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Journal of Integrative Plant Biology 2019年第9期61卷 974-980页

作者： Soohong Kim yunjin Choi Chian Kwon hye sup yun Department of Molecular Biology Dankook UniversityCheonan 31116Korea Department of Biological Sciences Konkuk UniversitySeoul 05029Korea

Excessive demand for translation and protein folding in the endoplasmic reticulum(ER) can cause ER stress in plants. Here, we show that CALRETICULIN 1(CRT1) and CRT2 are critical components in the accumulation of VESICLE-ASSOCIATED MEMBRANE PROTEIN 721(VAMP721) and VAMP722 during ER stress responses. We show that CRT2 interacts with VAMP722 and that CRT1/2 post-translationally maintain elevated VAMP721/722 levels under ER *** greater growth inhibition in VAMP721/722-deficient plants, induced by tunicamycin, suggests that plants under ER stress maintain physiological homeostasis, at least in part, by regulating VAMP721/722 levels, as VAMP721/722 are known to participate in various biological processes.

关键词： Endoplasmic reticulum VAMP721/722 in Arabidopsis

Unusual case of emphysematous cystitis mimicking intestinal perforation:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6943-6948页

作者： hye Yoon Kang Dae-sup Lee Donghyoun Lee Department of Surgery Samsung Medical CenterSeoul 06338South Korea Department of Emergency Medicine Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Surgery Jeju National University HospitalJeju National University College of MedicineJeju 63241South Korea

BACKGROUND Emphysematous cystitis(EC)is a bladder condition commonly caused by gasgenerating bacterial *** that increase the risk for developing this condition include female gender,age≥60 years,and diabetes mellitus,glycosuria,and urinary *** symptoms of EC often lack specificity,making diagnostic imaging techniques crucial for accurate identification of the *** SUMMARY This report presents an unusual case of EC that mimicked intestinal *** it was initially challenging to differentiate between intestinal perforation and EC on admission,the patient managed to avoid unnecessary surgery and made a good recovery solely through antibiotic *** Successful treatment of the patient described herein highlights the importance of accurately diagnosing EC,which can be difficult to differentiate from intestinal perforation.

关键词： Emphysematous cystitis Intestinal Bowel Perforation Bladder Case report

Factors affecting length of stay according to bronchopulmonary dysplasia severity:a nationwide cohort study in Korea

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World Journal of Pediatrics 2024年第5期20卷 470-480页

作者： hye Mi Lee Jeongmin Shin Sae yun Kim So Young Kim Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Pediatrics Yeouido St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea1063-roYeongdeungpo-guSeoul07345Republic of Korea

Background Longer hospitalizations for preterm infants with bronchopulmonary dysplasia(BPD)delay developmental outcomes,increase the risk for hospital-acquired complications,and exert a substantial socioeconomic *** study aimed to identify factors associated with an extended length of stay(LOS)at different levels of severity of *** A cohort study was conducted using the Korean Neonatal Network registry of very low birth weight infants with BPD between 2013 and 2017 through retrospective *** A total of 4263 infants were diagnosed with *** mild BPD,infants requiring surgical treatment for patent ductus arteriosus needed a longer LOS[eadjustedβcoefficients(adjβ)1.041;95%confidence interval(CI):0.01–0.08]and hydrocephalus(eadjβ1.094;95%CI 0.01–0.17).In moderate BPD,infants administered steroids or with intraventricular hemorrhage required a longer LOS(eadjβ1.041;95%CI 0.00–0.07 and eadjβ1.271;95%CI 0.11–0.38,respectively).In severe BPD,infants with comorbidities required a longer LOS:pulmonary hypertension(eadjβ1.174;95%CI 0.09–0.23),administrated steroid for BPD(eadjβ1.116;95%CI 0.07–0.14),sepsis(eadjβ1.062;95%CI 0.01–0.11),patent ductus arteriosus requiring surgical ligation(eadjβ1.041;95%CI 0.00–0.08),and intraventricular hemorrhage(eadjβ1.016;95%CI 0.05–0.26).Additionally,the higher the clinical risk index score,the longer the LOS needed for infants in all *** The factors affecting LOS differed according to the severity of *** approaches to reducing LOS may be devised using knowledge of the various risk factors affecting LOS by BPD severity.

关键词： Bronchopulmonary dysplasia Length of stay Very low birth weight

SARS-CoV-2 mutations, vaccines, and immunity: implication of variants of concern

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1638-1639页

作者： Ji yun Noh hye Won Jeong Eui-Cheol Shin Division of Infectious Diseases Department of Internal MedicineKorea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Division of Infectious Diseases Department of Internal MedicineChungbuk National University College of MedicineCheongjuRepublic of Korea The Center for Epidemic Preparedness KAISTDaejeonRepublic of Korea

In a recent study published in Nature,Wang et al.1 investigated the neutralizing activities of antibodies elicited by COVID-19 mRNA vaccines and natural infection with SARS-CoV-2 against SARS-CoV-2 *** devastating impact of the ongoing COVID-19 pandemic on public health,the economy,and society has made vaccine development a top priority for global ***,vaccine development is progressing at an unprecedented pace as an urgent response to COVID-19.

关键词： immunity vaccines variants

Lactic Acid Fermentation from Coffee Ground Waste Hydrolysate by Lactobacillus rhamnosus

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Journal of Renewable Materials 2019年第4期7卷 365-372页

作者： Ja-Ryong Koo hye Min Park Se Kyung Kim Hyun Shik yun Department of Biological Engineering Inha UniversityIncheon 22212Korea Institute of Industrial Biotechnology Inha University Research and Business FoundationIncheon 22212Korea

Lactic acid is an important organic acid that is widely used in the food,pharmaceutical,and cosmetic *** acid was produced from coffee ground waste which contains fermentable sugars and is increasingly generated from our daily dietary *** 114 strains of Lactobacillus species,Lactobacillus rhamnosus ATCC 10863 was selected for the production of lactic acid from coffee ground *** alkali pretreatment and saccharification,cellulose and hemicellulose in coffee ground waste were converted into fermentable *** experiments were conducted at various alkali solution,concentrations,and *** pretreatment with 35 g/L of KOH at 121oC for 60 min,the highest concentration of fermentable sugars was *** optimum concentration of Viscozyme L was 2%when saccharification was proceeded at 55oC for 7 *** productivity of lactic acid fermentation was the highest(0.59 g/L/h)at 100 g of coffee ground waste(1x concentration),whereas the lactic acid concentration was the highest at 600 g of coffee ground waste(6x concentration).As the concentration of coffee ground increased,the lactic acid concentration was also increased,however,the amount was not proportional to the coffee ground waste *** this study,it was found that coffee ground waste could be used as a culture medium for Lactobacillus rhamnosus ATCC 10863 through pretreatment and saccharification for the production of lactic acid.

关键词： Coffee ground waste Lactobacillus rhamnosus lactic acid fermentable sugars saccharification alkali pretreatment

Progress in development of electrocatalyst for CO2 conversion to selective CO2 production

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Carbon Energy 2020年第1期2卷 72-98页

作者： Dang Le Tri Nguyen Younghye Kim yun Jeong Hwang Da hye Won Clean Energy Research Center Korea Institute of Science and TechnologySeoulRepublic of Korea Division of Energy and Environmental Technology KIST SchoolKorea University of Science and TechnologySeoulRepublic of Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoulRepublic of Korea

The conversion of carbon dioxide(CO2)to valuable fuels and chemicals offers a new pathway for sustainable and clean carbon ***,the focus has been on electrochemical CO2 reduction on heterogeneous electrode catalysts,leading to remarkable achievements in the reaction *** date,CO2 to carbon monoxide(CO)conversion is considered as the most promising candidate reaction for the industrial market,owing to its high efficiency and reasonable technoeconomic ***,CO has been proposed as a key intermediate species for further reduced hydrocarbons,which can pave the way for various fuel *** study sets out to describe recent progress on the electrochemical CO2 reduction to CO in a heterogeneously catalyzed *** review includes understanding of the catalytic material employed and engineering strategies implemented by adjusting the binding energy of key *** material design approaches,such as nanostructuring,alloying,doping,and so forth,have pioneered breakouts in the intrinsic catalytic nature of transition metal ***,recent advances in systematic design are summarized,with focus on practical industrial ***,perspectives on the design of electrocatalyst materials for CO production by electrochemical CO2 reduction are presented.

关键词： CO production CO2 reduction reaction electrocatalyst

Assessment of risk of complications in cirrhosis using portal thallium scans

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World Journal of Gastroenterology 2014年第1期20卷 228-234页

作者： hye-Jin Tae Dae-Won Jun yun-Young Choi Min-Jung Kwak Min-Ho Lee Department of Internal Medicine Hanyang University School of MedicineSeoul 133-792South Korea Department of Nuclear Medicine Hanyang University College of MedicineSeoul 133-792South Korea Department of Computer Science and Statistics Pyongtaek UniversityPyongtaek 450-701South Korea

AIM:To investigate the usefulness of a novel thallium scan shunt index for assessing portosystemic shuntrelated cirrhotic ***:We enrolled 209 chronic hepatitis B-related cirrhosis *** rectal thallium instillation,radioactive isotope activity in the heart and liver was *** ratio of radiation uptake between the heart and the liver was calculated(the shunt index).This value indicates the degree of portosystemic circulation *** tests,serum biochemistry tests,abdominal ultrasonography,gastroscopy and examination of clinical features such as the occurrence of varices,bleeding and hepatic encephalopathy were *** analysis was used to identify independent risk factors for *** compared the cumulative incidence rates of complications during the follow-up ***:The thallium scan shunt index was significantly higher in the decompensated liver cirrhosis group than in the compensated liver cirrhosis group(0.91±0.39 vs 0.39±0.32,P<0.001).It was also higher in the varices group,the hepatic encephalopathy group,and the variceal bleeding group than in the control group(P<0.001).Multivariate analysis showed that the index was an independent risk factor for predicting decompensated liver *** the cut-off value was 0.75,the shunt index had a sensitivity of 82.6%,a specificity of 84%,a positive predictive value of 61.5%,and a negative predictive value of 94.4%in diagnosing decompensated *** the shunt index was greater than 0.75,there was a significant increase in the number of decompensated ***:The thallium shunt index is a good predictor of cirrhosis-related complications.

关键词： Liver cirrhosis Portosystemic shunt Decompensation

Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss

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Nano-Micro Letters 2024年第4期16卷 269-292页

作者： Moon Sung Kang Yeuni Yu Rowoon Park hye Jin Heo Seok Hyun Lee Suck Won Hong yun Hak Kim Dong‑Wook Han Department of Cogno‑Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Republic of Korea Medical Research Institute School of MedicinePusan National UniversityYangsan 50612Republic of Korea Department of Anatomy School of MedicinePusan National UniversityYangsan 50612Republic of Korea Engineering Research Center for Color‑Modulated Extra‑Sensory Perception Technology Pusan National UniversityBusan 46241Republic of Korea Department of Biomedical Informatics School of MedicinePusan National UniversityYangsan 50612Republic of Korea Periodontal Disease Signaling Network Research Center and Dental and Life Science Institute School of DentistryPusan National UniversityYangsan 50612Republic of Korea BIO‑IT Fusion Technology Research Institute Pusan National UniversityBusan 46241Republic of Korea Present Address:Osstem Implant Inc. Seoul 07789Republic of Korea

Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient *** overcome these limitations,tissue-engineered scaffolds have emerged as a promising *** this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue *** PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and *** vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 ***,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML *** insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT ***,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast *** findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery.

关键词： Ti_(3)C_(2)T_(x)MXene nanoparticle Ternary nanofibrous matrices Myogenesis Regeneration of volumetric muscle loss Next generation sequencing

Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 980-984页

作者： So Jung Kim So yun Park Sun-Mee Hong Eun-hye Kwon Taek-Kyun Lee Gyeongbuk Institute for Marine Bio-Industry South Sea Environment Research Department Korea Institute of Ocean Science and Technology

Objective: To determine skin whitening and wrinkle improvement efficacy, glycoprotein fractions were extracted from liquid extracts of boiled sea cucumber and their effects on tyrosine and elastase inhibitory activities were assayed. Methods: Fractions above and below 50 k Da(>50 kD a and 50 kDa enhanced tyrosinase and elastase inhibitory activities by 50.84% and 28.78%, respectively. Correlations of the >50 kD a concentration with tyrosinase inhibitory(R^2=0.968) and elastase inhibitory(R2=0.983) efficacy were significant. Conclusions: >50 kD a glycoprotein fraction isolated from liquid extracts of boiled sea cucumber, which can serve as a functional cosmetic ingredient for whitening and wrinkle improvement of skin.

关键词： Sea cucumber Glycoprotein Cytotoxicity Tyrosinase Elastase

A computational study of the chemokine receptor CXCR1 bound with interleukin-8

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Chinese Physics B 2018年第3期27卷 534-543页

作者： Yang Wang Cecylia Severin Lupala Ting Wang Xuanxuan Li Ji-hye yun Jae-hyun Park Zeyu Jin Weontae Lee Leihan Tan Haiguang Liu Complex Systems Division Beijing Computational Science Research Center Beijing 100193 China Genome Center University of California Davis 451 East Health Science Drive Davis CA 95616 USA Department of Engineering physics Tsinghua University Beijing 100086 China Department of Biochemistry College of Life Science ＆ Biotechnology Yonsei University Seou103722 South Korea Department of Physics and Institute of Computational and Theoretical Studies Hong Kong Baptist University Hong Kong China

CXCR1 is a G-protein coupled receptor, transducing signals from chemokines, in particular the interleukin-8 （1L8） molecules. This study combines homology modeling and molecular dynamics simulation methods to study the structure of CXCRI-IL8 complex. By using CXCR4-vMIP-II crystallography structure as the homologous template, CXCRI-IL8 complex structure was constructed, and then refined using all-atom molecular dynamics simulations. Through extensive simulations, CXCRI-IL8 binding poses were investigated in detail. Furthermore, the role of the N-terminal of CXCR1 receptor was studied by comparing four complex models differing in the N-terminal sequences. The results indicate that the receptor N-terminal affects the binding of IL8 significantly. With a shorter N-terminal domain, the binding of IL8 to CXCR1 becomes unstable. The homology modeling and simulations also reveal the key receptor-ligand residues involved in the electrostatic interactions known to be vital for complex formation.

关键词： CXCRI-IL8 complex homology modeling ligand binding molecular dynamics