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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： hye Jin Shin Wooseong l.e Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-won Oh Al.em Siddiqui Seong-Jun Kim Department of Convergent Research of emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular al.erations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the eGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial.elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the eGFR signal cascade and subsequently induces mitochondrial.eGFR trafficking,contributing to abnormal OXPHOS process and viral *** eGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced eGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACe2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced al.erations in mitochondrial dynamics and eGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that eGFR is an attractive host target for combating COVID-19.

关键词： al.erations aberrant thereby

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Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil.engineering 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Zehra N.KUTlU İsmail.e.KIlIÇ Department of Civil.engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vul.erability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vul.erability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vul.erability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vul.erability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is bel.eved to advance the current applications for vul.erability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vul.erability assessment cultural heritage local site effect

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When Fl.eing Matters:Differences in escape Behaviours of Three Northeast Asian Anurans

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Asian Herpetological Research 2024年第1期15卷 41-48页

作者： Yoonjung YI Zoljargal PUReVDORJ Irina MASlOVA Yikweon JANG Amaël BORZÉe laboratory of Animal Behaviour and Conservation College of Life SciencesNanjing Forestry UniversityNanjing 210037JiangsuChina Division of ecoScience and Department of life Sciences Ewha Womans UniversitySeoul 03760Republic of Korea Department of Biology School of MathematicsMongolian State University of EducationUlaanbaatar 210648Mongolia Department of Forest and environmental Resources Chungnam National UniversityDaejeon 34134Republic of Korea Federal Scientific Center of the east Asia Terrestrial Biodiversity Far Eastern Branch of Russian Academy of SciencesVladivostok 690022Russia

Prey species may have their own optimal.escape strategy to balance predation risks and the energetic cost of *** species have an advantage when maintaining a short fl.eing distance,while others may favour an earl.er escape based on microhabitat,size,or body ***,we examined the escape behaviour of the three syntopic Northeast Asian anuran species:Mongolian toads(Strauchbufo raddei),Amur brown frogs(Rana amurensis),and Japanese treefrogs(Dryophytes japonicus)in Mongolia,Russia,China and DPR *** examined flight initiation distance(FID;the distance from a potential predator to the point when the individual starts to fl.e)and distance fled(DF;distance between flight initiation and flight termination points)of each species and the effects of microhabitat,sex,and body *** raddei and *** had a longer FID than ***,and *** also had a longer DF than *** trends remained similar when dividing FID and DF by a size proxy(snout-vent length)for all *** suggests that the treefrog *** used a strategy to stay immobile even when they were detected,and the toad *** reacted quicker and more sensitively to predators despite the presence of *** *** had a significantly longer FID than males suggesting that females are more sensitive to predation risk in this species,but body size was not significant for any of the three *** results indicate that the three sympatric species have different escaping strategies,likely related to differences in physiology and crypticity.

关键词： amphibian distance fled escape behaviour flight initiation distance predation

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Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh Wan-Cheng Chow Wah-Kheong Chan Grace lai-Hung wong Wai-Kay Seto Yi-Hsiang Huang Han-Chieh lin I-Cheng l.e hye won l.e Seung Up Kim Vincent Wai-Sun wong Jian-Gao Fan Center for Fatty liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFlD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFlD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFlD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFlD and transient elastography examination from eight Asian centers were enrol.ed in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(CKD)were defined by an estimated glomerular filtration rate(eGFR)with val.e ofl/min/1.73 m^(2) andl/min/1.73 m^(2),respectively,as estimated by the CKD-epidemiology Collaboration(CKD-ePI)***:Among 529 included NAFlD patients,the prevalence rates of impaired renal function and CKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for CKD(Permore,increased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(Ped with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/l or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(Plusions:Agile 3+and Agile 4 are reliable for identifying NAFlD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

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Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： leonardo Goliatt C.M.Saporetti l.C.Oliveira e.Pereira Department of Computational and Appl.ed Mechanics Federal University of Juiz de Fora Department of Computational Modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOC content is the best indicator of the organic matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it rel.es on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. Machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential.evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOC. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. Core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOC. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning evolutionary algorithms Geology

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elK3-ID4 axis governs the metastatic features of triple negative breast cancer

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Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG PARK SeUNG Hee CHOI eUN-SU KO hye JUNG JANG KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that elK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether elK3 regulates the extravasation of TNBC by forming the elK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently infl.encing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of elK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the elK3-ID4 axis regulates the metastatic features of ***:We found that elK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of e-cadherin in TNBC was regulated by the elK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in elK3-knockdown MDA-MB-231(elK3KD)cells restored the ability to extravasate and ***:The results indicate that the elK3 regulates ID4 promoter activity,and that the elK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the elK3-ID4 axis regulates metastasis of TNBCs by modulating expression of e-cadherin.

关键词： e-cadherin extravasation Colonization

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exploring the effects of anthropogenic disturbance on predator inspection activity in Trinidadian guppies

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Current Zoology 2024年第1期70卷 109-111页

作者： Alix J.P Brusseau laurence e.A.Feyten Adam l.Crane Grant e.Brown Department of Biology Concordia UniversityMontrealQCH4B 1R6Canada Department of Biomedical Sciences WCVMUniversity of SaskatchewanSaskatoonSKCanada

Prey animals are often faced with uncertainty due to having imperfect information regarding current local conditions,including predation risks and the availability of reliable foraging opportunities(Dall 2010).As this uncertainty increases,the probability of making costly behavioral.errors also increases,leading to more risk averse behavioral tactics(Feyten et al.2019).For example,Trinidadian guppies Poecilia reticulata are far more risk averse when faced with multiple unknown sources of risk assessment information than when faced with a mix of known and unknown cues(Feyten et al.2019).Prey can reduce uncertainty by gathering and integrating private and social information regarding current risk levels within microhabitats(Dall 2010;Munoz and Blumstein 2012).

关键词： human disturbance information availability information reliability predator-prey interactions risk assessment uncertainty

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Using proteomics to compare the molecular structures of sulfide and permeate-depilated sheepskins

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Collagen and leather 2024年第1期6卷 70-84页

作者： Yi-Hsuan Tu Trevor S.loo Mark l.Patchett Gillian e.Norris School of Natural Sciences Massey UniversityPalmerston NorthNew Zealand

An environmentally friendly method using real or artificial bovine milk permeate to both depilate and preserve sheepskins has been reported which completely and cleanly removed the wool from the hair follicle and had no detrimental.effects on the skin.A proteomic analysis,assessing the relative abundance of proteins in matched permeate-depilated and chemically depilated(sulfide)sheepskins,showed variations in the levels of specific collagen types in the skin's basement membrane and other proteins associated with the *** findings were corroborated by biochemical analyses of matched permeate depilated and raw skin samples,and provide cl.es to the mechanism of non-invasiveand complete *** also support the observation that permeate-depilated skins were smoother than their sulfide-depilated counterparts and resul.ed in leather with a superior surface.

关键词： Collagen Collagen crosslinks Glycosaminoglycan Proteomics Relative abundance

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exploring unconventional attributes of red blood cells and their potential applications in biomedicine

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Protein & Cell 2024年第5期15卷 315-330页

作者： Alkmini T.Anastasiadi Vasiliki-Zoi Arvaniti Krystalyn e.Hudson Anastasios G.Kriebardis Constantinos Stathopoulos Angelo D’Alessandro Steven l.Spitalnik Vassilis l.Tzounakas Department of Biochemistry School of MedicineUniversity of Patras26504 PatrasGreece Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York CityNY 10032USA laboratory of Reliability and Quality Control in laboratory Hematology(HemQcR) Department of Biomedical SciencesSchool of Health&Caring SciencesUniversity of West Attica(UniWA)12243 EgaleoGreece Department of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus13001 AuroraCOUSA Present address:Institute for Fundamental Biomedical Research(IFBR) Biomedical Sciences Research Center“Alexander Fleming”Vari11527 AthensGreece

We need to talk about red blood *** cells are defined as cells containing distinct nuclei and other membranous ***,red blood cells(RBCs)lack a nucleus and organel.es—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are fil.ed with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.

关键词： membranous maintain

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effect of biochar on the metabolome of soybean seedlings

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Oil Crop Science 2024年第1期9卷 60-68页

作者： Nathalia e.Silva Mariana G.Aguilar Osania e.Ferreira Gleicia M.Paulino Jaqueline C.l.Carvalho lúcia P.S.Pimenta Alan R.T.Machado Programa de Pos-graduaçao em Ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de engenharia Aplicada e Tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de Ciencias exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biochar can have several.effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(SCB300),400℃(SCB400)and 600℃(SCB600).Then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the number of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).The extracts were submitted to metabolomics analysis by Proton Nuclear Magnetic *** Relative Germination,Relative Average Radicle Growth and Germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for SCB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most infl.ential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： Germination Metabolomics 1H NMR Pyrolysis Sugarcane bagasse

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