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The Adsorption of GSH in the Liquid Environment

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生物物理学报 2009年第S1期25卷 367-367页

作者： NIU Jianlong WU Xue LI Feng ZUO Zhentao The school of physics, Nankai university,tianjin,300071,P.R.china

The phenomena of molecular adsorption in the nanometer are significant to the research of biological and medical materials, bio-medical engineering and other fields. As

关键词： GSH The Adsorption of GSH in the Liquid Environment

LARGE-SCALE PETROL-medical ENTERPRISE TECHNOLOGY INNOVATION SYSTEM MODELING AND IMPLEMENTING

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LARGE-SCALE PETROL-MEDICAL ENTERPRISE TECHNOLOGY INNOVATION ...

第十二届工业工程和工程管理国际会议

作者： SHEN Jiang LI Gang XU Man Management school tianjin university tianjin P. R. . china 300072

＜正＞In order to solve the implementation problems on complexity,multi-layer and span-platform in tech-nology innovation of large-scale petrol-medical enterprises, a method of technology innovation modeling based on virtual enterprise was *** this method,the technology innovation system consisted of strategic partnership selecting,virtual organization constructing and business process reengineering,and network platform and Virtual Enterprise Technology Innovation Decision Support System（ VETI-DSS）*** applying characteristic eigenvector, the technology innovation system was regarded as a virtual enterprise or a contractual organization to model the technology innovation system. Adopting data mining, OLAP, and decision model and algorithm, the VETI-DSS was *** *** solution on process management,acquisition process of product information, trial-production process of new products,data modeling of system,and information sharing in the core estate of technology innovation were put *** last,the implementing effects of this system applied in large-scale petrol- medical enterprises were analyzed.

关键词： Virtual Enterprise Technique Innovation Decision Support System information integrated

IL-17,combined with GM-CSF,modulates the functional differentiation on bone marrow-derived dendritic cells

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IL-17,combined with GM-CSF,modulates the functional differen...

2012全国临床微生物与感染免疫学术研讨会

作者： Zhao Guosheng,Ren Jianyun,Zhang Yongci,Wang Haiping,Tang Xiaofei,Bai Hong Department of Immunology,tianjin Key Laboratory of Cellular and Molecular Immunology and Key Laboratory of Educational Ministry of china,school of Basic medical Sciences,tianjin medical university,tianjin,china

GM-CSF,combined with other growth factors,was used to induce the differentiation of bone marrowderived ***-17(IL-17),as a new proinflammatory cytokine,has been shown to play a protective role in host defense against extracellular and intracellular *** address a possible mechanism,we examined the influence of IL-17 on the differentiation and function of bone marrow-derived cells(BM-DC) induced by GM-CSF with LPS in *** data suggest that IL-17 promoted the maturation of DC progenitors and increased cell surface expression of costimulatory molecules(CD40,CD80,CD86)and MHC classⅡ.IL-17 had a lesser effect on the phenotype of more fully differentiated myeloid *** addition,IL-17 treatment of LPS-stimulated BM-DC significantly up-regulates the expression of DC co-stimulatory molecules and induces strong secretion of IL- 12p40 and *** findings suggest that IL-17 plays an important role in promoting type1 T cell immunity that may be mediated in part via a maturation-inducing effect on DC.

关键词： IL-17 Bone marrow-derived dendritic cells Costimulatory molecules IL-12P40 IL-10

Effects of Electrical Stimulation on Growth and Metabolism of Cardiomyocytes in vitro

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Effects of Electrical Stimulation on Growth and Metabolism o...

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Yong Guo 1 ,Xizheng Zhang 1 ,Chun-qiu Zhang 2 ,Rui-xin Li 1 1 tianjin Institute of medical Equipment,tianjin,PR china,300161 2 school of Mechanical Engineering,tianjin university of technology tianjin,PR china,300191

＜正＞In vivo,cardiomyocytes are stimulated by electricity *** electrical stimulation is an indispensable factor for cardiomyocytes cultured in *** this study,the experimental

关键词： electrical stimulation cardiomyocyte culture in vitro effect

Key Techniques and Application Progress of Molecular Pharmacognosy

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Chinese Herbal Medicines 2011年第2期3卷 106-116页

作者： XIAO Xue-feng1,HU Jing1,XU Hai-yu2,5,GAO Wen-yuan3,ZHANG Tie-jun4,LIU Chang-xiao2 1.school of Chinese Materia Medica,tianjin university of Traditional Chinese Medicine,tianjin 300193,china 2.The National Key Laboratory of Pharmacokinetics and Pharmacodynamics,tianjin Institute of Pharmaceutical Research,tianjin 300193,china 3.school of Pharmaceutical Science and Technology,tianjin university,tianjin 300072,china 4.Research Center of Modern Chinese Medicines,tianjin Institute of Pharmaceutical Research,tianjin 300193,china 5.Institute of Chinese Materia Medica,china Academy of Chinese medical Sciences,Beijing 100700,china school of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Tianjin 300193 China The National Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Tianjin 300193 China Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China school of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China Research Center of Modern Chinese Medicines Tianjin Institute of Pharmaceutical Research Tianjin 300193 China The National Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Tianjin 300193 China

At the boundary between pharmacognosy and molecular biology,molecular pharmacognosy has developed as a new borderline *** paper reviews the methods,application,and prospect of molecular *** marker is one of genetic markers and some molecular marker methods which have been successfully used for genetic diversity identification and new medicinal resources *** DNA technology provides a powerful tool that enables scientists to engineer DNA *** chip technique could be used in determination of gene expression profiles,analyses of polymorphisms,construction of genomic library,analysis of mapping,and sequencing by *** the methods and theory of molecular biology and pharmacognosy,molecular pharmacognosy represents an extremely prospective branch of pharmacognosy and focuses on the study of systemic growth of medicinal plants,identification and evaluation of germplasm resources,plant metabolomics and production of active ***,the great breakthrough of molecular pharmacognosy could be anticipated on DNA fingerprint analysis,cultivar improvement,DNA identification,and a global DNA barcoding system in the future.

关键词： DNA marker genetic diversity molecular biology molecular pharmacognosy pharmacognosy

Zinc oxide nanoparticles affect neuroplasticity and spatial learning and memory ability in hippocampus of wistar rats

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Zinc oxide nanoparticles affect neuroplasticity and spatial ...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Da-Dong HAN~1 Jin-Xia ZHAO~2 Tao ZHANG~2 Guo-Gang REN~3 Zhuo YANG~(1 *) 1 Laboratory of Neurophysiology medical school Nankai university tianjin 300071 china 2 Laboratory of Bioinformatics Life Science Institute Nankai university tianjin 300071 china 3 university of Hertfordshire Hatfield Herts AL10 9AB UK

＜正＞Objective Zinc oxide nanoparticles（ZnO） are widely applied in toothpaste,beauty products,sunscreens, coating and textiles as base material or *** biological properties of the ZnO have been investigated in etiology,pathology,physiology and *** study focuses on the effects of ZnO nanoparticles on neuroplasticity and spatial learning and memory in hippocampus of Wistar *** underlined mechanism to interpret the interactive behaviour was studied *** Experimental methods involved using ZnO nanoparticles suspension （4mg/kg,0.4mg/mL,i.p.,b.i.w.） which was injected into 4-week-old male Wistar rats,for 8 weeks and subsequently long- term potentiation（LTP） and long-term depression（LTD） were evaluated and numerically *** water maze （MWM）,including place navigation test,spatial probe test and reversal acquisition phases,was also detected and ***’s and HE staining processes were employed in order to define pathological ***（1） It is shown that the LTP was significantly enhanced,including slope of field excitatory postsynaptic potential（fEPSP, 168.156±4.540） and amplitude of population spike（PS,286.872±16.587）,in rats treated by ZnO,compared to those of the control group（fEPSP,126.465±3.767;PS,175.773±10.042,P＜0.01,P＜0.01）.However,no change was found in the LTD and, neither the slope of fEPSP nor amplitude of the PS（P＞0.05） was shafted.（2） In the mentioned navigation test,the escape time was prolonged in rats treated by ZnO（18.355±2.956） compared with control group（10.838±2.346）.In spatial probe test, the ratio of time spent in the target quadrant（36.283±5.372） was reduced and the number of crossing the plate（2.8333+0.7923） was decreased in ZnO treated group compared with those of control group（6.667±0.803;55.817±3.051,P＜0.01,P＜0.01）.In reversal acquisition phase,the escape time was prolonged（18.384±4.404） in ZnO-treated group compared with that of control group（9.205±2.516,P＜0.01）.（3） Nissle’s staining

关键词： zinc oxide nanoparticles neuroplasticity LTP LTD spatial learning and memory Morris water Maze hippocampus

MKI67-siRNA可抑制QGY-7703细胞的生长

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中国生物化学与分子生物学报 2011年第5期27卷 480-485页

作者：侯艳艳刘涛李欣刘民汤华天津医科大学基础医学院天津市生命科学中心实验室天津300070

为了探讨MKI67在肝癌细胞发生发展中的作用,采用实时定量PCR方法检测人肝细胞癌QGY-7703细胞中MKI67基因表达水平,以及MKI67在肝细胞癌组织和癌旁正常组织中的表达情况,设计并合成针对MKI67的siRNA,利用脂质体转染法将其转入QGY-7703细... 详细信息

为了探讨MKI67在肝癌细胞发生发展中的作用,采用实时定量PCR方法检测人肝细胞癌QGY-7703细胞中MKI67基因表达水平,以及MKI67在肝细胞癌组织和癌旁正常组织中的表达情况,设计并合成针对MKI67的siRNA,利用脂质体转染法将其转入QGY-7703细胞内,通过MTT和细胞集落形成实验观察MKI67-siRNA对QGY-7703细胞生长活性和增殖能力的影响.实时定量PCR结果表明,MKI67在肝细胞癌组织中的表达水平明显高于癌旁正常组织(P<0.01).MTT和细胞集落形成实验结果显示,转染MKI67-siRNA的QGY-7703细胞生长活性和集落形成率明显低于对照组(P<0.01).由此得出结论:MKI67在肝癌细胞系QGY-7703细胞中的表达水平较高,且它在肝癌组织中的表达水平明显上调.同时,MKI67-siRNA可以有效抑制QGY-7703细胞的生长活性和增殖能力,提示MKI67可能与肝细胞癌的发生、发展相关.

关键词：肝细胞癌 MKI67 增殖 RNA干扰小干扰RNA

Damage to the spermatozoa of adult men exposed to the processing of electronics waste

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Damage to the spermatozoa of adult men exposed to the proces...

中国毒理学会第五次全国学术大会

作者： Jia Cao~1,Qiang Liu~1,Ke Qiu Li~3,Xu Hong Miao~3,Hui Zhao~2,Jian Li~3,Guang Li~3,Fei Yue Fan~1 1 Institute of Radiation Medicinek Chinese Academyu of medical Sciences & Peking Union medical College,tianjin 300192 2 Biopharmaceutical Laboratory,school of Chemical Engineering and Technology,tianjin university,tianjin 300072 3 Department of Biology of tianjin medical university,tianjin 300070

＜正＞Background,aim,and scope Electronic wastes （e-wastes）are being the fastest growing type of solid waste. Most of them were transported to the developing nations and about 50%to 80%of them were exported to Asia and *** has become a major global environmental problem to manage and recycle the e-wastes.E-wastes were widely processed by manually disassembling or burning in Jinghai,a county of china, which has become the largest e-wastes disposal centre in northern china in recent *** cytogenetic damage effects have been found among the residents in our previous *** reported, polybrominated diphenyl ethers（PBDEs）and polychlorinated biphenyls（PCBs）were widely used as coolants and lubricants in electrical transformers and ***-containing wastes could release PCBs or dioxin-like PCBs if they were not processed ***,PCBs and PBDEs may have toxic effect to damage both male and female reproductive *** study analyzed the potential damaging effects of pollutants generated by the electronic waste disposal process on human reproductive function,especially to the spermatozoa of adult men.

关键词： Electronic waste Environment pollution spermatozoa Single-cell gel electrophoresis Comet assay DNA damage

Optical Properties Effects upon the Precision of Dynamic Spectrum

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Optical Properties Effects upon the Precision of Dynamic Spe...

第2届世界华人生物医学工程研讨会

作者： Xiaoxia Li 1 2 Gang Li 1 Ling Lin 1 Yuliang Liu 1 Yan Wang 1 Jian Li3 1. College of Precision Instrument and Opto-Electronics Engineering tianjin university tianjin 300072 china 2. school of electrical and automatic engineering Hebei university of Technology tianjin 300130 china 3.school of electrical and automatic engineering tianjin university of Technology tianjin 300000 china