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Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2015年第45期21卷 12787-12799页

作者： Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon kim Yeon Seok Seo Hyung Joon Yim Kwan soo Byun Department of Internal Medicine Korea University College of Medicine

AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) ***: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of ***: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD.

关键词： Nonalcoholic fatty liver disease Nonalcoholic stea

应用重组PDGF—BB或釉基质蛋白衍生物重建人拔牙窝颊侧骨壁缺损

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中国口腔医学继续教育杂志 2013年第4期16卷 209-217页

作者： Marc L. Nevins Marcelo Camelo Peter Schupbach Myron Nevins soo-Woo kim David M. kim 陈欣戬(译) 闫福华(审) 不详福建医科大学附属口腔医院牙周科福州市杨桥中路246号350002 南京大学口腔医学院附属口腔医院南京市鼓楼区中央路30号210008

本研究的目的是评估拔牙窝颊侧骨壁缺损的骨性愈合。试验对象分为4组：A.仅使用矿化胶原骨替代物支架材料（MCBS）;***＋重组人血小板生长因子BB（rhPDGF-BB）．03mg／ml；***＋釉基质蛋白衍生物（EMD）;***与陶瓷化骨替代物联合应用。... 详细信息

本研究的目的是评估拔牙窝颊侧骨壁缺损的骨性愈合。试验对象分为4组：A.仅使用矿化胶原骨替代物支架材料（MCBS）;***＋重组人血小板生长因子BB（rhPDGF-BB）．03mg／ml；***＋釉基质蛋白衍生物（EMD）;***与陶瓷化骨替代物联合应用。光学显微镜，背散射扫描电镜，组织形态测定术检测评估骨质量初期结果。二次手术观察愈合后的骨嵴形态。16名伴有拔牙窝颊侧骨壁缺损的患者随机等分为4个治疗组。拔牙后即刻做移植手术并颊侧瓣前移闭合创口。术后5个月．植入种植体前在种植位点行环钻中心组织穿刺活检术。组织学检测围绕在生物支架材料周围形成的愈合。性新骨。各治疗组未发现统计学意义上的差别。而组织形态测定术检测倾向于B组新骨形成最多．该组具有最佳骨嵴形态而有利于种植体的植入。

关键词：蛋白衍生物骨壁缺损联合应用拔牙窝颊侧 PDGF 基质重组

Dual Channel SIS Receiver of Trao Telescope

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天文研究与技术 1999年第S1期 82-85页

作者： Jong Ae Park 1,2 , Seog Tae Han 1, Tai Seong kim 1, Kwang Dong kim 1, Hyo Ryoung kim 1, Hyun soo Chung 1, Jae Hoon Jung 1, Chang Hoon Lee 1, Se Hyung Cho 1, Jongmann Yang 2 1. Taeduk Radio Astronomy Observatory (TRAO), Hwaam dong,

We have developed the dual channel receiver with 100GHz and 150GHz band, which is used to make the simultaneous observation with two bands. The SIS mixers are used in both bands. The constructed dewar for receiver has the performance with the vacuum of 10 -8 Torr and the temperature of 4 2K. The receiver noise temperature is 50K (DSB) for 100GHz band and 80K (DSB) for 150GHz band ,respectively. In order to achieve the simultaneous observations, the quasioptical system is precisely designed, and also evaluated by the measurement in the laboratory. We have observed the various sources using this receiver since October 1998. The relative pointing offset between two bands is 3″.

关键词： SIS Dual Channel SIS Receiver of Trao Telescope

Surface plasmon excitation in semitransparent inverted polymer photovoltaic devices and their applications as label-free optical sensors

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Light(Science & Applications) 2014年第1期3卷 5-12页

作者： Byoungchoo Park soo Hong Yun Chan Youn Cho Young Chan kim Jung Chul Shin Hong Goo Jeon Yoon Ho Huh Inchan Hwang Ku Youn Baik Young In Lee Han Sup Uhm Guang Sup Cho Eun Ha Choi Department of Electrical and Biological Physics Kwangwoon UniversitySeoul 139-701Republic of Korea Department of Electronic Materials Engineering Kwangwoon UniversitySeoul 139-701Republic of Korea

Herein,we report on surface plasmon(SP)-sensitive semitransparent inverted polymer photovoltaic(PV)devices that are based on multilayered material systems consisting of poly(3-hexylthiophene):fullerene-derivative bulk-heterojunction PV layers and thin gold or silver *** demonstrate that these PV devices allow the simultaneous generation of both electrical power and SPs on their anodes for photoexcitation just above the optical absorption edge of the PV layers,resulting not only in attenuated total reflection,but also in attenuated photocurrent generation(APG)under the SP resonance(SPR)***,we also confirm that the biomolecular interaction of biotin–streptavidin on the PV devices can be precisely detected via apparent SPR angle shifts in the APG spectra,even without the need for complex attenuated total reflection *** highlight our view that APG measurements made using these PV devices show great potential for the development of future generations of compact and highly sensitive SPR-based optical sensors.

关键词： attenuated total reflection optical sensors photocurrent generation polymer photovoltaic devices surface plasmon

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物流业上市公司的盈余管理模式研究

物流技术 2010年第13期29卷 47-50,57页

作者：金炳秀李贞南开大学商学院天津300071

针对中国物流业的发展现状,以分析上市公司盈余管理的动机为起点,对物流业的盈余管理模式进行剖析。

关键词：物流业上市公司盈余管理

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浅析寒地城市公园声环境的存在问题与对策

工业设计 2021年第3期 97-98页

作者：吕海景金秀峰东北农业大学艺术学院 Keimyung University

城市进程的快速发展导致社会的复杂化,噪音问题成为严重影响人们生活的污染问题,城市声环境的问题研究也有一定的进展,对于城市公园内的声环境研究尚在探索中。本文首先阐述了寒地城市公园声环境研究的必要性,然后分析寒地城市公园声环... 详细信息

城市进程的快速发展导致社会的复杂化,噪音问题成为严重影响人们生活的污染问题,城市声环境的问题研究也有一定的进展,对于城市公园内的声环境研究尚在探索中。本文首先阐述了寒地城市公园声环境研究的必要性,然后分析寒地城市公园声环境的存在问题,并提出相应的对策。以期丰富声景观学理论,为当代风景园林设计实践起到指导作用。

关键词：寒地城市公园声环境问题对策

区段截骨即刻复位结合正畸精细调整治疗恒磨牙阻生：临床病例报告

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中国口腔医学继续教育杂志 2011年第2期14卷 104-113页

作者： Yoon-Goo Kang Ji-Yong kim Young-Jun Lee Baek-soo Lee 禹洁（译）姜若萍（审）不详北京大学口腔医学院正畸科北京市中关村南大街22号100081

恒牙萌出紊乱对临床医师来说是一个挑战．如后牙阻生引起的侧方开骀即可能严重影响患者的咬合功能。本病例报告介绍了一种通过外科区段截骨结合正畸精细调整治疗恒磨牙阻生的方法。采用一步或两步法单牙区段截骨术．将两颗处于不同萌出... 详细信息

恒牙萌出紊乱对临床医师来说是一个挑战．如后牙阻生引起的侧方开骀即可能严重影响患者的咬合功能。本病例报告介绍了一种通过外科区段截骨结合正畸精细调整治疗恒磨牙阻生的方法。采用一步或两步法单牙区段截骨术．将两颗处于不同萌出阶段的阻生恒磨牙复位到骀平面，术后再通过正畸手段将牙一牙槽骨段调整到理想的咬合位置。

关键词：区段截骨牙齿萌出紊乱牙齿骨粘连

Biopathologic features and clinical significance of micrometatasis in the lymph node of early gastric cancer

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World Journal of Gastroenterology 2015年第2期21卷 667-674页

作者： Min Jung Jo Ji Yeon Park Joon Seon Song Myeong-Cherl Kook Keun Won Ryu soo-Jeong Cho Jun Ho Lee Byung-Ho Nam Eun Kyung Hong Il Ju Choi Young-Woo kim Gastric Cancer Branch Research Institute and HospitalNational Cancer CenterGoyang-si 410-769South Korea Department of Pathology Research Institute and HospitalNational Cancer CenterGoyangsi 410-769South Korea Cancer Registration and Biostatistics Branch and Center for Clinical Trial National Cancer CenterGoyangsi 410-769South Korea

AIM: To evaluate the biopathologic features and clinical significance of nodal micrometastasis(MI) in early gastric cancer(EGC).METHODS: Among 1022 EGC patients who underwent gastrectomy with lymphadenectomy of D1 + β or more from March 2001 to December 2005 at the Korean National Cancer Center, available nodal metastasis was found in 90 p T1N1 patients. Nodal metastasis was confirmed by immunohistochemistry(IHC) with cytokeratin and patients were classified into MI and macrometastasis(MA) groups based on the main tumor burden according to the 6th International Union Against Cancer/American Joint Committee on Cancer staging system; the main tumor burden with a diameter of greater than 0.2 mm but no greater than 2 mm as MI, and greater than 2 mm as MA of the representative metastatic node. Proliferative and apoptotic activities of the primary tumor and the nodal metastasis were measured by IHC with Ki-67 and terminal deoxynucleotidyl transferase d UTP nick end labeling, respectively. Biopathologic and clinical features of the patients were analyzed and compared between MI and MA groups. Patients with recurrence were compared with those without recurrence to identify risk factors for ***: Thirty-seven patients showed MI and the other 53 patients revealed MA in the lymph node; the incidence of patients with MI and MA was 41.1% and 58.9%. The main tumor burden was 0.9 and 4.6 mm in the representative metastatic node, respectively. Japanese N2 stations were more frequently involved in MA group(20.9%) than in MI group(10.3%) butthe difference was not statistically different(P = 0.338). Proliferative and apoptotic activities of MI were decreased than those of MA(26.7% vs 40.5%, P = 0.004 and 1.0% vs 3.0%, P < 0.001, respectively). However, nodal MI in the current study showed a relatively high proliferative activity and an equivalent apoptotic activity compared to other cancers in the previously published studies. Recurrence was observed in 6 patients during

关键词： Early gastric cancer Sentinel node biopsy Lymphade

Clinical significance and risk factors of postembolization fever in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第2期19卷 284-289页

作者： Chung Hwan Jun Ho Seok Ki Hoon Ki Lee Kang Jin Park Seon Young Park Sung Bum Cho Chang Hwan Park Young Eun Joo Hyun soo kim Sung Kyu Choi Jong Sun Rew Division of Gastroenterology Department of Internal MedicineChonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate tumor response and survival in patients with postembolization fever(PEF) and to determine the risk factors for ***:Four hundred forty-three hepatocellular carcinoma(HCC) patients who underwent the first session of transcatheter arterial chemoembolization(TACE) between January 2005 and December 2009 were analyzed *** was defined as a body temperature greater than 38.0 ℃ that developed within 3 d of TACE without evidence of *** tumor progression-free interval was defined as the interval from the first TACE to the second TACE based on mRECIST *** staging was based on the American Joint Committee on Cancer tumor,node,metastases(TNM) classification of malignant *** patients were admitted before their 1 st TACE treatment,and blood samples were obtained from all patients before and after *** variables and host-related variables were compared between two groups:patients with PEF vs patients without ***,variables related to 20-mo mortality and tumor progression-free survival were ***:The study population comprised 370(85.4%) men and 73(14.6%) women with a mean age of 62.29 ± 10.35 years.A total of 1836 TACE sessions were conducted in 443 patients,and each patient received between 1 and 27(mean:4.14 ± 3.57) TACE *** mean follow-up duration was 22.23 ± 19.6 mo(range:0-81 mo).PEF developed in 117 patients(26.41%) at the time of the first TACE *** was not associated with 20-mo survival(P = 0.524) or computed tomography(CT) response(P = 0.413) in a univariate analysis.A univariate analysis further indicated that diffuse-type HCC(P = 0.021),large tumor size(≥ 5 cm)(P = 0.046),lipiodol dose(≥ 7 mL,P = 0.001),poor blood glucose control(P = 0.034),alanine aminotransferase(ALT) value after TACE(P = 0.004) and C-reactive protein(CRP) value after TACE(P = 0.036) served as possible risk factors correlated with *** ALT value after TACE(P = 0.02

关键词： Chemoembolization Therapeutic Fever Carcinoma Hepatocellular Prognosis Progression-free survival