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Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4^(+)T cells

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Cellular & Molecular Immunology 2023年第5期20卷 525-539页

作者： Jiung Jeong In Kang Yumin kim Keun Bon Ku Jang Hyun Park Hyun-Jin kim Chae Won kim Jeongwoo La Hi Eun Jung hyeon cheol kim Young Joon Choi Jaeho kim Joon kim Heung Kyu Lee Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Internal Medicine Seoul National University HospitalSeoul 03080Republic of Korea Department of Biological Sciences KAISTDaejeon 34141Republic of Korea Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea.

CD4^(+)T cells play major roles in the adaptive immune system,which requires antigen recognition,costimulation,and cytokines for its elaborate *** studies have provided new insight into the importance of the supramolecular activation cluster(SMAC),which comprises concentric circles and is involved in the amplification of CD4^(+)T cell ***,the underlying mechanism of SMAC formation remains poorly ***,we performed single-cell RNA sequencing of CD4^(+)T cells left unstimulated and stimulated with anti-CD3 and anti-CD28 antibodies to identify novel proteins involved in their *** found that intraflagellar transport 20(IFT20),previously known as cilia-forming protein,was upregulated in antibody-stimulated CD4^(+)T cells compared to unstimulated CD4^(+)T *** also found that IFT20 interacted with tumor susceptibility gene 101(TSG101),a protein that endocytoses ubiquitinated T-cell *** interaction between IFT20 and TSG101 promoted SMAC formation,which led to amplification of AKT-mTOR ***,IFT20-deficient CD4^(+)T cells showed SMAC malformation,resulting in reduced CD4^(+)T cell proliferation,aerobic glycolysis,and cellular ***,mice with T-cell-specific IFT20 deficiency exhibited reduced allergen-induced airway ***,our data suggest that the IFT20-TSG101 axis regulates AKT-mTOR signaling via SMAC formation.

关键词： CD4^(+)T cell Intraflagellar transport 20 Tumor susceptibility gene 101 AKT-mTOR signaling Asthma Supramolecular activation cluster

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R相热处理对抗扭强度和循环疲劳断裂的影响

热处理技术与装备 2013年第2期34卷 54-54页

作者： Jung-Hong Ha Sung Kyo kim Nestor Cohenca hyeon-cheol kim

本项目的目的是在有相同几何特性的仪器上用新的R相热处理研究对扭应力和循环疲劳的抗力。研究选用尺寸为#30/.04和#30/.06的K3XF和K3锉(每组10把)。为了评估抗扭强度要记录在屈服点、极限点和断裂点的扭力载荷和扭角。直到断裂的韧性... 详细信息

本项目的目的是在有相同几何特性的仪器上用新的R相热处理研究对扭应力和循环疲劳的抗力。研究选用尺寸为#30/.04和#30/.06的K3XF和K3锉(每组10把)。为了评估抗扭强度要记录在屈服点、极限点和断裂点的扭力载荷和扭角。直到断裂的韧性是计算的。用确定每台仪器结束时的周期数来估算循环疲劳抗力。用非参数惠特尼U检定(对扭转抗力)和独立的t试验(对循环疲劳)进行统计分析。经扭转和循环疲劳测试后,在扫描电镜下观测所有的断口评估断裂表面的断口形貌。虽然K3XF和K3显示优良的循环抗力,根据极限强度、断裂角和不考虑仪器的锥形体在K3XF和K3的两个标记之间的韧性,扭转抗力没有明显的差别。断裂横截面的表面呈现典型的循环疲劳断口和扭转断口。K3XF的独特的表面上有许多不规则微孔。采用R相热处理工艺的热处理K3XF的仪器,如果不降低扭转强度此仪器能提高循环疲劳抗力。

关键词：循环疲劳疲劳断裂抗扭强度热处理 R相疲劳抗力几何特性统计分析

Formation of spherical alloy microparticles in a porous salt medium

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Journal of Materials Science & Technology 2020年第8期36卷 189-196页

作者： Hayk HNersisyan Suk cheol Kwon Vladislav E.Ri Wan Bae kim Woo Seok Choi Jong hyeon Lee RASOM Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Graduate School of Materials Science and Engineering Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea

This study describes the development of a one-pot strategy to produce spherical alloy microparticles for advanced near-net-shape manufacturing processes, including additive manufacturing and powder injection molding. The Al Si12 eutectic alloy(ca. 12 wt% Si) system was chosen as the model with which the main experiments were carried out. The proposed process synergistically integrates a few common,low-cost processing techniques including the mixing of Al micrometer size particles with silicon and sodium chloride, heat-treating the mixture at temperatures of 650–810°C, and the dissolution of salt in water to produce spherical Al Si12 alloy particles without the need to rely on costly melting and atomizing techniques. This new process can use laow-cost source Al and Si powders as the raw materials to produce10–200 um-sized spherical particles of Al Si12. The Ansys-CFX computational fluid dynamics software was used to analyze the flow behavior of Al Si12 liquid droplets and particle size refinement in the narrow voids of the sample.

关键词： AlSi(12)alloy Morphology evaluation Particle distribution Simulation Solid-liquid transition Spheroidization

Modulating the synergy of Pd@Pt core-shell nanodendrites for boosting methanol electrooxidation kinetics

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Journal of Materials Science & Technology 2023年第34期165卷 153-160页

作者： hyeon Jeong kim cheol Joo Moon Seokhee Lee Jayaraman Theerthagiri Jong Wook Hong Myong Yong Choi Young Wook Lee Department of Chemistry and Research Institute of Natural Sciences Gyeongsang National UniversityJinju 52828Republic of Korea Core-Facility Center for Photochemistry&Nanomaterials Gyeongsang National UniversityJinju 52828Republic of Korea Energy&Environment Division Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Chemistry University of UlsanUlsan 44610Republic of Korea Department of Education Chemistry and Research Institute of Natural Sciences Gyeongsang National UniversityJinju 52828Republic of Korea

The single-pot production of Pd@Pt core-shell structures is a promising approach as it offers large surface area,catalytic capability,and *** this work,we established a single-pot process to produce Pd@Pt core-shell nanodendrites with tunable composition,shape and size for optimal electrochemical ***@Pt nanodendrites with diverse compositions were synthesized by tuning the ratios of Pd and Pt sources in an aqueous environment using cetyltrimethylammonium chloride,which functioned as both the surfactant and the reducing agent at an elevated temperature(90°C).The synthesized Pd5@Pt5 nanodendrites showed exceptional electrochemical action toward the methanol oxidation reaction related with another compositional Pd@Pt nanodendrites and conventional Pt/C *** addition,Pd5@Pt5 nanodendrites exhibited good CO tolerance owing to their surface features and the synergistic effect among Pt and ***,nanodendrites with a Pt-rich surface provided exceptional catalytic active *** with the conventional Pt/C electrocatalyst,the anodic peak current obtained by Pd5@Pt5 nanodendrites was 3.74 and 2.18 times higher in relations of mass and electrochemical active surface area-normalized current density,*** approach offers an attractive strategy to design electrocatalysts with unique structures and outstanding catalytic performance and stability for electrochemical energy conversion.

关键词： Core-shell nanostructure Pd@Pt electrocatalysis One-pot synthesis Formation mechanism of nanodendrites Methanol oxidation reaction

Computational approaches for fast generation of digital 3D video holograms(Invited Paper)

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Chinese Optics Letters 2009年第12期7卷 1083-1091页

作者： Seung-cheol kim Eun-Soo kim 3D Display Research Center Department of Electronic Engineering Kwangwoon University

Several approaches for fast generation of digital holograms of a three-dimensional （3D） object have been discussed. Among them, the novel look-up table （N-LUT） method is analyzed to dramatically reduce the number of pre-calculated fringe patterns required for computation of digital holograms of a 3D object by employing a new concept of principal fringe patterns, so that problems of computational complexity and huge memory size of the conventional ray-tracing and look-up table methods have been considerably alleviated. Meanwhile, as the 3D video images have a lot of temporally or spatially redundant data in their inter- and intra-frames, computation time of the 3D video holograms could be also reduced just by removing these redundant data. Thus, a couple of computational methods for generation of 3D video holograms by combined use of the N-LUT method and data compression algorithms are also presented and discussed. Some experimental results finally reveal that by using this approach a great reduction of computation time of 3D video holograms could be achieved.

关键词： LUT Computational approaches for fast generation of digital 3D video holograms CGH

Weighted Norm Inequalities of the Maximal Commutator of Quasiradial Bochner-Riesz Operators

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Acta Mathematica Sinica,English Series 2013年第9期29卷 1743-1756页

作者： Yong cheol kim Department of Mathematics Education Korea University

In this paper, we obtain certain Lpw（Rn）-mapping properties for the maximal operator associated with the commutators of quasiradial Bochner-Riesz means with index δ under certain surface condition on Σed , provided that δ （n-1）/2, b ∈ BMO（Rn）, 1 p ∞ and w ∈ A1 . Moreover, if δ （n-1）/2, then we prove that the above maximal operator admits weak type （H1w（Rn）, L1w（Rn））-mapping properties for b ∈ BMO（Rn） and w ∈ A1 under the surface condition on Σed .

关键词： Commutator quasiradial Bochner–Riesz operators weighted norm inequalities

The electronic structure and intervalley coupling of artificial and genuine graphene superlattices

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Nano Research 2016年第4期9卷 1101-1115页

作者： Pilkwang kim cheol-Hwan Park Department of Physics and Astronomy Seoul National University Seou108826 Republic of Korea

The so-called artificial graphene is an artificial material whose low-energy carriers are described by the massless Dirac equation. Applying a periodic potential with triangular symmetry to a two-dimensional electron gas is one approach to make such a material. According to recent experimental results, it is now possible to realize artificial graphene in the lab and to even apply an additional lateral, one-dimensional periodic potential to it. We name the latter system an artificial graphene superlattice in order to distinguish it from a genuine graphene superlaedce made from graphene. In this study, we investigate the electronic structure of artificial graphene superlattices, which exhibit the emergence of energy band gaps, merging and splitting of the Dirac points, etc. Then, from a similar investigation on genuine graphene superlattices, we show that many of these features originate from the coupling between Dirac fermions residing in two different valleys--the intervaUey coupling. Furthermore, contrary to previous studies, we find that the effects of intervalley coupling on the electronic structure cannot be ignored, irrespective of the length of the spatial period of the superlattice.

关键词： graphene artificial graphene graphene superlattice intervaUey coupling

Influence of Center of Gravity Location on Flight Dynamic Stability in a Hovering Tailless FW-MAV: Lateral Motion

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Journal of Bionic Engineering 2020年第1期17卷 148-160页

作者： Loan Thi kim Au Hoon cheol Park Department of Smart Vehicle Engineering and Artificial Muscle Research Center Konkuk UniversitySeoul 05029Korea

This paper reports the effect of the Center of Gravity(CG)position on lateral flight dynamic stability of hovering KUBeetle,a tailless FW-MAV,providing further insights on the effects of asymmetries in body mass distribution and wing *** the current study,the standard linearized equations of motion were applied as in the previous work on longitudinal dynamic *** stability derivatives were acquired using the computational fluid dynamic methods via the commercial software of ANSYS *** exists a stable region for CG between 2.6%and 3.5%of the mean chord below the wing pivot point,in which the lateral motion of hovering KUBeetle is passively *** CG below the stable region,because of an unstable oscillatory mode,the lateral motion of the FW-MAV is unstable but can be stabilized using rolling rate *** CG above the stable region,because of a divergence mode,the system remains unstable even with the rolling rate *** with other works on an FW-MAV based on a quasi-steady aerodynamic model and on insect showed similar characteristics for flapping *** is also interesting to note that the asymmetries in body mass and wing kinematics can enlarge the stable region of the system by a non-zero Ixz which approaches the root square of√IxIz,a negative LrNp,and a positive Ix2(Ir+Np).Combining the current result with that of the previous work on longitudinal motion,the most beneficial region of the CG for full 6-DOF flight dynamic stability of hovering KUBeetle was suggested.

关键词： FW-MAV center of gravity flight dynamic stability lateral motion asymmetry computational fluid dynamics bioinspired flight

Nanostructure and corrosion behaviors of nanotube formed Ti-Zr alloy

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中国有色金属学会会刊：英文版 2009年第4期19卷 1005-1008页

作者： Won-Gi kim Han-cheol CHOE Department of Dental Materials & Research Center of Nano-Interface Activation for Biomaterials College of DentistryChosun University

In order to investigate the nanostructures and corrosion behaviors of Ti-Zr alloys,nanotube formed Ti-Zr(10%,20%,30% and 40% in mass fraction) alloys were prepared by arc melting and the condition of controlling nanostructure was at 1 000 ℃ for 24 h in argon atmosphere;formation of nanotubes was conducted by anodizing a Ti-Zr alloy in H3PO4 electrolyte with a small amount of fluoride ions at room *** corrosion properties of specimens were examined through potentiodynamic test(potential range of -1 500-2 000 mV) in 0.9% NaCl solution by using *** of the alloys were observed by optical microscope(OM),field emission scanning electron microscope(FE-SEM) and X-ray diffractometer(XRD).Diameter of nanotube does not depend on Zr content,but interspace of nanotube predominantly depends on Zr content,which confirms that ZrO2 oxides play a role to increase the interspace of nanotube formed on the surface.

关键词：钛锆合金纳米结构腐蚀行为扫描电子显微镜 NaCl溶液阳极氧化光学显微镜 X射线衍射