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New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase Ⅱ trial

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World Journal of Gastroenterology 2017年第32期23卷 5977-5985页

作者： Jae Yoon Jeong Joo Hyun Sohn Yang Hyun Baek Yong Kyun Cho Yongsoo kim hyeonjin kim Department of Internal Medicine Hanyang University Guri HospitalHanyang University College of Medicine Department of Internal Medicine Dong-A University HospitalDong-A University College of Medicine Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Department of Radiology Hanyang University Guri HospitalHanyang University College of Medicine Department of Radiology Seoul National University Hospital

AIM To evaluate the efficacy and safety of HL tablet extracted from magnolia officinalis for treating patients with nonalcoholic fatty liver disease(NAFLD).METHODS Seventy-four patients with NAFLD diagnosed by ultrasonography were randomly assigned to 3 groups given high dose(400 mg) HL tablet, low dose(133.4 mg) HL tablet and placebo, respectively, daily for 12 wk. The primary endpoint was post-treatment change of hepatic fat content(HFC) measured by magnetic resonance spectroscopy. Secondary endpoints included changes of serum aspartate aminotransferase, alanine aminotransferase(ALT), cholesterol, triglyceride, free fatty acid, homeostasis model assessment-estimated insulin resistance, and body mass index(BMI).RESULTS The mean HFC of the high dose HL group, but not of the low dose group, declined significantly after 12 wk of treatment(high dose vs placebo, P = 0.033; low dose vs placebo, P = 0.386). The mean changes of HFC from baseline at week 12 were-1.7% ± 3.1% in the high dose group(P = 0.018),-1.21% ± 4.97% in the low dose group(P = 0.254) and 0.61% ± 3.87% in the placebo group(relative changes compared to baseline, high dose were:-12.1% ± 23.5%, low dose:-3.2% ± 32.0%, and placebo: 7.6% ± 44.0%). Serum ALT levels also tended to decrease in the groups receiving HL tablet while other factors were unaffected. There were no moderate or severe treatment-related safety issues during the *** HL tablet is effective in reducing HFC without any negative lipid profiles, BMI changes and adverse effects.

关键词： Botanical drug Nonalcoholic fatty liver disease Magnetic resonance spectroscopy Randomized controlled trial Magnolia officinali

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Tuning static drop friction

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液滴(英文) 2023年第1期2卷 56-63页

作者： Alexandre Laroche Abhinav Naga Chirag Hinduja Azadeh Aghili Sharifi Alexander Saal hyeonjin kim Nan Gao Sanghyuk Wooh Hans‐Jürgen Butt Rüdiger Berger Doris Vollmer Physics at Interfaces Max Planck Institute for Polymer ResearchMainzGermany School of Chemical Engineering&Materials Science Chung‐Ang UniversitySeoulRepublic of Korea Department of Mechanical Engineering University of BirminghamBirminghamUK

The friction force opposing the onset of motion of a drop on a solid surface is typically considered to be a material property for a fixed drop volume on a given ***,here we show that even for a fixed drop volume,the static friction force can be tuned by over 30%by preshaping the *** static friction usually exceeds the kinetic friction that the drop experiences when moving in a steady *** forces converge when the drop is prestretched in the direction of motion or when the drop shows low contact angle *** contrast to static friction,kinetic friction is independent of preshaping the drop,that is,the drop *** friction forces reflect the material properties.

关键词： friction properties forces

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Speed vernalization to accelerate generation advance in winter cereal crops

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Molecular Plant 2022年第8期15卷 1300-1309页

作者： Jin-Kyung Cha Kathryn O'Connor Samir Alahmad Jong-Hee Lee Eric Dinglasan hyeonjin Park So-Myeong Lee Dominique Hirsz Soon-Wook Kwon Youngho Kwon Kyeong-Min kim Jong-Min Ko Lee T.Hickey Dongjin Shin Laura E.Dixon National Institute of Crop Science RDAMiryang 50424Korea School of Biology Faculty of Biological SciencesUniversity of LeedsLeeds LS29JTUK Queensland Alliance for Agriculture and Food Innovation The University of QueenslandSt.LuciaQLDAustralia Department of Plant Bioscience Pusan National UniversityMiryang 60463Korea

There are many challenges facing the development of high-yielding,nutritious crops for future *** limiting factor is generation time,which prolongs research and plant breeding *** advances in speed breeding protocols have dramatically reduced generation time for many short-day and long-day species by optimizing lightand temperature conditions during plant ***,winter crops with a vernalization requirement stillrequire upto 6-10weeks in low-temperature conditions before thetransition to ***,we tested a suite of environmental conditions and protocols to investigate whether the vernalization process can be *** identified a vernalization method consisting of exposing seeds at the soil surface to an extended photoperiod of 22 h day:2 h night at 10°C with transfer to speed breeding conditions that dramatically reduces generation time in both winter wheat(Triticum aestivum)and winter barley(Hordeum vulgare).Implementation of the speedvernalization protocolfollowed byspeedbreedingallowed the completion ofuptofivegenerations per yearforwinter wheat or barley,whereas only two generations can be typically completed under standard vernalization and plant growth *** speed vernalization protocol developed in this study has great potential to accelerate biological research and breeding outcomes for winter crops.

关键词： speed breeding photoperiod temperature wheat barley breeding

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Seven synchronous early gastric cancer with 28 lymph nodes metastasis

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World Journal of Gastroenterology 2013年第44期19卷 8141-8145页

作者： hyeonjin Seong Jin Il kim Hyun Jeong Lee Hyun Jin kim Hyung Joon Cho Hye Kang kim Dae Young Cheung Dong Jin kim Wook kim Tae-Jung kim Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul 150-713 South Korea Department of Surgery College of Medicine The Catholic University of Korea Seoul 150-713South Korea Department of Hospital Pathology College of Medicine The Catholic University of Korea Seoul 150-713South Korea

An 85 year male patient complaining epigastric discomfort was *** the esophagogastroduodenoscopy,three early gastric cancer(EGCa)lesions had been identified and these were diagnosed as adenocarcinoma with poorly differentiated cell *** patient underwent *** the post-operative mapping,however,additional 4 EGCa lesions were found,and the patient was diagnosed with 7 synchronous *** of the 7 EGCa lesions,6 had shown invasion only to the mucosal layer and one had shown invasion into the 1/3layer of *** spite of such superficial invasions,28 of 48 lymph nodes had been identified as *** multiple lesions of EGCa do not increase the risk of lymph node metastasis,but if their differentiations are poor or if they have lympho-vascular invasion,multiple lymph node metastases could incur even if the depth of invasion is limited to the mucosal layer or the upper portion of the submucosal layer.

关键词： Early gastric cancer Synchronous Metastasis Lymph node Endoscopy

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