driven light-emitting-diode pulse width control total harmonic distortion flicker triac

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A New FIR Filter for State Estimation and Its Application

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Journal of Computer Science & Technology 2007年第5期22卷 779-784页

作者： Pyung-Soo kim myung-Eui Lee Department of Electronics Engineering Korea Polytechnic University Shiheung CityKgunggi-DoKorea School of Information Technology Korea University of Technology and Education Cheonan City Chungnam-DoKorea

This paper proposes a new FIR （finite impulse response） filter under a least squares criterion using a forgetting factor. The proposed FIR filter does not require information of the noise covariances as well as the initial state, and has some inherent properties such as time-invariance, unbiasedness and deadbeat. The proposed FIR filter is represented in a batch form and then a recursive form as an alternative form. Prom discussions about the choice of a forgetting factor and a window length, it is shown that they can be considered as useful parameters to make the estimation performance of the proposed FIR filter as good as possible. It is shown that the proposed FIR filter can outperform the existing FIR filter with incorrect noise covariances via computer simulations. Finally, as a useful application, an image sequence stabilization problem is considered. Through this application, the FIR filtering based approach is shown to be superior to the Kalman filtering based approach.

关键词： state estimation FIR (finite impulse response) filter Kalman filter least squares forgetting factor

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Microstructure and Mechanical Properties of Hyper-eutectic Al-Si Alloys Fabricated by Spray Casting

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Journal of Materials Science & Technology 2008年第1期24卷 48-50页

作者： Min Ryou Chul-Hyun kim myung-Ho kim School of Materials Science and Engineering Inha University 253 Yonghyun-DongNam-GuIncheon 402-751Korea Dong Yang Piston Co. LTD 1050Singil-DongDonwon-GuAnsanKyungki-DoKorea

Microstructure and mechanical properties of hyper-eutectic Al-Si alloy fabricated by spray casting were in- vestigated and then these results were compared with those by squeeze *** spray-cast specimen was found to have finer Si particles （～5μm） compared to the squeeze-cast specimen （10-25μm）.The tensile strength and elongation of the spray-cast specimen are also higher than those of the squeeze cast *** was considered that the increased mechanical properties of the spray-cast specimen were mainly due to finer size of the Si particles distributed in Al matrix.

关键词： Hyper-eutectic Al-Si alloy Squeeze casting Spray casting

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Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN kim YUN SUN LEE SEUNG myung DONG hyo JUNG kim DA EUN LEE HYEON WOONG KANG MYEONG JIN kim JOON SEONG PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

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Species delimitation in the green algal genus Codium (Bryopsidales) from Korea using DNA barcoding

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Acta Oceanologica Sinica 2015年第4期34卷 114-124页

作者： LEE Hyung Woo kim myung Sook Department of Biology Jeju National University

Codium, one of the largest marine green algal genera, is difficult to delimit species boundary accurately based on morphological identification only. DNA barcoding is a powerful tool for discriminating species of seaweeds. The plastid elongation factor TU （tufA） is considered as maker to perform DNA barcoding of green algal species than rbcL gene due to universality and rapid evolution rate. We conducted DNA barcoding application to Codium specimens from the Jeju Island, Korea to overcome the limit of morphological identification and to confirm the species diversity. As a result of applying tufA marker, we newly generated fifty-five tufA barcodes to resolve eight species. TufA marker exhibited 6.1%–21.8% interspecific divergences, wider than the gap of rbcL exon 1, 3.5%–11.5%. Molecular analysis of rbcL exon 1 sequences of Codium revealed eight distinct species like tufA analysis separated in five phylogenetic groups. DNA barcoding of the genus Codium using tufA marker is more helpful to overcome the limit of morphological identification, and this is more potential to reveal cryptic species and to resolve the relationships among subspecies than rbcL analysis alone. The complement of tufA barcoding and rbcL analyses including morphology for the genus Codium in the northwestern Pacific will give much more reliable achievement for discovering species diversity and resolving the phylogenetic relationships.

关键词： Codium DNA barcoding rbcL Species delimitation tufA

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Optimal design considering structural efficiency of compressed natural gas fuel storage vessels for automobiles

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 199-204页

作者： myung-Chang KANG Hyung Woo LEE Chul kim National Core Research Center for Hybrid Materials Solution Pusan National University Research Institute of Mechanical Technology Pusan National University

The shape and thickness of the dome were investigated with the aim of optimizing the type II CNG storage vessels by using a finite element analysis technique. The thickness of the liners and reinforcing materials was optimized based on the requirement of the cylinder and dome parts. In addition, the shape of the dome, which is most suitable for type lI CNG storage vessels, was proposed by a process of review and analysis of various existing shapes, and the minimum thickness was established in this sequence： metal liners, composite materials and dome parts. Therefore, the new proposed shape products give a mass reduction of 4.8 kg（5.1%）

关键词： CNG fuel storage vessel mechanical property dome part bursting structural analysis

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