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Technical issues and new devices of ESD of early gastric cancer

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World Journal of Gastroenterology 2011年第31期17卷 3585-3590页

作者： Wan Sik Lee jin Woong cho Young Dae Kim Kyu Jong Kim Byung Ik Jang Division of Gastroenterology Department of Internal MedicineChonnam University Medical School Division of Gastroenterology and Hepatology Department of Internal MedicinePresbyterian Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of MedicineChosun University Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine Division of Gastroenterology Department of Internal MedicineYeungnam University College of Medicine

Endoscopic submucosal dissection(ESD) is a highly refined technique compared to conventional endoscopic mucosal *** enables complete resection of early gastric cancer(EGC) which has no possibility of lymph node *** for ESD of EGC generally entails early gastric cancer confined to the mucosa with well differentiated histology,though there are clinically suitable expanded *** ESD requires specific skill and expertise,endoscopists need to be familiarized with basic methods and the use of special *** essence of the technique is to dissect the submucosal layer with direct vision and maintain thecutting plane above the underlying proper muscle *** there are some differences in the detailed technical aspect,the cardinal method of ESD is now well established and ***,research and development of new ESD devices that render more efficient,safe ESD are still in progress to improve the overall result of ESD on early gastric cancer.

关键词： Endoscopic submucosal dissection Technique Device Early gastric cancer

Clinical application of repetitive transcranial magnetic stimulation in stroke rehabilitation

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Neural Regeneration Research 2012年第8期7卷 627-634页

作者： Joonho Shin EunJoo Yang KyeHee cho Carmelo L Barcenas Woo jin Kim Nam-Jong Paik Department of Rehabilitation Medicine Bundang Hospital College of Medicine Seoul National University

Proper stimulation to affected cerebral hemisphere would promote the functional recovery of patients with stroke. Effects of repetitive transcranial magnetic stimulation on cortical excitability can be can be altered by the stimulation frequency, intensity and duration. There has been no consistent recognition regarding the best stimulation frequency and intensity. This study reviews the intervention effects of repetitive transcranial stimulation on motor impairment, dysphagia, visuospatial neglect and aphasia, and summarizes the stimulation frequency, intensity and area for repetitive transcranial magnetic stimulation to yield the best therapeutic effects.

关键词： stroke repetitive transcranial magnetic stimulation rehabilitation review

FET-based nanobiosensors for the detection of smell and taste

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Science China(Life Sciences) 2020年第8期63卷 1159-1167页

作者： Dongseok Moon Yeon Kyung Cha So-ong Kim Seongyeon cho Hwi jin Ko Tai Hyun Park School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea

Various nanobiosensors composed of biomaterials and nanomaterials have been developed,due to their demonstrated advantage of showing high *** various biomaterials for biological recognition elements of the nanobiosensor,sensory receptors,such as olfactory and taste receptors,are promising biomaterials for developing nanobiosensors,because of their high selectivity to target ***-effect transistors(FET)with nanomaterials such as carbon nanotube(CNT),graphene,and conducting polymer nanotube(CPNT),can be combined with the biomaterials to enhance the sensitivity of ***,many efforts have been made to develop nanobiosensors using biomaterials,such as olfactory receptors and taste receptors for detecting various smells and *** review focuses on the biomaterials and nanomaterials used in nanobiosensor systems and studies of various types of nanobiosensor platforms that utilize olfactory receptors and taste receptors which could be applied to a wide range of industrial fields,including the food and beverage industry,environmental monitoring,the biomedical field,and anti-terrorism.

关键词： nanobiosensor olfactory receptor taste receptor field-effect transistor(FET)

Effect of Cristobalite and Quartz on the Properties of Gypsum Bonded Investment

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Journal of Materials Science & Technology 2008年第1期24卷 143-144页

作者： Yun-Jong Kim Sang-Bae Kim Hyun-hye Park Myeong-Deok Seo Byoung-Cheon Lee Man-So Han Taik-Nam Kim Sung-Baek cho Korea Institute of Geoscience and Mineral Resources (KIGAM) Gajeong-dong 30 Yuseong-kuDaejeon 305-350Korea Department of Materials Engineering Graduate School Paichai UniversityDaejeon 302-735Korea Dept.of Dental Laboratory Technology Daejeon Health Science College Korea

Generally the gold investment material consists of cristobalite,quartz and *** physical property of gold investment materials depends on its thermal expansion coefficients,compressive strength,and particles size *** the thermal expansion coefficient of cristobalite and quartz are 2.6×10^-6/℃and 2.32×10^-6/℃respectively,the composition ratio of each components influence the thermal and physical properties of gold investment *** the clinical applications,it is necessary to improve the properties of gold investment materials such as homogeneous size distribution and thermal expansion *** the present study,effect of inorganic fillers such as cristobalite and quartz on gold alloy investment was investigated to improve the properties of *** compressive strength and thermal expansion coefficients of the specimens were *** results showed that cristobalite and quartz were homogeneously distributed by milling. The optimum compressive strength was obtained at the ratio of 42：22 cristobalite and quartz,respectively.

关键词： Investment Cristobalite Quartz Thermal expansion coefficient Compressivestrength

Serial evaluation of myocardial function using the myocardial performance index in Kawasaki disease

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World Journal of Pediatrics 2018年第3期14卷 259-268页

作者： Eun Song Song Somy Yoon Joo Hyun cho Eun Mi Yang Hwa jin cho Young Youn choi Jae Sook Ma Gwang hyeon Eom Young Kuk cho Department of Pediatrics Chonnam National University HospitalChonnam National University Medical School42 Jebong-roDong-guGwangju 501-757South Korea Department of Pharmacology and Medical Research Center for Gene Regulation Chonnam National University Medical School160 Baekseo-roDong-guGwangju 61469South Korea Department of Pediatrics KS HospitalGwangjuSouth Korea

Background Kawasaki disease (KD) is known as systemic vasculitis, and more than half of the patients with KD have myo-carditis, which can induce ventricular dysfunction. In this study, we evaluate left ventricular (LV) dysfunction in patients with KD based on the myocardial performance index (MPI) using pulse Doppler (PD) and tissue Doppler imaging (TDI), from the acute to convalescent phases. Methods We retrospectively studied 89 children diagnosed with KD from January 2010 to August 2012. We assessed the presence of coronary artery lesions (CALs) and the LV ejection fraction, PD-MPI, and TDI-MPI at diagnosis, and 2, 14, and 56 days after intravenous immunoglobulin (IVIG) treatment. We enrolled 70 healthy children as a control group. Results The ejection fraction in patients with KD at diagnosis (67.3 ± 0.9%) was lower than that in the control group (69.8 ± 0.8%,P = 0.035), and the LV TDI-MPIs for patients with KD at diagnosis (0.49 ± 0.01) and 2 days after IVIG treatment (0.48 ± 0.01) were higher than those in the control group (0.45 ± 0.01,P = 0.002,P = 0.033, respectively). No signifi cant diff erences were found in the LV dysfunction between the patients with complete and incomplete KD. Septal TDI-MPIs in patients with KD with CAL at diagnosis (0.52 ± 0.02) were higher than those in patients with KD without CAL (0.47 ± 0.01,P = 0.019). Conclusions Transient LV dysfunction occurred in patients with complete and incomplete KD in the acute stage. In patients with KD with CAL at diagnosis, the LV dysfunction was more prominent. The PD-MPI and TDI-MPI are useful parameters for assessing LV function in patients with KD.

关键词： Kawasaki disease Myocardial function Myocardial performance index Tissue Doppler imaging

Efficacy and safety of 0.4 percent sodium hyaluronate for endoscopic submucosal dissection of gastric neoplasms

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World Journal of Gastroenterology 2013年第20期19卷 3069-3076页

作者： Young Dae Kim Jun Lee Ju Yeon cho Seok Won Kim Seong Hwan Kim Young Kwan cho jin Seok Jang Ji Sun Han Joo Young cho Division of Gastroenterology and Hepatology Department of Internal MedicineMedical SchoolChosun UniversityGwangju 501-717South Korea Department of Internal Medicine Eulji HospitalEulji UniversitySeoul 139-872South Korea Department of Internal Medicine Dong A University College of MedicineBusan 602-715South Korea Department of Internal Medicine Institute for Digestive ResearchDigestive Disease CenterSoonchunhyang University College of MedicineSeoul 140-743South Korea

AIM:To evaluate the efficacy and safety of sodium hyaluronate solution(SH) in endoscopic submucosal dissection(ESD) of gastric ***:A prospective multicenter randomized,double blind,controlled trial was designed and utilized in this study.A total of 76 patients with 5-20 mm sized gastric neoplasms were enrolled at three academic hospitals in South Korea from June 2011 to October *** were randomly assigned to the 0.4% sodium hyaluronate or control *** lesions underwent endoscopic *** was performed with 0.4%SH and normal saline(NS) solution for submucosal *** was assessed using en bloc resection and the number of additional *** evaluation variables were the volume of injection material,steepness of mucosal elevation,bleeding rate,procedural time and operator ***,the safety was assessed by analyzing adverse events during the ***:The usefulness rate in the 0.4%SH group and the controlled group had statistically significant difference under intention to treat(ITT) analysis(90.91% vs 61.11% P = 0.0041).Under per protocol(PP),the usefulness rate is statistically significant different(93.10% vs 61.76%,P = 0.0036).The difference in volume of the solution injected between 0.4%SH group and the controlled group and NS group was also statistically significant under intention to treat and per protocol analysis(ITT:0.03 ± 0.02 mL vs 0.06 ± 0.03 mL,P = 0.0003,PP:0.03 ± 0.02 mL vs 0.06 ± 0.03 mL,P = 0.0004).Satisfaction above the grade good was significantly higher in the SH group under intention to treat and per protocol analysis(ITT:90.91% vs 61.11%,P = 0.0041,PP = 93.11% vs 61.77%,P = 0.0022).Adverse events above grade 3 were not noticed in either *** adverse events were treated and were judged as not associated with the submucosal injection ***:0.4%SH solution is a safe and effective agent that doesn't cause any significant adverse events and is useful for submucos

关键词： Sodium hyaluronate Endoscopic submucosal dissection Gastric neoplasm Endoscopic mucosal resection

Evaluation of non-ampullary duodenal polyps: Comparison of non-neoplastic and neoplastic lesions

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World Journal of Gastroenterology 2010年第43期16卷 5474-5480页

作者： Sung Hoon Jung Woo Chul Chung Eun Jung Kim Seol hye Kim Chang Nyol Paik Bo In Lee Young Seok cho Kang-Moon Lee Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To evaluate duodenal polyps, divided into nonneoplastic and neoplastic lesions. In addition, the clinical characteristics of duodenal hyperplastic polyps are determined. METHODS: We analyzed medical records of 50 114 consecutive patients submitted to for first diagnostic esophago-gastroduodenoscopy between January 2004 and December 2009. We excluded lesions on the ampulla of Vater and submucosal tumors. We studied 510 cases that were diagnosed endoscopically with duodenal polyps and enrolled a total of 221 cases that had undergone tissue biopsy. We analyzed the differences between non-neoplastic and neoplastic lesions, and determined the clinical features of duodenal hyperplastic polyps. RESULTS: Non-neoplastic lesions were found in 196 patients and neoplastic lesions in 25 patients. On uni-variate analysis, there were significant differences in shape, location, and size. Polyps more than 10 mm in diameter or polyps in the second portion had independent risk factors for being neoplastic lesions, as identified by multivariate analysis. In 23 cases of hyperplastic polyps (79.3%), they were accompanied by gastroduodenal pathology, which was possibly associated with Helicobacter pylori . CONCLUSION: Polyps of more than 10 mm or polyps in the second portion of the duodenum should be evaluated by histological examination.

关键词： Duodenum Polyp Helicobacter pylori

Myelophil, a mixture of Astragali Radix and Salviae Radix extract, moderates toxic side effects of fluorouracil in mice

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World Journal of Gastroenterology 2008年第15期14卷 2323-2328页

作者： Jang Woo Shin Myong Min Lee jin Young Son Nam Heon Lee chong Kwan cho Won Kyu Chung Jung Hyo cho Chang Gue Son East-West Cancer Center Dunsan Oriental Hospital of Daejeon University 1136 Dunsan-dong Seo-gu Daejeon 302122 Korea Department of Radiotherapy Hospital of Konyang University 865 Gasuwon-dong Seo-gu Daejeon 302718 Korea

AIM: To evaluate the efficacy of Myelophil, an extract containing Astragali Radix and Salviae Radix, for reducing complications induced by 5-fluorouracil (5-FU) in a gastrointestinal cancer model. METHODS: We injected 5-FU into mice and then administered Myelophil to examine the ability of the drug to treat the side effects of 5-FU in mice. Peripheral blood counts, histological examinations, and colony-forming assays of bone marrow were conducted, followed by swimming tests and assessment of survival times. RESULTS: Myelophil restored red and white blood cells and platelets in blood, and recovered cell density in bone marrow to levels comparable to those observed within the control group. In addition, Myelophil significantly increased colony-forming unit granulocyte-macrophage (CFU-GM) and CFU-erythroid (CFU-E) compared to the control group. We confirmed that interleukin-3 gene expression was upregulated by Myelophil in spleen cells. Myelophil administration also doubled the survival rate of mice that were severely myelosuppressed as a result of 5-FU injection at a lethal dose of 70%. Finally, the swimming performance of mice significantly improved as a result of Myelophil treatment. CONCLUSION: These results provide experimentalevidence in support of clinical applications of Myelophil to minimize 5-FU-induced myelosuppression and improve general post-chemotherapy health.

关键词： Astragalus membranaceus Salvia miltionrhizae Myelosuppression Immunosuppression Chemotherapy

FIDS:Filtering-Based Intrusion Detection System for In-Vehicle CAN

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Intelligent Automation & Soft Computing 2023年第9期37卷 2941-2954页

作者： Seungmin Lee Hyunghoon Kim Haehyun cho Hyo jin Jo Department of Software Soongsil UniversitySeoul06978Korea

Modern vehicles are equipped with multiple Electronic Control Units(ECUs)that support various convenient driving functions,such as the Advanced Driver Assistance System(ADAS).To enable communication between these ECUs,the Controller Area Network(CAN)protocol is widely ***,since CAN lacks any security technologies,it is vulnerable to cyber *** address this,researchers have conducted studies on machine learning-based intrusion detection systems(IDSs)for ***,most existing IDSs still have non-negligible detection *** this paper,we pro-pose a new filtering-based intrusion detection system(FIDS)to minimize the detection errors of machine learning-based *** uses a whitelist and a blacklist created from CAN *** whitelist stores the cryptographic hash value of normal packet sequences to correct false positives(FP),while the blacklist corrects false negatives(FN)based on transmission intervals and identifiers of CAN *** evaluated the performance of the proposed FIDS by implementing a machine learning-based IDS and applying FIDS to *** conducted the evaluation using two CAN attack datasets provided by the Hacking and Countermeasure Research Lab(HCRL),which confirmed that FIDS can effectively reduce the FP and FN of the existing IDS.

关键词： Controller area network machine learning intrusion detection system automotive security