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Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization

Bioactive Materials 2024年第6期36卷 185-202页

作者： Hayeon Byun Yujin Han Eunhyung Kim Indong Jun Jinkyu Lee hyewoo jeong Seung Jae Huh Jinmyoung Joo Su Ryon Shin Heungsoo Shin Department of Bioengineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea Division of Engineering in Medicine Department of MedicineHarvard Medical SchoolBrigham and Women’s HospitalCambridgeMA 02139USA Environmental Safety Group Korea Institute of Science&Technology Europe(KIST-EUROPE)Saarbrücken 66123Germany Department of Biomedical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Institute of Nano Science and Technology Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Wound healing in cases of excessive inflammation poses a significant challenge due to compromised ***,we propose a multi-functional composite hydrogel engineered to overcome such conditions through recruitment and activation of macrophages with adapted degradation of the *** composite hydrogel(G-TSrP)is created by combining gelatin methacryloyl(GelMA)and nanoparticles(TSrP)composed of tannic acid(TA)and Sr^(2+).These nanoparticles are prepared using a one-step mineralization process assisted by metal-phenolic network formation.G-TSrP exhibits the ability to eliminate reactive oxygen species and direct polarization of macrophages toward M2 *** has been observed that the liberation of TA and Sr^(2+)from G-TSrP actively facilitate the recruitment and up-regulation of the expression of extracellular matrix remodeling genes of macrophages,and thereby,coordinate in vivo adapted degradation of the *** significantly,G-TSrP accelerates angiogenesis despite the TA’s inhibitory properties,which are counteracted by the released Sr^(2+).Moreover,G-TSrP enhances wound closure under inflammation and promotes normal tissue formation with strong vessel *** analysis confirms macrophage-mediated wound healing by the composite ***,these findings pave the way for the development of biomaterials that promote wound healing by creating regenerative environment.

关键词： Immunomodulation Wound healing Neovascularization Multi-functional nanoparticles Composite hydrogels

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