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糖尿病与唾液中DNA、蛋白质和脂类氧化损伤

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甘肃医药 2011年第1期30卷 1-6页

作者：苏海翔 Ana M.Velly Mark Trifiro hyman M.schipper Mervyn Gornitsky 甘肃省医学科学研究院甘肃省肿瘤医院甘肃兰州730050 Lady Davis医学研究所麦吉尔大学神经科学和神经外科学系麦吉尔大学牙科系蒙特利尔犹太总院牙科明尼苏达大学诊断和生物科学系美国明尼阿波利斯市55455 蒙特利尔犹太总院内分泌科麦吉尔大学内科系

目的:观察糖尿病是否与唾液中氧化还原动态平衡的改变相关。方法:用ELISA方法分析148名糖尿病患者和475名对照的非刺激性唾液中氧胁迫损伤标志物8-羟基-2′-脱氧鸟苷(8-hydroxy-2'-deoxyguanosine,8-OHdG)、蛋白质羰基(Protein carbonyl... 详细信息

目的:观察糖尿病是否与唾液中氧化还原动态平衡的改变相关。方法:用ELISA方法分析148名糖尿病患者和475名对照的非刺激性唾液中氧胁迫损伤标志物8-羟基-2′-脱氧鸟苷(8-hydroxy-2'-deoxyguanosine,8-OHdG)、蛋白质羰基(Protein carbonyls,PC)和8-异前列腺素F2α(8-epi-prostaglandin-F2α,8-epi-PGF2α)的含量。用逻辑相关分析的统计学方法分析氧胁迫损伤指标与使用胰岛素、二甲双胍和餐饮控制糖尿病患者之间的相关性。结果:(i)与对照组相比糖尿病组唾液中的Log8-OHdG、LogPC和Log8-epi-PGF2α明显升高;(ii)I型糖尿病组唾液中的LogPC明显较对照组高,II型糖尿病组Log8-OHdG、LogPC和Log8-epi-PGF2α均较对照组有明显升高;(iii)二甲双胍治疗组和单纯餐饮控制的糖尿病组唾液Log8-OHdG和LogPC水平较高;(iv)单纯胰岛素治疗组和胰岛素及二甲双胍联合治疗组唾液LogPC水平高于对照组;(v)多变量分析和条件逻辑回归分析表明Log8-OHdG、LogPC、Log8-epi-PGF2α和糖尿病间存在明显的相关性。结论:糖尿病患者唾液中氧化性DNA、脂类和蛋白质损伤产物8-OHdG、8-epi-PGF2α、PC水平均明显升高,表明存在唾液中的氧化还原动态平衡紊乱。唾液氧胁迫指标的分析有可能成为一种新的疾病监测方式,并且提示一种疾病干预的新途径。

关键词：糖尿病氧胁迫 8-羟基-2′-脱氧鸟苷蛋白质羰基 8-异前列腺素F2α

AB038. Pathological neovascularization in retinopathy of prematurity is regulated by heme-derived iron trafficking

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Annals of Eye Science 2019年第1期 213-213页

作者： Tapan Agnihotri Nicholas Kim Gael Cagnone Jin Sung Kim Emilie Heckel Sheetal Pundir Perrine Gaub Florian Wunnemann Walter Szarek hyman schipper Jean-Sebastien Joyal Department of Pharmacology and Therapeutics McGill UniversityMontréalQCCanada Department of Pediatrics Pharmacology and OphthalmologyCHU Sainte-Justine Research CenterUniversitéde MontrealMontréalQCCanada Department of Chemistry Queen’s UniversityKingstonONCanada

Background:Retinopathy of prematurity(ROP)is an eye disease of the immature newborn characterized by pathological neovascularization(NV).ROP classically arises due to changes in oxygen availability in the ***,other factors,such as red blood cell(RBC)transfusion,independently contribute to disease *** molecules,rich in RBC,are the primary source of endogenous *** is metabolized by heme oxygenase(HO)into biliverdin,carbon monoxide,and ferrous *** iron levels stabilize hypoxia-inducible factor 1α(HIF1α),the main transcription factor of vascular endothelial growth factor(VEGF)that drives *** we investigate the role of heme metabolism in pathological ***:ROP was studied using the well-characterized oxygen-induced retinopathy(OIR)mouse ***-type(WT)pups are exposed to high oxygen concentrations(FiO275%)for 5 days,from the post-natal day(P)7 to 12,and subsequently returned to room air until retinal collection at P12,P14,&*** are then analyzed via single-cell RNAseq,RT-qPCR,western blot,Prussian blue staining,and immunostaining techniques to elucidate the effect of OIR on iron metabolism and *** OIR,we quantified vaso-obliteration(VO)and pathologic neovascular(NV)areas at P17 to assess the effects of1 Hmox1 competitive inhibition,and2Hmox1 allosteric ***:Iron trafficking genes across different retinal cell-types were upregulated in OIR,including CP,FTH1,IREB2,TF,and ***,Prussian blue staining suggests iron accumulation in retinal vessels exposed to ***1 mRNA(n=7,P<0.01 at P17)and protein expression(n=3,P<0.05)were increased 3.8-fold from P12 to *** and single-cell RNAseq confirmed that Hmox1 predominantly resides in retinal microglial *** and allosterically Hmox1 inhibition decreased NV by 15%(n=15,P=0.02)and 60%(n=5,P<0.01)***:Iron metabolism has seldom been explored in the context of *** microglial heme metabolis

关键词： Retinopathy of prematurity(ROP) iron metabolism microglia

Construction of a nano-rectangular Zn-Nd complex with near-infrared luminescent response towards metal ions

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Chinese Chemical Letters 2021年第1期32卷 569-572页

作者： Xia Liu Xiaoping Yang Yanan Ma Jieni Liu Dongliang Shi Desmond schipper College of Chemistry and Materials Engineering Zhejiang Key Laboratory of Carbon MaterialsWenzhou UniversityWenzhou 325035China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Department of Chemistry and Biochemistry The University of Texas at AustinAustin 78712United States

One 6-metal Zn-Nd complex[Zn_(2)Nd_(4)L_(2)(OAc)_(10)(OH)_(2)(CH_(3)OH)_(2)](1)with Schiff base ligand bis(3-methoxysalicylidene)ethylene-1,2-phenylenediamine(H_(2)L)was constructed,and it has nanoscale rectangular structure(8×11×28 A).Excited by ligand-centered absorption bands,1 shows NIRemission of Nd^(3+)***,1 exhibits lanthanide luminescent response towards metal ions,especially to alkali metal ions(Li^(+),Na^(+) and K^(+))at ppm level.

关键词： Construction Zn-Ln complexes Schiff base ligand NIR luminescence properties Luminescent response

Construction of an Octanuclear Zn(Ⅱ)-Yb(Ⅲ)Schiff Base Complex for the NIR Luminesce nt Sensing of Nitrofuran Antibiotics

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Chinese Journal of Chemistry 2021年第8期39卷 2083-2087页

作者： Mengyu Niu Xiaoping Yang Yanan Ma Chengri Wang Wenxin Hao Dongliang Shi Desmond schipper College of Chemistry and Materials Engineering Wenzhou UniversityWenzhouZhejiang 325035China Department of Chemistry and Biochemistry The University of Texas at Austin1 University Station A5300AustinTexas78712United States

One near-infrared(NIR)luminescent octanuclear Zn(Ⅱ)-Yb(Ⅲ)complex[Zn_(6)Yb_(2)L_(4)(OAc)_(2)(DMF)EtOH](1)was obtained from a new multidentate Schiff base *** exhibits interesting luminescent sensing activity to antib... 详细信息

关键词： Zn(Ⅱ)-Yb(Ⅲ)complex Schiff base Near-infrared(NIR)luminescence Luminescent sensing Antibiotics

Validity of Amontons's law for run-in short-cut aramid fiber reinforced elastomers:The effect of epoxy coated fibers

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Friction 2020年第3期8卷 613-625页

作者： M.KHAFIDH D.J.schipper M.A.MASEN N.VLEUGELS W.K.DIERKES J.W.M.NOORDERMEER Faculty of Engineering Technology University of TwenteEnschede 7500AEThe Netherlands Dutch Polymer Institute Eindhoven 5600AXThe Netherlands Department of Mechanical Engineering Universitas Islam IndonesiaYogyakarta 55584Indonesia Department of Mechanical Engineering Imperial College LondonLondon SW72AZUnited Kingdom

Friction between two contacting surfaces is studied *** of the k n o w n friction theories is Amontons,law which states that the friction force is proportional to the normal ***,Amontons7 law has been found to be invalid for *** the present study,the validity of Amontons7 law for short-cut aramid fiber reinforced elastomers is *** types of fillers are used to reinforce the elastomers,namely highly dispersible silica and short-cut aramid ***-cut aramid fibers with two different surface treatments are used,namely non-reactive fibers with standard oily finish(SF-fibers)and fibers treated with an epoxy coating(EF-fibers).A pin-on-disc tribometer is used to investigate the frictional behavior of the composites in sliding contact with a granite counter *** results show that,after the run-in phase,Amontons,law is valid for those composites that are reinforced by short-cut aramid fibers(without reinforcing filler,i.e.,silica)if the contact pressure is below a threshold ***,once the contact pressure exceeds this threshold value,Amontons'law will be *** threshold contact pressure of the composites containing EF-fibers is higher than of the composites containing *** composites that are reinforced by silica and short-cut aramid fibers do not follow Amontons7 law.

关键词： Amontons's law elastomer epoxy coated fiber short-cut aramid fiber

Baird’s tapir density in high elevation forests of the Talamanca region of Costa Rica

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Integrative Zoology 2012年第4期7卷 381-388页

作者： JoséF.GONZÁLEZ-MAYA Jan schipper Beth POLIDORO Annelie HOEPKER Diego ZÁRRATE-CHARRY Jerrold L.BELANT Sierra to Sea Institute ProCAT Internacional/ColombiaLas AlturasCoto BrusPuntarenasCosta Rica Instituto de Ecología Universidad Nacional Autónoma de México(IE-UNAM)Ciudad UniversitariaDFMexico Carnivore Ecology Laboratory Forest and Wildlife Research CenterMississippi State UniversityMississippiUSA Big Island Invasive Species Committee University of HawaiiHiloHawaiiUSA Old Dominion University NorfolkVirginiaUSA

Baird’s tapir(Tapirus bairdii)is currently endangered throughout its neotropical range with an expected popula--lished in Valle del Silencio within Parque Internacional La Amistad(PILA).Seventy-seven tapir pictures of 15 individuals comprising 25 capture-recapture events were analyzed using mark-recapture *** 100%minimum convex polygon of the sampled area was 5.7 km2 and the effective sampled area using half mean max-imum distances moved by tapirs was 7.16 *** estimated a tapir density of 2.93 individuals/km2 which rep-resents the highest density reported for this *** valleys can represent unique and important habitats for large mammal ***,the extent of isolation of this population,potentially constrained by steep slopes of the cordillera,remains *** genetic and movement studies are required to un-derstand meta-population dynamics and connectivity between lowland and highland areas for Baird’s tapir con-servation in Costa Rica.

关键词： camera trap capture Central America populations tapir

Future Directions for Chinese Accounting Research

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China Journal of Accounting Research 2008年第1期1卷 1-10页

作者： Qi Chen Katherine schipper Duke University

Introduction and Summary Capital-markets based accounting research in China has a relatively short history;the two principal stock exchanges in Shanghai and Shenzhen have operated for less than 20 *** accounting resea... 详细信息

关键词： accounting exchanges operated adopt stock listed r

Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy

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World Journal of Gastroenterology 2016年第47期22卷 10465-10470页

作者： Maartje M van de Meeberg Lauranne AAP Derikx Harm AM Sinnige Peet Nooijen D Lucette schipper Loes HC Nissen Department of Gastroenterology and Hepatology Jeroen Bosch Hospital Department of Hematology Jeroen Bosch Hospital Department of Pathology Jeroen Bosch Hospital

Hepatosplenic T-cell lymphoma(HSTCL) is a rare nonHodgkin lymphoma with a high mortality rate. Higher incidence is reported in patients with inflammatory bowel disease, specifically in male patients that are younger than 35 years, and have been treated with thiopurine and tumor necrosis factor(TNF)-α inhibitor combination therapy for over 2 years. In this case report we describe a 47-year-old patient with Crohn's disease(CD) who developed HSTCL after having been treated with thiopurine monotherapy for 14 years. To our best knowledge, only eleven cases exist of patients with CD who developed HSTCL while on thiopurine monotherapy. We report the first patient with CD, older than 35 years, who developed HSTCL while on thiopurine monotherapy. This emphasizes that HSTCL risk is not limited to young men receiving both thiopurines and TNF-α inhibitors.

关键词： Hepatosplenic T 房间淋巴瘤 Thiopurine Crohn’ s 疾病免疫力的抑制

The True Form----Reflections on the Liturgical Basis of Taoist Art

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The True Form----Reflections on the Liturgical Basis of Taoi...