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Consecutive occurrence of benign epilepsy with centro-temporal spike and childhood absence epilepsy: true coexistence or atypical evolution?

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World Journal of Pediatrics 2018年第4期14卷 410-411页

作者： eun hye Lee Hoi Soo yoon Department of Pediatrics College of MedicineKyung Hee UniversitySeoulKorea

We read with great interest the recent review of benign epilepsy with centro-temporal spikes (BECTS) and child-hood absence epilepsy (CAE) by Verrotti et al. (1)BECTS and CAE are the most common epilepsy syndromes in childhood and share certain clinical features: similar age at onset, overall good prognosis, and genetic predispo-sition. Several studies have reported the coexistence of the two syndromes, and recently, Verrotti et al. analyzed 19 cases reported to have clinical features of CAE and BECTS. Among the total 19 cases, three cases had fea-tures of both syndromes contemporarily;three cases expe-rienced absence seizures initially followed by BECTS;and the other 13 cases experienced BECTS at onset and had absence seizures later.

关键词： Consecutive occurrence benign epilepsy centro-temporal spike childhood epilepsy true coexistence atypical evolution

Epidemic obesity in children and adolescents:risk factors and prevention

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Frontiers of Medicine 2018年第6期12卷 658-666页

作者： eun Young Lee Kun-Ho yoon Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Korea Institute of Catholic Ubiquitous Health Care The Catholic University of KoreaSeoul 06591Korea

The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity children adolescents epidemiology risk factor prevention

Sargassum horneri extracts loaded nanostructured lipid carriers:Preparation,physicochemical properties,and in vitro antioxidant activity studies

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Food Bioscience 2023年第3期53卷 2812-2824页

作者： hye-yoon Yi Ji-Yeon Chun Department of Food Bioengineering Jeju National UniversityJeju63243South Korea

This study tried to establish optimal conditions for Sargassum horneri extracts loaded nanostructured lipid carriers(SHE-NLCs).Therefore,we observed various physicochemical analyzes,sugar and phenolic contents,and anti-oxidants while storing the SHE-NLCs for 28 days at different SHE addition amounts(0%-0.5%)and storage temperatures(25 and 65℃).All SHE-NLCs stored at 25℃ showed a small hydrodynamic diameter(20.1-25.4 nm)and high encapsulation efficiency(64.1%-89.3%)for 28 *** the amount of SHE increased,the pH and electrical conductivity of SHE-NLCs significantly decreased and increased,respectively(p<0.05).Also,at 25℃,prevented a sharp decrease in the total phenolic content and antioxidant activity of SHE-NLCs as the storage period increased compared to 65℃.SHE 0.25%loaded NLCs can stably maintain the formulation structure for 28 days at room temperature while being an amount sufficiently containing the functionality of SHE.

关键词： Sargassum horneri Nanostructured lipid carriers MCT oil Storage stability Antioxidant activity

Metabolic relationships between marine red algae and algae‑associated bacteria

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Marine Life Science & Technology 2024年第2期6卷 298-314页

作者： Kyung Hyun Kim Jeong Min Kim Ju hye Baek Sang eun Jeong Hocheol Kim Hwan Su yoon Che Ok Jeon Department of Biological Sciences and Biotechnology Hannam UniversityDaejon 34054Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Republic of Korea

Mutualistic interactions between marine phototrophs and associated bacteria are an important strategy for their success-ful survival in the ocean,but little is known about their metabolic ***,bacterial communities in the algal sphere(AS)and bulk solution(BS)of nine marine red algal cultures were analyzed,and Roseibium and Phycisphaera were identified significantly more abundantly in AS than in *** metabolic features of Roseibium RMAR6-6(isolated and genome-sequenced),Phycisphaera MAG 12(obtained by metagenomic sequencing),and a marine red alga,Porphyridium purpureum CCMP1328(from GenBank),were analyzed ***6-6 has the genetic capability to fix nitrogen and produce B vitamins(B1,B2,B5,B6,B9,and B12),bacterioferritin,dimethylsulfoniopropionate(DMSP),and phenylacetate that may enhance algal growth,whereas MAG 12 may have a limited metabolic capability,not producing vitamins B9 and B12,DMSP,phenylacetate,and siderophores,but with the ability to produce bacitracin,possibly modulating algal *** CCMP1328 lacks the genetic capability to fix nitrogen and produce vitamin B12,DMSP,phenylacetate,and *** was shown that the nitrogen-fixing ability of RMAR6-6 promoted the growth of ***-pureum,and DMSP reduced the oxidative stress of *** metabolic interactions between strain RMAR6-6 and *** CCMP1328 were also investigated by the transcriptomic analyses of their monoculture and *** together,potential metabolic relationships between Roseibium and *** were *** study provides a bet-ter understanding of the metabolic relationships between marine algae and algae-associated bacteria for successful growth.

关键词： Metabolic relationship Marine red algae Symbiotic bacteria Roseibium Phycisphaera Porphyridium

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

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Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim Hyun-Ju Park Hyo Won Chang Ji Hyun Back Su Jin Lee Yae eun Park eun hye Kim Yeonsun Hong Gijung Kwak Ick Chan Kwon Ji eun Lee yoon Se Lee Sang yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells

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Chinese Journal of Natural Medicines 2020年第2期18卷 114-122页

作者： Lee Jong-eun yoon Sung Sik Lee Jae-Wook Moon eun-Yi Department of Bioscience and Biotechnology Sejong UniversitySeoul 05006Republic of Korea

Glioblastoma is the deadliest neoplasm with the worst 5-year survival rate among all human *** promotes autophagic cell death or blocks the induction of apoptosis in eukaryotic ***,we investigated whether varying levels of autophagic flux in glioblastoma lead to different efficacies of curcumin treatment using U87 MG and A172 human glioblastoma *** number of LC3 puncta,the number of cells with LC3 puncta and the level of LC3 Ⅱ,Atg5 and Atg7 protein were higher in U87 MG cells compared with A172 *** the cells were incubated with curcumin for 24 or 48 h,the percentage of cell death was higher in A172 cells compared with U87 MG *** the level of LC3 was lower,that of curcumin-induced LC3 was higher,in A172 cells than in U87 MG *** relative increases in cell death and LC3-mediated autophagy were greater under serum starvation in A172 cells compared with U87 MG ***-induced A172 cell death was reduced by serum *** both types of cells were transfected with LC3-GFP,the percentage of cell death was higher in A172 cells than that in U87 MG *** together,the data demonstrate that curcumin-mediated tumor cell death is regulated by the basal level of autophagic flux in different glioblastoma *** suggests that prior to the use of various curcumin therapeutics,the level of basal or induced autophagic flux should be carefully examined in tumor cells for the best efficacy.

关键词： Glioblastoma A172 U87MG Autophagic flux Curcumin

The effectiveness of emotion-focused art therapy on the resilience and self-image of emergency physicians

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World Journal of Emergency Medicine 2022年第6期13卷 479-484页

作者： Soo Kyung Eo Chanwoong Kim Kyung hye Park eun Kyung Eo Graduate School of Art Therapy at CHA University Pocheon 11160Republic of Korea Department of Emergency Medicine Chung-Ang University College of MedicineSeoul 06974Republic of Korea Department of Medical Education Yonsei University Wonju College of MedicineWonju 26426Republic of Korea Department of Emergency Medicine Wonju Severance Christian HospitalWonju 26426Republic of Korea Department of Emergency Medicine Soonchunhyang University Bucheon HospitalBucheon 14584Republic of Korea

INTRODUCTION Resilience refers to the quality of being able to overcome adversity.[1]Studies conducted in the United States[2]and China[3]following the 2019 coronavirus disease(COVID-19)pandemic reported reduced resilience levels among medical *** resilience levels are associated with low burnout levels among residents.[4]Physician burnout affects patients’safety and quality of care.[5]In particular,emergency physicians(EPs)are more prone to exhaustion or poor resilience,as their turnover intention tends to be higher.[6]Therefore,improving EPs’resilience is imperative.

关键词： image physician overcome

Recent aspects of ketogenic diet in neurological disorders

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Acta Epileptologica 2021年第1期3卷 134-140页

作者： hye eun Kwon Heung Dong Kim Department of Pediatrics International St.Mary’s HospitalCatholic Kwandong UniversityCollege of MedicineIncheonSouth Korea Division of Pediatric Neurology Severance Children’s HospitalYonsei University College of Medicine50 Yonsei-roSinchon-dongSeodaemun-guSeoulSouth Korea

The ketogenic diet(KD)is a high-fat,low-carbohydrate diet,in which fat is used as the primary energy source through the production of ketone bodies(KBs)in place of *** KD was formally introduced in 1921 to mimic the biochemical changes associated with fasting and gained recognition as a potent treatment for pediatric epilepsy in the *** clinical and basic scientific knowledge that supports the anti-seizure efficacy,safety,and feasibility of using the KD in patients with epilepsy is ***,the International Ketogenic Diet Study Group’s consensus guidelines provide practical information in 2009 and *** KD is a broad-spectrum therapy for drug resistant epilepsy and is gaining attention as a potential therapy for other neurological *** article will review recent aspects on the use of the KD,including its mechanisms of action,KD alternatives,expanding its use across different age groups and regions,its use as a treatment for other neurologic disorders,and future research subjects.

关键词： epilepsy disorders neurological

Prognostic value of single-nucleotide polymorphisms for extranodal natural killer/T-cell lymphoma:the identification of risk factors in the molecular era

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Cancer Communications 2021年第11期41卷 1232-1233页

作者： Sang eun yoon Won Seog Kim Division of Hematology-oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea

Extranodal naturalkiller/T-cell lymphoma(ENKTL)is a distinct subtype of non-Hodgkin lymphoma(NHL)with aggressive clinical course and is closely associated with Epstein Barr virus(EBV)infection[1].Due to the unique feature that majority of ENKTL patients have involvement of the upper aerodigestive tract(UADT),the commonly used international prognostic index(IPI)system for NHL is not applicable for ENKTL as most of the patients would be divided into the low-risk group[2].Thus,an optimal prognostic system for ENKTL remains *** models particularly constructed for ENKTL have been reported and several potential risk factors such as regional lymph node involvement,nasal type disease,primary tumor invasiveness,and EBV-DNA,were identified as independent prognostic factors[3–5].

关键词： involvement killer lymphoma