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Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 374-379页

作者： mi-Ja Kim hye Kyung Kim Department of Food and Biotechnology Hanseo UniversitySeosan 356-706Republic of Korea Department of Pharmacology school of MedicineKyunghee UniversitySeoul 130-701Republic of Korea

Objective:To explore the anti-diabetic activity of Ecklonia cava(EC) in streptozotocin(STZ)-induced diabetic ***:Diabetes was induced by a single intraperitoneal injection of STZ(90 mg/kg).Normal and diabetic mice were treated with 0%,3%,and 5%EC diet for 4 weeks. Serum glucose and insulin concentrations,serum lipid profile,oral glucose tolerance test,and liver and pancreaticβ-cell histopathological observations were *** addition,in vitro glucose-induced insulin secretion was determined using pancreaticβ-islet ***:EC supplementation significantly and dose-dependently decreased serum glucose concentration, and improved glucose homeostasis in diabetic mice by preventing loss ofβ-cell mass resulting in increase of insulin *** triglyceride and total cholesterol concentrations in the serum and liver were markedly reduced by EC treatment in STZ-diabetic ***,LDL-,and HDL-cholesterol levels were ameliorated in EC supplemented diabetic *** steatosis induced by STZ was ameliorated by EC ***,in vitro insulinotrophic effect of EC extract was observed in pancreaticβ-***:This study demonstrated that EC is a potent and efficacious hypoglycemic and hypolipidemic agent,and prevents the loss ofβ-cell mass resulting in increase of insulin secretary capacity.

关键词： Diabetes Streptozotocin Insulin Lipid profile Pancreaticβ-cell

Protective effects of Ecklonia cava extract on the toxicity and oxidative stress induced by hair dye in in-vitro and in-vivo models

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Journal of Oceanology and Limnology 2019年第3期37卷 909-917页

作者： OH Jae-Young RYU Bo-mi YANG hye-Won KIM Eun-A lee Jung-Suck JEON You-Jin Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Jeju International Marine Science Center for Research & Education Korea Institute of Ocean Science and TechnologyJeju 63349Republic of Korea Research Center for Industrial Development of Seafood Gyeongsang National UniversityTongyeong 53064Republic of Korea

Oxidative hair dyes containingρ-phenylenediamine(PPD)are reported to induce an allergic reaction by promoting oxidative stress when absorbed through the *** the associated risk,these hair dyes remain popular owing to their convenience and sharpness of *** makes it important to minimize the cytotoxicity and oxidative stress induced by PPD-containing hair *** cava extract has been evaluated in different studies for its protective effects against external stress in fibroblasts and *** study was aimed at using in-vitro and in-vivo models to investigate the extract’s effects on cytotoxicity of and oxidative stress induced by PPD-containing hair *** of CIEL*a*b*Color space was first used to determine the range of *** extract that would not interfere with the coloring ability of the dye upon ***,the set ranges of *** extract(5% and 7%)were added to the hair dye and their toxicity assessed by evaluating the viability of fibroblasts and *** effects on developmental phenotypes and induction of oxidative stress by hair dye were evaluated and compared with those of hair dyes containing different contents of *** extract using an in-vivo zebrafish *** results showed that *** extract in hair dye could significantly decrease the cytotoxicity and levels of oxidative stress caused by hair dyes containing PPD in both in-vitro and in-vivo *** results suggest that the addition of 7% *** extract to 250μg/mL hair dye does not interfere with the coloring ability of the dye while showing significant protective eff ects against the hair *** study proposes that the use of *** extract as an adduct to hair dyes containing PPD reduces the cytotoxicity and oxidative stress induced by these hair dyes.

关键词： hair dye Ecklonia cava cytotoxicity oxidative stress in-vitro and in-vivo models

Catalysts for electrochemical ammonia oxidation:Trend,challenge,and promise

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Science China Materials 2022年第12期65卷 3334-3352页

作者： Sol A lee mi Gyoung lee Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Electrical and Computer Engineering University of TorontoToronto M5S 3G4OntarioCanada Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea

Developing sustainable and clean energy technology is critial to address the current energy and environmental *** an energy carrier,hydrogen has been getting attention due to its abundance,high energy density,and zero carbon *** to the difficulty of hydrogen storage and transport,the electro-oxidation of ammonia shows great potential for renewable energy since it satisfies both energy supply and environmental protection as a carbon-free fuel with high hydrogen ***,ammonia electro-oxidation is a sluggish reaction and shows low *** the complicated mechanism and intermediates is conducive to developing efficient electrocatalysts with high catalytic activity and *** review begins with the ammonia oxidation technologies and their *** two typical mechanisms for ammonia electro-oxidation,Oswin-Salomon mechanism and Gerischer-Mauerer mechanism,are discussed,and attention to the poisoning species is ***,the electrocatalysts for ammonia reaction are classified into Pt-based catalysts and non-noble metal-based catalysts,and their performances are reviewed with various *** on the progress on the electrochemical ammonia oxidation catalysts,the challenges and future insight on ammonia oxidation reaction are discussed and proposed.

关键词： NH3 oxidation reaction electrocatalysts green hydrogen

Some Properties of Degenerate r-Dowling Polynomials and Numbers of the Second Kind

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 825-842页

作者： hye Kyung Kim Dae Sik lee Department of Mathematics Education Daegu Catholic UniversityGyeongsan38430Korea School of Electronic and Electric Engineering Daegu UniversityGyeongsan38453Korea

The generating functions of special numbers and polynomials have various applications in many fields as well as mathematics and *** recent years,some mathematicians have studied degenerate version of them and obtained many interesting *** this in mind,in this paper,we introduce the degenerate r-Dowling polynomials and numbers associated with the degenerate r-Whitney numbers of the second *** derive many interesting properties and identities for them including generating functions,Dobinski-like formula,integral representations,recurrence relations,differential equation and various explicit *** addition,we explore some expressions for them that can be derived from repeated applications of certain operators to the exponential functions,the derivatives of them and some identities involving them.

关键词： Dowling lattice Whitney numbers and polynomials r-Whitney numbers and polynomials of the second kind r-Bell polynomials r-Stirling numbers dowling numbers and polynomials

Degenerate s-Extended Complete and Incomplete Lah-Bell Polynomials

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Computer Modeling in Engineering & Sciences 2022年第6期130卷 1479-1495页

作者： hye Kyung Kim Dae Sik lee Department of Mathematics Education Daegu Catholic UniversityGyeongsan38430Korea School of Electronic and Electric Engineering Daegu UniversityGyeongsan38453Korea

Degenerate versions of special polynomials and numbers applied to social problems,physics,and applied mathematics have been studied variously in recent ***,the(s-)Lah numbers have many other interesting applications in analysis and *** this paper,we divide two *** first introduce new types of both degenerate incomplete and complete s-Bell polynomials respectively and investigate some properties of them ***,we introduce the degenerate versions of complete and incomplete Lah-Bell polynomials as multivariate forms for a new type of degenerate s-extended Lah-Bell polynomials and numbers *** investigate relations between these polynomials and degenerate incomplete and complete s-Bell polynomials,and derive explicit formulas for these polynomials.

关键词： Lah-Bell numbers and polynomials s-extended Lah-Bell numbers and polynomials complete s-Bell polynomials incomplete s-Bell polynomials s-Stirling numbers of second kind

Recognition of Association Between Blood Stasis Syndrome and Traumatic Injury among Doctors of Korean Medicine:A Cross-Sectional Observation Study

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Chinese Journal of Integrative Medicine 2018年第4期24卷 254-259页

作者： Jeeyoun Jung mi mi Ko Ju Ah lee Myeong Soo lee Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the diagnostic indicators and herbal treatments for blood stasis syndrome（BSS） patients with traumatic injuries and to identify the association between BSS and traumatic injury in Korea. Methods： Two-hundred and four patients with traumatic injury were recruited from the Gangnam and Daejeon branches of Jaseng Hospital of Oriental Medicine between June 2014 and December 2014. Two independent doctors of Korean medicine（DKMs） determined the diagnosis of BSS or non-BSS based on the subjects＇ signs and symptoms. The scores assigned to BSS symptoms and DKMs＇ reasons for diagnosing BSS in patients with traumatic injury were investigated. Both medication and herbal prescription records from a 3-month period were collected for all patients diagnosed with BSS by both DKMs. Results： A total of 169 of 204（82.8%） patients received consistent diagnosis related to BSS by two DKMs. Among them, 54.4%（92 cases） were diagnosed with BSS, and 45.6%（77 cases） were not diagnosed with BSS. DKMs most frequently cited symptoms of recent traumatic injury as justifications for BSS diagnoses, and also selected pain-related indicators such as abdominal pain, sharp pain and nocturnal pain as important reasons in diagnosing BSS. In addition, an inconsistency in the pattern identification theory with respect to traumatic injury was observed. Although only 92 cases（54.4%） of patients were diagnosed with BSS, 77.6% of them were prescribed decoctions for BSS. Conclusions： DKMs considered traumatic injury could cause BSS, and utilized decoction for BSS in patients with traumatic injury without confirming a diagnosis of BSS because they assumed the main symptoms or pathologies of traumatic injury to be closely related to BSS.

关键词： blood stasis syndrome Korean medicine traumatic injury herbal medicine diagnosis pattern identification

Groundwater contamination and natural attenuation capacity at a petroleum spilled facility in Korea

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Journal of Environmental Sciences 2011年第10期23卷 1650-1659页

作者： Hyun-mi Choi Jin-Yong lee Department of Geology Kangwon National University

As a remedial option, the natural attenuation capacity of a petroleum contaminated groundwater at a military facility was examined. Hydrogeological conditions, such as high water level, permeable uppermost layer and frequent heavy rainfall, were favorable to natural attenuation at this site. The changes in the concentrations of electron acceptors and donors, as well as the relevant hydrochemical conditions, indicated the occurrence of aerobic respiration, denitrification, iron reduction, manganese reduction and sulfate reduction. The calculated BTEX expressed biodegradation capacity ranged between 20.52 and 33.67 mg/L, which appeared effective for the reduction of the contaminants levels. The contribution of each electron accepting process to the total biodegradation was in the order： denitrification 〉 iron reduction 〉 sulfate reduction 〉 aerobic respiration 〉 manganese reduction. The BTEX and benzene point attenuation rates were 0.0058-0.0064 and 0.0005-0.0032 day-1, respectively, and the remediation time was 0.7-1.2 and 2.5-30 years, respectively. The BTEX and benzene bulk attenuation rates were 8.69 × 10^-4 and 1.05 × 10^-3 day-l, respectively, and the remediation times for BTEX and benzene were 7.2 and 17.5 years, respectively. However, most of the natural attenuation occurring in this site can be attributed to dilution and dispersion. Consequently, the biodegradation and natural attenuation capacities were good enough to lower the contaminants levels, but their rates appeared to be insufficient to reach the remediation goal within a reasonable time frame. Therefore, some active remedial measures would be required.

关键词： petroleum contaminated site BTEX electron acceptor expressed biodegradation capacity natural attenuation

Diagnostic Indicators for Blood Stasis Syndrome Patients with Gynaecological Diseases

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Chinese Journal of Integrative Medicine 2018年第10期24卷 752-757页

作者： Jeeyoun Jung mi mi Ko Myeong Soo lee So min lee Ju Ah lee Korea Medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the important diagnostic indicators for blood stasis syndrome （BSS） in patients of childbearing age with gynaecological diseases. Methods： A partial least squared-discriminant analysis （PLS-DA） were applied to BSS symptoms data of patients with gynaecological diseases, and the diagnostic indicators used by doctors of Korean medicine （DKMs） among BSS patients with gynaecological diseases were also investigated. Results： A total of 103 patients of childbearing age with gynaecological diseases and 40 healthy controls were enrolled. Among the 103 patients, 63 （61.7%） and 40 （38.8%） were diagnosed with BSS and non-BSS, respectively, and BSS patients exhibited a more severe extent of disease. A score plot of PLS-DA showed clearly different patterns among the 3 groups. Based on the variable importance on projection of PLS-DA model, menstrual pains, dark lumps in the menstrual blood, ileocoecal tenderness and resistance, sharp pains, and sublingual varicosities were selected as the top five most important indicators. Moreover, more than 75% of DKMs chose dark lumps in menstrual blood, menstrual pain, and dark menstrual blood as the diagnostic indicators of BSS in patients with gynaecological diseases, and more than 49% of them also considered sharp pains, dark red tongue, sublingual varicosities, and tendency to bruise easily as diagnostic indicators of BSS. Conclusion： DKMs focused on menstrual symptoms and certain gynaecological symptoms to diagnose BSS patients of childbearing age with female diseases.

关键词： blood stasis syndrome diagnosis gynaecological disease pattern identification

Percutaneous Coronary Intervention for a Recent Myocardial Infarction with an Anomalous Right Coronary Artery Arising from the mid Left Anterior Descending Coronary Artery

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Chinese Medical Journal 2016年第10期129卷 1259-1260页

作者： Sung-Gyu An hye-Won lee Department of Internal Medicine Division of Cardiology School of Medicine Pusan National University Hospital Pusan National University Busan Korea

To the Editor： Anomalous right coronary artery （RCA） is rare and usually originates from the left sinus of Valsalva. An anomalous RCA arising from the left anterior descending （LAD） coronary artery is extremely rare. It is important to be aware of coronary anomalies because they may be associated with potentially serious cardiac events. Therefore, we report a rare case of an anomalous origin of the RCA from the mid left anterior descending artery （mLAD）, which presented with acute myocardial infarction just proximal to the origin of the RCA, jeopardizing both the LAD and RCA.

关键词： PATIENT ORIGIN