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Roles of NADPH oxidase 2 and 4 in endothelial cell survival and death under serum depletion

Advances in Biological Chemistry 2014年第1期4卷 10-19页

作者： hyeona jeon Yong Chool Boo Department of Molecular Medicine Cell and Matrix Research Institute BK21 plus Program Kyungpook National University School of Medicine Daegu Republic of Korea

Oxidative stress and redox-signal pathways are known to be involved in endothelial apoptosis induced by serum depletion. However, the associated mechanism is not well understood and thus, was investigated in the present study focusing on NADPH oxidases (NOX). Serum removal from the culture medium led to an increase in reactive oxygen species (ROS) production and apoptotic death of human umbilical vein endothelial cells. Serum depletion also increased the gene expression of the NOX2 and NOX4 subunits. The selective suppression of NOX4 expression by small interfering RNA (siRNA) attenuated ROS production and cell death due to serum-depletion whereas siRNA for NOX2 increased cell death. Expression of exogenous NOX2 or NOX4 subunit alone had no significant effects on ROS production or cell death. Coexpression of the subunits of the NOX4 complex (NOX4 and p22phox) or the NOX2 complex (NOX2, p22phox, p47phox and p67phox) increased ROS production and cell death under serum-depleted conditions. This study suggests that endothelial cell survival and death are differentially regulated by expression levels of the subunits of NOX2 and NOX4 complexes.

关键词： Endothelial Cells Apoptosis Serum Depletion Reactive Oxygen Species NADPH Oxidases

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Heterostructured nickel-cobalt metal alloy and metal oxide nanoparticles as a polysulfide mediator for stable lithium-sulfur full batteries with lean electrolyte

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Carbon Energy 2024年第7期6卷 163-177页

作者： hyeona Park Suyeong Lee Hyerim Kim Hyunyoung Park Hun Kim Jongsoon Kim Marco Agostini Yang-Kook Sun Jang-Yeon Hwang Department of Energy Engineering Hanyang UniversitySeoulRepublic of Korea LG Energy Solution LtdCTOLG Science ParkSeoulRepublic of Korea Department of Energy Science Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea Dipartimento di Chimica e Tecnologia del Farmaco Universitàdi Roma La SapienzaRomaItaly Department of Battery Engineering Hanyang UniversitySeoulRepublic of Korea

Batteries that utilize low-cost elemental sulfur and light metallic lithium as electrodes have great potential in achieving high energy ***,building a lithium-sulfur(Li-S)full battery by controlling the electrolyte volume generally produces low practical energy because of the limited electrochemical Li-S ***,the high energy/high performance of a Li-S full battery with practical sulfur loading and minimum electrolyte volume is reported.A unique hybrid architecture configured with Ni-Co metal alloy(NiCo)and metal oxide(NiCoO_(2))nanoparticles heterogeneously anchored in carbon nanotube-embedded selfstanding carbon matrix is fabricated as a host for *** work demonstrates the considerable improvement that the hybrid structure's high conductivity and satisfactory porosity promote the transport of electrons and lithium ions in Li-S *** experimental and theoretical validations,the function of NiCo and NiCoO_(2) nanoparticles as an efficient polysulfide mediator is *** particles afford polysulfide anchoring and catalytic sites for Li-S redox reaction,thus improving the redox conversion *** at high sulfur loading,the nanostructured Ni-Co metal alloy and metal oxide enable to have stable cycling performance under lean electrolyte conditions both in half-cell and full-cell batteries using a graphite anode.

关键词： full cell high energy lean electrolyte Li-S batteries polysulfide mediator

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