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Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels

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Journal of Integrative Plant Biology 2024年第1期66卷 103-120页

作者： Hayeon Kim hye Won Kang Dae yeon Hwang Nayoung Lee Akane Kubota Takato Imaizumi Young Hun Song Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Biology Ajou UniversitySuwon 16499Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Graduate School of Science and Technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Department of Biology University of WashingtonSeattleWA 98195USA Institute of Agricultural Life Sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FLOWERING LOCUS T(FT).In Arabidopsis,FT messenger RNA levels peak in the morning and evening under natural long-day conditions(LDs).However,the regulatory mechanisms governing morning FT induction remain poorly *** morning FT peak is absent in typical laboratory LDs characterized by high red:far-red light(R:FR)ratios and constant ***,we demonstrate that ZEITLUPE(ZTL)interacts with the FT repressors TARGET OF EATs(TOEs),thereby repressing morning FT expression in natural *** LDs with simulated sunlight(R:FR=1.0)and daily temperature cycles,which are natural LD-mimicking environmental conditions,FT transcript levels in the ztl mutant were high specifically in the morning,a pattern that was mirrored in the toe1 toe2 double *** night-to-morning temperatures increased the inhibitory effect of ZTL on morning FT expression by increasing ZTL protein levels early in the ***-red light counteracted ZTL activity by decreasing its abundance(possibly via phytochrome A(phyA))while increasing GIGANTEA(GI)levels and negatively affecting the formation of the ZTL-GI complex in the ***,the phyA-mediated high-irradiance response and GI play pivotal roles in morning FT *** findings suggest that the delicate balance between low temperature-mediated ZTL activity and the far-red light-mediated functions of phyA and GI offers plants flexibility in fine-tuning their flowering time by controlling FT expression in the morning.

关键词： far-red light FLOWERING LOCUS T flowering time GIGANTEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEITLUPE

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Comparative associations of non-alcoholic fatty liver disease and metabolic dysfunction-associated steatotic liver disease with risk of incident chronic kidney disease:a cohort study

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 801-813,I0003-I0005页

作者： Ji hye Heo Mi yeon Lee Seong Hwan Kim Ming-Hua Zheng Christopher D.Byrne Giovanni Targher Ki-Chul Sung Department of Internal Medicine Hallym University College of MedicineChuncheonRepublic of Korea Division of Biostatistics Department of R&D ManagementKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulRepublic of Korea Division of Cardiology Department of Internal MedicineKorea University Ansan HospitalAnsanRepublic of Korea MAFLD Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Wenzhou Key Laboratory of Hepatology WenzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouChina Nutrition and Metabolism Faculty of MedicineUniversity of SouthamptonSouthamptonUK Southampton National Institute for Health and Care Research Biomedical Research CentreUniversity Hospital SouthamptonSouthamptonUK Metabolic Diseases Research Unit IRCCS Sacro Cuore-Don Calabria HospitalNegrar di ValpolicelleItaly Division of Cardiology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulRepublic of Korea

Background:We examined the comparative associations between non-alcoholic fatty liver disease(NAFLD)and metabolic dysfunction-associated steatotic liver disease(MASLD)definitions with risk of developing chronic kidney disease(CKD)and abnormal ***:We conducted a cohort study of 214,145 Korean adults with normal kidney function at baseline who underwent liver *** were further subdivided into no steatotic liver disease(no-SLD),NAFLD-only,MASLD-only,both NAFLD and MASLD,and SLD not categorized as NAFLD or MASLD *** proportional hazards models were used to analyze the risk of incident CKD and ***:Compared with either the no-NAFLD or no-MASLD groups,the NAFLD and MASLD groups were associated with a higher risk of incident CKD(NAFLD:adjusted hazard ratio(HR),1.18[95%CI,1.01-1.38];MASLD:adjusted HR,1.21[95%CI,1.04-1.39]).Among the five subgroups,both NAFLD and MASLD group had the strongest association with risk of incident CKD(adjusted HR,1.21[95%CI,1.04-1.42]).The MASLD-only group had the strongest association with incident abnormal albuminuria,with an adjusted HR comparable to that of the both NAFLD and MASLD group(adjusted HR 1.96[95%CI,1.44-2.67]for the MASLD-only,and adjusted HR 1.98[95%CI,1.58-2.49]for the both NAFLD and MASLD group versus the no-SLD group).The NAFLD-only group was not independently associated with risk of CKD or abnormal ***:These findings suggest that MASLD definition identifies individuals at high risk of developing incident CKD or abnormal albuminuria better than NAFLD definition.

关键词： Metabolic dysregulation non-alcoholic fatty liver disease(NAFLD) metabolic syndrome chronic kidney disease(CKD) albuminuria

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Production of chitosan-based composite film reinforced with lignin-rich lignocellulose nanofibers from rice husk

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Journal of Bioresources and Bioproducts 2024年第2期9卷 174-184页

作者： hye Jee Kang yeon Ju Lee Jin Kyoung Lee Irnia Nurika Sri Suhartini Deokyeong Choe Dong Hyun Kim Hoon Choi Natasha P.Murphy Ho Yong Kim Young Hoon Jung School of Food Science and Biotechnology Kyungpook National UniversityDaegu 41566Republic of Korea CPR S&T Co. Ltd.Gunpo 15880Republic of Korea Department of Agroindustrial Technology Faculty of Agricultural TechnologyUniversitas BrawijayaMalang 65145Indonesia Renewable Resources and Enabling Sciences Center National Renewable Energy LaboratoryGoldenCO 80401United States Center for Bio-based Chemistry Korea Research Institute of Chemical TechnologyUlsan 44429Republic of Korea

Lignocellulosic nanofibers(LCNFs),implying lignin-containing cellulose fibers,maintain the prop-erties of both lignin and cellulose,which are hydrophobic and hydrophilic,*** pres-ence of hydrophobic lignin in LCNFs is expected to be an economical and attractive option that can improve the thermal and mechanical properties of ***,this study was conducted to produce lignin-rich LCNFs from sugar-rich waste obtained from rice husks after acidic *** LCNFs were produced from the lignin-rich solid fractions obtained after pretreatment and enzymatic hydrolysis,which were then incorporated as an additive into a chitosan-based *** variations in lignin content in the range of approximately 50.6%-66.8%in differently obtained LCNFs gave significantly different optical strengths and mechanical *** controllable processes may allow for customized film ***,the glucose-rich liquid fractions obtained after pretreatment and enzymatic hydrolysis were used as a substrate for ethanol fermentation to achieve total utilization of rice husk biomass *** conclusion,the lignin-rich biomass fraction holds promise as a suitable material for chitosan-LCNF film and has the potential to increase the economic feasibility of the biomaterial industry.

关键词： Rice husk Lignocellulose nanofiber Lignin-based material Chitosan film Upcycling

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Orostachys japonicus ethyl acetate fraction suppresses MRSA biofilm formation

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Asian Pacific Journal of Tropical Medicine 2020年第1期13卷 38-45页

作者： Jae-Hyeon Kim Su-yeon Han Ji-hye Kwon Dong-Seok Lee Department of Smart Foods and Drugs Graduate School of Inje UniversityGimhae 50834Republic of Korea

Objective:To investigate the effect of Orostachys(O.)japonicus,a perennial herbaceous plant of the Family Crassulaceae,on biofilm formed by methicillin-resistant Staphylococcus aureus(MRSA).Methods:Powdered *** was extracted by 95%methanol,concentrated,and then,systematically fractionated with n-hexane,dichloromethane(DCM),ethyl acetate(EtOAc),n-butanol,and H2 O according to *** them,the flavonoid-rich EtOAc fraction demonstrated the highest antibacterial activity and was used in this *** the biofilm inhibition assay,cell-surface attachment assay,confocal laser scanning microscopy,latex agglutination assay,and real time qRT-PCR,we examined whether the EtOAc fraction inhibited the formation of MRSA ***:The EtOAc fraction exhibited distinct activity against biofilm formation and cell-surface attachment of MRSA up to 1 mg/m L through down-regulating the expression of mec A gene and the production and agglutination of penicillin-binding protein 2 a as solidly observed in biofilm inhibition assay,cell-suface attachment assay,confocal laser scanning microscopy,latex agglutination assay,and real time qRT-PCR ***:These results suggest that *** could be utilized as a potential resource for the development of new antibiofilm formation of MRSA and antibacterial agents in the future.

关键词： Orostachys japonicus MRSA Biofilm formation

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Repeated ventricular bigeminy by trigeminocardiac reflex despite atropine administration during superficial upper lip surgery: A case report

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World Journal of Clinical Cases 2022年第32期10卷 11967-11973页

作者： Su-yeon Cho Bo-Hyun Jang hye-Jin Jeon Dong-Joon Kim Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea

BACKGROUND The trigeminocardiac reflex(TCR)is usually caused by an increased parasympathetic tone when pressure or traction is applied to the surrounding tissue of the trigeminal ***,the inexperienced anesthesiologists may have challenges on the management of TCR *** SUMMARY This is the case of an 18-year-old woman diagnosed with hemangioma of the upper *** the operation,about 1 h after surgery started,a constant 1:1 premature ventricular complex was detected,and blood pressure was decreased when approaching the deeper part with more strong traction for exposure of the *** the management of arrhythmias,such as lidocaine and atropine,was injected,arrhythmia induced by surgical stimulation could not be eliminated *** the traction repeated,bradycardia was also repeated,despite injecting additional ***,the anesthesiologist and the surgeon decided to perform the operation only to the extent that the vascular tissue was selectively removed only at the site without the *** With TCR,anesthesiologists should perform appropriate *** addition to proper drug administration,surgeons should be consulted to cope with stopping the surgery and setting the scope of the surgery even if the site is superficial.

关键词： Trigeminocardiac reflex Bigeminy Arrhythmia Hypotension Atropine Case report

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Recurrent intramuscular lipoma at extensor pollicis brevis:A case report

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World Journal of Clinical Cases 2023年第3期11卷 684-691页

作者： Je yeon Byeon Yong Seon Hwang Ji hye Lee Hwan Jun Choi Plastic and Reconstructive Surgery Soonchunhyang University HospitalCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea

BACKGROUND This report describes and discusses recurrent intramuscular lipoma(IML)of the extensor pollicis brevis(EPB).An IML usually occurs in a large muscle of the limb or *** of IML is *** IMLs,especially those with unclear boundaries,necessitate complete *** cases of IML in the hand have been ***,recurrent IML appearing along the muscle and tendon of EPB on wrist and forearm has not been reported *** SUMMARY In this report,the authors describe clinical and histopathological features of recurrent IML at EPB.A 42-year-old Asian woman presented with a slowgrowing lump in her right forearm and wrist area six months *** patient had a history of surgery for a lipoma of the right forearm one year ago with a scar of 6cm on the right *** resonance imaging confirmed that the lipomatous mass,which had attenuation similar to subcutaneous fat,had invaded the muscle layer of *** and biopsy were performed under general *** histological examination,it was identified as an IML showing mature adipocytes and skeletal muscle ***,surgery was terminated without further *** recurrence occurred during a follow-up of five years after *** Recurrent IML in the wrist must be examined to differentiate it from *** to surrounding tissues should be minimized during excision.

关键词： Intramuscular Lipoma Recurrence Wrist Case report

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GC-MS analysis of volatile compounds of Perilla frutescens Britton var. Japonica accessions: morphological and seasonal variability

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Asian Pacific Journal of Tropical Medicine 2017年第7期10卷 705-714页

作者： Bimal Kumar Ghimire Ji hye Yoo Chang yeon Yu Ill-Min Chung Department of Applied Life Science Konkuk University Bioherb Research Institute Kangwon National University

Objective: To investigate the composition of volatile compounds in the different accessions of Perilla frutescens(P. frutescens) collected from various habitats of China and Japan. Methods: In the present study, the essential oil from the leaves of P. frutescens cultivars from China and Japan was extracted by hydro-distillation and the chemical composition and concentration of the volatile components present in the oils were determined by gas chromatography–mass spectrometry(GC–MS) analysis. Results: Among the volatile components, the major proportion was of perilla ketone, which was followed by elemicin and beta-caryophyllene in the Chinese Perilla cultivars. The main component in the oil extracted from the Japanese accessions was myristicin, which was followed by perilla ketone and beta-caryophyllene. We could distinguish seven chemotypes, namely the perilla ketone(PK) type, perilla ketone, myristicin(PM) type, perilla ketone, unknown(PU) type, perilla ketone, beta-caryophyllene, myristicine(PB) type, perilla ketone, myristicin, unknown(PMU) type, perilla ketone, elemicine, myristicin, beta-caryophyllene(PEMB) type, and the perilla ketone, limonene, betacryophyllene, myristicin(L) type. Most of the accessions possessed higher essential oil content before the flowering time than at the flowering stage. The average plant height, leaf length, leaf width of the Chinese accessions was higher than those of the Japanese accessions. Conclusion:The results revealed that the harvest time and geographical origin caused polymorphisms in the essential oil composition and morphological traits in the Perilla accessions originating from China and Japan. Therefore, these chemotypes with desirable characters might be useful for industrial exploitation and for determining the harvest time.

关键词： Perilla frutescens Essential oil GC–MS analysis Morphological character Harvesting time

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Epstein-Barr virus-positive diffuse large B-cell lymphoma with human immunodeficiency virus mimicking complicated frontal sinusitis:A case report

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World Journal of Clinical Cases 2021年第7期9卷 1654-1660页

作者： Seokho Yoon Kyeong Hwa Ryu hye Jin Baek Hyo Jung An yeon-Hee Joo Department of Nuclear Medicine and Molecular Imaging Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalChangwon 51472South Korea Department of Radiology Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalChangwon 51472South Korea Department of Radiology Institute of Health SciencesGyeongsang National University School of MedicineJinju 52727South Korea Department of Pathology Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalChangwon 51472South Korea Department of Otorhinolaryngology Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalChangwon 51472South Korea

BACKGROUND Primary non-Hodgkin’s lymphoma of the frontal sinus is extremely *** addition,Epstein-Barr virus(EBV)has been reported to play a role in the development of human immunodeficiency virus(HIV)-related malignant *** the best of our knowledge,there is no report for the HIVassociated,EBV-positive primary diffuse large B-cell lymphoma(DLBCL)in the frontal *** SUMMARY We present a unique case of HIV-associated,EBV-positive DLBCL in the frontal sinus in a 46-year-old *** tomography of paranasal sinuses revealed dense opacification of the right frontal sinus with combined soft tissue *** on the clinical and radiological findings,the initial diagnosis was complicated frontal sinusitis,presenting Pott’s puffy ***,HIV testing was positive on preoperative laboratory test,and the frontal sinus lesion was confirmed as EBV-positive DLBCL on *** Through this article,we suggest that EBV-positive DLBCL should be considered as possible diagnosis for patients with nonspecific space-occupying lesion of the paranasal *** also highlight an importance of clinical suspicion in diagnosing HIV infection because HIV serology is not routinely tested in patients with paranasal sinus problem.

关键词： Lymphoma Paranasal sinus Human immunodeficiency virus Epstein-Barr virus Computed tomography Case report

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Lemierre's syndrome caused by Klebsiella pneumoniae:A case report

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World Journal of Nephrology 2021年第5期10卷 101-108页

作者： So yeon Hwang Seok Joon Shin hye Eun Yoon Department of Internal Medicine Incheon St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaIncheon 21431South Korea

BACKGROUND Lemierre's syndrome is a disease that causes anaerobic sepsis,internal jugular vein thrombosis,and septic embolism in the lungs and other organs after acute oropharyngeal *** was named after André-Alfred Lemierre in *** SUMMARY Here,we have reported a case of Lemierre’s syndrome in a 56-year-old female patient who presented with a sore *** patient had septic shock,had not voided,and had severe hyperglycemia at the time of her *** tests revealed bilateral pneumonia,pleural effusion,pulmonary embolism,and renal vein *** patient was admitted to the intensive care unit and placed on mechanical ventilation due to acute respiratory distress *** renal replacement therapy was administered to treat renal failure with *** pneumoniae was cultured from blood and sputum *** reviewing various results,the patient was ultimately diagnosed with Lemierre’s *** patient was treated with appropriate antibiotics and thrombolytic *** was discharged from the hospital after *** Lemierre’s syndrome is associated with a high mortality ***,clinicians should be familiar with the signs and symptoms of this disease as well as the preemptive examinations,procedures,and treatments.

关键词： Lemierre's syndrome Klebsiella pneumoniae Diabetes Mellitus Pulmonary embolism Septic pneumonia Case report

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Room-temperature sputtered electrocatalyst WSe2 nanomaterials for hydrogen evolution reaction

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Journal of Energy Chemistry 2020年第8期29卷 107-111,I0004页

作者： Jae Hyeon Nam Myeong Je Jang hye yeon Jang Woojin Park Xiaolei Wang Sung Mook Choi Byungjin Cho Department of Advanced Material Engineering Chungbuk National UniversityChungdae-ro 1Seowon-GuCheongjuChungbuk 28644Republic of Korea Surface Technology Department Korea Institute of Materials Science797 ChangwonDaeroSungsan-guChangwon 51508Republic of Korea Advanced Materials Engineering Korea University of Science and Technology(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea Department of Chemical and Materials Engineering University of Alberta9211116 Street NWEdmontonAlberta T6C 1H9Canada

The low-temperature physical vapor deposition process of atomically thin two-dimensional transition metal dichalcogenide(2D TMD) has been gaining attention owing to the cost-effective production of diverse electrochemical catalysts for hydrogen evolution reaction(HER) applications. We, herein, propose a simple route toward the cost-effective physical vapor deposition process of 2D WSe2 layered nanofilms as HER electrochemical catalysts using RF magnetron sputtering at room temperature(<27℃). By controlling the variable sputtering parameters, such as RF power and deposition time, the loading amount and electrochemical surface area(ECSA) of WSe2 films deposited on carbon paper can be carefully determined. The surface of the sputtered WSe2 films are partially oxidized, which may cause spherical-shaped particles. Regardless of the loading amount of WSe2, Tafel slopes of WSe2 electrodes in the HER test are narrowly distributed to be ~120–138 mV dec-1, which indicates the excellent reproducibility of intrinsic catalytic activity. By considering the trade-off between the loading amount and ECSA, the best HER performance is clearly observed in the 200 W-15 min sample with an overpotential of 220 mV at a current density of 10 mA cm-2. Such a simple sputtering method at low temperature can be easily expanded to other 2D TMD electrochemical catalysts, promising potentially practical electrocatalysts.

关键词： Two dimensional nanomaterials Sputtering WSe2 nanofilm Electrocatalyst Hydrogen evolution reaction

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