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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

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Cellular & Molecular Immunology 2022年第1期19卷 79-91页

作者： seon-Yeong Lee Su-Jin Moon Young-Mee Moon hyeon-beom seo Jun-Geol Ryu A Ram Lee Chae Rim Lee Da-Som Kim Yang-Mi Her Jeong Won Choi Seung-Ki Kwok Sung-Hwan Park Mi-La Cho The Rheumatism Research Center The Catholic University of KoreaSeoulSouth Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Medical Lifescience College of MedicineThe Catholic University of KoreaSeoulSouth Korea These author contributed equally:seon-Yeong Lee Su-Jin MoonYoung-Mee Moon

OBJECTIVE:The interleukin(IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or ***-12 family members are generally heterodimers and share threeα-subunits(p35,p19,and p28)and twoβ-subunits(p40 and EBI3).However,aβ-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling ***,we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune ***:The presence of the p40-EBI3 heterodimer was confirmed by ELISA,immunoprecipitation,and western blotting.A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collageninduced arthritis(CIA).The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical,histological,and immune cell-regulating features in mice with ***:Clinical arthritis scores and the expression levels of proinflammatory cytokines(e.g.,IL-17,IL-1β,IL-6,and TNF-α)were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with *** joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer *** vitro,the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T)cells.p40-EBI3 also inhibited osteoclast formation in a concentrationdependent ***:In this study,p40-EBI3 ameliorated proinflammatory conditions both in vivo and in *** propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis.

关键词： cytokine p40-EBI3 Rheumatoid arthritis Autoimmune disease regulatory T cell

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A Solvent-Free Covalent Organic Framework Single-Ion Conductor Based on Ion-Dipole Interaction for All-Solid-State Lithium Organic Batteries

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Nano-Micro Letters 2024年第12期16卷 189-200页

作者： Zhongping Li Kyeong-seok Oh Jeong-Min seo Wenliang Qin Soohyoung Lee Lipeng Zhai Changqing Li Jong-beom Baek Sang-Young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)50 UNIST-GilEonyang-EupUlju-GunUlsan 44919Republic of Korea Henan Key Laboratory of Functional Salt Materials Center for Advanced Materials ResearchZhongyuan University of TechnologyZhengzhou 450007People’s Republic of China Department of Battery Conflation Engineering Yonsei University50Yonsei-RoSeodaemun-GuSeoul 03772Republic of Korea Department of Battery Engineering Yonsei University50Yonsei-RoSeodaemun-GuSeoul 03772Republic of Korea

Single-ion conductors based on covalent organic frameworks(COFs)have garnered attention as a potential alternative to currently prevalent inorganic ion conductors owing to their structural uniqueness and chemical ***,the sluggish Li+conduction has hindered their practical ***,we present a class of solvent-free COF single-ion conductors(Li-COF@P)based on weak ion-dipole interaction as opposed to traditional strong ion-ion *** ion(Li+from the COF)-dipole(oxygen from poly(ethylene glycol)diacrylate embedded in the COF pores)interaction in the Li-COF@P promotes ion dissociation and Li+migration via directional ionic *** by this single-ion transport behavior,the Li-COF@P enables reversible Li plating/stripping on Li-metal electrodes and stable cycling performance(88.3%after 2000 cycles)in organic batteries(Li metal anode||5,5’-dimethyl-2,2’-bis-p-benzoquinone(Me2BBQ)cathode)under ambient operating conditions,highlighting the electrochemical viability of the Li-COF@P for all-solid-state organic batteries.

关键词： Solid organic single-ion conductors Solvent-free covalent organic frameworks All-solid-state Li organic batteries Ion-dipole interaction Pore functionalization

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Removal characteristics of CO_2 using aqueous MEA/AMP solutions in the absorption and regeneration process

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Journal of Environmental Sciences 2009年第7期21卷 907-913页

作者： Won-Joon Choi Jong-beom seo Sang-Yong Jang Jong-hyeon Jung Kwang-Joong Oh Greenhouse Gas Research Center Korea Institute of Energy Research Daejeon 305343 Korea Department of Environmental Engineering Pusan National University Busan 609735 Korea Department of Health Administration Sorabol College Gyeongju 780711 Korea

The carbon dioxide （CO2） removal efficiency, reaction rate, and CO2 loading into aqueous blended monoethanolamine （MEA）＋ 2-amino-2-methyl-l-propanol （AMP） solutions to enhance absorption characteristics of MEA and AMP were carried out by the absorption/regeneration process. As a result, compared to aqueous MEA and AMP solutions, aqueous blended MEA ＋ AMP solutions have a higher CO2 loading than MEA and a higher reaction rate than AMP. The CO2 loading of rich amine of aqueous 18 wt.% MEA ＋ 12 wt.% AMP solution was 0.62 mol CO2/mol amine, which is 51.2% more than 30 wt.% MEA （0.41 mol CO2/mol amine）. Consequently, blending MEA and AMP could be an effective way to design considering economical efficiency and used to operate absorber for a long time.

关键词： carbon dioxide monoethanolamine 2-amino-2-methyl-1-propanol absorption regeneration

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Vaporization reduction characteristics of aqueous ammonia solutions by the addition of ethylene glycol, glycerol and glycine to the CO_2 absorption process

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Journal of Environmental Sciences 2012年第3期24卷 494-498页

作者： Jong-beom seo Soo-Bin Jeon Je-Young Kim Gang-Woo Lee Jong-hyeon Jung Kwang-Joong Oh Department of Environmental Engineering Pusan National University Busan 609735 Korea. Research Institute of Industrial Science & Technology Pohang 790330 Korea Research & Development Institute of Yoosung Co. Ltd. Ulsan 680070 Korea Faculty of Health Science Daegu Haany University Daegu 712715 Korea

Aqueous ammonia （NH3） solution can be used as an alternative absorption for the control of CO2 emitted from flue gases due to its high absorption capacity, fast absorption rate and low corrosion problem. The emission of CO2 from iron and steel plants requires much attention, as they are higher than those emitted from power plants at a single point source. In the present work, low concentration ammonia liquor, 9 wt.%, was used with various additives to obtain the kinetic properties using the blast furnace gas model. Although a solution with a high ammonia concentration enables high CO2 absorption efficiency, ammonium ions are lost as ammonia vapor, resulting in reduced CO2 absorption due to the lower concentration of the ammonia absorbent. To decrease the vaporization of ammonia, ethylene glycol, glycerol and glycine, which contain more than one hydroxyl radical, were chosen. The experiments were conducted at 313 K similar to the CO2 absorption conditions for the blast furnace gas model.

关键词： ammonia vaporization blast furnace gas ethylene glycol glycerol glycine

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Heating energy savings potential from retrofitting old apartments with an advanced double-skin façade system in cold climate

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Frontiers in Energy 2020年第2期14卷 224-240页

作者： Yeo beom YOON Byeongmo seo Brian Baewon KOH Soolyeon CHO College of Design North Carolina State UniversityRaleighNC27695-7701USA Sun&Light Corp.Ltd41Seocho-daero 42-gilSeocho-guSeoulRepublic of Korea

Apartments account for over 60%of total residential buildings and consume a significant portion of primary energy in South *** energy efficiency measures have been implemented for both new apartment constructions and existing apartment *** apartment structures have poor thermal performances,resulting in a high energy *** South Korean government initiated retrofitting projects to improve the energy efficiency in old *** owners typically replace old windows with high-performance windows;however,there is still a demand for better and more innovative retrofit methods for a highly improved energy *** paper proposes an advanced double-skin façade(DSF)system to replace existing balcony windows in old *** the cold climate conditions of seoul,South Korea,it mainly discusses heating energy *** case models were developed:Base-Case with existing apartment,Case-1 with typical retrofitting,and Case-2 with the proposed DSF *** EnergyPlus simulation program was used to develop simulation models for a floor radiant heating system.A typical gas boiler was selected for low-temperature radiant system *** air flow network method was used to model the proposed DSF *** heating months,i.e.,November to March,and one representative day,i.e.,January 24,were selected for detailed *** main heat loss areas consist of windows,walls,and *** results reveal that the apartment with the DSF retrofit saves 38.8%on the annual heating energy compared to the Base-Case and 35.2%compared to Case-1.

关键词： double-skin façade retrofitting high-rise apartment heating energy building simulation

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Understanding of the capacity Contribution of carbon in phosphorus-carbon composites for high-performance anodes in lithium ion batteries

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Nano Research 2017年第4期10卷 1268-1281页

作者： Jiantie Xu In-Yup Jeon Jianmin Ma Yuhai Dou seok-Jin Kim Jeong-Min seo Huakun Liu Shixue Dou Jong-beom Baek Liming Dai Institute for Superconducting and Electronic Materials University of Wollongong Wollongong NSW 2522 Austrafia School of Energy and Chemical Engineering/Low-Dimensional Carbon Materials Center Ulsan National Institute of Science and Technology (UNIST) UNIST-gi150 Ulsan 689-897 Republic of Korea Department of Macromolecular Science and Engineering Case Western Reserve University Cleveland OH 44106 USA

Phosphorus has recently received extensive attention as a promising anode for lithium ion batteries （LIBs） due to its high theoretical capacity of 2,596 mAh·g^-1. To develop high-performance phosphorus anodes for LIBs, carbon materials have been hybridized with phosphorus （P-C） to improve dispersion and con- ductivity. However, the specific capacity, rate capability, and cycling stability of P-C anodes are still less than satisfactory for practical applications. Furthermore, the exact effects of the carbon support on the electrochemical performance of the P-C anodes are not fully understood. Herein, a series of xP-yC anode materials for LIBs were prepared by a simple and efficient ball-milling method. 6P-4C and 3P-7C were found to be optimum mass ratios of x/y, and delivered initial discharge capacities of 1,803.5 and 1,585.3-mAh·g^-1, respectively, at 0.1 C in the voltage range 0.02-2 V, with an initial capacity retention of 68.3% over 200 cycles （more than 4 months cycling life） and 40.8% over 450 cycles. The excellent electrochemical performance of the 6P-4C and 3P-7C samples was attributed to a synergistic effect from both the adsorbed P and carbon.

关键词： phosphorus carbon synergistic effect anode lithium ion batteries

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Taraxacum offlcinale protects against cholecystokinin-induced acute pancreatitis in rats

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World Journal of Gastroenterology 2005年第4期11卷 597-599页

作者： Sang-Wan seo Hyun-Na Koo Hyo-Jin An Kang-beom Kwon Byung-Cheal Lim Eun-A seo Do-Gon Ryu Goo Moon Hong-Yeoul Kim Hyung-Min Kim Seung-Heon Hong Department of Pharmacology College of Oriental Medicine Kyung Hee UniversitySeoul South Korea Department of Oriental PharmacyCollege of PharmacyWonkwang University Iksan Jeonbuk South Korea Department of Pharmacology College of Oriental Medicine Kyung Hee University Seoul South Korea Department of Pharmacology College of Oriental Medicine Kyung Hee University Seoul South Korea Department of Oriental PharmacyCollege of Pharmacy Wonkwang University Iksan Jeonbuk South Korea School of Oriental Medicine Wonkwang University IksanJeonbukSouth Korea Department of Food and Nutrition School of Human Environmental Science Wonkwang UniversityJeonbukSouth Korea Institute of Oriental Medicine College of Oriental Medicine Kyung Hee University SeoulSouth Korea Department of Pharmacology College of Oriental Medicine Kyung Hee UniversitySeoulSouth Korea Department of Oriental Pharmacy College of Pharmacy Wonkwang UniversityIksanJeonbukSouth Korea

AIM: Taraxacum officinale (TO) has been frequently used as a remedy for inflammatory diseases. The aim of this study was to investigate the effect of TO on cholecystokinin (CCK)-octapeptide-induced acute pancreatitis in ***: TO at 10 mg/kg was orally administered, followed by 75 μg/kg CCK octapeptide injected subcutaneously three times after 1, 3 and 5 h. This whole procedure was repeated for 5 d. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60 and HSP72, and the secretion of pro-inflammatory cytokines. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally-induced ***: TO significantly decreased the pancreatic weight/body weight ratio in CCK octapeptide-induced acute pancreatitis. TO also increased the pancreatic levels of HSP60 and HSP72. Additionally, the secretion of IL-6 and TNF-α decreased in the animals treated with ***: TO may have a protective effect against CCK octapeptide-induced acute pancreatitis.

关键词： Acute pancreatitis Taraxacum officinale CCK octapeptide

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Does the bile duct angulation affect recurrence of choledocholithiasis?

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World Journal of Gastroenterology 2011年第36期17卷 4118-4123页

作者： Dong beom seo Byoung Wook Bang seok Jeong Don Haeng Lee Shin Goo Park Yong Sun Jeon Jung Il Lee Jin-Woo Lee Division of Gastroenterology Department of Internal MedicineInha University School of MedicineIncheon 400-711South Korea Division of Gastroenterology Department of Internal Medicine and Center for Advanced Medical Education by BK21 ProjectInha University School of Medicineand Utah-Inha DDS and Advanced Therapeutics Research CenterIncheon 400-711South Korea Department of Occupational and Environmental Medicine Inha University School of MedicineIncheon 400-711South Korea Department of Radiology Inha University School of MedicineIncheon400-711South Korea

AIM:To investigate whether bile duct angulation and T-tube choledochostomy influence the recurrence of ***:We conducted a retrospective study including 259 patients who underwent endoscopic sphincterotomy and cholecystectomy for choledocholithiasis between 2000 and *** imaginary line was drawn along the center of the bile duct and each internal angle was measured at the two angulation sites ofthe bile duct *** values of both angles were added *** then tested our hypothesis by examining whether T-tube choledochostomy was performed and stone recurrence occurred by reviewing each subject's medical ***:The overall recurrence rate was 9.3% (24 of 259 patients).The mean value of sums of angles in the recurrence group was 268.3°± 29.6°,while that in the non-recurrence group was 314.8°± 19.9° (P < 0.05).Recurrence rate of the T-tube group was 15.9% (17 of 107),while that of the non T-tube group was 4.6% (7 of 152) (P < 0.05).Mean value of sums of angles after T-tube drainage was 262.5°± 24.6° and that before T-tube drainage was 298.0°± 23.9° in 22 patients (P < 0.05).CONCLUSION:The bile duct angulation and T-tube choledochostomy may be risk factors of recurrence of bile duct stones.

关键词： Choledocholithiasis Common bile duct Cholecystectomy Recurrence Endoscopic retrograde cholangio pancreatography

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Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve

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Acta Pharmacologica Sinica 2006年第1期27卷 50-58页

作者： Tae-beom seo In-sun HAN Jin-hwan YOON In-chan seoL Yun-sik RIM Hyun-kyung JO Joung-jo AN Kwon-eui HONG Young-bae seo Dong-hee KIM Seung-kiel PARK Deok-chun YANG Uk NAMGUNG Korea Department of Oriental Medicine.Daejeon University Daejeon 300-716Korea Korea Department of Biochemistry College of Medicine Chungnam National University.Daejeon 301-130Korea Korea

Aim:Extract of Hominis Placenta (HP) has been used in oriental medicine as anagent for improving physiological *** present study was conducted toinvestigate whether HP treatment in an experimental sciatic nerve injury animalmodel produces growth-promoting effects on regenerating peripheral nerve fibersafter ***:After HP was injected into a sciatic nerve injury site,changesin protein levels were analyzed in the regenerating nerve area by Western blottingand immunofluorescence staining *** quantitative assessment of ax-onal regeneration,a retrograde tracing technique was used to identify the neu-ronal cell bodies corresponding to regenerating axons,and the extent of neuriteoutgrowth in cultured dorsal root ganglia (DRG) sensory neurons prepared fromanimals that had experienced a sciatic nerve crush injury 7d before neuron collec-tion was ***:Induction levels of axonal growth-associated protein(GAP-43) in the injured sciatic nerves were elevated by HP *** treat-ment also upregulated cell division cycle 2 (Cdc2) protein levels in the distalstump of the injured sciatic *** Cdc2 protein was detected in Schwanncells,suggesting that Cdc2 kinase activity may be involved in the growth-promot-ing activity of regenerating axons via Schwann cell *** body mea-surement by retrograde tracing indicated that HP treatment produced significantincreases in regenerating motor ***,HP treatment of cultured DRGsensory neurons significantly increased neurite arborization and ***:HP promotes the regeneration of injured sciatic axons by upregulatingthe synthesis of regeneration-related protein factors such as GAP-43 and Cdc2.

关键词： hominis placenta axonal regeneration sciatic nerve GAP-43 protein Cyclindepend kinase 2

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An Anionic Covalent Organic Framework as an Electrostatic Molecular Rectifier for Stabilizing Mg Metal Electrodes

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CCS Chemistry 2023年第11期5卷 2567-2575页

作者： Zhongping Li Hyunseok Moon seok-Kyu Cho Changqing Li Jeong-Min seo Jong-beom Baek Hong Xu Sang-Young Lee Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03772 School of Energy and Chemical Engineering Ulsan National Institute of Science and TechnologyUlsan 44919 UBATT Inc. Daejeon 34036 Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084

Despite its potential as a high-capacity battery electrode,magnesium(Mg)metals are highly susceptible to electrolytes,resulting in the formation of unwanted passivation layers,which hinder charge transfer ***,we first report an anionic covalent organic framework(a-COF)as an electrostatic molecular rectifier(that can preferentially trap solvent molecules)to stabilize Mg metal *** to a neutral COF(n-COF)as a control sample,the a-COF enhances Mg^(2+)transport by facilitating the desolvation of Mg^(2+)-solvent complexes and cationic mobility through its negatively charged one-dimensional columns,thereby achieving an ionic conductivity eight times higher than that of the *** addition,the anionic porous frameworks in contact with Mg metal electrodes enable a uniform Mg^(2+)flux and interfacial stability with Mg metal ***,the a-COF exhibited reversible Mg plating/stripping cyclability on Mg metal electrodes compared to the n-COF,demonstrating the electrochemical viability of the anionic frameworks for Mg metal electrode stabilization.

关键词： anionic covalent organic framework Mg metal electrodes ion transport interfacial stability Mg plating/stripping

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