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Effect of DA-9701 on gastric emptying in a mouse model: Assessment by ^(13)C-octanoic acid breath test

World Journal of Gastroenterology 2013年第27期19卷 4380-4385页

作者： Chul-Hyun Lim Myung-Gyu Choi hyeyeon park Myong Ki Baeg Jae Myung park Department of Internal Medicine The Catholic University of Korea College of Medicine

AIM:To evaluate the effects of DA-9701 on the gastric emptying of a solid meal using the 13C-octanoic acid breath test in a mouse model. METHODS:Male C57BL/6 mice aged > 8 wk and with body weights of 20-25 g were used in this study. The solid test meal consisted of 200 mg of egg yolk labeled with 1.5 L/g 13C-octanoic acid. The mice were placed in a 130 mL chamber flushed with air at a flow speed of 200 mL/min. Breath samples were collected for 6 h. The half-emptying time and lag phase were calculated using a modified power exponential model. To assess the reproducibility of the 13C-octanoic acid breath test, the breath test was performed two times at intervals of one week in ten mice without drug treatment. To assess the gastrokinetic effects of DA-9701, the breath test was performed three times in another twelve mice, with a randomized crossover sequence of three drug treatments:DA-9701 3 mg/kg, erythromycin 6 mg/kg, or saline. Each breath test was performed at an interval of one week. RESULTS:Repeatedly measured half gastric emptying time of ten mice without drug treatment showed 0.856 of the intraclass correlation coefficient for the half gastric emptying time (P = 0.004). The mean cumulative excretion curve for the 13C-octanoic acid breath test showed accelerated gastric emptying after DA-9701 treatment compared with the saline control (P = 0.028). The median half gastric emptying time after the DA-9701 treatment was significantly shorter than after the saline treatment [122.4 min (109.0-137.9 min) vs 134.5 min (128.4-167.0 min), respectively; P = 0.028] and similar to that after the erythromycin treatment [123.3 min (112.9-138.2 min)]. The lag phase, which was defined as the period taken to empty 15% of a meal, was significantly shorter after the DA-9701 treatment than after the saline treatment [48.1 min (44.6-57.1 min) vs 52.6 min (49.45-57.4 min), respectively; P = 0.049]. CONCLUSION:The novel prokinetic agent DA-9701 accelerated gastric emptying, assessed w

关键词： DA-9701 Gastric emptying Prokinetic agent Breath test Functional dyspepsia

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Preoperative serum carbohydrate antigen 19-9 levels predict early recurrence after the resection of early-stage pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Surgery 2021年第11期13卷 1423-1435页

作者： Sarang Hong Ki Byung Song Dae Wook Hwang Jae Hoon Lee Woohyung Lee Eunsung Jun Jaewoo Kwon Yejong park Seo Young park Naru Kim Dakyum Shin hyeyeon Kim Minkyu Sung Yunbeom Ryu Song Cheol Kim Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterSeoul 05505South Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Statistics and Data Science Korea National Open UniversitySeoul 03087South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of MedicineGyeonggido 11765South Korea

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a serious disease with a poor *** a minority of patients undergo surgery due to the advanced stage of the disease,and patients with early-stage disease,who are expected to have a better prognosis,often experience ***,it is important to identify the risk factors for early recurrence and to develop an adequate treatment *** To evaluate the predictive factors associated with the early recurrence of earlystage *** This study enrolled 407 patients with stage I PDAC undergoing upfront surgical resection between January 2000 and April *** recurrence was defined as a diagnosis of recurrence within 6 mo of *** optimal cutoff values were determined by receiver operating characteristic(ROC)*** and multivariate analyses were performed to identify the risk factors for early *** Of the 407 patients,98 patients(24.1%)experienced early disease recurrence:26(26.5%)local and 72(73.5%)distant *** total,253(62.2%)patients received adjuvant *** ROC curve analysis,the optimal cutoff values for early recurrence were 70 U/mL and 2.85 cm for carbohydrate antigen 19-9(CA 19-9)levels and tumor size,*** the 181 patients with CA 19-9 level>70 U/mL,59(32.6%)had early recurrence,compared to 39(17.4%)of 226 patients with CA 19-9 level≤70 U/mL(P70 U/mL(P=0.006),tumor size>2.85 cm(P=0.004),poor differentiation(P=0.008),and non-adjuvant chemotherapy(P=0.025)were significant risk factors for early recurrence in early-stage *** Elevated CA 19-9 level(cutoff value>70 U/mL)can be a reliable predictive factor for early recurrence in early-stage *** adjuvant chemotherapy can prevent early recurrence,it should be recommended for patients susceptible to early recurrence.

关键词： Pancreatic ductal adenocarcinoma Early recurrence Upfront surgery Carbohydrate antigen 19-9 Adjuvant chemotherapy

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