检索结果-南通市图书馆

Will the collaboration of surgery and external radiotherapy open new avenues for hepatocellular carcinoma with portal vein thrombosis?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第7期28卷 704-714页

作者： Jung Wan choe hye Yoon Lee Chai Hong rim Department ofInternal Medicine Korea University Ansan HospitalAnsan 15355South Korea Department of Surgery Korea University Ansan HospitalAnsan 15355South Korea Department of Radiation Oncology Korea University Ansan HospitalAnsan 15355South Korea

Portal invasion of hepatocellular carcinoma(HCC)occurs in 12.5%-40%of patients diagnosed with cancer and yields poor clinical *** it is a common cause of inoperability,sorafenib was regarded as the standard treatment for HCC in the Barcelona Clinic of Liver Cancer ***,the median survival of the Asian population was only approximately 6 mo,and the tumor response rate was less than moderate(<5%).Various locoregional modalities were performed,including external beam radiotherapy(EBRT),transarterial chemoembolization,hepatic arterial infusion chemotherapy,and surgery,alone or in *** them,EBRT is a noninvasive method and can safely treat tumors involving the major *** EBRT has been commonly performed,especially in East Asian countries,where locally invasive HCC is highly *** surgery is not commonly indicated,pioneering studies have demonstrated encouraging results in recent ***,the combination of neo-or adjuvant EBRT and surgery has been recently used and has significantly improved the outcomes of HCC patients,as reported in a few randomized *** systemic modality,a combination of novel immunotherapy and vascular endothelial growth factor inhibitor showed results superior to that of sorafenib as a first-line *** clinical trials investigating the combined use of these novel agents,surgery,and EBRT are expected to improve the prognosis of HCC with portal invasion.

关键词： Surgery Hepatocellular carcinoma Radiotherapy Systemic treatment

Suicide risk in juvenile open angle glaucoma patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1880-1886页

作者： hye-Jeong Seong Sukyoung Jung Sooyeon choe Department of Ophthalmology Chungnam National University HospitalDaejeon 35015Republic of Korea Department of Ophthalmology Chungnam National University College of MedicineDaejeon 35015Republic of Korea Department of Health Care Policy Research Korea Institute for Health and Social AffairsSejong 30147Republic of Korea

AIM:To investigate the association between juvenile open angle glaucoma(JOAG)and mental health among ***:This study used nationally representative data from the 8th Korea National Health and Nutrition Examination Survey(KNHANES)*** diagnosis followed the International Society of Geographical and Epidemiological Ophthalmology criteria based on glaucomatous structural defects,visual field defects,corrected vision,and intraocular *** outcomes,suicidal behaviors,psychiatric counseling,and depression were evaluated through mental health *** ratios(ORs)with 95%confidence intervals(CIs)were estimated using logistic regression models,adjusting for ***:Among 7090 participants,3446 met the inclusion criteria for analysis,and 88(2.6%)were diagnosed with open angle glaucoma(OAG).After adjusting for age,sex,and best-corrected visual acuity(VA),participants with OAG were revealed to have significantly higher odds of suicidal behaviors(i.e.,ideation,planning,or attempts)compared with those without OAG(OR:2.70;95%CI:1.12-6.54;P=0.028).This association remained significant after further adjustments for socioeconomic status,lifestyle factors,and presence of chronic conditions(P=0.031 and 0.035,respectively).However,there was no significant difference for the other two outcomes,psychiatric counseling and *** age-stratified analysis revealed a stronger association between OAG and suicidal behaviors in younger JOAG participants(<40y)than in older OAG participants(≥40y;OR:3.80 vs 2.22;95%CI:0.79-18.22 vs 0.56-8.80,respectively).CONCLUSION:OAG patients show a higher risk of suicidal behaviors than those without glaucoma particularly in JOAG patients.

关键词： glaucoma juvenile open angle glaucoma suicide suicidal behavior

Mechanisms linking gut microbial metabolites to insulin resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第6期12卷 730-744页

作者： hye rim Jang Hui-Young Lee Laboratory of Mitochondrial and Metabolic Diseases Department of Health Sciences and TechnologyGAIHSTGachon UniversityIncheon 21999South Korea Korea Mouse Metabolic Phenotyping Center Lee Gil Ya Cancer and Diabetes InstituteGachon UniversityIncheon 21999South Korea Division of Molecular Medicine Department of MedicineGachon University College of MedicineIncheon 21936South Korea

Insulin resistance is the rate-limiting step in the development of metabolic diseases,including type 2 *** gut microbiota has been implicated in host energy metabolism and metabolic diseases and is recognized as a quantitatively important organelle in host metabolism,as the human gut harbors 10 trillion bacterial *** microbiota break down various nutrients and produce metabolites that play fundamental roles in host metabolism and aid in the identification of possible therapeutic targets for metabolic ***,understanding the various effects of bacterial metabolites in the development of insulin resistance is ***,we review the mechanisms linking gut microbial metabolites to insulin resistance in various insulin-responsive tissues.

关键词： Insulin resistance Skeletal muscle Liver Adipose tissue Intestine Gut bacterial metabolites

Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第25期25卷 3256-3267页

作者： Hee Sun Park Won hyeok choe hye Seung Han Mi hye Yu Young Jun Kim Sung Il Jung Jeong Han Kim So Young Kwon Department of Radiology Konkuk University School of MedicineSeoul 05030South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Pathology Konkuk University School of MedicineSeoul 05030South Korea

BACKGROUND Accurate detection of significant fibrosis(fibrosis stage 2 or higher on the METAVIR scale)is important especially for chronic hepatitis B(CHB)patients with high viral loads but with normal or mildly elevated alanine aminotransferase(ALT)levels because the presence of significant fibrosis is accepted as the indication for antiviral *** biopsy is the reference standard for diagnosing significant fibrosis,but it is an invasive ***,noninvasive imaging-based measurements,such as magnetic resonance elastography(MRE)or two-dimensional shear-wave elastography(2DSWE),have been proposed for the quantitative assessment of liver *** To explore MRE and 2D-SWE to identify fibrosis stage,and to compare their performance with that of serum-based *** The study enrolled 63 treatment-na?ve CHB patients with high viral loads but with normal or mildly elevated ALT levels who underwent liver biopsy before a decision was made to initiate antiviral *** and 2D-SWE were performed,and serum-based indices,such as FIB-4 and aspartate transaminase to platelet ratio index(APRI),were *** diagnostic performances of MRE,2D-SWE,FIB-4,and APRI for assessing significant fibrosis(≥F2)and cirrhosis(F4)were evaluated with liver histology as the reference standard,using receiver operating characteristic *** The liver fibrosis stage was F0/F1 in 19,F2 in 14,F3 in 14,and F4 in 16 patients,*** significantly discriminated F2 from F0/1(P=0.022),whereas 2D-SWE showed a broad overlap in distinguishing those *** showed a higher correlation coefficient value with fibrosis stage than 2D-SWE with fibrosis stage(0.869 vs 0.649,Spearman test;P<0.001).Multivariate linear regression analyses showed that fibrosis stage was the only factor affecting the values of MRE(P<0.001),whereas body mass index(P=0.042)and fibrosis stage(P<0.001)were independent factors affecting 2D-SWE *** performance for diagnos

关键词： Antiviral therapy Chronic hepatitis B Liver fibrosis Magnetic resonance elastography Ultrasound elastography

Bone-targeted lipoplex-loaded three-dimensional bioprinting bilayer scaffold enhanced bone regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第4期3卷 138-148页

作者： Woo-Jin Kim Jeong-Hyun Ryu Ji Won Kim Ki-Tae Kim hye-rim Shin Heein Yoon Hyun-Mo Ryoo Young-Dan Cho Department of Molecular Genetics School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul03080Republic of Korea Department of Periodontology School of Dentistry and Dental Research InstituteSeoul National University and Seoul National University Dental HospitalSeoul03080Republic of Korea

Clinical bone-morphogenetic protein 2(BMP2)treatment for bone regeneration,often resulting in complications like soft tissue inflammation and ectopic ossification due to high dosages and non-specific delivery systems,necessitates research into improved biomaterials for better BMP2 stability and *** tackle this challenge,we introduced a groundbreaking bone-targeted,lipoplex-loaded,three-dimensional bioprinted bilayer scaffold,termed the polycaprolactone-bioink-nanoparticle(PBN)scaffold,aimed at boosting bone *** encapsulated BMP2 within the fibroin nanoparticle based lipoplex(Fibroplex)and functionalized it with DSS6 for bone tissue-specific targeting.3D printing technology enables customized,porous PCL scaffolds for bone healing and soft tissue growth,with a two-step bioprinting process creating a cellular lattice structure and a bioink grid using gelatin-alginate hydrogel and DSS6-Fibroplex,shown to support effective nutrient exchange and cell growth at specific pore *** PBN scaffold is predicted through in silico analysis to exhibit biased BMP2 release between bone and soft tissue,a finding validated by in vitro osteogenic differentiation *** PBN scaffold was evaluated for critical calvarial defects,focusing on sustained BMP2 delivery,prevention of soft tissue cell infiltration and controlled fiber membrane pore size in *** PBN scaffold demonstrated a more than eight times longer BMP2 release time than that of the collagen sponge,promoting osteogenic differentiation and bone regeneration in a calvarial defect *** findings suggest that the PBN scaffold enhanced the local concentration of BMP2 in bone defects through sustained release and improved the spatial arrangement of bone formation,thereby reducing the risk of heterotopic ossification.

关键词： 3D bioprinting bone-targeting lipoplex BMP2 bone regeneration

Three-Tesla magnetic resonance elastography for hepatic fibrosis:Comparison with diffusion-weighted imaging and gadoxetic acid-enhanced magnetic resonance imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第46期20卷 17558-17567页

作者： Hee Sun Park Young Jun Kim Mi hye Yu Won hyeok choe Sung Il Jung Hae Jeong Jeon Department of Radiology Konkuk University School of MedicineSeoul 143-729South Korea Digestive Disease Center Konkuk University School of MedicineSeoul 143-729South Korea

AIM: To evaluate the feasibility of 3-Tesla magnetic resonance elastography (MRE) for hepatic fibrosis and to compare that with diffusion-weighted imaging (DWI) and gadoxetic acid-enhanced magnetic resonance (MR) imag... 详细信息

关键词： Magnetic resonance elastography Hepatic fibrosis Diffusion weighted imaging Gadoxetic acid enhanced magnetic resonance imaging Serum markers

Lymphovascular invasion in more than one-quarter of small rectal neuroendocrine tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第42期22卷 9400-9410页

作者： Mi Jung Kwon Ho Suk Kang Jae Seung Soh Hyun Lim Jong hyeok Kim Choong Kee Park hye-rim Park Eun Sook Nam Department of Pathology Hallym University Sacred Heart Hospital Department of Internal Medicine Hallym University Sacred Heart Hospital Department of Pathology Kangdong Sacred Heart Hospital Hallym University College of Medicine

AIM To identify the frequency, clinicopathological risk factors, and prognostic significance of lymphovascular invasion(LVI) in endoscopically resected small rectal neuroendocrine tumors(NETs).METHODS Between June 2005 and December 2015, 104 cases of endoscopically resected small(≤ 1 cm) rectal NET specimens at Hallym University Sacred Heart Hospital in Korea were retrospectively evaluated. We compared the detected rate of LVI in small rectal NET specimens by two methods: hematoxylin and eosin(H&E) and ancillary immunohistochemical staining(D2-40 and Elastica van Gieson); in addition, LVI detection ratedifference between endoscopic procedures were also evaluated. Patient characteristics, prognosis and endoscopic resection results were reviewed by medical *** We observed LVI rates of 25.0% and 27.9% through H&E and ancillary immunohistochemical staining. The concordance rate between H&E and ancillary studies was 81.7% for detection of LVI, which showed statistically strong agreement between two methods(κ = 0.531, P 5 mm, P = 0.007), tumor grade 2(P = 0.006). Among those factors, tumor grade 2 was the only independent predictive factor for the presence of LVI(HR = 4.195, 95%CI: 1.321-12.692, P = 0.015). No recurrence was observed over 28.8 mo regardless of the presence of *** LVI may be present in a high percentage of small rectal NETs, which may not be associated with short-term prognosis.

关键词： Rectum Neuroendocrine tumor Lymphatic Immunohistochemistry Prognosis

Treatment for gastric ‘indefinite for neoplasm/dysplasia' lesions based on predictive factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第4期25卷 469-484页

作者： Mi Jung Kwon Ho Suk Kang hyeon Tae Kim Jin Woo Choo Bo Hyun Lee Sung Eun Hong Kun Ha Park Dong Min Jung Hyun Lim Jae Seung Soh Sung Hoon Moon Jong hyeok Kim hye-rim Park Soo Kee Min Jin won Seo Ji-Young choe Department of Pathology Hallym University Sacred Heart Hospital Hallym University College of Medicine Department of Internal Medicine Hallym University Sacred Heart Hospital

BACKGROUND Gastric ‘indefinite for neoplasm/dysplasia'(IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal *** To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND *** In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection(n = 134), surgery(n = 22), and follow-up endoscopic biopsy(n = 305) were performed to confirm the *** time interval from initial biopsy to cancer diagnosis was measured, and diagnostic delays were categorized as > 2 wk, > 2 mo, > 6 mo, and > 1 year. The IFND lesions presenting as regenerating atypia(60%) or atypical epithelia(40%)at initial biopsy were adenocarcinomas in 22.6%, adenomas in 8.9%, and gastritis in 68.5% of the *** Four clinical factors [age ≥ 60 years(2.445, 95%CI: 1.305-4.580, P = 0.005),endoscopic size ≥ 10 mm(3.519, 95%CI: 1.891-6.548, P < 0.001), single lesion(5.702, 95%CI: 2.212-14.696, P < 0.001), and spontaneous bleeding(4.056, 95%CI:1.792-9.180, P = 0.001)], and two pathologic factors [atypical epithelium(25.575,95%CI: 11.537-56.695, P < 0.001], and repeated IFND diagnosis [6.022, 95%CI:1.822-19.909, P = 0.003)] were independent risk factors for gastric cancer. With two or more clinical factors, the sensitivity and specificity for carcinoma were91.3% and 54.9%, respectively. Ten undifferentiated carcinomas were initially diagnosed as IFND. In the subgroup analysis, fold change(5.594, 95%CI: 1.458-21.462, P = 0.012) predicted undifferentiated or invasive carcinoma in the submucosal layers or deeper. Diagnostic delays shorter than 1 year were not associated with worse prognoses. Extremely well-differentiated adenocarcinomas accounted for half of the repeate

关键词： Gastric cancer Biopsy Endoscopic surgical procedure Diagnostic delay Prognosis

Different oncological features of colorectal cancer codon-specific KRAS mutations:Not codon 13 but codon 12 have prognostic value

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第32期29卷 4883-4899页

作者： Hong-Min Ahn Duck-Woo Kim Tae Gyun Lee hye-rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University HospitalSeoul 03080South Korea

BACKGROUND Approximately 40%of colorectal cancer(CRC)cases are linked to Kirsten rat sarcoma viral oncogene homolog(KRAS)*** mutations are associated with poor CRC prognosis,especially KRAS codon 12 mutation,which is associated with metastasis and poorer ***,the clinicopathological characteristics and prognosis of KRAS codon 13 mutation in CRC remain *** To evaluate the clinicopathological characteristics and prognostic value of codonspecific KRAS mutations,especially in codon *** This retrospective,single-center,observational cohort study included patients who underwent surgery for stage I-III CRC between January 2009 and December *** with KRAS mutation status confirmed by molecular pathology reports were *** relationships between clinicopathological characteristics and individual codon-specific KRAS mutations were *** data were analyzed to identify codon-specific KRAS mutations as recurrence-related factors using the Cox proportional hazards regression *** Among the 2203 patients,the incidence of KRAS codons 12,13,and 61 mutations was 27.7%,9.1%,and 1.3%,*** KARS codons 12 and 13 mutations showed a tendency to be associated with clinical characteristics,but only codon 12 was associated with pathological features,such as stage of primary tumor(T stage),lymph node involvement(N stage),vascular invasion,perineural invasion,tumor size,and microsatellite *** codon 13 mutation showed no associations(77.2%vs 85.3%,P=0.159),whereas codon 12 was associated with a lower 5-year recurrence-free survival rate(78.9%vs 75.5%,P=0.025).In multivariable analysis,along with T and N stages and vascular and perineural invasion,only codon 12(hazard ratio:1.399;95%confidence interval:1.034-1.894;P=0.030)among KRAS mutations was an independent risk factor for *** This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biom

关键词： Genes Ras Codon Colonic neoplasms Rectal neoplasms