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Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept

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Light(Science & Applications) 2021年第11期10卷 2173-2183页

作者： Ekaterina Pshenay-Severin hyeonsoo bae Karl Reichwald Gregor Matz Jörg Bierlich Jens Kobelke Adrian Lorenz Anka Schwuchow Tobias Meyer-Zedler Michael Schmitt Bernhard Messerschmidt Juergen Popp GRINTECH GmbH Schillerstr.107745JenaGermany Leibniz Institute of Photonic Technology Member of Leibniz Health TechnologiesAlbert-Einstein-Str.907745JenaGermany Institute of Physical Chemistry and Abbe Center of Photonics Friedrich Schiller University JenaHelmholtzweg 407743JenaGermany

Multimodal non-linear microscopy combining coherent anti-Stokes Raman scattering,second harmonic generation,and two-photon excited fluorescence has proved to be a versatile and powerful tool enabling the label-free investigation of tissue structure,molecular composition,and correlation with function and disease *** a routine medical application,the implementation of this approach into an in vivo imaging endoscope is ***,this is a difficult task due to the requirements of a multicolour ultrashort laser delivery from a compact and robust laser source through a fiber with low losses and temporal synchronization,the efficient signal collection in epi-direction,the need for small-diameter but highly corrected endomicroobjectives of high numerical aperture and compact ***,we introduce an ultra-compact fiber-scanning endoscope platform for multimodal non-linear endomicroscopy in combination with a compact four-wave mixing based fiber *** heart of this fiber-scanning endoscope is an in-house custom-designed,single mode,double clad,double core pure silica fiber in combination with a 2.4 mm diameter NIR-dual-waveband corrected endomicroscopic objective of 0.55 numerical aperture and 180µm field of view for non-linear imaging,allowing a background free,low-loss,high peak power laser delivery,and an efficient signal collection in backward direction.A linear diffractive optical grating overlays pump and Stokes laser foci across the full field of view,such that diffraction-limited performance is demonstrated for tissue imaging at one frame per second with sub-micron spatial resolution and at a high transmission of 65%from the laser to the specimen using a distal resonant fiber scanner.

关键词： fiber double scanner

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FAK and Pyk2 in disease

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Frontiers in Biology 2016年第1期11卷 1-9页

作者： James M. Murphy hyeonsoo Park Ssang-Taek Steve Lim Department of Biochemistry and Molecular Biology College of Medicine University of South Alabama Mobile Alabama 36688 USA

Focal adhesion kinase （FAK） and proline-rich tyrosine kinase 2 （Pyk2） are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. Current research of FAK and Pyk2 is greatly focused in cancer biology and several small molecule inhibitors are being tested under clinical development. Like cancer, certain chronic diseases such as cardiovascular disease, bone disease, fibrosis, rheumatoid arthritis, and neurological disorders, share malignant characteristics of cancer. Accumulating evidence has demonstrated that FAK and Pyk2 contribute to other proliferative and degenerative diseases. Thus, the goal of this review is to briefly highlight studies that have implicated FAK and Pyk2 as players in disease progression.

关键词： FAK Pyk2 FRNK disease

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Enhancing Hydrophilicity of Thick Electrodes for High Energy Density Aqueous Batteries

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Nano-Micro Letters 2023年第7期15卷 110-121页

作者： Jungeun Lee hyeonsoo Lee Cheol Bak Youngsun Hong Daeha Joung Jeong Beom Ko Yong Min Lee Chanhoon Kim Sustainable Technology and Wellness R&D Group Korea Institute of Industrial Technology(KITECH)102 Jejudaehak-RoJeju-SiJeju-do 63243Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Physics Virginia Commonwealth UniversityRichmondVA 23284USA

Thick electrodes can substantially enhance the overall energy density of ***,insufficient wettability of aqueous electrolytes toward electrodes with conventional hydrophobic binders severely limits utilization of active materials with increasing the thickness of electrodes for aqueous batteries,resulting in battery performance deterioration with a reduced ***,we demonstrate that controlling the hydrophilicity of the thicker electrodes is critical to enhancing the overall energy density of *** binders are synthesized via a simple sulfonation process of conventional polyvinylidene fluoride binders,considering physicochemical properties such as mechanical properties and *** introduction of abundant sulfonate groups of binders(i)allows fast and sufficient electrolyte wetting,and(ii)improves ionic conduction in thick electrodes,enabling a significant increase in reversible capacities under various current ***,the sulfonated binder effectively inhibits the dissolution of cathode materials in reactive aqueous ***,our findings significantly enhance the energy density and contribute to the development of practical zinc-ion batteries.

关键词： Thick electrodes Hydrophilic binder Sulfonation Aqueous zinc-ion batteries High areal capacity

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