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Drug-induced sarcoidosis-like reaction three months after BNT162b2 mRNA COVID-19 vaccination:A case report and review of literature

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World Journal of Clinical Cases 2023年第1期11卷 177-186页

作者： soo Ryang kim soo Ki kim Takako Fujii Hisato Kobayashi Toyokazu Okuda Takanobu Hayakumo Atsushi Nakai Yumi Fujii Ryuji Suzuki Noriko Sasase Aya Otani Yu-ichiro Koma Motoko Sasaki Tsutomu Kumabe Osamu Nakashima Department of Gastroenterology Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Radiology Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Clinical Laboratory Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Pharmacy Kobe Asahi HospitalKobe 6530801HyogoJapan Division of Pathology Department of PathologyKobe University Graduate School of MedicineKobe 6530801HyogoJapan Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 9208640IshikawaJapan Department of Gastroenterology Kumabe ClinicKumamoto 8611331KumamotoJapan Laboratory Services Center St.Mary's HospitalKurume 830-8543FukuokaJapan

BACKGROUND A 70-year-old man with hepatitis C virus-related recurrent hepatocellular carcinoma was admitted for further diagnosis of a 1 cm iso-hyperechoic nodule in segment(S)*** SUMMARY Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging(EOB-MRI)revealed the nodule in S5 with a defect at the hepatobiliary phase,hyperintensity on diffusion weighted imaging(DWI)and hypointensity on apparent diffusion coefficient(ADC)***-enhanced computed tomography revealed hypervascularity at the early phase,and delayed contrast-enhancement was observed at the late ***-enhanced ultrasound(US)revealed incomplete defect at the late vascular *** liver tumor,lymphoproliferative disease,intrahepatic cholangiocarcinoma(small duct type)and bile duct adenoma were suspected through the imaging *** guided biopsy,however,showed a noncaseating hepatic sarcoid-like epithelioid granuloma(HSEG),and histopathological analysis disclosed spindle shaped epithelioid cells harboring Langhans-type multinucleated giant *** month after admission,EOB-MRI signaled the disappearance of the defect at the hepatobiliary phase,of hyperintensity on DWI,of hypointensity on ADC map,and no stain at the early *** That the patient had received BNT162b2 messenger RNA(mRNA)coronavirus disease 2019 vaccination 3 mo before the occurrence of HSEG,and that its disappearance was confirmed 4 mo after mRNA vaccination suggested that the drug-induced sarcoidosis-like reaction(DISR)might be induced by the mRNA ***,rechallenge of drug-induced DISR with the third mRNA vaccination was not confirmed.

关键词： Drug-induced sarcoidosis-like reaction BNT162b2 mRNA COVID-19 vaccine Noncaseating granuloma Ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging Th1/Th2 profile Case report

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Mixed-phase composites derived from cobalt terephthalate as efficient battery-type electrodes for high-performance supercapattery

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Journal of Materials Science & Technology 2023年第26期157卷 220-233页

作者： Ramu Manikandan Antonysamy Dennyson Savariraj Goli Nagaraju A.M.Kale J.Puigdollers Hyejin Park Hyun-soo kim Jae-Min Oh C.Justin Raj Byung Chul kim Department of Energy and Materials Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Advanced Functional Nanohybrid Material Laboratory Department of ChemistryDongguk University Seoul-CampusJung-guSeoul04620Republic of Korea Department of Materials Imperial College LondonLondon SW72AZUnited Kingdom Department of Advanced Components and Materials Engineering Sunchon National University255Jungang-roSuncheon-siJellanamdo57922Republic of Korea Department of Enginyeria Electrònica Universitat Politècnica CatalunyaBarcelona 08034Spain Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)Changwon51543Republic of Korea Physics Division School of Advanced SciencesVellore Institute of Technology(VIT)Chennai CampusChennai600127Tamil NaduIndia

Interfacial engineering of two-dimensional(2D)monometallic phosphides enables remarkable structural and electrochemical properties in energy storage ***,2D nanosheets(NSs)of FeP_(2)/Co_(2) P were grown on Ni-foam(FCP)using a solution-based and phosphorization approach to be used as freestanding for high-performance energy storage *** effective phosphorization strategy is successfully de-veloped to improve the overall crystalline phase,tailor the morphology,and boost the electrochemical performances of *** FCP NSs electrode exhibits a battery-type redox behavior with a maxi-mum high areal capacity of 1.96 C cm^(-2) at 4 mA cm^(-2) in 6 M KOH aqueous electrolyte compared to the other *** superior electrochemical performance was achieved by increasing the electroac-tive sites and high conductivity via surface tailoring and fast redox ***,a supercapattery was assembled utilizing FCP and activated carbon(AC)electrodes and it revealed maximum specific en-ergy(E_(s))and specific power(P_(s))of 41.2 Wh kg^(-1) and 7578 W kg^(-1) with good cycling stability of 91%after 10,000 cycles at 5 A g^(-1).Eventually,the supercapattery has been explored in practical applications by lighting up light-emitting diodes(LEDs),representing the real-time performance of superior energy storage devices.

关键词： 2D nanosheet Monometallic phosphide Battery-type material Supercapattery Energy storage

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Devastating complication of negative pressure wound therapy after deep inferior epigastric perforator free flap surgery:A case report

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World Journal of Clinical Cases 2023年第1期11卷 143-149页

作者： sooA Lim Dong Yun Lee BumSik kim Jung soo Yoon Yea Sik Han SuRak Eo Department of Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent *** require immediate and appropriate management before they progress to an irreversible *** negative pressure wound therapy(NPWT)can prevent wound progression by increasing microcirculation,the inappropriate application of NPWT on complicationthreatened transferred and replanted tissues can induce an adverse *** SUMMARY A 48-year-old woman who underwent immediate breast reconstruction with a deep inferior epigastric artery perforator free *** applying a heating pad directly to the flap site,she sustained a deep second to third-degree contact burn over 30%of the transferred flap on postoperative 7 *** the necrotic changes had progressed,we applied an NPWT dressing over the burned area after en-bloc debridement of the transferred tissues on postoperative 21 *** 4 d of NPWT application,the exposed fatty tissues of the flap changed to dry and browncolored necrotic *** further debridement,we noted that the wound gradually reached total necrosis with a collapsed vascular pedicle of deep inferior epigastric *** Although NPWT has been shown to be successful for treating various wound types,the significant risk of NPWT application in short-lasting reconstructed flap wounds after thermal injury should be reminded.

关键词： Negative Pressure Wound Therapy Complications Breast reconstruction Deep inferior epigastric artery perforator Free flap Burn injury Case report

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Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon:A case report

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2266-2272页

作者： Hyeon Seok Baek Sang Wook kim soo Teik Lee Ho Sung Park Seung Young Seo Department of Internal Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju-si 56445Jeollabuk-doSouth Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjusi 56445Jeollabuk-doSouth Korea

BACKGROUND Large cell neuroendocrine carcinoma(LCNEC)accounts for about 0.25%of colorectal cancer ***,synchronous LCNEC and adenocarcinoma coexistence in the colon is very *** are usually aggressive and have a poor ***,colorectal LCNEC patients complain of abdominal symptoms such as pain,diarrhea or hematochezia because it is often diagnosed as an advanced disease that accompanies metastatic *** SUMMARY We describe a case of relatively asymptomatic synchronous LCNEC and colon adenocarcinoma.A 62-year-old male patient visited our hospital due to anemia detected by a local health *** did not complain of melena,hematochezia or abdominal *** examination was unremarkable and his abdomen was soft,nontender and nondistended with no palpable *** tests revealed anemia with hemoglobin 5.1 g/*** revealed an ulcerofungating lesion in the ascending colon and about a 1.5 cm-sized large sessile polyp in the sigmoid *** biopsy of the ascending colon lesion revealed the ulcerofungating mass that was LCNEC and endoscopic mucosal resection at the sigmoid colon lesion showed a large polypoid lesion that was *** liver,lung,bone and lymph nodes metastasis was found on chest/abdominal computed tomography and positron emission *** patient was diagnosed with advanced colorectal LCNEC with liver,lung,bone and lymph node metastasis(stage IV)and synchronous colonic adenocarcinoma *** this case,no specific symptom except anemia was observed despite the multiple *** patient refused systemic chemotherapy and was discharged after *** We report a case of silent LCNEC of the colon despite the advanced state and synchronous adenocarcinoma.

关键词： Large cell neuroendocrine carcinoma Colon Synchronous Adenocarcinoma Case report

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Cecal duplication cyst in an infant presenting as shock:A case report

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世界临床病例杂志 2023年第28期11卷 6931-6937页

作者： Seung Mo kim Sun Hyang Lee Ga Young Park Sung Shin kim Cheol Gu Lee soo Ji Jin Department of Pediatrics Soonchunhyang University Bucheon HospitalSoochunhyang University College of MedicineBucheon 14584Gyeonggi-doSouth Korea Department of General Surgery Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584GyeongGi-DoSouth Korea

BACKGROUND Although intestinal obstruction is one of the most common surgical emergencies in an infant,it is difficult to diagnose neonatal enteric duplication cysts(EDC)preoperatively owing to their rarity as a cause of intestinal *** describe a case report of a neonatal EDC presenting intestinal obstruction and *** SUMMARY A 32-d-old male infant with a prenatal sonographic finding of bladder distension was admitted to our hospital for a severely distended abdomen,fever,and *** first diagnostic hypothesis was septic shock and intestinal *** patient’s symptoms worsened;following an emergency surgical exploratory laparotomy and histopathological findings,the final diagnosis of cecal duplication cyst was *** patient’s postoperative course was uneventful,and on the fifth postoperative day,oral feeding *** days later,the patient was discharged from the *** Although EDC located in the cecum is exceptional,it should be considered when evaluating suspected intestinal obstruction and shock.

关键词： Duplication cyst Cecum Intestinal obstruction Infant Shock Case report

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Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress

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Acta Pharmaceutica Sinica B 2023年第1期13卷 174-191页

作者： Eun-Bin Kwon Wei Li Young soo kim Buyun kim Hwan-Suck Chung Younghoon Go Hyun-Jeong Ko Jae-Hyoung Song Young Ho kim Chun Whan Choi Jang-Gi Choi Korean Medicine(KM)Application Center Korea Institute of Oriental MedicineDaegu 41062Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Natural Product Research Team BiocenterGyeonggido Business and Science AcceleratorGyeonggi-Do 16229Republic of Korea Laboratory of Microbiology and Immunology College of PharmacyKangwon National UniversityChuncheon 24341Republic of Korea

The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral ***,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration(FDA)for the prevention and treatment of ***,we show that vitisin B(VB)inhibits NA activity and suppresses H1N1 viral replication in MDCK and A549 *** oxygen species(ROS),which frequently occur during viral infection,increase virus replication by activating the NF-κB signaling pathway,downmodulating glucose-6-phosphate dehydrogenase(G6PD)expression,and decreasing the expression of nuclear factor erythroid2-related factor 2(Nrf2)antioxidant response *** decreased virus-induced ROS generation by increasing G6PD expression and Nrf2 activity,and inhibiting NF-κB translocation to the nucleus through IKK *** addition,VB reduced body weight loss,increased survival,decreased viral replication and the inflammatory response in the lungs of influenza A virus(IAV)-infected *** together,our results indicate that VB is a promising therapeutic candidate against IAV infection,complements existing drug limitations targeting viral *** modulated the intracellular ROS by G6PD,Nrf2 antioxidant response pathway,and NF-κB signaling *** results demonstrate the feasibility of a multi-targeting drug strategy,providing new approaches for drug discovery against IAV infection.

关键词： Influenza Vitisin B Vitis vinifera L. Neuraminidase Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD

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Proxy-Based Hierarchical Distributed Mobility Management for Tactical Networks

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Computers, Materials & Continua 2022年第2期70卷 2381-2399页

作者： Myoung-hun Han Bong-soo Roh Kyungwoo kim Dae-Hoon Kwon Jae-Hyun Ham KyungHyun Yoon Sanghyun Seo Agency for Defense Development Daejeon34186Korea Department of Computer Science and Engineering Chung-Ang UniversitySeoul06974Korea College of Art&Technology Chung-Ang UniversityAnseong17546Korea

An important requirement in a military domain is a highly reliable mobility management method,especially when components of the networks aremoving in tactical network *** increase reliability,themobility management technology of the tactical network should be able to reflect the characteristics of the tactical network,such as a limited environment,failure,and hierarchical unit *** this paper,we propose a proxy-based hierarchical distributedmobilitymanagement scheme,which is highly focused on tactical *** the characteristics of tactical networks,the proposed scheme is composed of the following:1)a proxy-based method,2)a distributed mobility management method that synchronizes a mobility database between entities,and 3)a method of managing mobility by dividing the tactical network into upper and lower *** analysis and modeling and simulation results demonstrate that the method outperforms the existing state-of-the-art method in overcoming entity failure,handover cost,and delay in tactical environments.

关键词： Mobility management tactical networks PMIP DMM

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Investigation of prodromal features in metabolic syndrome based on transcriptome analysis

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Genes & Diseases 2023年第3期10卷 708-711页

作者： Sang-Min Park Musun Park Hyo-Jeong Ban Su-Jin Baek soo Yeon kim Siwoo Lee Hee-Jeong Jin Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea

Metabolic syndrome(MetS)is a complex condition that significantly increases the risk of several diseases,including heart disease and *** with MetS show both pro-inflammatory and pro-thrombotic states;however,the state... 详细信息

关键词： diseases Metabolic Patients

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Rationally designed graphene channels for real-time sodium ion detection for electronic tongue

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InfoMat 2023年第7期5卷 43-58页

作者： Chung Won Lee Sang Eon Jun Seung Ju kim Tae Hyung Lee Sol A.Lee Jin Wook Yang Jin Hyuk Cho Shinyoung Choi Cheol-joo kim soo Young kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwonRepublic of Korea

Monitoring taste-inducing ions and molecules continuously in liquids or solutions is of great considerable matter for the realization of the electronic tongue(E-tongue).Particularly from the five major tastes,the highly selective,sensitive detection of Na^(+)in real-time is *** is due to the saltiness of food is the key ingredient in most ***,existing Na^(+)detecting devices have relatively low performances of selectivity,sensitivity,and lack of on–off ***,conventional devices significantly deteriorate in capac-ity due to repetitive usage or lifetime shortage by degradation of the sensing ***,a graphene-based channel was rationally designed by the facile decoration of Calix[4]arene and Nafion to address this *** act as a receptor and a molecular sieve,respectively,to enhance selectivity and sensitivity and elon-gate the life expectancy of the *** device was merged with a microfluidic channel to control the injection and withdrawal of solutions to fulfill dynamic on–off *** fabricated device has highly selective,sensitive Na^(+)detection properties compared to other 10 molecule/ionic *** on–off functions of the device were available,also possesses a long lifespan of at least 220 ***,it can precisely discriminate real beverages containing Na^(+),which can be observed by principal component analysis *** features offer the possibility of ascending to a platform for E-tongues in near future.

关键词： electronic tongue graphene microfluidic channels Na^(+)sensors solution-gated field-effect transistors

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“One stone,two birds”solvent system to fabricate microcrystalline cellulose–Ti_(3)C_(2)T_(x)nanocomposite film as a flexible dielectric and thermally conductive material

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Nano Research 2023年第2期16卷 3240-3253页

作者： Yong-Zhu Yan Shuwei Li Sung soo Park Wei-Jin Zhang Jun Seok Lee Jung Rae kim Dong Gi Seong Chang-Sik Ha Department of Polymer Science and Engineering School of Chemical EngineeringPusan National UniversityBusan 46241Republic of Korea School of Chemical and Biomolecular Engineering Pusan National UniversityBusan 46241Republic of Korea Division of Advanced Materials Engineering Dong-Eui UniversityBusan 47340Republic of Korea

A strategy for fabricating microcrystalline cellulose–Ti_(3)C_(2)T_(x)(MCC–MXene)nanocomposite films with high relative permittivity,high thermal conductivity,and excellent mechanical properties was *** MCC–MXene nanocomposite film was fabricated by casting a solution containing N,N-dimethylacetamide/lithium chloride(DMAc/LiCl)-soluble MCC and DMAcdispersible MXene nanosheets,followed by humidity control *** MXene nanosheets greatly enhanced the permittivity of the nanocomposite films owing to interfacial ***,the nanocomposite film with 20 wt.%MXene content achieved a desirable permittivity of 71.4 at 102 Hz(a 770%improvement against that of neat cellulose),while the dielectric loss only increased by 1.8 times(from 0.39 to 0.70).The obtained nanocomposite films with 20 wt.%and 30 wt.%MXene exhibited remarkable in-plane thermal conductivities of 8.523 and 9.668 W∙m^(−1)∙K^(−1),respectively,owing to the uniform dispersion and selfalignment of the MXene layered ***,the uniformly dispersed MXene nanosheets in the MCC network with interfacial interaction(hydrogen bonding)and mechanical entanglement endowed the nanocomposite films with excellent mechanical properties and ***,the thermal stability,water resistance,and antibacterial properties of the nanocomposite films were effectively improved with the introduction of ***,using DMAc/LiCl as the solvent system not only improves the compatibility between MCC and MXene but also avoids the problem of easy oxidation of MXene in aqueous *** the high stability of the MCC–MXene solution and enhanced properties of the MCC–MXene films,the proposed strategy manifests great potential for fabricating natural biomass-based dielectric materials.

关键词： Ti_(3)C_(2)T_(x) microcrystalline cellulose flexible dielectric thermally conductive N,N-dimethylacetamide/lithium chloride(DMAc/LiCl) compatibility

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