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Polymyxin B hemoperfusion as a feasible therapy after source control in abdominal septic shock

World Journal of Gastrointestinal Surgery 2019年第12期11卷 422-432页

作者： Jin Joo kim Young Jun Park Ki Yoon Moon Jin hyeong Park Yong Ki Jeong Eun Young kim Division of Trauma and Surgical Critical Care Department of Surgery Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea

BACKGROUND Polymyxin B hemoperfusion(PMX-HP)has been used as a treatment for intraabdominal septic shock by absorbing and removing endotoxins of gram-negative *** To investigate the clinical efficacy of PMX-HP in patients with gram-negative septic shock who underwent abdominal *** From January 2012 to December 2018,patients who had septic shock secondary to peritonitis were *** were classified into PMX-HP treated and control groups based on postopreative intervention using *** clinical outcomes were compared using 1:1 propensity score matching methods to balance the overall distribution between the two *** After propensity score matching,40 patients were analyzed(20 patients in the PMX group and 20 patients in the control group).The scores of total Sequential Organ Failure Assessment(SOFA)score,renal SOFA and coagulation SOFA were significantly improved in the PMX group but not in the control group.(from 11.2±5.8 to 4.7±3.5 in PMX group vs 10.0±4.0 to 8.7±7.3 in control group,P=0.047 from 2.6±1.0 to 0.7±1.0 in PMX group vs 2.6±1.5 to 2.8±1.6 in control group,P=0.000,from 1.6±1.5 to 1.3±1.3 in PMX group vs 1.2±1.2 to 2.8±1.8 in control group,P=0.014,respectively).Further,the length of intensive care unit(ICU)stay was significantly shorter in PMX ***,no statistically significant difference was found in ICU mortality(50%in PMX group vs 50%in control group).CONCLUSION PMX-HP is a feasible adjunct treatment for peritonitis in ICU patients with peritonitis for improved organ impairment and to stabilize *** would be helpful to enhance clinical outcomes especially in patients with complete elimination of the source of gram-negative bacilli infection by surgical procedure accompanied with conventional treatment of sepsis.

关键词： Intraabdominal septic shock Panperitonitis Polymyxin B hemoperfusion Sepsis Toraymyxin

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Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

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World Journal of Gastroenterology 2017年第9期23卷 1627-1636页

作者： hyeong Seok Nam Dae Hwan Kang Hyung Wook kim Cheol Woong Choi Su Bum Park Su Jin kim Dae Gon Ryu Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan-siGyeongsangnam-do 50612South Korea

AIM To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of selfexpandable metal stent(SEMS).METHODS This was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography(ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis(PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were *** Among the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients,pancreatic cancer in 79, and non-pancreatic or nonbiliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients(3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy(cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP *** Limited ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.

关键词：内视镜的 sphincterotomy 内视镜后退 cholangio pancreatography 复杂并发症胰腺炎流血 Cholestasis 自我可扩充的金属 stent

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Emamectin benzoate 9.7%SL as a new formulation for a trunkinjections against pine wood nematode,Bursaphelenchus xylophilus

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Journal of Forestry Research 2020年第4期31卷 1399-1403页

作者： Sung-Chan Lee Hyo-Rim Lee Dong-Soo kim Jun-hyeong Kwon Min-Jung Huh Il-Kwon Park Department of Forest Sciences College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Agriculture and Life Science College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Forest Biomaterials Research Center National Institute of Forest ScienceJinjuGyeongnam 52817Republic of Korea

In this study,we investigated the preventive effects of emamectin benzoate 9.7%SL,which was newly developed to reduce the injection volume and number of injection holes required to protect against pine wood *** of the Pinus thunbergii trees injected with emamectin benzoate 9.7%SL at 0.3 mL/cm diameter at breast height(DBH)died within 2 years of inoculation with pine wood *** benzoate 9.7%SL injected at 0.6 mL/cm DBH resulted in no tree mortality for 3 *** residue of emamectin benzoate 9.7%SL in pine twigs injected with 0.3 mL/cm DBH was 0.490μg/g at 1 year after injection and 0.303μg/g after 2 *** residues values are greater than 0.031μg/g,previously determined IC95 value for emamectin benzoate against the pine wood *** field experiment and residue analysis showed that emamectin benzoate 9.7%SL could be a substitute agent for emamectin benzoate 2.15%EC,which is widely used to prevent pine wood nematode in the field and that injection volume and number of injection holes can be greatly educed using this new formulation,which will reduce injury to the cambium,interruption of water movement,and infection of inoculation wounds by wood-decay or blue stain fungi.

关键词： Emamectin benzoate 9.7%SL Emamectin benzoate 2.15%EC Trunk injection Pine wood nematode Residue

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Recurrent massive bleeding due to dissecting intramural hematoma of the esophagus: Treatment with therapeutic angiography

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World Journal of Gastroenterology 2009年第41期15卷 5232-5235页

作者： Jaejun Shim Jae Young Jang Young Hwangbo Seok Ho Dong Joo hyeong Oh Hyo Jong kim Byung-Ho kim Young Woon Chang Rin Chang Department of Internal Medicine Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoongu Seoul 130-702 South Korea Department of Diagnostic Radiology Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoon-gu Seoul 130-702 South Korea

Spontaneous or traumatic intramural bleeding of the esophagus, which is often associated with overlying mucosal dissection, constitutes a rare spectrum of esophageal injury called dissecting intramural hematoma of the esophagus (DIHE). Chest pain, swallowing diffi culty, and minor hematemesis are common, which resolve spontaneously in most cases. This case report describes a patient with spontaneous DIHE with recurrent massive bleeding which required critical management and highlights a potential role for therapeutic angiography as an alternative to surgery.

关键词：替代治疗血管造影内出血血肿食道动脉夹层潜在作用

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Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats

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Neural Regeneration Research 2011年第27期6卷 2085-2093页

作者： Sun-Hwa Lee Byung-soo Ahn Bong-soo Lim Seong-Kyu kim Sam-Ki kim Dae-Il Lee Sung-rae Cho Deok-Gon kim Jae-Bok Han Byung-Il Min Department of East-West Medicine Graduate SchoolKyunghee University Department & Research Institute of Rehabilitation Medicine Yonsei University Department of Oriental Pediatrics Kyunghee Medical CenterKyunghee University Department of Physiology College of MedicineKyunghee University

We investigated the effects of ethanol extracted Scutellaria baicalensis（EESB） on spatial memory function and neurogenesis in the hippocampal dentate *** Sprague-Dawley rats were orally administered 50,100,or 200 mg/kg of EESB for 6 successive *** radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult *** microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine（BrdU）-and neuron-specific nuclear protein-positive cells in the granular cell layer,and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone.200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular *** findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.

关键词： Scutellaria baicalensis neurogenesis dentate gyrus hippocampus bromodeoxyuridine neuron-specific nuclear protein glial fibrillary acidic protein neural regeneration

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Simple black holes with anisotropic fluid

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Chinese Physics C 2019年第2期43卷 125-131页

作者： Inyong Cho hyeong-Chan kim School of Liberal Arts Seoul National University of Science and Technology School of Liberal Arts and Sciences Korea National University of Transportation

We study a spherically symmetric spacetime made of an anisotropic fluid whose radial equation-of-state is given by p_1=-ρ. This case allows analytic solutions and is a good example for studying the static configuration of a black hole plus matter. For a given equation-of-state parameter w_2 = p_2/ρ for angular directions, we find the exact solutions of the Einstein equation described by two parameters. We classify the solutions into six types based on the behavior of the metric function. Depending on the parameters, the solutions can have event and cosmological horizons. One of the solution types corresponds to a generalization of the Reissner-Nordstr(o|¨)m black hole, the thermodynamic properties for which are obtained in a simple form. The solutions are stable under radial perturbations.

关键词： black hole exact solution general relativity

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Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

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Nano Research 2015年第7期8卷 2340-2350页

作者： Doo-Won Lee Jinhwan Lee II Yung Sohn Bo-Yeong kim Young Min Son Hunyoung Bark JaehyuckJung Minseok Choi Tae hyeong kim Changgu Lee Nae-Eung Lee Department of Advanced Materials Science & Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Department of Mechanical Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST) Sungkyunkwan University Suwon Gyeonggi-do 440-746 Republic of Korea New Materials Team Future Device R&D Department LG Electronics Advanced Research Institute Seou1137-724 Republic of Korea These authors contributed equally to this work.

A field-effect transistor （FET） with two-dimensional （2D） few-layer MoS2 as a sensing-channel material was investigated for label-free electrical detection of the hybridization of deoxyribonucleic acid （DNA） molecules. The high-quality MoS2-channel pattern was selectively formedthrough the chemical reaction of the Mo layer with H2S gas. The MoS2 FET was very stable in an electrolyte and inert to pH changes due to the lack of oxygen-containing functionalities on the MoS2 surface. Hybridization of single-stranded target DNA molecules with single-stranded probe DNA molecules physically adsorbed on the MoS2 channel resulted in a shift of the threshold voltage （Vt,） in the negative direction and an increase in the drain current. The negative shift in Vth is attributed to electrostatic gating effects induced by the detachment of negatively charged probe DNA molecules from the channel surface after hybridization. A detection limit of 10 fM, high sensitivity of 17 mWdec, and high dynamic range of 106 were achieved. The results showed that a bio-FET with an ultrathin 2D MoS2 channel can be used to detect very small concentrations of target DNA molecules specifically hybridized with the probe DNA molecules.

关键词： two-dimensional(2D)materials, MoS2,field-effect transistor, biosensor,deoxyribonucleic acid (DNA) hybridization

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Glutathione-S-transferase (GSTM1,GSTT1) and the risk of gastrointestinal cancer in a Korean population

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World Journal of Gastroenterology 2009年第45期15卷 5716-5721页

作者： Jin-Mei Piao Min-Ho Shin Sun-Seog Kweon Hee Nam kim Jin-Su Choi Woo-Kyun Bae Hyun-Jeong Shim hyeong-Rok kim Young-Kyu Park Yoo-Duk Choi Soo-Hyun kim Department of Preventive Medicine Chonnam National University Medical School Gwangju 501-746 South Korea Jeonnam Regional Cancer Center Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Genome Research Center for Hematopoietic Diseases Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Surgery Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Pathology Chonnam National University Medical School Gwangju 501-746 South Korea Department of Laboratory Medicine Chormam National University Medical School Gwangju 501-746 South Korea

AIM: To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean ***: We conducted a population-based, largescale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypesof GSTM1 and GSTT1 were determined using realtime ***: The null genotypes of GSTM1 and GSTT1 were not signifi cantly associated with elevated risk of gastric (OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively) or colorec-tal cancer (OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively). The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal ***: GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans.

关键词： GSTM1基因谷胱甘肽S 胃肠道肿瘤韩国人转移酶风险人口聚合酶链反应

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Nanoscale Materials and Deformable Device Designs for Bioinspired and Biointegrated Electronics

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Accounts of Materials Research 2021年第4期2卷 266-281页

作者： Woongchan Lee Huiwon Yun Jun-Kyul Song Sung-Hyuk Sunwoo Dae-hyeong kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea

Electronic devices whose structural and functional features are inspired by living creatures have unique performance and unconventional features that are not found in conventional electronic *** addition to such bioinspired electronics,with the rise of new fields such as personalized healthcare,mobile electronics,and big-data analysis,biointegrated electronic devices that can collect biomedical information from the human body through various biosensors and deliver appropriate therapeutic feedback stimulations in real time on the spot where immediate treatment is needed have become *** body parts and internal organs of living creatures,including humans,have curvilinear shapes and comprise mechanically soft tissues,such bioinspired and biointegrated electronic devices are required to match the soft and deformable features of biological *** soft and deformable features of electronic devices can be achieved by employing flexible and stretchable materials and unconventional device design *** soft materials and deformable device designs dissipate stress originating from mechanical deformation of the device and thus retard crack generation and/or propagation in the ***,technologies for nanoscale materials have shown a significant level of progress on their material performance and processing *** nanoscale dimension of the electronic materials could achieve extremely small flexural rigidity in comparison to the bulk state of the same ***,techniques to form a well-percolated network of nanomaterials in the elastomeric matrix and to build a pathway for the facile electron and hole transport inside the polymer have induced dramatic performance advances of soft electronic materials,which led to nanocomposites that can accomplish both high mechanical deformability and high electrical performance at the same *** addition,deformable device designs such as buckled structures and serpentine des

关键词： buckling rigidity electronics

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Meta-analysis on randomized controlled trials for scalp acupuncture treatment of stroke：A systematic review

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Journal of Traditional Chinese Medicine 2018年第4期38卷 465-479页

作者： Young-Nim You Min-Yeong Song Gwang-Cheon Park Chang-Su Na Jae-Young Han Myung-rae Cho Jae-Hong kim Clinical Research Center Dong-Shin University Gwangju Oriental Hospital Gwangju City 61619 Republic of Korea Department of Acupuncture and Moxibustion Medicine College of Korean Medicine Dong-Shin University Naju City 58245 Republic of Korea Department of Korean Rehabilitation Therapy College of Korean Medicine Dong-Shin University Naju City 58245 Republic of Korea Department of Meridians and Acupoints College of Korean Medicine Dong-Shin University Naju City 58245 Republic of Korea Department of Physical & Rehabilitation Therapy Chonnam National University Medical School & Hospital Gwangju City 61619 Republic of Korea

OBJECTIVE:To conduct a systematic review to assess the clinical effectiveness of scalp acupuncture(SA) for ***:Literature searches were performed in7 databases up to 16 August 2014,and all the randomized controlled trials(RCTs) in which SA therapy was administered to stroke patients were *** quality was assessed using the Jadad score,the Cochrane risk of bias assessment,and the Standards for Reporting Interventions in Clinical Trials of ***:Of a total of 2086 papers,21 RCTs were ***-analysis revealed significant differences in the total efficacy rates of the SA group and the body acupuncture(BA) group vs the medication group(P < 0.002,P < 0.000 001,respectively),the SA plus BA group vs the BA group(P < 0.001);in the motor function of the SA plus BA group vs the BA group(P = 0.077);and in the nerve function of the SA group vs the SA plus BA group(P < 0.0001).CONCLUSION:The results of our systematic review showed that SA therapy may exhibit effects in treatment efficacy and in the recovery of motor and nervous functions in patients with acute to chronic ***,because of the lack of methodological quality,the thoroughly planned clinical studies are still required.

关键词：随机化试用控制针灸头皮评论系统数据库

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