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Ethyl acetate fraction of Sargassum pallidum extract attenuates particulate matter-induced oxidative stress and inflammation in keratinocytes and zebrafish

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 137-146页

作者： Wook Chul Kim Ji-Won Park Bohyun Yun WonWoo Lee Kyung-Min choi Seung-Hong Lee Department of Medical Science Soonchunhyang UniversityAsan 31538Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do 58762Republic of Korea Department of Pharmaceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

Objective:To evaluate the effect of the ethyl acetate fraction derived from Sargassum pallidum extract against particulate matter(PM)-induced oxidative stress and inflammation in HaCaT cells and ***:HaCaT cells and zebrafish were used to evaluate the protective effects of the ethyl acetate fraction of Sargassum pallidum extract against PM-induced oxidative stress and *** production of nitric oxide(NO),intracellular ROS,prostaglandin E_(2)(PGE_(2)),and pro-inflammatory cytokines,and the expression levels of COX-2,iNOS,and NF-κB were evaluated in PM-induced HaCaT ***,the levels of ROS,NO,and lipid peroxidation were assessed in the PM-exposed zebrafish ***:The ethyl acetate fraction of Sargassum pallidum extract significantly decreased the production of NO,intracellular ROS,and PGE_(2) in PM-induced HaCaT *** addition,the fraction markedly suppressed the levels of pro-inflammatory cytokines and inhibited the expression levels of COX-2,iNOS,and NF-κ***,it displayed remarkable protective effects against PM-induced inflammatory response and oxidative stress,represented by the reduction of NO,ROS,and lipid peroxidation in ***:The ethyl acetate fraction of Sargassum pallidum extract exhibits a protective effect against PM-induced oxidative stress and inflammation both in vitro and in vivo and has the potential as a candidate for the development of pharmaceutical and cosmeceutical products.

关键词： Particulate matter Inflammation Oxidative stress Sargassum pallidum Ethyl acetate fraction Zebrafish

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Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells

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World Journal of Stem Cells 2020年第12期12卷 1511-1528页

作者： Soyoun Um Jueun Ha Soo jin choi Wonil Oh hye jin jin Research Team for Immune Cell Therapy Biomedical Research InstituteMEDIPOST Co.Ltd.Seongnam 13494South Korea Research Team for Osteoarthritis Biomedical Research InstituteMEDIPOST Co.Ltd.Seongnam 13494South Korea Biomedical Research Institute MEDIPOST Co.Ltd.Seongnam 13494South Korea

Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and *** the high latent selfrenewal and differentiation capacity of these cells,the safety,efficacy,and yield of MSCs expanded for ex vivo clinical applications remains a ***,immunomodulatory effects have emerged in various disease models,exhibiting specific mechanisms of action,such as cell migration and homing,angiogenesis,anti-apoptosis,proliferation,anti-cancer,anti-fibrosis,anti-inflammation and tissue ***,we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies,and discuss the concerns regarding the safety and mass production issues in future applications.

关键词： Umbilical cord blood Mesenchymal stem cell Stem cell therapy Immunomodulation Regenerative medicine Therapeutic cell manufacturing processing

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Unlocking power of neighboring vacancies in boosting hydrogen evolution reactions on two-dimensional NiPS3 monolayer

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eScience 2024年第3期4卷 104-115页

作者： Hyun Gu Han Jae Won choi Minsu Son Ki Chul Kim Computational Materials Design Laboratory Department of Chemical EngineeringKonkuk UniversitySeoul 05029The Republic of Korea Division of Chemical Engineering Konkuk UniversitySeoul 05029The Republic of Korea

This study investigates the effect of defect engineering on the catalytic activity of a NiPS3 monolayer catalyst for the hydrogen evolution reaction(HER).Three different types of vacancies on the basal plane of the monolayer are explored through a multi-step mechanism involving the dissociative adsorption of a water molecule and subsequent electrochemical adsorption of the dissociated ***-formation of vacancies in both Ni and S sites is found to be the most effective in enhancing the catalytic performance of the monolayer.A key resource for the reaction thermodynamics is the S-substitution-like physisorption of a water molecule on a vacant S site,followed by the dissociative occupation of OH and H into vacant sites of S and Ni elements,boosted by the NiS di-vacancy configuration with low activation energy *** reveals the highest contribution of bonding orbitals to the monolayer-H bond makes it the most desirable defect engineering approach for transition metal phosphorus chalcogenides with high HER ***,this study highlights the significance of controlled defect engineering in augmenting the catalytic performance of NiPS3 monolayer catalysts for HER.

关键词： Hydrogen evolution reaction Defect engineering Transition metal phosphorus trichalcogenide Density functional theory Reaction thermodynamics

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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One dimensional pea-shaped NiSe_(2) nanoparticles encapsulated in N-doped graphitic carbon fibers to boost redox reversibility in sodium-ion batteries

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Journal of Materials Science & Technology 2024年第1期168卷 215-226页

作者： Hyunjeong Gim Achmad Yanuar Maulana Jiwon choi Jungwook Song Boram Yun Yuri Jeong Nahyun An Myeongkee Park Cybelle M.Futalan Jongsik Kim Department of Chemical Engineering(BK21 FOUR Graduate Program) Dong-A UniversityBusan 49315Korea(the Republic of) Department of Chemistry Dong-A UniversityBusan 49315Korea(the Republic of) Department of Chemistry Pukyong National UniversityBusan 48513Korea(the Republic of) Institute of Civil Engineering University of the PhilippinesDiliman 1127Philippines

In recent years,sodium-ion batteries(SIBs)have emerged as a promising technology for energy storage systems(ESSs)because of the abundance and affordability of ***,metal selenides have been studied as promising high-performance conversion-type anode materials in *** them,nickel se-lenide(NiSe_(2))has received considerable attention due to its high theoretical capacity of 495 mAh g^(-1)and ***,it still suffers from poor cycling stability because of the low electrochemical reactivity,large volume expansion,and structural instability during *** address these challenges,NiSe_(2)nanoparticles encapsulated in N-doped graphitic carbon fibers(NiSe_(2)@NGCF)were synthesized by using ZIF-8 as a ***_(2)@NGCF showed a high discharge capacity of 558.3 mAh g^(-1)with a fading rate of 0.14%per cycle after 200 cycles at 0.5 A g^(-1)in 0.01-3.0 *** a very high current density of 5 A g^(-1),the capacity still displayed excellent long-term cycle life with a discharge capacity of 406.1 mAh g^(-1)with a fading rate of 0.016%per cycle after 3000 *** mechanism of the excellent electrochem-ical performance of NiSe_(2)@NGCF was thoroughly investigated by ex-situ XRD,TEM,and SEM ***,NiSe_(2)@NGCF//Na_(3)V_(2)(PO_(4))_(3)full-cell also delivered an excellent reversible capacity of 378.7 mAh g^(−1)at 0.1 A g^(−1)after 50 cycles,demonstrating its potential for practical application in SIBs.

关键词： Sodium-ion batteries Anode materials Nickel selenide N-doped graphitic carbon fibers One-dimensional electrode

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A Toast to Toastmasters Helping non-native English speakers improve more than just language skills

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空中英语教室（高级版．彭蒙惠英语） 2024年第11期 34-35,50页

作者： Hojun choi 不详

Daisy Xiao,51,felt her hands trembling as she stood at her first Toastmasters Club *** aware of her shortcomings in English,it was why she thought she'd check *** decades,Texas Dragon Toastmasters Club,part of Toastmasters International,has helped people like Xiao improve their English and public *** weekly meetings are more than just a place to improve your English and speech,*** are also a place for sharing;a place where they can tell stories of personal struggles and improvement and let sometimes-stifled personalities shine through.

关键词： Toastmasters speakers shortcomings

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Effects of Desalination Processes on the Water Circulation and Earth System

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Journal of Environmental Protection 2024年第3期15卷 338-342页

作者： Jae-Woo choi Center for Water Cycle Research Korea Institute of Science and Technology Seoul Korea Division of Energy & Environment Technology KIST School Korea University of Science and Technology Seoul Korea

Desalination is emerging as a promising alternative among various technologies to resolve water shortage. However, desalination requires a sufficient energy and cooling device and therefore poses limitations for its installation and application. In particular, many countries suffering water deficits are economically underdeveloped and cannot afford the technology. As this technology, which changes seawater into freshwater, has little environmental impact, developed countries will need to assist less developed countries to introduce this technology as a humanitarian effort. This will help reduce the number of countries that have experienced difficulty with development.

关键词： Desalination Earth System Humanitarian Effort Water Shortage

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Surface doping effect on the optoelectronic performance of 2D organic crystals based on cyano-substituted perylene diimides

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Chinese Chemical Letters 2024年第9期35卷 193-197页

作者： Jaeyong Ahn Zhenping Li Zhiwei Wang Ke Gao Huagui Zhuo Wanuk choi Gang Chang Xiaobo Shang Joon Hak Oh School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826South Korea State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Center for Ordered Nanoporous Materials Synthesis School of Environmental Science and EngineeringPohang University of Science and TechnologyGyeongbuk 37673South Korea Instrumental Analysis Center of Xi’an Jiaotong University Xi’an 710049China

Compared to organic thin films,organic single crystals offer significant potential in organic phototransistors(OPTs)due to their enhanced charge transport,large surface area,and defect-free ***,the development of n-type semiconductors has lagged behind p-type *** enhance semiconductor device performance,a doping process can be employed,which typically involves the introduction of charged impurities into the crystalline semiconducting *** aim is to reduce the Ohmic losses,increase carrier density,improve transport capabilities,and facilitate effective carrier injection,ultimately enhancing the electrical properties of the *** doping processes,however,often pose a risk of damaging the structure of single *** this study,we have synthesized novel cyanosubstituted chiral perylene diimides,which self-assemble into two-dimensional single crystals that can be used for n-type semiconductor *** have employed a surface doping strategy using diethylamine vapor without disrupting the crystal *** fabricated devices exhibit significantly higher charge transport properties after doping,achieving a maximum electron mobility of 0.14 cm^(2)V^(-1)s^(-1),representing an improvement of over ***,the optoelectronic performance of the doped devices has significantly improved,with the external quantum efficiency increased by over 9 times and the significantly improved response *** results suggest that our surface doping technology is a promising way for enhancing the performance of 2D organic single-crystal OPTs.

关键词： Doping effect Phototransistors Perylene diimides Organic crystals Cyano substitution

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Flower morphology of Allium(Amaryllidaceae)and its systematic significance

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Plant Diversity 2024年第1期46卷 3-27页

作者： Ju Eun Jang Shukherdorj Baasanmunkh Nudkhuu Nyamgerel Seung-Yoon Oh Jun-Ho Song Ziyoviddin Yusupov Komijlon Tojibaev hyeok Jae choi Department of Biology and Chemistry Changwon National UniversityChangwon51140Republic of Korea Department of Forest Biodiversity and Herbarium Korea National ArboretumPocheon11186Republic of Korea Department of Biology Chungbuk National UniversityCheongju28644Republic of Korea International Joint Lab for Molecular Phylogeny and Biogeography Institute of BotanyAcademy of Sciences of UzbekistanTashkent100125Uzbekistan

Allium is a complicated genus that includes approximately 1000 *** its morphology is well studied,the taxonomic importance of many morphological traits,including floral traits,are poorly ***,we examined and measured the floral characteristics of 87 accessions of 74 Allium taxa(belonging to 30 sections and nine subgenera)from Central to Eastern Asian *** then examined the taxonomic relationships between select flower characteristics and a phylogenetic tree based on ITS *** results confirm that floral morphology provides key taxonomic information to assess species delimitation in *** found that perianth color is an important characteristic within the ***,Polyprason,and *** ***,Cepa,and Rhizirideum,significant characteristics include ovary shape,perianth shape,and inner tepal *** species in ***,the key taxonomic character is ovule number(only one ovule in per locule).In the ***,Cepa,Polyprason,and Reticulatobulbosa,which belong to the third evolutionary line of Allium,hood-like appendages occur in the ovary,although these do not occur in *** results also indicated that the flower morphology of several species in some sections are not clearly distinguished,e.g.,***(***)and ***(***).This study provides detailed photographs and descriptions of floral characteristics and information on general distributions,habitats,and phenology of the studied taxa.

关键词： Allium Flower morphology Pistil character Statistical analysis Significant characteristic Species level

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Selective conversion of N_(2) to NH_(3) on highly dispersed RuO_(2) using amphiphilic ionic liquid-anchored fibrous carbon structure

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Journal of Energy Chemistry 2022年第4期31卷 474-482页

作者： Kahyun Ham Muhammad Salman Sunki Chung Minjun choi HyungKuk Ju hye jin Lee Jaeyoung Lee School of Earth Sciences and Environmental Engineering Gwangju Institute of Science and Technology(GIST)123 Cheomdangwagi-RoGwangju 61005South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GIST123 Cheomdangwagi-RoGwangju 61005South Korea Ertl Center for Electrochemical and Catalysis GIST123 Cheomdangwagi-RoGwangju 61005South Korea Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University80 Daehak-RoDaegu-city 41566South Korea Hydrogen Research Department Korea Institute of Energy Research152 Gajeong-RoYuseong-guDaejeon 34129South Korea

Ammonia (NH_(3)) plays a key role in the agricultural fertilizer and commodity chemical industries and is useful for exploring hydrogen storage *** electrochemical nitrogen reduction reaction (NRR) is receiving attention as an environmentally sustainable NH_(3) synthesis replacement for the traditional Haber–Bosch process owing to its near ambient reaction conditions (<100℃ and 1 atm).However,its NH_(3) yield and faradaic efficiency are extremely low because of the sluggish kinetics of N≡N bond dissociation and the hindrance from competitive hydrogen *** overcome these challenges,we herein introduce a dual-functionalized ionic liquid (1-(4-hydroxybutyl)-3-methylimidazolium hydroxide[HOBIM]OH) for a highly dispersed ruthenium oxide electrocatalyst to achieve a biased *** observed uniform distribution of RuO_(2) on the carbon fiber and increase in the surface area for N_(2) adsorption by limiting proton access can be attributed to the presence of imidazolium ***,extensive N_(2) adsorption contributes to enhanced NRR selectivity with an NH_(3) yield of 3.0×10^(-10)mol cm^(-2)s^(-1)(91.8μg h^(-1)mg^(-1)) and a faradaic efficiency of 2.2%at-0.20 V_(RHE).We expect our observations to provide new insights into the design of effective electrode structures for electrochemical NH;synthesis.

关键词： Ammonia synthesis Nitrogen reduction reaction Imidazolium-based ionic liquid Ruthenium oxide

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